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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
AXIN1 8312 axin 1  16PPP1R49 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
10700176   2000Cell line : -

Source : Department of Gastroenterological Surgery, Kyoto University Graduate School of Medicine or Municipal Ikeda Hospital.

Sample Type : CRC tumor

No. of Sample : 100

Stage : -

SSCP,Sequence analysis and Southern blotting ,ImmunocytochemistryMutation-APC, CTNNB1 or�AXIN1�mutation, suggesting that axin may be an effective therapeutic molecule for suppressing growth of hepatocellular andcolorectal�cancers.

14566817   2003Cell line : -

Source : Xijing Hospital, the affiliated hospital of the Fourth Military Medical University, China.

Sample Type : CRC tumor

No. of Sample : 54

Stage : -

SSCP,PCRPolymorhpism-Found 3 silent mutations, 6 missense point mutations in different functionally important regions.

21541676   2011Cell line : -

Source : -

Sample Type : Tumor tissue

No. of Sample : 50 tumor and adjacent normal tissue

Stage : -

 DNA sequencingPolymorhpism-Axin 1 and Axin 2 gene mutations have been found to be involved in the development of colorectal cancers, it seems to be a relatively rare event in Kashmiri population.In exon 1c of Axin 1 a SNP was detected at codon D726D (GAT>GAC) at a frequency of 62.5% (31/50).


Gene Details



NC_000016.9 (337440..405244, complement)

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Gene Type protein coding
Gene Family Serine/threonine phosphatases / Protein phosphatase 1, regulatory subunits
Description This gene encodes a cytoplasmic protein which contains a regulation of G-protein signaling (RGS) domain and a dishevelled and axin (DIX) domain. The encoded protein interacts with adenomatosis polyposis coli, catenin beta-1, glycogen synthase kinase 3 beta, protein phosphate 2, and itself. This protein functions as a negative regulator of the wingless-type MMTV integration site family, member 1 (WNT) signaling pathway and can induce apoptosis. The crystal structure of a portion of this protein, alone and in a complex with other proteins, has been resolved. Mutations in this gene have been associated with hepatocellular carcinoma, hepatoblastomas, ovarian endometriod adenocarcinomas, and medullablastomas. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]  
Chromosome 16
Location 16p13.3
Start 337440  
End 405244  
Strand -  
Gene Sequence

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Length 67805  
OMIM ID 603816   
HGNC ID HGNC:903   
Unigene ID Hs.592082   
Ensembl ID ENSG00000103126   
PharmGKB ID PA25195   

mRNA Information


mRNA ID ?NM_003502.3
Exon join(1..84,6292..6440,46815..46955,51429..51525, 57057..57194,63247..63776,64272..64442,67780..68010, 71891..72058,73250..74058)  
mRNA Sequence

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Length 2518  



CDS Information


   
Location172..1836
CDS Sequence

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CCDS ID CCDS10405.1



Protein Information


      
Protein IDNP_003493.1
Protein Nameaxin 1
Molecular Wt. (Da)71028
Protein Sequence

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Length 862  
Uniprot IDQ9Y6L6
Ensembl Protein ID ENSP00000256958  



Post-translational Modification Information (Source : HPRD)


Residue Type site
KSumoylation857
KSumoylation860
KSumoylation821
SPhosphorylation614
SPhosphorylation614
SDephosphorylation222
SDephosphorylation222
SPhosphorylation77
SPhosphorylation77
TPhosphorylation213
TPhosphorylation213
SPhosphorylation217
SPhosphorylation217
SPhosphorylation493
SPhosphorylation493
YPhosphorylation148
TPhosphorylation160
YPhosphorylation148
TPhosphorylation160

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

                                                                                                                                                                                                                                                
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
324APC1439NP_000029.2in vivo;yeast 2-hybrid112   975   469   734   785   
1452CSNK1A12739NP_001020276.1in vitro;in vivo1   188   439   517   318   170   
1454CSNK1E2919NP_001885.1in vitro;in vivo;yeast 2-hybrid1   148   757   812   000   790   
1499CTNNB1286NP_001895.1in vitro;yeast 2-hybrid12   000   790   104   881   000   000   000   
1855DVL13220NP_004412.2in vitro;in vivo;yeast 2-hybrid94   827   341   033   040   300   000   000   
1856DVL23690NP_004413.1in vivo10829020   
3728JUP1414NP_002221.1in vitro;in vivo10488109   
4041LRP54616NP_002326.2in vivo11336703   
4087SMAD23221NP_005892.1in vivo11438668   
4088SMAD34380NP_005893.1in vitro11438668   
4092SMAD74241NP_005895.1in vitro;in vivo16601693   
5516PPP2CB1487NP_004147.1in vitro;in vivo9920888   
5527PPP2R5C3385NP_002710.2in vivo10698523   
8125ANP32A9014NP_006296.1in vitro;yeast 2-hybrid16169070   
10813UTP14A6712NP_006640.2yeast 2-hybrid16169070   
54778RNF1119318NP_060080.6in vitro;in vivo16601693   


Pathway Information


                                          
Pathway Name Pathway ID
Basal cell carcinoma hsa05217
Colorectal cancer hsa05210
Endometrial cancer hsa05213
Hippo signaling pathway hsa04390
Pathways in cancer hsa05200
Signaling pathways regulating pluripotency of stem cells hsa04550
Wnt signaling pathway hsa04310


Structure Information


No matching records could be found.

Domain Information




ID Location Description
cd0870789-209  RGS_Axin
cl0256589-209  RGS superfamily
cd11582Nov-80  Axin_TNKS_binding
cl16934Nov-80  Axin_TNKS_binding superfamily
pfam0061588-210  RGS
pfam00778783-862  DIX
cl02426783-862  DIX superfamily
smart0031588-210  RGS
smart00021780-862  DAX
cd0744093-209  RGS
cd0871389-209  RGS_RGS3
cd0871292-209  RGS_RGS18
cd0871789-209  RGS_RGS5
cd0871589-208  RGS_RGS1
cd0870689-209  RGS_R12-like
cd0874662-207  RGS_RGS20
cd0874585-207  RGS_RGS19
cd0874189-209  RGS_RGS10
cd0871885-207  RGS_RZ-like
cd0872392-209  RGS_RGS21
cd0870992-209  RGS_RGS2
cd0871184-209  RGS_RGS8
cd0871092-207  RGS_RGS16
cd0874381-209  RGS_RGS14
cd0871489-209  RGS_RGS4
cd0874485-207  RGS_RGS17
pfam08833464-496  Axin_b-cat_bind
cl07441464-496  Axin_b-cat_bind superfamily
cd0871698-207  RGS_RGS13
cd0870584-207  RGS_R7-like
cd0873984-209  RGS_RGS9
cd0874084-207  RGS_RGS11
cd0872192-207  RGS_AKAP2_2
cd0874292-209  RGS_RGS12
cd0872293-209  RGS_SNX14
cd0873098-286  RGS-like_3
cd0872993-208  RGS_PX
cd0874798-212  RGS_GRK2_GRK3
cd0872092-207  RGS_SNX25


Ontology Information


   
HPRD ID6147
Molecular ClassAdapter molecule
Molecular FunctionMolecular function unknown (GO:0005554)
Biological ProcessBiological_process unknown (GO:0000004)  



SNP Information


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Drug Information


No matching records could be found.

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO