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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
ATF2 1386 activating transcription factor 2  2TREB7, CRE-BP1, HB16 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
23077639   2012Cell line : SW620, HT29, HCT116, Colo 320, MCF 7

Source : ATCC

Sample Type : -

No. of Sample : -

Stage : -

Western Blotting ,Cell Viability Assay,Flow CytometryUp-regulation-Ad�(ST13)�CEA�E1A(?24) caused cell apoptosis through P38 MAPK (i.e. P38) which upregulated CHOP and ATF2 expression


Gene Details



NC_000002.11 (175936978..176032934, complement)

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Gene Type protein coding
Gene Family basic leucine zipper proteins
Description This gene encodes a transcription factor that is a member of the leucine zipper family of DNA binding proteins. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions This protein binds to the cAMP-responsive element (CRE), an octameric palindrome. It forms a homodimer or a heterodimer with c-Jun and stimulates CRE-dependent transcription. This protein is also a histone acetyltransferase (HAT) that specifically acetylates histones H2B and H4 in vitro; thus it may represent a class of sequence-specific factors that activate transcription by direct effects on chromatin components. The encoded protein may also be involved in cell's DNA damage response independent of its role in transcriptional regulation. Several alternatively spliced transcript variants have been found for this gene [provided by RefSeq, Jan 2014]  
Chromosome 2
Location 2q32
Start 175936978  
End 176032934  
Strand -  
Gene Sequence

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Length 95957  
OMIM ID 123811   
HGNC ID HGNC:784   
Unigene ID Hs.592510   
Ensembl ID ENSG00000115966   
PharmGKB ID PA25084   

mRNA Information


mRNA ID NM_001256092.1
Exon join(1..157,17049..17147,31721..31795,38000..38069, 49838..49956,50089..50217,53339..53517,54099..54213, 56553..56639,70614..70763,74940..75146,87442..87547, 93372..95957)  
mRNA Sequence

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Length 4096  



CDS Information


   
Location377..1720
CDS Sequence

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CCDS ID CCDS2262.1



Protein Information


      
Protein IDNP_001243021.1
Protein Nameactivating transcription factor 2
Molecular Wt. (Da)47882
Protein Sequence

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Length 447  
Uniprot IDP16234
Ensembl Protein ID ENSP00000257290  



Post-translational Modification Information (Source : HPRD)


Residue Type site
SPhosphorylation112
TPhosphorylation69
TPhosphorylation71
SPhosphorylation90
TPhosphorylation69
TPhosphorylation71
TPhosphorylation73
TPhosphorylation116

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

                                                                                                                                       
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
367AR2437NP_000035.2in vitro9920921   
1050CEBPA296NP_004355.2in vitro;in vivo;yeast 2-hybrid913   973   914   734   562   
1457CSNK2A1277NP_001886.1in vitro9685505   
1459CSNK2A2279NP_001887.1in vitro9685505   
4683NBN4050NP_002476.2in vivo15916964   
8349HIST2H2BE3494NP_003519.1in vitro10821277   
8433UTF111964NP_003568.2in vitro9524124   
11016ATF76968NP_001123531.1in vitro12805554   
23054NCOA65599NP_054790.2in vitro;in vivo1   473   456   211   302   750   


Pathway Information


                                                                                                                        
Pathway Name Pathway ID
Adrenergic signaling in cardiomyocytes hsa04261
Alcoholism hsa05034
Aldosterone synthesis and secretion hsa04925
Amphetamine addiction hsa05031
cGMP-PKG signaling pathway hsa04022
Cocaine addiction hsa05030
Dopaminergic synapse hsa04728
Epstein-Barr virus infection hsa05169
Estrogen signaling pathway hsa04915
Glucagon signaling pathway hsa04922
Hepatitis B hsa05161
HTLV-I infection hsa05166
Influenza A hsa05164
Insulin secretion hsa04911
Longevity regulating pathway - mammal hsa04211
MAPK signaling pathway hsa04010
PI3K-Akt signaling pathway hsa04151
Thyroid hormone synthesis hsa04918
TNF signaling pathway hsa04668
Viral carcinogenesis hsa05203


Structure Information


No matching records could be found.

Domain Information




ID Location Description
cd14687354-414  bZIP_ATF2
cl21462354-414  bZIP superfamily
cd1219265-102  GCN4_cent
cl1709765-102  GCN4_cent superfamily
smart00338351-414  BRLZ
cd14686353-406  bZIP
cd14699354-412  bZIP_Fos_like
cd14692352-415  bZIP_ATF4
cd14696353-413  bZIP_Jun
pfam00170353-412  bZIP_1
cd14722354-415  bZIP_ATF3
cd14704355-404  bZIP_HY5-like
pfam07716348-404  bZIP_2
cd14705351-409  bZIP_Zip1
cd14721354-415  bZIP_Fos
cd14688350-412  bZIP_YAP
cd14690354-407  bZIP_CREB1
cd14691352-409  bZIP_XBP1
cd14700361-402  bZIP_ATF6
cd14809353-399  bZIP_AUREO-like
cd14706352-408  bZIP_CREBZF
cd14810353-405  bZIP_u1
cd14812359-395  bZIP_u3
cd14695353-410  bZIP_HLF
cd14709359-409  bZIP_CREBL2
cd14693350-409  bZIP_CEBP
cd14697355-416  bZIP_Maf
cd12193350-412  bZIP_GCN4
cd14689355-409  bZIP_CREB3
cd14710361-406  bZIP_HAC1-like
cd14701352-409  bZIP_BATF
pfam03131343-410  bZIP_Maf
cd14712344-412  bZIP_CEBPB
cd14708354-398  bZIP_HBP1b-like
cd14811355-389  bZIP_u2
cd14713349-410  bZIP_CEBPG
cd14813353-406  bZIP_BmCbz-like
cd14703362-406  bZIP_plant_RF2
cd14717354-409  bZIP_Maf_small
cd14719352-412  bZIP_BACH
cd14694353-410  bZIP_NFIL3
cd14718353-410  bZIP_Maf_large
pfam09770133-357  PAT1
PHA03247115-447  PHA03247
PRK14951202-330  PRK14951
PRK12727187-412  PRK12727
pfam0510966-351  Herpes_BLLF1


Ontology Information


   
HPRD ID3954
Molecular ClassTranscription factor
Molecular FunctionCatalytic activity (GO:0003824)
Biological ProcessMetabolism (GO:0008152); Energy pathways (GO:0006091)  



SNP Information


View SNP Geneview Report   

Drug Information


Uniprot ID DrugBank ID Name Type
P15336DB00852PseudoephedrineSmallMoleculeDrug

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO