Search results:
General Information
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 22631637 | 2012 | Cell line : - Source : Affiliated Cancer Hospital of Zhengzhou University. Sample Type : CRC tumor and normal tissue No. of Sample : 66 Stage : TNM Stage I-IV | Immunohistochemistry, chi-square test or Fisher's exact test,Kaplan-Meier analysis and Cox regression analysis. | Down-regulation | - | The ATF1 protein expression was significantly lower in tumor tissues than corresponding normal tissues.Higher ATF1 expression is a predictor of a favorable outcome for the overall survival and progress free survival in CRC. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | basic leucine zipper proteins |
| Description | This gene encodes an activating transcription factor, which belongs to the ATF subfamily and bZIP (basic-region leucine zipper) family. It influences cellular physiologic processes by regulating the expression of downstream target genes, which are related to growth, survival, and other cellular activities. This protein is phosphorylated at serine 63 in its kinase-inducible domain by serine/threonine kinases, cAMP-dependent protein kinase A, calmodulin-dependent protein kinase I/II, mitogen- and stress-activated protein kinase and cyclin-dependent kinase 3 (cdk-3). Its phosphorylation enhances its transactivation and transcriptional activities, and enhances cell transformation. Fusion of this gene and FUS on chromosome 16 or EWSR1 on chromosome 22 induced by translocation generates chimeric proteins in angiomatoid fibrous histiocytoma and clear cell sarcoma. This gene has a pseudogene on chromosome 6. [provided by RefSeq, Aug 2010] | Chromosome | 12 |
| Location | 12q13 |
| Start | 51157789 |
| End | 51214943 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 57155 |
| OMIM ID | 123803 |
| HGNC ID | HGNC:783 |
| Unigene ID | Hs.648565 |
| Ensembl ID | ENSG00000123268 |
| PharmGKB ID | PA25083 |
mRNA Information
| mRNA ID | XM_011538387.1 |
|---|---|
| Exon | join(1..32,16431..16529,32200..32300,45747..45880, 50301..50483,50571..50730,55926..57458) | mRNA Sequence | Download Select all |
| Length | 2242 |
Protein Information
| Protein ID | XP_011536689.1 |
|---|---|
| Protein Name | activating transcription factor 1 |
| Molecular Wt. (Da) | 29101 |
| Protein Sequence | Download Select all |
| Length | 271 |
| Uniprot ID | P40692 |
| Ensembl Protein ID | ENSP00000231790 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| S | Phosphorylation | 36 |
| S | Phosphorylation | 63 |
| S | Phosphorylation | 63 |
| S | Phosphorylation | 63 |
| S | Phosphorylation | 63 |
| S | Phosphorylation | 63 |
| T | Phosphorylation | 183 |
| S | Phosphorylation | 198 |
| S | Phosphorylation | 186 |
| T | Phosphorylation | 197 |
| T | Phosphorylation | 188 |
| S | Phosphorylation | 47 |
| S | Glycosylation | 189 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 672 | BRCA1 | 218 | NP_009231.2 | in vitro;in vivo;yeast 2-hybrid | 10945975 |
| 1390 | CREM | 444 | NP_853549.1 | in vitro | 12805554 |
| 1459 | CSNK2A2 | 279 | NP_001887.1 | in vitro;in vivo | 9685505 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Aldosterone synthesis and secretion | hsa04925 |
| HTLV-I infection | hsa05166 |
| Transcriptional misregulation in cancer | hsa05202 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd14690 | 215-269 | bZIP_CREB1 |
| cl21462 | 215-269 | bZIP superfamily |
| pfam00170 | 216-268 | bZIP_1 |
| smart00338 | 214-263 | BRLZ |
| cd14686 | 216-263 | bZIP |
| pfam02173 | 50-83 | pKID |
| cl03479 | 50-83 | pKID superfamily |
| cd14687 | 215-265 | bZIP_ATF2 |
| cd14691 | 213-263 | bZIP_XBP1 |
| cd14811 | 216-257 | bZIP_u2 |
| cd14704 | 216-262 | bZIP_HY5-like |
| cd14699 | 215-263 | bZIP_Fos_like |
| cd14709 | 215-263 | bZIP_CREBL2 |
| cd14700 | 216-264 | bZIP_ATF6 |
| cd14706 | 222-268 | bZIP_CREBZF |
| pfam07716 | 215-264 | bZIP_2 |
| cd14809 | 213-261 | bZIP_AUREO-like |
| cd14689 | 214-260 | bZIP_CREB3 |
| cd12193 | 214-263 | bZIP_GCN4 |
| cd14696 | 215-264 | bZIP_Jun |
| cd14812 | 216-255 | bZIP_u3 |
| cd14810 | 216-264 | bZIP_u1 |
| cd14702 | 223-267 | bZIP_plant_GBF1 |
| cd14694 | 222-264 | bZIP_NFIL3 |
| cd14688 | 215-265 | bZIP_YAP |
| cd14707 | 215-261 | bZIP_plant_BZIP46 |
| cd14692 | 215-263 | bZIP_ATF4 |
| cd14722 | 215-263 | bZIP_ATF3 |
| cd14710 | 219-266 | bZIP_HAC1-like |
| cd14703 | 219-263 | bZIP_plant_RF2 |
| cd14697 | 213-263 | bZIP_Maf |
| cd14698 | 213-267 | bZIP_CNC |
| cd14693 | 209-264 | bZIP_CEBP |
| cd14701 | 215-263 | bZIP_BATF |
| cd14695 | 219-264 | bZIP_HLF |
| cd14721 | 215-262 | bZIP_Fos |
| cd14708 | 219-263 | bZIP_HBP1b-like |
| cd14719 | 219-264 | bZIP_BACH |
| pfam03131 | 213-259 | bZIP_Maf |
| cd14813 | 215-263 | bZIP_BmCbz-like |
| cd14713 | 209-264 | bZIP_CEBPG |
Ontology Information
| HPRD ID | 2533 |
|---|---|
| Molecular Class | Transcription factor |
| Molecular Function | Protein serine/threonine kinase activity (GO:0004674) |
| Biological Process | Cell communication (GO:0007154); Signal transduction (GO:0007165) |
Drug Information
| Uniprot ID | DrugBank ID | Name | Type |
|---|---|---|---|
| P18846 | DB00852 | Pseudoephedrine | SmallMoleculeDrug |