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General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| ATG5 | 9474 | ATG5 autophagy related 5 homolog (S. cerevisiae) | 6 | ASP; APG5; APG5L; hAPG5; APG5-LIKE |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 21664058 | 2011 | Cell line : - Source : - Sample Type : - No. of Sample : 45 gastric, 45 colorectal, and 45 hepatocellular carcinomas and protein expression in 100 gastric, as well as in 95 colorectal and hepatocellular carcinomas Stage : - | SSCP and Immunohistochemistry | Down-regulation | - | ATG5 somatic mutation in 45 gastric, 45 colorectal, and 45 hepatocellular carcinomas and protein expression in 100 gastric, as well as in 95 colorectal and hepatocellular carcinomas were identify. Two somatic missense mutations of ATG5 gene in the coding sequences p.Leu112Phe and p.His41Tyr were detected. Somatic mutation and loss of expression of ATG5 gene might play a role in gastrointestinal cancer pathogenesis by altering autophagic and apoptotic cell death. |
| 22993366 | 2012 | Cell line : - Source : - Sample Type : - No. of Sample : 40 patients CRC Stage : - | Immunohistochemistry | Down-regulation | - | ATG5 is strongly down-regulated in colorectal cancer. Increased ATG5 expression is associated with lymphovascular invasion. ATG5 could be a potential prognostic or diagnostic biomarker. |
| 19197948 | 2009 | Cell line : - Source : - Sample Type : - No. of Sample : 32 gastric carcinomas with high MSI (MSI-H), 13 gastric carcinomas with low MSI (MSI-L), 43 colorectal carcinomas with MSI-H and 15 colorectal carcinomas. Stage : - | SSCP | Mutation | - | Frameshift mutations in ATG genes with mononucleotide repeats are common in gastric and colorectal carcinomas with MSI-H. these mutations may contribute to cancer development by deregulating the autophagy process. Analyse the mononecleotide repeats in ATG2B, ATG5, ATG9B and ATG12 in 32 gastric carcinomas with high MSI (MSI-H), 13 gastric carcinomas with low MSI (MSI-L), 43 colorectal carcinomas with MSI-H and 15 colorectal carcinomas. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | - | Chromosome | 6 |
| Location | 6q21 |
| Start | 106184476 |
| End | 106325820 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 141345 |
| OMIM ID | 604261 |
| HGNC ID | HGNC:589 |
| Unigene ID | Hs.486063 |
| Ensembl ID | ENSG00000057663 |
| PharmGKB ID | - |
mRNA Information
| mRNA ID | NM_001286111.1 |
|---|---|
| Exon | join(1..295,9555..9720,77577..77671,123732..123849, 139145..141345) | mRNA Sequence | Download Select all |
| Length | 2890 |
CDS Information
| Location | join(9613..9720,17330..17457,32715..32793,45998..46160, 77577..77671,123732..123849,139145..139281) |
|---|---|
| CDS Sequence | Download Select all |
| CCDS ID | CCDS5055.1 |
Protein Information
| Protein ID | NP_001273035.1 |
|---|---|
| Protein Name | ATG5 autophagy related 5 homolog (S. cerevisiae) |
| Molecular Wt. (Da) | 32316 |
| Protein Sequence | Download Select all |
| Length | 275 |
| Uniprot ID | Q99814 |
| Ensembl Protein ID | ENSP00000263734 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 9140 | ATG12 | 8496 | NP_004698.2 | in vitro;in vivo | 1 248 261 111 825 910 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Longevity regulating pathway - mammal | hsa04211 |
| Longevity regulating pathway - multiple species | hsa04213 |
| Regulation of autophagy | hsa04140 |
| RIG-I-like receptor signaling pathway | hsa04622 |
| Shigellosis | hsa05131 |
Structure Information
No matching records could be found.
Ontology Information
| HPRD ID | 2474 |
|---|---|
| Molecular Class | Cytoskeletal protein |
| Molecular Function | Transmembrane receptor protein tyrosine kinase activity (GO:0004714) |
| Biological Process | Cell communication (GO:0007154); Signal transduction (GO:0007165) |
Drug Information
No matching records could be found.