CoReCG

Search results:

General Information

Gene_Symbol	Gene_ID	Gene_Name	Chromosome	Alias
B4GALT1	2683	UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1	9	beta4Gal-T1

Evidence
Gene
mRNA
CDS
Protein
PTM
Enzyme
PPi
Pathway
Structural
Domain
Ontology
SNP
Drug
External Links

Evidence Information

Pubmed ID	Year	Sample Information	Techniques	Mechanism	Fold Change	Remark
22927297	2012	Cell line : - Source : - Sample Type : CRC tumor and Normal tissue No. of Sample : 130 colorectal adenocarcinomas, 13 adenomas, and in paired normal tissue Stage : TNM Stage I-IV	Methylation specific PCR	Methylation	-	Glycogene B4GALT1 represent a valuable candidate biomarker of invasive phenotype of colorectal cancer. B4GALT1 methylation is a frequent and specific event in colorectal cancer and correlates with downregulation of mRNA expression.

Gene Details

Chromosome 9 - NC_000009.12 (33110637..33167358, complement)
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Gene Type	protein coding
Gene Family	Beta 4-glycosyltransferases
Description	This gene is one of seven beta-1,4-galactosyltransferase (beta4GalT) genes. They encode type II membrane-bound glycoproteins that appear to have exclusive specificity for the donor substrate UDP-galactose; all transfer galactose in a beta1,4 linkage to similar acceptor sugars: GlcNAc, Glc, and Xyl. Each beta4GalT has a distinct function in the biosynthesis of different glycoconjugates and saccharide structures. As type II membrane proteins, they have an N-terminal hydrophobic signal sequence that directs the protein to the Golgi apparatus and which then remains uncleaved to function as a transmembrane anchor. By sequence similarity, the beta4GalTs form four groups: beta4GalT1 and beta4GalT2, beta4GalT3 and beta4GalT4, beta4GalT5 and beta4GalT6, and beta4GalT7. This gene is unique among the beta4GalT genes because it encodes an enzyme that participates both in glycoconjugate and lactose biosynthesis. For the first activity, the enzyme adds galactose to N-acetylglucosamine residues that are either monosaccharides or the nonreducing ends of glycoprotein carbohydrate chains. The second activity is restricted to lactating mammary tissues where the enzyme forms a heterodimer with alpha-lactalbumin to catalyze UDP-galactose + D-glucose <=> UDP + lactose. The two enzymatic forms result from alternate transcription initiation sites and post-translational processing. Two transcripts, which differ only at the 5' end, with approximate lengths of 4.1 kb and 3.9 kb encode the same protein. The longer transcript encodes the type II membrane-bound, trans-Golgi resident protein involved in glycoconjugate biosynthesis. The shorter transcript encodes a protein which is cleaved to form the soluble lactose synthase.
Chromosome	9
Location	9p13
Start	33110637
End	33167358
Strand	-
Gene Sequence	>gi\|568815589:c33167358-33110637 Homo sapiens chromosome 9, GRCh38.p2 Primary Assembly GCGCCTCGGGCGGCTTCTCGCCGCTCCCAGGTCTGGCTGGCTGGAGGAGTCTCAGCTCTCAGCCGCTCGC CCGCCCCCGCTCCGGGCCCTCCCCTAGTCGCCGCTGTGGGGCAGCGCCTGGCGGGCGGCCCGCGGGCGGG TCGCCTCCCCTCCTGTAGCCCACACCCTTCTTAAAGCGGCGGCGGGAAGATGAGGCTTCGGGAGCCGCTC CTGAGCGGCAGCGCCGCGATGCCAGGCGCGTCCCTACAGCGGGCCTGCCGCCTGCTCGTGGCCGTCTGCG CTCTGCACCTTGGCGTCACCCTCGTTTACTACCTGGCTGGCCGCGACCTGAGCCGCCTGCCCCAACTGGT CGGAGTCTCCACACCGCTGCAGGGCGGCTCGAACAGTGCCGCCGCCATCGGGCAGTCCTCCGGGGAGCTC CGGACCGGAGGGGCCCGGCCGCCGCCTCCTCTAGGCGCCTCCTCCCAGCCGCGCCCGGGTGGCGACTCCA GCCCAGTCGTGGATTCTGGCCCTGGCCCCGCTAGCAACTTGACCTCGGTCCCAGTGCCCCACACCACCGC ACTGTCGCTGCCCGCCTGCCCTGAGGAGTCCCCGCTGCTTGGTAAGGACTCGGGTCGGCGCCAGTCGGAG GATTGGGACCCCCCCGGATTTCCCCGACAGGGTCCCCCAGACATTCCCTCAGGCTGGCTCTTCTACGACA GCCAGCCTCCCTCTTCTGGATCAGAGTTTTAAATCCCAGACAGAGGCTTGGGACTGGATGGGAGAGAAGG TTTGCGAGGTGGGTCCCTGGGGAGTCCTGTTGGAGGCGTGGGGCCGGGACCGCACAGGGAAGTCCCGAGG CCCCTCTAGCCCCAGAACCAGAGAAGGCCTTGGAGACTTCCCTGCTGTGGCCCGAGGCTCAGGAAGTTTT GGAGTTTGGGTCTGCTTAGGGCTTCGAGCAGCCTTGCACTGAGAACTCTGGTAGGGACCTCGAGTAATCC ACTCCCTTTTGGGGACTGACGTGAGGCTCCCGGTGGGGAAGGAGACTGACCTCTCGGTTCACGTGTCTTG CCATAGAGCCACTCTCCTGAGTGGGTTTTTCTCCTGATCGTTTGGGCCAAGTGACTTCTCTCTGAACCTC ATATTTCTCTTCTGGGATAATAAATGGTCACCCTTTCAAGGGGTTGTTTTGGAAGATATTGTGAACAATG GTAAATAAGGGCTTAATTAATGAGGGTAAGCCCTCAGTAAATTGTCACTGTGTGTTCATTTCTTCCTCTG TGTGGATCGTGACCGAGAGCCCTTCCCCCTAGCCTCCTCCTGGTATGGGTACCCAAAACCTAGGTGAGCA GGGATCTCTCCCAGGGGCAGAGAGCTTGTGTACTCTGGGTGTTAGAGGGCTAAAATATAACCAGTCAACA CCACGTTGCCCATTTCTGGTACTTCCGGTAGCAGCCTGAGTCTCAATTATCTTGCCCAGATGATCTGAAC TCTGACCTCTAGCCTGTTTCAGCATAGGCAGAGAGCTTGAGTAGGTGAGTTTGCATTCCTCATAGCAGCT GGCTGAGCCTAGTCTGGACTTCTCTTTGACCTGTAACCTACAGGCCCACAGGCCCAAGGCAACCACAGGT TGCTTCCAGGGTTACCACACAGGTGGTTTCTCATTTCTAATGCTAGGTTTTAGATAATTGTTGTAAGTGA GGGGCCCTGGCAGGCAGGATGACATCCTGCCAATAGGAGTTTTCTGTCACTTTCCCACAGAGCCCTGGCT ACTACATACTCTTGCTCAATTTCGCCAGTAATTGCGTCAATGTGTTCATATCAAGTTTGGGAAGAACATC TTGGAATTGGTCAGACGTGAACTGTGGTAATAATGGGGGCTTGTTTTTTTAAGCAGATAATTAAATTCCT TTGCATTTGATGATTATTCTGGGAAGCAGACTAGTCCCATAAAATGAAATGGACTCTGCCTTGCTGCTAA GTGTCTGACTTGAGACATGCTATCGAGTTTCTCAAAATCTCTTCCTTGTGTAAAATGTGGTTGTCGATGA TTACCTTACAGGGGTTTTTTTAAGACTAAATGAGATCGTGTACATTAAATACAGGCACTCAGGCTGGGCA TGGTGGCTCACGCCTGTAATCCTAGCACTTTGGGAGGCTGAGGGGAGTGGATCACTTGAGGTTAGGAGTT TGAGACCAGCCTGGCCAATATGGTGAAACACCATCCCATCTCTACAAAAATACAAAAAAGTTAGCCAGGG GTGGTGGCATCGCAGCTACTCAGGAGGCCGAGGCAGGAGAATTGCTTGAACCTGGGAGGCAGAGGTTGCA GTGAGTCAAGATTGTGCCAGTACACTCCAGCCTGGGCGACGAAGCAAGACTGTCTAAAAAAAAAAAAAAA AAAAAAAATACGGGCACTCAATACACCGTATAATAATAATATAGTAATAATATTTGCTTAGGATCTTTAA AAAGTTTCATTTTTTCAGACTCCCACAGAAATGGCTCTGCACAGCAGAGTGAAGGGGGAGAGAGACTGAG TCTCCAGGCCAGAAAAAGGCCAGGTTTTTTGCTTTTGTTTTTAGTTGTTGCCTGGATATTGCACAGAAAG AAAAAATAATTAGCAAGTTAAACAAAAGTACCGCAAAGTTGATTACATTGGTATTTGAGTATCACATCTT CTCTCAGAAGCGTAAGAGACAAGGTCGTGACCATACCTCTGCTTAGTTTTGTTTTGTAATGGTGTTGCTA GTGATCGGCTTGTCACCAGTTACTGGTGTTTCTAAATGGACTATAATTGGCTACTTGAAAGGACTTCCTG AGAAAGAACATTTTGGAGGACGAGGAGAGAGTGCCTTCTCTATTTTGGCTGCTTTCATGTGACATGCAAG AGACCATGACGTTTAGGCTGCTGCTGAGGCAGCCCCAGAAATGGGGGCCGAGAGGTCTTTTCTTCATTTT AATAGGGTCTGTAGGTTTGGGTGGTTAGGTACAGTTCTCAGAATGGAGGTTCCTGGCTATGAGGCCTTGA GAAAGCTGAAAGTCTCCTTGGGAGTGTGTGGGTGGGGGGAGTCGAGCCCATCTGTTCATGGGCAGGTGTC AGCCAAAGCCCTTGCGGGTGGTTTTGAGGTTGGTGGGAGAAAGCATCCGTGGGGTTTAGAGTTGTGGCCT TTTCACTACTTGCAGTTCCTTTCCCCGACTTGGCTTTACTTTCTGGTGTCCAGGGGTCTGGGCCAGATGC TGAGATTCCTCTCAGCTGACAGGTGTGGGTTATGGGCAAACCCTTCCCTGGAGGACATAAGGCACCGGAT TGGACTGCTGATGGGTTGCTGTTGGAGTTGTCAGGGCCTTGGAATAGTCTTCAGATAGACTTGGGTTAGT GTGACCTGGGGCAGGCTGCAGGTTTGGAGCCATAGTACCCCCCGCCCCCACACCGGGCACCCTGCTCTGG GCTAATGTGAGGCTTGCAGGAGTGAGTGATGCAGTGGGAAGGGGGGCCTTTCCTGAGGATTCTACAGCTT TCTCCAGGGAATCCTCCCAGGTAGTTTAGGCCTGCAGGTGCTATGCTATCCTTCTTTCCTAACCCTGTCT CAGGTCCTCAGCGGGGCCATGCGGCATCCACTTATAACCCTGCAGCGAGGCCCTCTTTTCTGGCCACCTG GGTGTTTGCCTGCTGAGATGGGAGGAACAGTGGCCTTGGGCTTCTTCCCCCGTCATGTTTATCTCTGCTC AGATTGGGCAGCAGCTCAATGGGACTTGACCAGCTGTGGCACTGCCAGTCTGAAGATGAGTAGGGTGATG GGGGGAGGTGGGCAGTACCTGAAGCTGAACTGGTGAGAGAGGCAGGCTGGCCTGGGGGCTCAGCTGGGGC CTGGGATGGTTGGTACAGTCCCCTCAGGGGGGTAGGGGAGTGAGTGTTAGACTGCTTAAGCCTCAGAGGC CGCTCTTGCCCACCTATGCTTTGAGGAGATCCTCTTCATTTGTTCAAAGGGAAGACTCTGATCTAGAGAT GGGCACTTGGACCAGCAAACAGCAGCTACAGGTAGCCAGGGCACCCGAGGAGCACTTGCTCATGAGCCGG TTTCCCTGGTTTTTATGGGGGCTGTTGCTGAGCGTCTGCCAGGGTTTGTGTCCTAGCACTTGCTGGTCTT TGCTGGGCTCTCAGCTCTCAGGTGTTTCTCTACCAGCACGTTTCCCCCTCCCTCATATGCACACATGTGG ACACAAGCAGGCTGCCCAGGACAGAGTGTACTTTGAGGCTTGGGAAAGGACTCTCTCTCGCCCTTTTGGG GATGAGCCTTGGAACCTCATCACCTTCCGGCTTGGGGTGGAGCTTCATCCTGGGGGTTGAAGCTTTAGGC TCAGATAACTAGTCTTGTAAGCCAGTTTTGTCCTGTTGTTTTTTTCGTGGAAAATAATGTATTGACGTAT ACACAGACATTCTTTGTCTAACAGTCTGAGATTGAGAAATACCCTCCATGACTATTTGGTTTGCTTTCAT GGTGAAACTTGGTCGCTTTCTTAGACACAGCCTATGGCAATAAGAGTGATCCCTGGCTGCTGTAATTCAT TCCAGACTTTGAGCAAACACAAGGCACCGCCTCCACCTGCAGTGGAGCCTCTGATGAACCAAATGGAAAC TCCTTGGGGAATGGGGAGTAAGAGCCAAATGTGGGATTGGACTTAAACTGCAGCTTCTTAGAACTGTAGC ATTCCACGATGGGATTGTCTAGTGCTCTTCCTGGAGGTTACTATTCAATAGTTGGCTAGTGCACAGGTTC AGGGGTGACCTGATATGCCCTAGCGTTTCAGAAGATCCCTGCAAGGTGTGTCTTTTGGTCCATCTGAAGG GTCTTGTATGGTGATCTTGTATGGATATCCGTGACGGCTAAGGCATCTGATAACTTCATTCCTTCAGTTC CAGCAGTGTTCCTGTATTATGCTGGGCACTAGAGCTACAAAGAAGAAAACAAAGTGCCTCCTCTTCAGGA ACTCTTAATTTAGGCAGGGGAGGCATAATTGAACAGTGCTGAGGTCATCTAGGGGAACCAAAGTGTGTAT TTATCCCCTTCCCTATCACTCCCCTCCCTCCTTCATTTCTTCCTTTCTTCTTTCAGAAACTCCAAGTTCA TATCAAAATTCTCCAGCCCTGGTTTTATTTGGTTGTGTGAAAATTTTCCTCTAATTTCTGAAGCTATGCA TTAGTTCTGCTGAGTAATCTTTAACTTGCTGCTTTATAATGATTATAATGAGATATCACTGGGTATTATG GTCTTTGGGTAGCAGCAGGGTAGGGATTTCCAGGCTGGGACTAAGCTAATTTATGGGTTGGGAATTATGG GGCAGTTAATAGCAAGGCAGTCCAAGCTTTCCACAGATTCCACCCTAGGGACCATCCAGACTTAAGGAAC AGGGCCGGCAGGCTCATCCCCTTTGCACTCAGCTGGGCTATGGGTGTGTGTTTGTGAAAGAGGTTTATTC AGTAGTCATACCTGCTGATTTCCCTGCTATCTGTTTACCCAGTGCCTCCTGTACCTTGTTTCTTACTCTT TGTTCTCTGCTCTTACTATGAAGAAGCAGAGACTGGAATTCTGCTTGAACCCACATCTACCTGGAAATTC CAGTTTTTCTTGTCCAGTGGAGCAGCAATCCAGTTGTTTTAGGACAAATGGTCTGCCCTTGAAGCTTAAA TCCTTTGAGGGCCTGGCATGGTGACAGTTTTACATTTGGCTTTGGTATAGACTGGTGTGGTCCCTGGGCA GTGAGGTCACTGTAAGGCCAGCCAGCCAGACCCTGGCTCCTAGGGGAATTAACAAGGCATGGGATTAGAC TCACAGGGTCCCTCCTGTCCCTAAACTTGGTAGGGGTTCCTGGGAGCCAGACTGCGATTAAGATTGTAGA GACCTGAGACCTGAGTTGTAGGGGCCTCTGTGTTGATCTGGGCCATTGCCGGGTGAGCTGAGGCGGTCAC TAGCTCAAGGAGTGATCTCAGGATATTGTTCTGTAAGTCAGAGACCTCCAGGTTGGAGAGTGGGGCTTGG GGGTGGGGGACAGGGTTTAGTGGGGAGCTGGTTCTGGGTGAATGTGGCCTAAAGGGATTTGTCCTTAGAA GACAGAGGGGTGAGTCACACACTCAGTGCTTCAGGTTCCACTTTGCGGCTTGGCCTCAGCCCGCCCCTTC CCTGCACAAATGAAGGCCAGGGGCTATATAATTGGCTGTTGCTGAATTCTTTGGCAGTGATTTTAAAGTC TGGTCTGGGTGTGTTATGTAGCTGCTTCTCTATCCACTCCCCACACCCGCTGCTTCTCCAGAGCCCCTCA CAAAGCCCAGGCAGAGAGAGAGAGAGAGAGAGAGAGAATGACTTGCCTCACAGAGATGTTGGGGATAGGG ATAGGGGTATGGGTCTTTGCTTTTGCCTTTTGAGGGGGGATAATCTCTTCCTTCATTTTAAAAGTAAAAA GTAATGCAGGCTCATTGAAAATAATTTGAAAAGTTGAAAGAGATATAAAAGCACACCCAAATTCCTATCA CCCAAAAGAAACATACCGGCATATTTCCTACTAGTCTTTTTCATGTTTAAGAATATAGCTGATATATTTT TTTTTCTTTTTCTTTTTGAGACAGGGTTTTTGCTCTGTCACCCAGGCTGGAGTGCAGTGATCACGGCTCA CTGCAGCCTCGACCTCTCGGGCTAAGCGATTCTCCCACTTCAGTCTCCCGAGTTGCTGGGACCACAGGTG CACACCGCCATGCCTGACTAATTTTTGTATTTTTTGTAGAGATGGGGTTTTGCCATGTTGCCTAGGCTGG TCTCGAACTCCAGAGCTCAAGTGATTCACCTGCCTTGGCCTCCCAAAGCGCTGGGATTATAGGTGTCAGT CACCACACCCAGTGTTATAGCTGTTGTCTTTATAGATGAACAGATAGATTGACATAGATTCATGTAGATA GCCTGGTGTTCAGCATTTTTCATTTAAGATTCTGTCACAGACTTGACCCTATACCTTTAAAAATCACAAA GGCAGTATCATAGTCTGTCAGCTGAATATGCCATAACTTAAAAAAATCATTCAACTGTTGCTGAACACAC ACATATACATATATAGTTTTTGTTTTTTCTTAGTGATGTAGTGATGCTTGTGCAGAAAGCTTTATGTACT TTTTGGATGGTTTCTGTAGGAGAGCTTTCTAAAAAAGGAAAAAAAGTGTTGAATGTTTTTTGAGAAGGGC TAGATTTTCAAGCCAGTCTTACAAAAGGATAGACTCATTGGAAATTCCAGATTTGCTTAGTGCTGGCAGA TGAGTATCACTTATTGCTGAACAATGTGTCTAGAATTCTGATTAAAAAAGAAACTAGGTCCAGGAAGTGC CTGGGGGCAGGGGCAAAGGGCCAGGCTGCAGGATAGGCTCTTAGGATCTGGCTGAGCAGAAATCTGCTGT GAACAGAATCGGTGGGGGTGATGCTTTCTCAGTAACTTCTCCATTTGTTTCTTTAGCAGCTAAGTCCCTG TGCTGGACTTCTGTGGACTACTGTGGCTCTGGGGCTGTGGTTGTGGGTGAACAACAGCTAGCTAAACCAG TGCTGTTGACATCATTGAGATGTGACGCACAGGAAGGTGGGAGCAAGCTTGCAAATCAGATTCTGAAACA TATAGCACAGCTCTCCCACCTCCAGGTGGTCCTGAGATCTAGGGAGGAGCCATAGTGAGAAACTTTAGGT TTCTAGGAATTCTCTTAGGGAGAAGCTCTCTTAGGGAGAGGCAGAACCTGGTTCTCAGTTGGGGCTGATT CAGGTGGGTTAGATCAATAAAGCCTCAGGCCAGTGTGCCAGGCTATTCCCAAGGAGTATACTTTGAAGTT ACTCCCTTTAGAATGTCCTCAGTGGAGATAAATTCTCTCTGAGGAGCAGTTTTGTCTGCCGGGGTCATTT GGCACAAAGCCTGGAGTGCTAGGGCGAGGTTGCACTGAGGGAAGGGGCAGGATTATGTCAGCAGTGTGAC GGATACAGTGTGAGGTCAGGCTCCTTCCTGCCCCACCACGGGGGCCTAGAGGTCATGGGGAGGGTCCCTG GCAGGGGATTCAATCATTGCTTGGCCCCATGACAGAGTATATTCTAAAAATGCCTTAAGTTTTTTTCTTT CAAAGTTTCTTCCTGTTTTGCATAATGGCCTTTTGCCTTTGACATCCTGAAACCGCAGAGCTGTCATTGG TGTTGCAGGACACTGCCAGCTTGAAAAAAATCAACAACAAAAAAAGAAACAGGAAAGGATGTGGAGTTCA GGGTGCGGCCTAGGGAAGCTGGTATTTGCGTTATGGGATTGTGGGGATGTGGTATTAAGGTGTTGGGTAG CGCCTGACATTTAGAGGAGTACTCTGGGCAGAGTCCCTGCCTGCCCAAGAATAGGTAGAATTGAGTCTTC ACACCAAAGTCAGGAGAGACCCCCTCCCCCCAGGAAGAGAATGAACAGGGACTCATTTCCTCATTCAGCA AACTTTTATTGGTAACTACACTATATGAAGTGTGAGAGATAGACATGAACAAGAGAGGCCCCCACTCTTG GGCAGTCCCTTAGTAGTAGTAGATAGACTCTGGCAATATGGTGTGGTCAGAGAGAGGAAGCCTGGGTGCT TTGAGGGTACTGAGGAGGTGCAGGGAGCCAAATGGGTGGTCTGGGCCAGGGCCAGAGTCAGAATGAAGGA CCTCTCTTCCAGACGTTGATTTTAGCATCTCTGTCTCTCAGTATGTTTGAACAGTCTCCCTTATTGGAAG GGCAGGAGTCTACTGCTAAAAGTAACCTGCGATTTCCTCTACTTGCTGTCATGTGGAAAGAATACTAAAG CTGAAATTCCAAAAGTTGCACACCTTTACCAGCAGGGCAGGAGAGGAAAGGAAATGGAGGCAGAGTGAGC TGAAGATGATAAAAGAAAGAGAAGGTGGTGCAGTTTGGACTGTTATGGACAGAGGAAGTCTGAGGGTAGC TGGACTGAGGGATCAAAGGGAGGCAGTTGAAAGGGAAGAGAGCTGCAGAGAGGGATTTCTTGGTCTGCAG AGGGTAGGAGCAAGCCTTGAAGGCTGCTGGAGTGAGGATTCCGAGCCCTGGTCTTTATTCTTTTTCTAAT TCATTACATCATTTTAGGCAAGTCCTAACTCCTTTGGTCTCTGTTGTCTTTCTGAAATTTGAGTGGGCTG GGCCTGCTGGTCTTTAGCCTCTGTCTTTCTCTACCTCCTAGATTCCAGTTTGGCGAGTGGGGGGGAAAAC CTGGTTGTATATGCAACGTGAAAGGCCTCTGGAATTCCTTTTGAAGCTCACTACCCATGAGGCTTCTGCT AAGGATTTCATCATGTCTGTCTAAGCAGACATAAAAATTTTAGCAGGTGGATGACCCGTAGAAATGGCAC AAGGAATGTTTCTTTCTGTCACACTGTGGTATTTGATTTAAGAAAGTTGTTATCCTCTCTGTGCCTCAGT GTTCTCACTTGTAAAATGGCAATAACAGTATCCACCTCATAGATGTTATGAAATACAGGTAGTAGCCACG AAAGGGCTTAAAACAGTGCCTAACACAGAATAAGTTGTGAATATATGTTATTTATTATTGGTAGTATAAT GCTTATTTGTGAAGATTTTGGCTTTTGCTTTATAGGACCTTTTTTTTTTTTAGTTGAAAATACAATGTTA CCATGTTAAATGTTAAAAAAAATTCTACTTACCATTGTAACAGAACATGCTCCCACTTCTGTAACAGAGC TTGCTATTACTTTTCAAATGCATACATATTCCAATGCATATATTCCAATGCAGTTGTAGAGTGAAACTGT TTGCATGCAGCCATTTTTATCCAACATTATCTTATAAAATGTTATGTTGTTTATGATTATCCTAATTATC TTTTGTTGCTGTCTAGTATCCTTATAGATATTCCATTAGCATACACTATTCCAGGTTTCACTATCGTCGA TAATCTAGATATGAACATTTTTGTAGTGTGTAGCTCTTTGCTTCAGTTGAATTACTTTCCTGGGATAAAT TCCTGGGGAAGAATTTCTAGGCCAGAGGATATGGTCATCTTGACAATACTGATTCACATTGCTGCATTGC TTTCCAAGAGGTTTGGAATCATTCACAGGTTCTAAATTGGAAAATCCTGGCTTTTGAAGTATGTGGATTC TAAGGGCGATTTGGATCTAGCTGGAGCCTCACACTGACACTTCCAGCCAGTGTGTGTGTGTGTGTGTGTG TGTGTGTGTGTGTGTGTAGTTCCCTATGCTGGACACCGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTG TGTGTAGTTCCCTATGCTGGACACCATGTGGCCTTTCTGGACATTAGGGTTTTCCTGTGATTGCCTCAGA GCAGTTCCTGTTGAATTCACTCTGTGTCCACAAAAGGAGCCTTACTGTGGCTCTTTCAACACCCACCTAC CTTTGCCAAGTTGGTTTACAGAAAGTAAGAACATTCTTTCCTTCTTCCTTGATATGTGGCGCTAAACCTA TAGCATGGGGCAGGCTCTGGCTTTAAAAACCTGACTTAAAAATAATGGTGTTGATCAAAAAGTTTGTGGA TCAGTTTTTGGAAACACTGCATGTAGCCATCCATAGAAACTTATATTCTGTTGGGCTAGCCTGGGCGCCT GATCATTTAACTCATGTGGATGAACTTCTATGTAATAGCCCTGGTGTATGGGATCCAGAAACAGGGCCCT AATGAAGAAAGGCTTTTAAATTATGTTGGATAAAAATAAGTTGTTACAATAGCCCAAAGTCTGCAAATAT GAATTGCCAGTTCTGTCCTTGTAGTCATCCACCATGTGCCTGCATCTTTTGTAGACTCTTGTAGATTCAG AAGCCCACTGAATTGCATAAATGATGGAATGATTTTAGACTTAGTGATTTCAGTGACTAAAAGTTTACAG ATCCTGGCCGGGCACAGTGGCTCACACCCGTATTCCCAGCACTTTGGGAGGCCGAGGTGGGTGGATCACC TGAGGTCAGGAGTTTGAGACCAGCCTGGCCAACATGGTGAAACCTTGTCTCTACTAAAAATACAAAAATT AGCCGGGTGTGGTGGCATGCACCTGTTGTCCCAGCTACTTGGGAGGCTGAGGTGGGAGAATGGCTTGAAC CTGGGAGGCGGAGGTTGCAGTGAGCCCACATCAGGCCACTGCACTCCAGCCTGGGTGACAGAGTGAGACT CTGTCTCCACCTCCCCCGCCCCCCGAAAAAAAAAAAAGTTTACAGATCCAGCAGATGGGGCATATTCAAT TTGTGACAGCCACTCCCTTCACCTTATAGCTATGTCATATGTCTTCTTCTCCTTTGACTGCATTCTGCAG CAGTCAGTTGTGACTTAATATGGCACTCTGGGCCCACTGAATTAGGTCAGAGCTGCTAGTAGTATATTGT TCCTAGAGACCTAGGGCAAGATTTTCTTACTACATAAAATGAGGGAGATAATTTCTTACCTCAAGATGTT GGTAAGAGGAGTGAATGAGGTTAGTTATATGGTAATATCAGTACTCTGAATGTCTTTTGATCAATGCCTA ACTCATCTTCTTGGGCACAAAAGGCATACAGTCAGCACCCTTAGGCCACATATAAAATTCCTCCAAATGC AGGTTTTCATCTGCCTTGGGGCAGAGTCAAGAGAAAGAAGAGGAAGAGGCGTGAGGCTCTGACCACAACT TAGGGACAGAATATAGCCCAAAGCGAGTACCCCAGGCCACAAGGAGAAGGCCGCTATCTTGTTGAATCCA CAGCACTGGAAACTTGGAGTGTGTGTTCCCCTGTGTCAGTTACACTGGAATTTTATGGCTGCTCACATTC TTCCCTTCAGGTGGACGTTGTTCATCAGTATCCTGGGCAAGAGGCCATCATAAACCACAGACAGCTGAGT GATTAGGAAGAGGAGCTGAAGAGGGAGCATTAGATGTTTGATTGAGTCTTAGGTGAGAAAGTATATCATT AAAACAAAAAGATAGATGTAGGCGGGCTCAGTCTTGTGTGCCTGGTGTGTTGGTAGAAAAACTAAAGCAC AAGCCTGTAGATAACCTGCTTTATTCTACCTCGGGGCTGGTGTTGGAATCCAGGATGCCAGACCCTAAAG TCCAGCTCTCTTTCCAACCTACTGAATAATCCGAGAGAAATCATGTTCTCTCTCTGGGCCTCAGTTTGCC CATGTATAAAATGAGATGAAGGATTGGCTGGGATGCTCTCCAGAGTCTCTTCCTGCCTGGAGTTCTGACG TAGCCATGTACTCCTGCTCAGCATCGCTAAATGGCTTTGTGGTAGGACCATTGAGTGCTGCCTCCATTAG GGCCAGCTATGTAATGCTGGGGTGGCTGTCACTGGGCCCTAAGAGCCAGGATTGGTCTTACTGGAGAAAT CCACATCCACCTAAACTTAAGACCCAGGGGTGTCCAATCTTTTGGCTTCCCCAGGCCACACTGGAAGAAG AATTGTCTTGGACCGCATATAAAATACACTAATTATAGCCGATGAGGTTAAAAAAAAAAAACTCAATATT TTAAGAGAGTTCATGAATTTGTGTTGAGCTGCATTCAAAGCCATCCTGGCCGCATGTGGCCCATGGGCCA TCGGTTGGACATGCTTGCTTTAGACCTCCCAGCAATTCTAGTCTCTAAACAGGAAATCAAAAGTCAAGAT GAATAGATAAGTTGGTCAGTGTGAAAAAGTAATTGGTGGGAGCCACTGTAGATGCAGGGTTCTAGGCTCC ATCAACAACCACCTACATCACTGAACGAAAGATAATGCTTGTTCAGCACTTATTACATGCCAACCATGGT AAAAATACTTCAGATGCATTGTTTTCATGAACTCTCACAGCAGCTCTTTTTCTTGCCTAAATGCCCCGTT AGAACCTCCAGTACAATGTTAAATAGATATGCTAAGAGACAACATATGTGTCTTGTTAGGGGGAAAATAT CCAGTCTTTGACTATTAAGAATGGTGTTAGCAGTGGGTTTTTCCTAGGTGCCCTTTATCAGGTTGAGGAA GTTCCTTTCTATTCCTGGTTTGTTGAGTATTTTTATCATGAAAAGGTGATGGGTTTTGTCAAATGCTTTT CTGTGTCTGTTGAGATGATCATGTTTTTTTGTCATTTATTCTATTGATATGGTATATTATACATTGATTT TTCAGATATTAATCTTGCATACCTGGGATAAATCCCACTTGGTCATGGTGTATAATTCTTTTTATTTGTT GCTGGATTGAGTTTGCTAGTATTTTGTTGATTTGTATTCATAACAGATAGTGGTCTGTAGTCTTTCCCTC CCTCCCTCCCTCCCTCCCTCCCTCCCTTCCTTCCTTCCTCTCTCTCTCTCTCTCTCCCCTCCCCTCCCTT CTTTTCCCCTCCTCTCCCCTCCCCTTCCCTTTCTTCTCTTTCATAGTTGTTTACCACTGTCAGAAAAGGT CTGTTCGTTTTCTTTCGTCGTGAGATCTTTGTTTGGTTTTGGTATCAGGGTAATACTGCCTCAAAAAATG AGTAGGGAAGTGTTCCTTCCTCTTCTGTATTTTGAGAGAGTTTGTGGTCGGTTTTTATTAATTCTTCTTT AAATATCTGGTAGCGTTCACCAGTAAAGCCATCTGGGCCTGATGTTTTCTTTGTGGAAAACTTTTTGATT CCTAATTCAGTTTCTGGTTATAGGTCTATTCAGACCTTCTATTTTTTCTTAAGTCAGTTTTGATAGTTTG TGTCTTCCAAGGAGTTTGCTTCATCTAAGTCATCTAATTTGTTGGCATACATTTCATAGTGATTCCTTAT GATCCTTTTTATTTCCGTTAAAGTTGGTGTAGGGATAGTCCCTCTTTCATTACTGATTATAATAATTTGA ATTTTCTTTTTTTCTTAGTCTTGCCAAAAGCTTGTCATTTTTATTGATCTTTTCAGAGGACCAACTTTGA GTTCATTATTTGTTCTCTTTGTTCTTATTTTTCTGCTTCATTAACTTCTCTAATCTTTATTCTTTCATTC TGCTTGCTTTTGGTTAAGTTTGCTTTTTCTGGTGTCTTAAGGTAGAAGGTTAGGTTACTGATTTGAGATT TAAAGATCATGCTCTTTAAACGTTTTGATAGATACTGTCAGTTTGCCCTCTGGCTTTTTCTCATTAACAG TGTATAGGAGTGCTTATTCCTCACACTCATACCAGCCCTGGGTGTTACTAACCTTTATATATTTGCCAGT ATCATATTCAGACATAGTATCTTGTTTTAATATGTTTCTCTGATTACTGATGAAGTTAAGCAAATTTTCA CGTGTTTATTGGCCATCTGTCTTTCTTTTTTCATCCTTTCTTTCAAGATGGGAGTCTTTGCCATGTTGCC CAGGCTGGACTCGAACTCCTGGGCTCAAATGATCTTCCTGCCTCAGCCTCCTGAGTAGCTGGGACTATAG GCGTGAGCCACCATGGCTGGCTTGCCCATTTGTATTTCTTATGTGAGTATTTTTTCTTTTTTTTTGAAGT GGAGTCTCACTCCATCCCCCAGAGTGGAGTGCAGTTGTCCGATCTTGGCTCACTGCAACCACCGCCTCCC AGGTTCAAGTGATTCTCACACCTTAGCCTCCCAAGTATCTGGGACTATAGGTGTGTGCCACCACACCTGG CTAATATTTGTATTTTTAGCAGAGATGGGGTTTCACCATGTTGGCCAGGCTGGTTTCAAACTGGCCTCAA GTGATTCACCTGCCTCGGCCTCCCAAAGTGCTGGGATTACAGGTGTGAGCCACTGTGCCCAGCTGACTTT TTTTTTCTTTTTTTTAACCCTTTTTTTTTTTTACCCTTTTTTTGGCCCATTTTTTTTTACCCTTTTTCTT TTAACCCATTTTTCTATTAGTTTTAAAAATATGTTTGCAGGAGCTTTTTATATTGTGGATTTTTCTTGTT TATTACATATCATTTGTAAATATGGTCTCTCCATCTGTCACTCTTCTTTATCTCTGGTTTCTTTAGCTAT GTAGAAGTTGTTATGTTATGTTATGTTATGTTATGTTATGTTATGTTATGTTATGTTATGTTATGTTATT TTTTGGAGAGGGAGTCTTGCTCTGTCGCCCAGGCTGGAGTGCAGTGGTGAAATCTCGGCTCACTGCAACC TCTGCCTCCTGGGTTCAAGCGATTCTCCTGCCTCAGCTTCCCGAGAAGCTGTGATTACAGGCACCCGCCA CCACACCCAGCTAATTTTTGTGTTTTAGTAGAGACGGGGTTTCACTATGTAGGTCAAGCTGATCTCAAAC TCCTGATCTCAAATGATCCTCCCAAAGTGCTGGGGTTACAGGCGTGAGCCACTGCACTCGGCCAGAAGTT TTGAATTTTTATGTGTTTAAATCTATGTTTTCCTTTATGACTTCAGGTTGCTTTCATACTTAAGCAGGTC TTCACCATCCCAAAATGATAAAATTTTTCTCCTGAGTTTTCTTCTAAGTTGGTTCTTTAGAAGCCACCAA CTTGGCTTCGACAGCAAAAGATGAACAGAATTTCTGTTCAACTCTCATGCTGCAAGAAGCTTTATGTAAT ACTCCAGGGACCCTTTAAGGTCCCAGAGTTTTCCTCCAAATCTATCAGTGATTCTAGTGGCTAAGAGTAG AAATGTGAAAATTTAGCCATGTGTGCTGATAGAGCTGTAGTAATTTGTAAGCTCTGAAGTTCTAAGGAGT CAGGGGAGAAGGGAAAGTAACATTTATTGAACATCTATTAGCTCAATAAGAACATGCGATAAGTATGTAT ATGTATTATTTCACTTACATCTGAAAGGAAGGCATAATTATCCCCACTCCTTAGAGAAGGAAATTGGAGC TGGCTACATTTAAAGTAGTCCTGACACCAGAGAGATATTGCCAGGAGTACTTGGCTGGCTGAGTGCCCAG ATGGCCCATAGGAGTAGTGGGCCCTCCACAGTCCAAGGTCTGGTTCTAGGTGGAGAGAGAAGGATGTGCT CGTAGTCAGCACCGCAGCTCCAGAAAATCTGCTGGGGCTCCAAAACTGATTAGAGGGGCAGCTGACTCAG TAATAAAACTCCCAGGAGACTTACTTACATACTGGAATGCAAAGTTGCAGCTTTACTGGGAAGATTAGAA CTGTTATTGAGTAGCTTAGAAATCTCTGGCTGAATTCACTGCAAGGGAAGCCGCAGGATAAGCTAACTGC TGGTGAGTCAGCAGTCAGAGCAGGGAAGTGAATTTAACATTAGATGGGTCAGTCTCTCGTGGCTGATGAA TTCATCCCCACAATACTGTACACCTGCCTTAGGGACCTTTGTCTGGACTAGGGGTTGGGGTCCCCCTCCT TTGTACAGCCCTGGAAGGACACATCCAGCTCCATCCGCCATCTCTCCCTTACTTATTTCCTTCCTTCCTT CCTTCTTTCCATCCAGCCATCAAGCTTCCTTTCATGGCCAATAATCATCATTGGGGTCTACTCATGGACT CTCTTGCCTCATGTATTTGTTTTATTTTGTCCTCATTCCCACTTCTATTTCCCAGGTATATCACAGGCAA CTATTCTAACGTATTTATAGTTTGTGTATCTGTTTTTGCTCTTGCCAAAATGGAAGCCACTGCTTTATAC ATAGATGTATTCTTAACTTTAAAAAAAATTTTTTTAGATTAACCTACAATAAAATTGGCTTTTTGGCATA TAGTCTATAAATTTTAACACATACATATTTTTGTGTATCTACCACCACAATCAGGATACAGAACAGTTCC ATCACCCCAAAAAAATCCCTCTTGTAGTCACATTCTCCTCCCACCCTTAATCCCAGGCAACCACTGATCT ATTCTTCATTACTATTGTTTTGTCTTTTTGAGGATGTCACATAAATGGAGTCACACAGTATATATACATT TTTTTAAACATATGTAAATGGCATTTTATAGCTCATTTTGATTATATGTTTTTCATCCAGTTCTGTTTTT TTTTTTTATTTTTAAAAAGTTTGACATAACTTCAGACTTACAGAAAAGTTGTTAGACTAATACAAAGAAT TCCTGGATATCCTTTGGAGTCCCTAAATGTTAACATTTTACTATATTTACTTTTTCCTTCTCTCTCTCTC TCTCTCTCGCTCTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTATCTACCTGTAGATAGATAGATATT AATATAATTTTAGATAGATGTATCTAGATCTCTCTCTCTCATATATATGTGTGTGTGTATATATCTATAT CTATATCTATATATATCTCCTTTTACCCTTAAATATTCAGTGTATATTTCCTAACAACAAGGTGATTTAA AAATATATATATAAACATAGTATAATTAACAATCAGGACATCAACATTGAAACATTTCTGCTATGTCATC TACAGGCCTTAGGAAGACTTTGTCAGGTGCCCCAATAATAGCCTTGATGGTAGAAGAAAACCATGTGTTG TATTCAGTTGTCATGTCTCTTAGTGTCTTGTAATCTGAAATAATTCCCAAGCCCTTTGGATTTCATGACA GTGACATTGTTGAAGAGTACAGGCCAGTTATTTTGTAGAAGGTCTCTCAGTTTAGGTCTGTCTGATGTTT CCTCCTGATCAGATTCAGGTTATTCACTTTTGACAGGAATACCACTGAAATGATGCTGAGTTCTTCTCAG TGTAACGAGATCTAGAGACACACACTGTCAGTTTGTTCCTTATTGGCAGTGTGAACCTTGAGGATTTCAT TGTAGTGGCATTTGGCATTACTCCATTATAGTTACTATTTTACCATTTTAAATTAAAACTATCTGGCCGG GCGTAGTAGCTCATGTCTGTAATCCCAGCACTTTAGGAGGCTGAGGCGGGCAAATTGCTTGAGGTCAGAA GTTTGAAACCATCCTAGCCAACATAACATGGTGAAACGCCATCTCTATAAAAAATACAAAAAATTAGCCT GGCGTGGTGGCGCATTTGTAGTTCCAGCTACTCAGGAGGCTGAGGCACAAGGCTTGCTTGAGCCTGGGAG GCGGAGGTTGCAGTGAGCTGAAATCACGCCACTGCACTCTAGCCAGGGTGACAGAGTGAGACTCTGTCTC AAAAAAAAAAAGTAAATAAATAAAAAAATTTTTTAAGTATCTTATGGGCATATACTTGTCCTGTTACTCC TCAAACTTTCATCCACTTTTTTTTTTTTAAATTTTTTTTCTTACCTTTCATCGTTTTCTTGATATCCACT GGGTTTTAGCATCTACAAATGATTCTTGCCTGAATCAGTTATTATGGTAGTTGATGGTTTTCTAATTCCA TTATTCCTTCTATGTTTGTTAATTTTGGCATTCTTCTATAAGGAAGAGCTTACCCTTTTTCCCTATTAAT TAATTCATATATTAATGCAGACCTATGCATTCTTACTTCATTAAATCATAATCCTTTACTATCATTATGT ATTCTGATGTTCAGACTATCCCAGATTTAGCCAATAAGATCCCCTTCAGGGGAATGGTCTTTGGGATTCC TCTTTAGAGGTTCCTGGTTCCTGTTTTCTTTTGACATATCCTATTACTCTTTGAGCATTTTTTTTTTTTT TTTTACTTTTAGGCACAGCAAGAAGTTCCATGGTCCTCTTGTTCTTTCCCCAACTCAGCCCTAGAGTCAG TCACTTCTCCAATGAGCTCTAGTTCCTTTTAGTAGAGAATCATAATTAGAAAACAAGAATCAGTGCCAAG TGTGCACCTTTGTTTTTAAGGTCCATCCACGTTGCCGTGTATATGTCCAGCATGTTGATTCTAACTGCTG AATAATACCTCATGATTGTCATCCATCCCAGTGTTTCTTTTTCCCTTCTGTAATGAGGGACTCCTGGACT GCCTCCAGCATTACCTTCACAAATATTGCTGTGAGGAAAATCCTTAAACGTTTCCTTTATGGGCAACGTG TGAGCATGTTTATGTTGATTCAGGGGTGCCAGACACAGCTCCAGAATGGCTGCCTCAGTTTACATTTCCA CCAGCAGAGCATGACAGGCTCTGTGTCTCCGTGAATAATCAGCATTAACCAGCTTCCTATTTTTTGCCAA ACTAATAGATGTGCTAGGATAACTCTTTGTTTTAACTTGTTTTTCTCTGATTACCAATGAGCTGGAGCAT TTCTTCATATGCCTGATGGTCTTTGGGATTCCTCTTAGGTAAATTGCTTATTCATTATAATCCTTTGCCT GTTTTTCACTGGAGTTCTTATATTTTTCTTGAAGATATGCAGGAATTCCTTATACATCCTAGATATTAAT CCCTTCCTGGTCTCAGACATTGCAGATATCTTCTGAATCTGTTATTTACTTATTTATTTACAATTTTTTT TTTAAGAGTTGGGGTTTTGCTCTGTCACCCAGACTGGAGTGCAGTGGTATGATCATGACTCATTGTGGCC TCGCAATCCTGGGCTTAAGCGATCCTCCCACCTCAGCCTCCTGAGTAGTTGGGACTACAGGTATGCACCA CCAGACTTGGCTAATTTTATTTTATTTTTTAGAGATGGAAGTCTTAATATGTTGCTCAGGCCAATCTTGA ACTCCTGGCCTCAAGCAATCTTTCCACCTCAGCCTCCTGCATCTATTATATATATGTTCACTTTGCTCAT GCTGTATTTTGTTGCAACATAAAACTATTTTTCCCATTGTTTTGTGCAGTCTCTCACCAGCACTCTTCTT TTTCTGTAACTGTGTTAATGCCCTTTGTTCTTCCATATGTTAGGTATGCTGGTATAGTTGAACTCTGCTG ACTCTCCTCAGTAAACAGTCTCTTTTTATGACACCTTATCCTCTACTGAATTCTCTCTATCAAGAATGAC TTGGCCGGGCATGGGGGCTCATGCCTGTAATCCCAGCATTCTGGGAGGCCGAGGTGGGCAGATCACCCGA GGTCAGAAGTTCAAGACCAGCCCGGCCAACACGGTGAAACCCTGTCTCTATGAAAATACAAAAATCAGCT GGGCGTGGTGGCAGGTGCCTGTAATCCCAGCTACTTGGGAGGCTGAGGCGGGAGAATCACTTGAACCTGA GGGGGAGGTTGCAGTAAGCCGGGATGGCACATTGCACTCCAGACTGGGTGATGGAGAAACTCCATCTCAG GGGGAAAAAAAAAAAAAAAAAAAGAATGACTTGTCTTCCTCTTAGAGTGTGAGGTCTACATACAAATATT ATTCTTGTATTCAGCAAATGTATGTCATAGGCCTAGTGTGTGTTAGGAACTGTGCTGTCACCAACAAAGT TTAGAGAGGTTATAAAACTTGACTGTAGCTTTTTAGAGGTGGAGGAGTGATTTGAAACCTAGGCTGTAAT TCCTTCCTCCTGTGATTCCTTCCTACTGTGTTGCCTTCCCTTGAAAATTGCATTTGGGGGCCAGGTGTGG TGGCTCTCGCCTGTAATCCCAGCACTTTGGGAGGCTGAGGCGGGTGGATCACCTGAGGTCAGGAGTTCAA GACCAGCCTGGCCAACATGGCGAAACCCCGTCTTTACTAAAAATACAAAAATTAGCTGGATGTGGTGTGT GGTGACATGCACCTATATTCCCAGGTACTCAGTAGGCTGAGGCAAGAGAATCACTTGAACCCAGGAGGCA GAGGCTGCAGTGAGCTGAAATTGCACCACTGCACTCCAGCCTGAGTGACAGAGTGAGACTCTGTCTCAAA AAAAAAAAAAAGAAAAGAAAGAAAATTGCATTTAGTTCCTGTAGACTGTGTGTCAAATGTCTAAATCTCT TCTAACAAATGGCCTAAGGAGGTGCAAAGCGAAGCATCCTCACCAGCATCCTGACTTGGCAGTGAGGCAT GGGACCCTGGAGGGAGTAGTGGTAAGTGTGACTCTGGAATTCTTCCTGGGCTACTTGTCAGTGACTGGCT CCAGATTGAGAGGAGAGCCCAGAGGACACAGGTGGCTGCCCCAGCCTGGAGGTGAAAGTCTTAAAATAAA ATGCCAGATGCCTAGACCATTCTAAACCTTTCTGAGAAGCTGAAATCATCCCTTCTGGAAGCGCTCTAGT TCTAAAAGGACAGATATACAGCAAGATCTTCCTGGGGCTAATATGGAGTTTATAGGCAAGTAGGCCTCAG AACCTTTCCCTGGTAGTGATATCTGTGGGCAGGCACAGTTTCCACACTTTCCAGAAATTCCAGCGGAAGG AGTGAGAAGGAGGAATCTGCCCTTGAGTGAGGACCAAAGAAAGCAGAAATTCCTCTTGGGAATTTTTCCT CCAGAGACCAAACACTACTTGGGAGCTTGTTTACTGGGCTTTAAAAGCTTGTGACCCCCAGTCACTCTTT CTTGACCCCAAGGCTTTGCATTTCTGTGGCTTCCCCACTGGACAGAAGTGGAACTGTCATGCTGCCTGTT CTGGGGTCTCCCAGAGGTTTCCCCATGTCCTCTCCTTGCTTCTACTGCCCCACAGAATTGGGGATCTGTG ACCACATATGGTATAGAATTAATGCTTGAGAATGGTTTAGTTCAGTGATGTCAAATAAGATTCACTTTTA TGCCACCTCCATCAGTTGAAGGCCCCCCTGGCCCCTAAATTGGAAAAGATTCTGAGACAGAATCCCCGTG GGTACAGCGCAGGGACAGTAAAGGCACGTGTGCTGTGATTTGCTATCCACTGTGTGGATGCATCCAGGAA TATCAGAACCCTGGAAGATTATTTAAGGGGAAGTTAGGACAGCTTTTTTGCCAATCCAAGGGTGTTCTTG AGGAAGTCTGTCTTCCTGTATGGCCTTCAGTTTCTTTCCTGTGTAACCATGGGGCCAACACATAATTCCC ACAGCTCTATTGGCCCTTGTCTGCCAGGATTCTCTAGGGTCTGATTCGAGGTGGATCCTGGCCCTTTGAG GTGGCAGAATCTGATCATGGTGCTGTTTCCTTAGATTTAGGCCTTGATACCCTTGGCGAGAGCATCCTGG GCTGAGTGACCACCTGAGGTTTTTCTGGTGATTTTGTGACCCATGTAAAACTTTGAGCTTTGGGATTATT CTCTCAAGGAAATAGTGACATTTGGTGAAGAGCCTGTTTGGTGTGGCTATGTGAGGCTTAGCCAAGAAAA TGCACCATTTTTATTAGGAGGTTAGGCCATCCGTTGCCACAAAGTGTCAGATGCTAGGCCTAGAGCCTGG AGAAAACTTATTTTAAAATTGATGGGGTGCTGGAGGGGTTGGGGGGTGGTGGCTGTAGCTCATGAATCAG GTGCTAAACCTAGAAACAAAAGGCCTCATGTGGCAGACTGTTTCTGAGCACAGATGAATGGATGAGCAAC TGGCGCAACTTTGCCCAGTTGGTCCAGCTTCCCACTTGGCCACCTAGGCTTGCTGTGAAGACCTCGTCTG GCAGAAATGAGAGTGTTTTTGCCCCATCTTGATCTTAACTGTAATTTAAGACTAAAATCTTAGATTCTAA AACATCAAAGGCAAGATGGCTCCCAGCTCTGTGAGCTCAGCTTCTCACCTCTTAGTTGAACAAGTGCAGT GTGGGTCAATACATGATTGCTGCTCTTGCTGCCAGGAACTGTCCCAGCATAGAAAGGAATGGGACACAAT CCCTGCCGTCAAGATTCTAAGGGAGGAAGCAGGCAGGTCGACTGGTGCCTCATCTCTGCAGGGCTCCAGC CAAGGTTTGTGAAGGATTTTGCAGGCATATGGAGTGGGGACTGATTGATCCCGAGAGGGGACTGGGGAAA GCTCTGAAGAGGGGATGACATTTGGTTTGAACTCCAAAAAATGGTTGCTTTACCTGTTTCCTGAAGTTTT TGAGGTGGCTTATAAGAACATATACCATAAAAAGGACCAATATAAATTTAAAATCAGAAAAAGAGAAAAT GGGCTGGGCATGGTGGCTCATGCCTGTAATCCCAGCACTTTGGGAGGCCAAGGTGGGTGGATCGTGAGGT CAGGAGATCGAGACCATCCTGCCTGGCCAACATGGTGAAACCCCGGCTCTACTAAAAATACAAAAAATTA GCTGGGTGTGGTGGCACATGCCTGTAGTCCCACCTACTTGGGAGGCTGAGGCAGGAGAATCGCTTGAAAC CTGGGAGGCGGAGGTTGCAGTGAGCTGAGATCGCACCACTGCACTCCAGCCTGGGCGACAGAGTGAGACT CCTCCTCAAAAATAAATAAATAAAGAGAAAATGGAACTTAGAAAATTAAGAGGAAGAGTGAAAAGGTAGA TATTTAGTCAGGCACAGTGGCTCATGCCTGTAATCCCAACACTTTGGGAGGCCAAGACAGGAAAATCTCT TGAGACCAGGAGCTTGAGACTTGCCTGGCAACATCTCAGGTGAGACCTTATCTCTACAAAAAATTTAAAA ATTAGCTGAGCTGTGTGGCTCGTGACTGTGATCCCAGCTACTCAGGAGGCCGAGACCACAGCCCAGGAGG ATCGCTTGGGCCCAGCAGTTTGAGGCTGCAGTGAGCTGGCACCACTGCAATTCAGCCTGGGCTACAGAGC AAGACCCAGTTTAAAAAAAAAAAAAAAGATATTCAAACCATGGGTCCCAACGTAGTTATTATATTTGACC ATTTGCAAAAGCTGAAAGCAAAACATGTTACACATTTTCAGAGAGGAAAATACACAGTAGTTCCTGAGTG TAAGTTGTTTTTCTTGACCTCATTCTTAAATTGCTTCATGAGGGTGGGAGGGAAGTGGTAGTTAATAAGT GAACCTGTAAACCAGCGTTTCTCAAAATGTAGTCCAGGGAATTGCATCAAAATTGCAGTTACCTACAGTG CTTGTTAAAATGCAGATTCCTGGGCCCCTGCCCCAGGCTTATCAAATCAATCTGGTGAGTAGGACTCAAG AACCTGTAAATTCACATACTTCTGCAGATGATTCTTCTTGCACTGCACAGCATGAAAGCCTCTGCAATAG ACAGAAAGCTACCAGCATTGCGAAAGCAACTTGAGTGCTTGGCCTTTGAAGGTTGAGTGGGACTTTAATG AGGGAGAGAGTAAGGCATGAGAAATGGCAGTTCCACTGAGGTCAGTCAGTGGTTCATTGCTGACGAAGTC ACTTTTAAGTCATGTTTTAGAAGAACTACCAAGTGTGGCAGGTCAGGCATGTGGCAGGACTGTTTCTGAG CACAGATGAATGGATGAGCACCTGGCCCCACTGTGCCCAGTTGGTCTAGCTTCCCACTTGGCCACCTACG GTCTGCTGTGTGGACCTTGTCTGGCAGTCTCCTTTAATTTATTTTTTATTATTTTTTTCTTTTTGAGATG GAGTCTTGCTTTGTTGCCCAGGCTAGAGTGCAGTGGCATGATCTCGGCTCACTGCAGCCTCCACTTCCCA GGTTCCAGCGATTCTCCTGCCTCAGCCTCCCAGGTAGCTGGGATCACAGGCAAGTGCCACCACGCCCAGC TAATTTTTGTATTTTTAATAGAGACATGGTTTTACCATGTTGGCCAGGCTGGTCTCGAACTCCTGACCTC AGGTGATCCACCCATCTCAGCCTCCCAAAATGCTGGAATTACAGGTGTGAGCCACCGCACCTGGCCTATT TTTTTTCAGCAAATTCTTTGTTTTTCTCTCTGTTCCCAAATGCAGGGTACTGAGACCACAGATGTATTCT GTTTCCTGTTGAAAAAATGTTTCTCACTTAGCTGGGTGTGGTAGCATGCACTGCAGTCCCACGGGAGGCT GAGGCGAGAGGATTGCTTGAGCCCAGGAGTTCGATAATCATGCCATTGCACTCTGGTCTGGGTAACAGAG CGAGAAACTGTCTCTTAAAAAAAAGAAAAAGAAAAAGAGGTCCTAGGGAAAGAAACAAATAGTGGCTTGG ATGGTGAGTTGGTGGAAAGAACAGTGGGTGTTGGGGGTGTTGAACTTGTGTTTGTGTGTGGTGTACCCAA GACATATCATGTCAGCATTAAGAATAGACTATTCCTGTTTTCTGGTCACTGAGTTGTATGTTTTGACATC CTTATTTTGGAAGATACTTCCTTACTAGGAATGGGATAGGGAGGGGGTCACCTTTCCCATCTGTGGGTCA TATTTTAAAATATTTATTGTTCAAGTTTAAAGATATAACCAAAGGTATAAAGAAAAATACCACAAACATC TGATTTAAGAAACAAACCAGCCGAGCGCGGTGGCTCGTGCCTGTAATCCCAGCACTGTGGGAGGCCGAGG CAGGCAGATCATGAGGTCAAGAGATCGAGACCATCCTGGCCAACATGGTGAAACCCCGTCTCTACTGAAA ATACAAAAATTAACTGGTCATGGTGGTGTGTGCCTGTAGTCCCAGCTACTCGGGAGGCTGTGGCAGGAGA ATCGCTTGAACCCAGGAGGCGGAGGTTGTAGTGAGCCAAGATTGTGCCACTGCATTCTAGCCTGGCGACA GAGTGAGACTCCGTCTCAAAAAGAAAAAAAAAAGAAAGAAATCATTTCCTACACCTTCGAAGCCTTCATG AGTTAGATTTTGAAACAGTGCAAAATGCTTCACGTGAGAATCGAGAGTCCCTTCTGGTGGCTCTCCATCC CCTGCTCTTCTGTCAGGTTTTCTTGTAGGTTTATGGAAACCTTTGTTACTTGTGCAGGTGGCAGAGAAGC AGAGAGGATAGCTGCGCGCCACCCACACAGCTAGGATTTATTGGCGTACTCCCACGTGCATGGCAGCCAA GTGGACACAACTCTGTGATGAATCCTCCCAAGAGAACTGAGGGGCCCTGATGGAGGAGCTGCTTCTTTGC AAAGCTTTCCTTGACTCTCTTCCTGTCCCCTAGTTGATTCCCCTTCTGTGCTAGTTTTAGCTTATTGTTT GTTACCTGTCACACTTAGCAGTACTGTTGGCTTTGCTGGTCTCCTTGACTACTGGGGGTAAAGACCTTTT GTTGTTGTTGTTGAGACAGAGTCTTGCTCTGTCGCCCAGGCTGGAGTGCAATGGCGTGATTTCGGCTCAC TGCAACCTTCACCTCCCAGGTTCAAGAGATTCTCCTGCCTCAGCCTCCTAAGTAGCTGGGATTACAGCTA CACCACACCCGGTTAATTTTTGTATTTTTAATAGAGATGGGGTTTAGTAGAGATGGGGTTTCACCATGTT GGCCAGGCTGGTCTCAAGCCCCTGACCTCAAGGTGACCTGCCTGTCTCAGCCTCCCAAAGTGCTGGGATT ACAGACATGAGCCACCATGCCCAGCCTCAAAGACCTCTTCTTTACTTGCTCACCCTGCCGCCCACTCCCC TACCAACCCCTGCATGCCCTATACCACCTGGCACATGATACATACTAACTGGGTACATGTTTGAATATGA ATGGATGTGGTGCTGTGAATGCTTAGGGGAAGTGGGTGAAATGCTTAAGAACCAACCTTGAGTGGTCTGG GAAGGCTTCCTGGGAGGGTGGTGTTTGAGCTAAGGCCAGGCAGCTGTTAGATTTGTTAGACTGAAGCCCT TGCAGACTTAGAGAGCTTGTGCTCTTCCCAGAATGACGGGTGAGCCACGTACAGTAAATGGTGCTTCTCA TTTCTAGCCCAAGGGGCCTCAAGGGGCACCGTGATTTCACGAGAATGCTGCAAGCAAATCTTTTCTCAAG CTGGGGAATTTGGTGGTAATGCCTGGCTCAGCTTGCGGTGCGCACCTGGCCTTTGGAAGATTGGTACAGA GAGAAGCGGCCCATCCACATGAGCCTGTGGAACAGCACTGGTGGGGGAGCTGATTTGTGAAGAGGGGCTG TGCAGTGTACTGTCAGGTCTGAGACCCAGGAAGAAATTCCAGTATCCCAGCTCTCAGAATCACAGAGTTC TAGGCACTGCCTAGTTCCACGTGTTCCCAAATGTTTCCTGAATACTTGGATTTCCTGTCCAGAGAATTTT CAAAACAAACTTAGAGGCCTGACCCATGGCTGCCAAGGAAGGATTTTTTTTTTAAATTAAATTTTAAAAA TCAGTCCAGCATGAAAATCTATGATGATTTCATAAGAGAAAGGACATTTTAATATTCAAAGAGTAAGAAG CACTTAATCTTGGAAGAAAGGGCATTCCTATACTTTGATTACCTTTAGTTTAATTAAAAAACACCTACAT GGTCTTTACTTCTGTGATTTCATTCCTGGGCTAGTGAAACATTGTCACAATAAAGCATCAGGCCAACGCT TCTTTCGACCCACTGGCCAATCAGTTGACAAACAGTGACTAGATGTTTCAGCCTATTTTGCTGAGGCTAA AGGATTGAACTAGTGCTTCAGCCAGCATGAAAACCAGTCAGGAGTCCGTGCTGGTGTTGGCTTAGATTAG CAGGGCCTTTGATGGAGGGGCATGTATGTGTTTGGGTTTGCTGTGCCAGGCAGGGGAGCAGTGGAATTTG TCTGAATTGAGCTCACACATTGAAGTTATTGAGCGACTTACATGCAAGGCCATGACCTGGACTCCCAGCC GAGAGGCCCACGTGGCGGGGCTTGAGCTGGGGGAGCCGAGGACAGCTTACATCTGCTCATCTGCTTACGT AACCCTGCCTCCCAGCTTCCAGAGCCAAGAAAACACACAAGCCAGCCCAGCGGGGCCGAGAGCCTGTGGT AGCACACGCCATGCGCCGCACAGCAAGGGCGCCTTGGCTCGGCTTGAGGCCTGTCATGAAGCCCTCAGCC CTCTGCCTCCTCCCAGAGCTTCTCCCCACCACCCCAGGCAGTGGCTCTGAAACCTGGTCGCAGGTCTGCA TGATTCTGAACAGAGGTAGTCGTTGCCTTCCTGGAGTCTGAGCTCTCTGGAGTTTCTCACTGGGACAGAG CCAGGTGTGTAGCAGAGCATGGTCCCTGCAGTATGGCAGGAGGTGTGCAGGGCATTCAGGAGGCCTCCTG GCTGGCACTCGACCCAATTAGTCATTCAACGCCAGGTCTGGGGCTGCTGTCTGTTGTCTCAAAGGTGTGA GCTGCAAGATCCTTAGAGTTGTGGAGAAAAAATTGCCAGATTGGCAAGAAGGGCAGGATTGGGGGTCAAG GTGTCTCAGTGTGTTGGAAGCATGATGGGGGTTGTGCAAGGGGCACAGCGAGTTCAGAAGGGAGCAGGAG AGTGAGAAGAGGCTGTTCAGTGATAAAGCTCTGCACAGAGCCATTGGAGGAGCAAGCTCCTTGACCATCC TTAAACCAGGGTAATTTTCATTTAGGTTCTGCCACACGCTCAGCAGGGAACTCCTGGAAGGCAGGATTTG TCTTGTCCATCCTCCCTCCCTACCTCAACCCACTCCTCCTTGGGCTGGCACACAGTAGGTACCCAGAAAG TATCAATTGAAACAAATTGAAAGTGGTCTTGATACATATCACAGGGCAAGTTTGCAGTTAACAGACATTT CAGAGTAAAGACTCTCTGGCTTGGTGCTCGATCGGCTTCTGTGGGTTGTCAGCATGCTGTGGACAGCCCC GGCATGGGAGCGAGTGGGCGTGTGTGTGTGTGTATGTGAGGGTGAGAGAGCGTTAGTGTGTGTGTTGGGG TTGGGGAGAGAGGAGGGGGAATAGAAGATGGACCACCCGGGTATCAGCTTCTGCCCTGGGGAGATGGTGG TGTCAGTTGCTGAGGGAATCCTGAGAAGCAGGTCTGGCTGTAGGTGGTGATGGTGGTGGGGTTGCATGAG AATCCATTTGGGGCAGGTTGAATTTGAGGTGCCCATGACATATGGCTAGCCATGTTCTGTTGGCTGTGAG GTCAGGAGAGAGACATGAGATGGAAACAGAGGTTTGGGAACTGTCATGTGCTTAAACCAAAGACCTGGGT ATAGGGAGAGTGAGAAGAGAAGGGGGCAAAGATGGACATCCAAGAAAGAAGCTGAGAAAGCCTAGGAATT TGAGGTAAGAGGAGACGTAGGTAAATGTGACGCTTGGTGATCAAGGCTTCTTTCCACCTCTCCTATGCTG GACACTCACGTCTCCTGTCTGCTTGGAAATTCATGCTGAGGGCAGGGAAGGTGGGAGCAAGGATTTGTCT AAAGATCTTGCTTTGGATCCCTGCACTCCTCCTGGTTTACCAAGTGTCACTGGACACGTCAGGGCGTTCT GAGACCTTAGAGAGCATCCAGTCCTGTCCCTGCAGTTTACAAATGAGGAAACCAGTACCCTGAGAGTGGC TGTACTATCCACTCTCAGGATACCAAAGATCATCTGGAAAGTCACTGGTGGAGCTGGACCGGGGCCCAGG CATCTCTTCTCCTGTCCGGGGCTCTTGACTTCAGGACCACCTTTCTGAAACCCATGATGGGGCAACACCA GGACACTTTCCAGCCTGCAGGTGTCTGTCCCGCGGAAGCGAGCCAGGCCACATGTGAATTCCTGTTTTCT GGGTGGGTTTCAGAAGGTACGAGCAAGTCGGCAGGGTGACAGCCCAGGTGCTTCTTGGGTTCCCCAAAAC GCGGTTATGTTTAGCAGCATCCTCAGAACCAAAGGTGGGGTGGGGGCTGCAGATGTTGTGGGGGCCCTCT GAAGTGAAAAGAGCCCTGTGACAGATCTTTTCTTCATGTTTTTCACAAGTTCACTGTGCAGCAGGGCCCC CCCAGTAGCCTTTGCCCAGGGTTGGGTGTTGGGCAGCCCAGGCCTGGCTGACCTTGTGGGGAAGGGTGTG AATGGTGGGAATCCCCGAGGGCCCTCTTTGCCCGAAAGCCCTAAGCCTTGACATCAGATGCCCATCAGAT GGTCCATCGGAGCCCTACTACCCAGCTTGCCCAGTGAGAATCATCTGGGCTCCTTGTTAGGTAGCCATTT AGGTCCTTCCCAAAATCCACAGACTCTCTAAGGGAAGGGCCCGAGATGCTGTACTTGTACTAACTTCCTC AAGCAATTCTTGTGATAGGTTTGGGAAAAACTTGTCCAGGGTGACCACTGACTGAGTCCTGGTCTTCTCT GAAGAGCACAGTGCCTGCTCACTTTAGGGCACCCTGGGAGGTGGGAGCTGGCTCAGCAGGCAGTCTTATA AGGGACTGAGCTTCAAGGCCTCTGTCCCTCCAGGAGGGAGGTGCATGACCAGAGAGGGAGGCCTGAGGAT CTTCTTCCCTGCCCCAGAGGGTCTGCTGCCTGAGCTCTGTGATAGCGCAGAGAGTAAAAGGATCAAGCTT GATTGAGGCCTATCTCTCAATGCGAAAGTTTGCTAGTTAAGAGGAGAGTGGGAAGGGCATTTCTGGCAAA GAGAAAAGTGTGGACAGGCATGGCTTAAGGGATGGGGAGGGAGACAGACAGAGCTGAGGGTGAAGGGCCT TTTGCTCAGCTGTGGGCCTTGGCCTTCCCTTGTGCAGGGACACACAGCCTTAGAGCCACTGGAGGTTTTA GTGGGAAAGTAATATGGTCGGGGCTGTATCTCAGAAGAAAACAAACTAATGGGAACAGGTCCTGTGATGG TGGACCTGGGTCAGCTACGGAGGGAGGGAAGATGTGAGATGTGTACTGGGGAAGGGGGTGGAAGTGGCAG CTATCTGGTGAGAGGAAGCAGGCCCACAGCTTTTTTTCTCAAGCTGTTGAATTCAGAAGGGCGAGTGATT CCGGGAGTAGGGGGTGCTTGGAGAGCCACGCGTTATTGATAAACAGGGCAGGCTGAAGCCTGCTCACTGG CCCTGGGCGGGTTCTCACCAGCATGTTTCAGGTTTTGATCTGTGCTTGTGGTTGGTGTTCCTACCTGTTC TCTAGGTTCCTTCCTTTGTTCTTGTGGCTCATTTGCTTCACAGGTGAAGCTGGTTACACTAGAGTAACAG TTCCCAAAGTGTGTTCCCTGGAAAAATGGTTCTGTAGCCAAATAAGCTTGGGAAATGGTGGGTTAAATAT AACGAAGGGGGTTTTTCGACTGCACAACTTCTCAGAGCCTTTGGTGTGTGTCGTGACTTTGCAGAAGCAG GATTTAATACGCAGCATTCCCGTTCTTATTTGACCACGAGACATGTTTTTCCATTAAGCATCTTGCTGGG TCTGATGTTTTCTGGAACCCATTTTGAGGCGGTCTGGTCTGCAGAGAGTATGGGGAGCCTGGGTTCAAGC CTTGGCTCTTGACTCTCAGCAGAGCCTTGATTCCCTGTGTTGCCTGGACTGCACCACGTGTACCACATAC CCGGTATGTGACGTTTTCCTCATCCCTCTTCCCACCTGCCGTTACCTCACAATCCACAATCTGCACCTCA TCCATTTTTCTTCTGAGGCAAGCACTCTCTTACTAACTTACTTATCTCATCTGCATCCATGTTCTTCTAG GCCAGAAACTTGGGAGTCATCCCTCCCTCTTTGTTACTTCTTCTTCCTCTTTGTTACTTTATCCCCTCTG TTACTAAACATTCTTCTGTGTTTCCAGCTATTTCTTTTATTTTCCCTCGGTCTCCTTTGGGGTTTCTTTG CCTCCATCTCTCCCAGACCTTGGTTCACCTTCCATCGAGTCCCTTCCTGGGACATGGGCACTCATGCCAC TCCTGCTACCTTCCACTTCGAAGCTAACTCCCTCCACACTGACGTCCCCAACATGCATGCATACACACAC ACACACACACACACACATACACACACACACACACACACTTCCCCAGTTAGGCTAGAATCAGAGAGATGAT GTCAGCCATTTGTCCAAGGCCACGCAGCTGGGAGGTCACAGAGCTAAGTCTCAACCTCAGGGGTTTTGAG AAATTGCCTTCTCATCCGTGATCACTGATTTCTACAACAGCCTGTCAGGAAGTCTGGGTAGAAATTACTT CCATTTTACAGTGGAGTCAGAGCGGGGAGGGTCCTGGGCAGGCGAGTGCTTCACAGAGTGACCAACCATC TAGGTTTGCCCCACACTGAAGGGGGTTTCTGGGGATGGTTGGTCACCCTAATGCTGGATGTGGTGCCTGA TGCTGGGCAGGAGGGCCCTCTCCGTGGCCACGTTGCCTCCCAGGAGGAGACATTTCCTCTGCAGCTGCAG CTGCAGCCTGGCCATCTGATGCAGCCTGTGGAGCGGTGGCGAGTCCTGTGGCCTGCTAACTTCTCCCTCC CTCCACCTCTCTAGTGGGCCCCATGCTGATTGAGTTTAACATGCCTGTGGACCTGGAGCTCGTGGCAAAG CAGAACCCAAATGTGAAGATGGGCGGCCGCTATGCCCCCAGGGACTGCGTCTCTCCTCACAAGGTGGCCA TCATCATTCCATTCCGCAACCGGCAGGAGCACCTCAAGTACTGGCTATATTATTTGCACCCAGTCCTGCA GCGCCAGCAGCTGGACTATGGCATCTATGTTATCAACCAGGTGAGGCCTGGGAAGGTGGAATGAGAGAGG GTGTGTGTGCATGCAGATGTGTATCAGATGTGTGTGTAATGAGGGCAGGGGAAGGGGAGTGATTTCACAG ACACCTGGCACTTACAGCGAGGAACCAGCCCCCCAGCCACCACCAGTGCAGATGAGGTAAACGCCAAACA GTGTGCTTGCCTATTGCTGTCAACTCTATAGCCAAGGGAAATGCTGGAGTGTTTTCGTTGTTCTGTTTTT GTTTTCTGGAAGTAGCCTTCCAGCAAGATTGGGAAAAAAGACAACCCTAATTATTCCAAAGTACACACTG ATTATTCCCTGGCTTTGTGTAGCTGTGTATTTTCCTTTTAAAAATAAAACCACCATTTAGATGTCAGACT TTTAGGTAACTTCAAAGTTTATCCAGTCAGTCAGAGCGTGTCTCCTGGGGCACCTGGAGACAGTGCCCTT AGTTCAGGTCACATGCCTACATGCCAGCCCCTGGTGAAATATCTGGAGAAGTCTGATTCGTGGGCCATCT GAGAGTTATGTGGACTGGGCCGAGTCTGAGAAAAAGTTTCTCACTGCTCGTCTGATCCATATGTGTTGGG CTTTAGCCCTGCTTAGGAAAGTAATGCTAAGGATAGGTCAACTTTCATCACCATGGCATGGAGAATCAGA TTGATCTAAGAGGCATCTTTATTGAAATAAATTTTTCAGTTTATTTGAGGAGCATTATTTTCCCAAGAGT ATAACTTTGATATTTCAAGATTACCCCTAACACTTAAATTCATGTTTTTAGACTATAACCTCCTAGGTGC AATGACACATCTAACTTATCTAAGCACCCAGTTTCATTGAAATTCATTTGAAGAGTCTGAGTACGCCCAT TTCTACAAGGCCCAATGTCCATTTCATTTCGAGATAAACTCTGCTTTAGGTAGGAGGATTGTTGGCAGTT TACGGCTTCCATCAAGGTCAAGGAACTCTGTGCACCTTCCCTATGACCCCAGGGGAAGCACTCGAGGACT GCTGTGGCATTGTGCTGCATCACTTGCTGCAGGGAGATTCTGAAGAAGTGTAAGGTCTCAGTCCTGCCCT GTCCCGAAGCCTCCAACCCACTTCTGGCAAGTGGGACCTTCCCAGGGAACAATTTGTTAACAGACCCAAA TATCCTGTGATTGGATGGTGGCTGCCAAATGCTTTGGAAGCTCAGAGGAAGGAGAGAGAGCAATGGCTTG GAAGAACCAGGATATAAACTAGGTTCTAAAGTCTGCAGGGAGATGGGCTTCTCAGCTGGGGCCAGTGAGC AGGGACCTTAAGGCAGAAAGGAGCCTTGCATGTTCCTGGAAATTGAGATGCCCACTGGGGTAGGAAAGCA CCAGAAGCTCTGGGACCAGGTGTCAGAGTTAAGCCTGTGAGGCAGGAGAGAGCAGAACAAGCCCTGTTAC AAGGAAACTGAAGCAGGAGAGCAGGTGGTGGGCAAACCCCTTGAGGCTGTTTGAATTCTTCGGCCAAGTG AGGTACAGACCAGGGCCCTATGAACACCTGCAAGCAAGACAGCCACGCAGTTGTGGGTCACCTTGGAAGA ATATTGGAGAATGCAAGAGAGAACAGGTAAATGTCCTGCAAAATGCGGGTCACTTTAACCCAACACATAT TCATTTAAGAAAAGCTCTGTGATTGAGAAACATTTGTCTGATGCCAGTTAGCACATACCAATGACGGCAA GATTCAGGAGCCTGTTATTAAAGCAGTGGCAGCGAGCACCTGGAAGAGGCGGCCACCATCACCAGGAGCC AGCAGGGATGACTAATAAGCCGTGCCAGCTGCATCTCGTTTCTCTCTTGACAGTTGCTATGCCAGTAGAT GAGGGATGTACTGTGGATACAATGCTGTCATATCTTATTCAGCAGGGCATCTGATAGCATCCCACAAATC TGCCTGAGTAGAAGACAGACAGCTGTGGTCTGGGTGCCATATAGGTAGGTTAAAATATATATTTGGGCCT AGGCGCAGTGGCTCATGCCTGTAATCCCAGCACTTTGGGAGGCCAAGGCAGGCGGATCACTTGAAGTCAG GAGTTCAAGACCAGCCTGGCCAACATGGCGAAACCCCGTCTCTACTAAAAATACAAAAATTAGCTGGACA TAGTGGTGGGCGGCTGTAATCCCAGCTACTCGGGAGGCTGAGGCAGGAGAATCTCTTGAACCCAGGAGGC AGAGGTTGCAGTGAGCCGAGATCATGCCACTGCACTCCAGCCTGGGCAACAGAGTGAGACTCTGTCTCAA AAAAATAAAATAAATAAATAAATAAATAAAATATATACTTGGGTAAAGAGGATAAAAGAGTTAGCGATGA TGCTGAATTTTTGAACTGAGGTGGCTGTTTTCAAGGAAGACTGGAGGGTGGGATGCTACGTCTAGATATG TTGCAGTTTAGGTGAATGTGAGACTTCCCTGTTTTGAAGTCAAATATTGGACCAGTAAAATCTAGCCATC AGCTTAAATTCCTATGATACAATTTACATACTCCCCAGGCTCAACACAGTAGATTTCTGAATGTCCTCTG CCAGCTACATGCTCCTGCCCACCTCAATCCGAGTAGATGGAACAACTAACCAAGCCAGCTCAGACCGGTG GCACAGCTGTGCTGGCTAACACTGGGCACCACCTAAGAGAGTGCTTCTCCAAAAGTGTGCTTCCCCAAAT GGAGCGAAATACGCTTGAGGAATGTTGGGTTGAACCATGTAAAGCAGGTCTCATTCCCGCAGAGCCTTTG GTACCCCGGTGTACACTGTAACCCCAGAAGTGTTTCCTGAGCTTGCCTGACGAGACAACTTTTCCAAGAA CCGTCTCAAGTGATGAGTGTTTTGTGAGTCACACTTTGGGGAAAGCGGGCCTAAGTTAGCATCTCCTCCC AGCTGCCTCCCTGCTTTCCCTGGAACACTAGGAACTGCCCGTCCTCCCTCCCTCCCTCCTCTTCCCACTT CACAACTTAGCATCAGGAATATTTTAGTTTTGGTTTTTCAAACATATATACCTCCTTTTTTCTTATCTTG TCAATATCATCTTTTTTTTTTCTTTGCTTTTCCTCATACTTTTTTTTCTCTTCATCCTTTCCTTCTCCAA GGGTTAACTTTCCACCTTAGGAGAATCTTTTCTGCTTTTTCTCCCACTTCCCCAGCTACTCTCTTATCAT CTGCTCCAATCTCACCCTAATTGATCATTTTGGGAAAATATGGTCAGAGTCCAGATAACTAAGTTGAGAA ATGCTTAAACTCTGCCATACCTTTCCAGTAAAGAATATTACCTAATAAATAATAAAATGGTAATGGGAAA CCTGAACCCTGAAAAAAAAGAGGTGGAAGGAGAAACATTTGGAGCACATCCTGTCTACAAATTAGGAACT GCCTGTGTTATCTGTTTTATGGTTATATTCTAGAAGAAGAAAGGGATTTTGTAGCACCTGGTTTTGACCT TTCTGCACTGTTTGTTGAGCAAATAAACCTTATGGGCTGTTAGCCCTCTTTATAGCCTCTCAGCTTATCC CTGGCCCAGACACCCTGCTGTCATTTTGACTTTTCATTCCCACACACACATACACATGCACACACATGTA CACACACACACATACCATTTAAGATTAGACAGAAGTAATGCTCAAAATGGAGTGGCTTCTGAGACATTTA GTCCAAGGGTTCCCAAACAGGCTTTTCAGTATCAGATTTCTTTCTGCCCCATTGAAATGCTACACAACCT TCCGCTTACAGCAGGTCACAAGGGTTTCATTCTACTTGAAGTAGGGGCCATGTCCCATTTCCACTTCCTT GGCTTCCCATTCAGTCACTGCTAGGATTTGCCTAGACCCCTGAGGCCAGACAATGTAGAAACTTCTGCTC CATGTCACAGGTGAGGAAACAGGCTCAGAGAGGGACAGGCTCCGAAAGTCACATAGACAACAGTAGGGCT GCGGCTCAAACCCCAGCGTCTGACTCCAGGTTTAGTGCCTTCTCAGGGCATCAGTGACACTCCTCATGGC CAGGGTGCCCCCAGTGTTGCTCACAGTCTGGTATCCAGGGCTGAGAGTGTGCTGTGTGCTCAGACTGCCT GGGTTCAGTCCTGGCACTGCCACTTTACAGTCAGTGACCTCAGGCAGGTTACTTAAGCTCTGCAGGCCTC AGTTTCCTCCTTGGTGGGGAGGGTTATGAGGCATCCTTCTCATGGTAAACCTTCAGTAAATACCAGCCGT TACTAGGAGGGTCCACTCCTGCCTCTCCACTCTCCATTCATCCTGCCTGTTTCCTCTGCCTGCTTCCTCT GCCTGCTTCTGTGGTGGTGAATTCTTCATGGCTCCCACCGCCTCCTGCTGCACCCCCACTCAGGGCCCGC ATCAGGACCCTTCCTCCTATTGGTTTGAACTCCTTGGAGTCAGAGGGTAATGGATAGTGGAGTGAGCCAG GTGGCAGAATCTCAGAGGCCATCCCGGGCCTATAAGCCTCTTCAAAATAGGGCCACGTATCAAGCTTTAC ACACAGGAGTGAACTTTCACAAGTTGTTATGACTCATACTCTGTCTATAGTAAGCTGTTAACCACTCCCA TTTGGCTTATGCCTCTGTAATTATTGTACTAACTTATATCTTAAAATAAGGATATTGAAGGAATGAGCCG GGAGAGGCTTTCCTGGTTGAGATATAGAAGAACAAGAGTTGCTCTTTTTCCTTAAGGTCTCTCCTCCCAC CCCTGACCTTAGCTCACCAGCATGGGAGAATACTATTTGACTCCTTGTACTCTGAGACGTGGATTTCAAG ATATAGCATTCCAACTTCAACGGCAGCAAGAAAAGAAGCAACAGAAGGAGAAGACATCATAGCAAACAGG GATGCATGCTGCATTTCCTAATACTCAAACCCGGAAACGAGACTTCACTCAAGGTGAAGGGAGGGCAGGT CACCACCTGGTAGCACTAGCCCTAAATTAAGGAATGCAGAATGTTTGTGGGATTGCCCATCATAAAAATT ACAAAATGAGTAAGGAATGCAGGCACAGCTGGCCAGGTGGGTTTGTCACAACCATGGCAGCCCTTTGCCC CACAGCCAGTACACAGAACTGGTCTCTCCAATTCCGATTGCATATCTTCTGGCACCTCTGTTCCTCTCCC TCAGCTGCCCAGGATTTTTCTGGTTCTGACCATGTTACTTCCTCTTTTAAACCTGTTAGCATTTCACGAC TGCCTACAGGCAACGGTCTAAATGGTCGGAAGGCCCAAGCTTAGCATCCGAGACCCTGACCTACCTCCAG CCACTTCCTCCTCCTCTCCACTTCACTGGACTCCCCATCTCCACCCAGACACCTCTGTTCTCCCCTCTGT GTGCCTTTGCTTATGCTGTCCCCTGTGTTCCTAGTGTGTCTCTGGCTATCTTTTAAGCTTCCCTCCCCAA CCTCATTAGTTCTGTGGAGCCCCTGGAATAGAGCTGACTTCTCCTTCCCTGCTGCTCCCAGGCTGCTCAG AACTTTCTGGAAAGGGATGATTATCTGAGTTCCAGCCTCACCCCAGCCCCCGGACTCTGAGTCCCTCATG TCTGCCTCCCTTCTTTCTCTCTGACCACACAGCTGGTACATAGTCAGTACAGACGCAGTCAGTGAGTGGA GCACGGGGCTTCTCTCCAGGATTCCTGCCCCTTTGTTTATCCCTAGTCTCAGGACTCCCTACTCCTGGTC TTCTGCCTAAATCTGTGCCTCTTGGAAGTGAAGCCTCCGTTCCCAGTGGGGCCAGGTCCTGACCCTTGGG AACTTGCAGGATCCCTCCCTTGGGCCTCTCCCCGAAGCTTCCAGCTCAATGCTGACCAGAGCACAGGCTG CCTGTGACAGTCCTTGGGGTGACCTCCCTTATCAGGAAAAATGCAGAAAACCTATTAATACCTTAGCCTT GTGATTGTTAATGGTCACAAAACTCCTTTAGGGTCCTTTGGACTCAGCACCTTTATGGTCTCACTTTGAA TTTTGAACCTCCCACCTCCCCCCATCCCCCAGAGTAAGGCAAATGGTCTTCTGATTGTTCCTGCAGAGGG AAGGCTCCACAGGTAAGCACACGATGGCCAGGAAGCAGAGCTGGAGCCTGCCTGAAAGGCTGTGGAGAAA TGGAGGGAGGGCTGCCCTGAGGACTCTGTCTGGCTTTGAAGTTTTCTACTGTTTCCTTTTCTTCTGTGCA CTGTTTTAGGATGATGGGGTGATAGTTCCAGGCTGGTTGAGGATGGATTTGGAGACAGTCCTTTGTACCC TCAGTGAGCAAGAGTATCTGTCACCCTACCTCAGCAGTTGTCTCTGTCACTGGTCCAAGCAGCTGGTTCC TACACAAGGTCAAGATCAACTGGGGAGAAGCAGACTCCTGGGTCTATCCCATTAGTGAGGACAGCTGCCT GGGCTTATGGCCTCATTGGTTTGGTTTCTATCTTGATCATCTCTACCATCCCCCCATCCCGGCCTTCCAT TTTCTACCTCAGCTGTCAGTGCACAGATTGATGTGTGTGGGAACGGAGCTTGGGAGGAGTGGGGTAGGGC TGGTCCTGTCCTGTAGCCTCCCCTTCCTTCGGGCACTTGGACCCTTTGGAGCTTGCCGGGGTGGGGAATG GGAGTGGGAAGGCCAGGGAGTGTCTCTGCACCATCACTGTTTGAGTGTTGCCCCTTTGCTGTGTGCCCCA CCTAGTCTATGTGTGTCTCTGTTCTCTGGGGACTCAATTTGCTGGTGAATTGCTTCCATGGACATTGTTC TGGGAAATGCCATTTTTTCTGCTCACCCATGACTCTGTGACAAGGAATGACAGCTTATTAGGAATTTGTT TTTGCATTGGAACAGTGGTCATCAGAATGGGCCCCTTTTCCCTTGCAGCTTTGACATTTGCCTCTCTTTT CCTCACCTCTCTCCCTTGCATCCACCCTTTTCTCTTTTTCTTCTTTTTTGTTTTCCTTCTAGCAGGGGCC TTTTACCTTTACTTGTTAATCCTGTTTGTAGCAAAGCAAGTGGAAGGAGGAGTTCCTCTCTGATCTGCTT CTTATTCTCCACCTACCTTCTCTTCTGTACTTTCCGCCTCCTAGAGAGAGAGAGAGAGAGAGGAATGCCG ACCTAACTACCGCTGCCACTGCTGCTGCCACCACCGCTGCCACCACCACCCTGGTAATGTTCACATGTCC TCAAATCAACCCAGAGCCAGGGCCCTGCTGGTCAGGGGGAGGCTATGTAAATAATCCCATGAGTGTGCCA TCCTCAGGCCCTGGGGTCTCCTAGGCAAGACCAGGGCCTCTGTGGGCTCTCTCGGAAATGCTGAGGTTGC TGGAAGCCAGCCCGTCATACAGGGTCTGAGAGTTTAACTTCTTTTAAATTAAACCACAGTTGAGCTCATG CTGTGTGTGTATAAACTTTTGTATCCTGCTTTTTCCTTAAATTCTTTATCATCAGCATCTTCCCATGTTA TTTCATAGTCTTCATCATCATCACTTTCCATACCTTCATAGTAGTTGATCGTAGAATTCCATCATAATTA ACTTGTCTTTTCTCTCTTAGAAGTCCCTTAGGTAATGTCCAATTTTCCGTGAGTGTAAGTAATACCATAA TGAACATCTTGGAGTCTGAAGTTTATTCTGTGTTGGTTTGTTCCACATTTAGGATCATTTTCCCAGGCTA GATTTTCAGATGTGGGATTATGGGTTCAGATATGGTTTACACATTTTTATAGTTCTTAATACAGATGGCC AAATTGCTTTCTGAAAGAGAAGCTTTTCTTAAGTATTTTTCTCCAACTTGTATCTTAAACATCCTGAACA TGCTTAGCACCACTGTCTTGATATATCTGCGGAAAGCCACGTCTCCACTTTTCAGTGTGTCGGGCCCTGG GAGAGGCAGGCATCCTGCGCTGGCTCCTTGGAGCTGGGTTTAAAATTGTCTCCTCTGGCTGGGCGTGGTG GCTCACACCTGTAATCCCAGTACTTTGGGAGGCCGAGGTGGGCGGATCACTAGGTCAGGAGATCGAGACC ATCCTGGCTAACATGGTGAAACCCCGTCTCTACTAAAAATACAAAAAATTAGCCGGGCGTGGTGGCGGGC ACTTGAAAAGTCCCAGCTACTCGGGAGGCTGAGGCAGGAGAATGATATGAACCCGGGAGGCGGAGCTTGC AGTGAGCCGAGATCGCGCCACTGCACTCCAGCCTGGGCGACAGAGTGAGACTCCATTTTAAAAAAACAAA CAAACAAAACAAAAAAACAAACAAACAAAAACTGTCTCTTCTGTGCTCACTTCACCCAGAATCCCTGTTG GGCTCTTCAAGGAGCTCAGTTCTCTCTGAAAGCAACTTTATAGCCTCAGTCCAGTCTGTGTTCCTGTGTG GCAGGGGTCAAGGGTATGCTCACTCTTGAGAGTGGTGTCTTTGGTTGACCAAGAACCACTCCCATAGCCT GGTCCCTAACCCTTGAAGGCCCATCTCTCTCACTCACTGGGGTGAAGAGTTTAAATCTCAGATCCAAGTT TTGTTGAGAGCTCTGAGCTACCATATTGCTATGGTTAACAATAGTTAACAATGTTAACAATGGTTAACTA TGGTTAACAATAGTTAACAATGTTTAACAACTAGAGCCCAGCTGGGTGTGGTGGCATGTGCTAACAGTCC CAGCTTCTCAAGAGGCTGAGGTGAGAAGATTGCTGGAGTCCAGGAGCTCAAGGCCAGCCTGGGCAACATG GCGAGACCCTGTCTCCCCTGCAAAAAAACAACAACAACAAAAGCAAAACTAGAGCCCAACTGCTGTGAAC TCATGGCTGAGTAGATATTATTAGCCCTCCACAAACTCAGCATTTGTATAATCCCAGGCTGTTTCCAGTA ATTCTCTGGGGATCATCTCCCAGCCTGTCCACTGTTCCAGGATCCACACTTAGGCCTATAGGAATGCCCC GTCAGAGCTTCTGCTGCCGCTGATCTGTTACTGTTTCATGCAACCCACTCGGCCTAGTTCCTTCCTCTTA CTGTCTCAGTGGGCACAGAAAAGCATACAGAGGGTGTTTCAGCAAACATTGCCACTGGCTGCAGACCTGC CCCCGGATCTGTCCTGTTGAGAGCTTAGTGCTGCGTTCTTGCATGGTGGGGAGGGGTGTGGCTCTGTGAT GAGCCAGGGCATGTGTATAGGAGCAACAGTGTCTCTCTTATCACGTAGAAGTTCTGACTCATTGCGAGTC TTGGCTTTGGGTTAATGGTTCCAGCCATGTTGCTGCTGTGTCTTTTGGTGCAGGAGAGGCTGGGCACAGT TGGTCCCTAAGCCATTATGGATAAGGGATGTGTCTGCTGATATACACACATGGACCTGACATCCAGGGAA GGCAGGGTGATTGGACAGAACAGTTCTTCCAGAAGCTGTTGGAACTTGGACAAGAGTGGCCCTTGGCTTT CTGTAGTTGGTCATCTGTCCCCTGTTGCAATCAGGGGAAGGCCACACTTGCCTTCCTTAACCACAGTTAG GATTTTCTTGGGGATTAGACCAGATTCTAGCACCTGTCCTGAACCTCTCGCCCCGCCCCTACAAAGGCTG CTTGCAAGTGTAGTGCACATACACAGGGAGCAGGTGGGGCATGGAAGTGGAAGTGGAGCCCCTGCCTTTG GCCCTTGGGGGAGGCACTGTCTGCTTACCCACGGTTGTTGCCTCATAGGAATCATACAACAGCTTCCTAA CTGGTCTCCTTGCCTTCAGTTGGATTGGGGCACAAATCCCTCCTTGACATATAAACCATGGTTTAAGGCT CCCTGTGGCCTAAATAAAGATAAAGCTTAAGTATCTTAACAAGCACCTAACCCTTCTCCCCAGCCTCGGT GATTTGGCTCATCGCTGCCTTCATGTTTCATTCTGGCTTCACTCATTCGGAATTTCTTGTAGTTCCTTGG CTGTTCTCTTTTCCTTACCGCCTTTACAAATGCTCTCACCATGCATGCTTTTCTCTGCTCCTACAGATGC CTTCTCTCCCAGCACCGCCTCCAGAGTCTATGTCTGGTCGATTCTGTCTGCTGTCTCCAGTCCCCATCTT GTGGCAGTCTCTGCTCAATCATTTGGGGATTTTATATGTTTTCTGGCCTTTCTTTTGGGGGCCTGTCTTC TCCTTCTAAAAGCAGCCAGTTGACCTAGAAGGAAGGGATAACTGTAACTCTTGTCTACCAACATAAGATT AGGCCCACCCTTTAAAAGCTGCGTCTTTGAAAGGGACACCTGCACCCAGCATGCTGGCTTCTCTTCACCA AGCGTGACTTCCTACGCATTTCACAGGCCTCCAGAGGTCCCCCTGACTCTCTTCTGCTGTGAGAAACTCT AATCATGTAAGCCACAGGCTAATTCCCTTGAGCCTTAAATGTTTTTAGTAATTTCCCATTCATCAGAGAA GCAGGATTTGGGAGGAATTTTGAAGCAAACACTACAGAAGGCAGAGTCTCCAGGTAGGATATCTAAGAGA CATTTGGAATGGTCTGACTGTTCAAGATGGATGGGAAAGCCTCTTCCTGTAATGATAGTAGCCAACATTT GTTGTCAGGCAGTGGGGCCCCATTTTTGAGATGGGGTCTCTGTCACCCAGGTTGGAGTGCGGTGGTGCTG TCATGGCTCACTGCAACCTCAGCCTCCCCGGGCTGGGTCTTCTTAATTCTGAAAAACCCAGCTTTTAAAG GGTGGACCTAATCTTATGTTGGTAGACAATGTTGTCTCATTTAATACAATGCACATGCTCTCCCCATAAC ACAAAAGAGGGAACTGAGGCCTGGAGGTGTGATGTACCCCAAGTCACATAGCTAATAAATAAAGAAGCCA GCATTCCTGGGATTAAAAATGCATGTGTCTGTCACTGTGGTGTATTTGGTGCTTGATCAATGTTTACTTG AGCAAATGGAGGGGCAGAGGTACCGATGAGTGTGCTCAGTGAGGAGGGCAGGAGTGAAGCTGGGCGTCTT CCCGCCTCTTGTGAGTGGTGGGGCTTGGTGAGCTTGCCAGGGCCTGTCTTTCTTATCAAAGAAGGTGTGT GCCCCAGTGTTACAGCATTTCACCCAAAGCAGCCTAGAAAATGCTTGACTTTTCTGTCATTCCGGGGAGG ACACTTTCCTCCTCCACTGTTCTGCTGGCCTGGTGTACCCACGGCCCCTGATAGATGATAGCACCTGCTA AAGTGCACCATGCCCTTCCGTCTCACTGCATCCCACAGATGAGGCCAGGCTGGGATGAGGGAGAAAGGGA GGGATATATAGTTCAGGTTATTTTGGAAAACTGCCTGACCAATTTTAAGTCTGGGCCGGACACTGGGGCA TCTCACCACGTTGAAAGGGCCGTGGCACCCCGGGCGGTGAAAGGGGCTGGAACCAGGTCTGCTTCTTGGG CTTCTCCTCCAGGGTGCCATTGCTCATGGGCCTTGGCTGCAGAGGTGCTCATTCGTGGTTCCAAAATTCC AATTCCTGGGAGAGGAAAAATGCTTAGTTCAGTCTCAGTTAGGCCTCTGCTTAGATCAAACAGCCAAGGC CAGTAGGCCCAGTCCTATGGTAGAGACATGGCCTCAAAGAGCCCTCTGCTGCAGTTGTTGGGGAGTGTAC CAAGAGAAGGGAGCATTGTCCTGGGCTGGGCAGCCCTGGGGGTCTAGTGCATAGATGTAGAAAGGCTCTG TTGGTATACCTCCCTTTGCTTGTTGGAAAGTGCTCAACGGGGCTGAATTGTGTTTGACAGTGTAAGTCTG GGCTGGGGTGAGGGTTGTTACAAGATTGTCAAGATGATTAAATGAAATGCCATTTGAAACACTTATCCAT GCCTTGTGTATGGTATCCCCACCAGTGAATATTCACAGTATATTATAATAATTCCAACAACTTCATAATT TTCATATGCAATTTCTAAACTTTGAACTTTTTTTTTTTTTTTTTTTTTTTTGAGACAGTGTCTCGCTCTG TTGCCCAGGCTGGAGTGCAGTGGCGCAATCTTGGCTCACTGCAACCTCCACCTCCCGGCTTCAAGTGATT CTCCTGCCTCAGCCTCCTGAGTAGCTAGGAATCCAGGCGCCCGCCACCACACCCAGCTAATTTTTGTATT TTTAGTAGAGACGGGCTTTCGCCATGTTGGCCAGGCTGGTCTCAAACTCCTGACCTGAGGTGATCCACCG CCTTGGCCTTCCAAAGTGCTAGGATTACATACGTGAGCCACTGTGCCCGGCAATTTTTTGTGTTTTTAGT AGAGATGGGGTTTCACCATGTTGGCCAGGCTGGTCTCGAACTCCTGACCTCAAGTGATCTGCCCGCCTCA GCCTCCCTAATGCTGGGATTACAGGTGTGAGCCACCACGCCCAGCCTAAACTTTGAATTTCTTTGAACCC ATGACTTACACAGAATTAGCTGAACGCAGAATTCCAAATCAACTCAGCCTGTGGGACAGCCAAAAAACAC AGTGTGCCTTTGGGCTCCTTCACTCACCACGCGGGGTTAGAAAACTTTGTCAGAGGCTTTAAAAAAGGAG CTCTTGTGTGTAAAATGTTTCCTTGATTCTCTTTCTGGTGCCTCTCTTTCTCTAAGTGGTTTGCTTCCCC AAGTTCCCCACCTGAGTCTGGGTGGCTGTGGCACATCTGTGCATTCTGTACGCACACAGGCAGCCTTTTG GAGTGCCAGTTTCCAGGTCTTGGTTTTATTTATTTATTTATTTATTTTTTTGAGATGGGGGTCTCACTCT GCCGCCCAGGCTGGAGTGCAGTGGTGCCGTCATGGCTCACTGCAACCTCAACCTCCCTGGGATCAGTTGA GCCTCCTACCTCAGCCTCCAGAGTACTAGGGACCACCATGCCTGGCAAATTTTTGTAATTTTTTGTAGAG GCAGAGTCTCACCATGTTGCTCAGGCTGGTCTCGAGCTCCTAGACTCAAGTGATCTGCCCACCTTGGCCT CCCAAGTGTTAGGATTACAAGTGTGAGCCACCATGCCCAGCCCAGGTCATCTTTTGAGGGCATGGAGAGA AGACTTTGAGCATCCCACTTTTGAGATTGTGTACCAGTCGCAAGCCCCTATGACACACTTTTTCCCCAAA GTAGAGGGCTCTGACTATGTTGATCCCAAGAGAGATGGGAAAGAGCATTGAATGAGGATTCCAAAGTATT GGGCCTTAGTTCGTTTCCTCATGTTGGTGTTGTGAAGATTCTGGTTAGGATAACAGCATGTGTGCAGGAG GCTTTGTGAACTGCTGAGAGTGAGGCGTGGCAATGTCAGTGCTAGGTTTGTCCTTACTAACCTGGGGCCA TGGGAATTGATAAGACCAGATTCCCAACTCTACCCCACAATGTGATCCCTGTGGTGACCCCTCACAGGGC TCTTTGGTCGAGCTTCCCAGAAGGGATCACCATCTGCCATTGTATGTTGAACCCCATTCATTCATTCATT CATTCAGCCAACCAGCAACTATTTGTTGAGCTCTTATTGTGTGAGAAGCAGTCTTCAAGGAACTGGGTGA ATAAAAAAAACAAAACATCCTAACCTTCATTGAGCTTACATTCTTACTGAAAGAAAACAAATAAAACATA CATGTAATCCTAGCACTTTGGGAGGCCAAGGCAGGCGGATCACTTGAGGTCAGGAATTTGAAACCAGCCT GGCCAACGTGAAACCCATCTCTACTGAAAATTAAAAAAAAAAAAAAAAAAAAGCCGGGCATGGTGGCACA TGCCTGTAATCCCAGCTACTCGCGAGGCTAAGGCAGGAGAATCGCTTGAATCCTGGAGGCAGAGGTTGCA GTGAGCCAAGATCATACCATTATACTCCAGCCTCAGTGATGAAGCAAGACTCCATCTCAAAAATAAAAAA TAAAAATAAAAATATGCATTCCCTTTGCACCAGCACACTTGGTGCCTGGGGACCTCGTGGTTGGCACCCT GAAGCAGGTGTCCCTCTTCTGTCTTGCACACCTTGCTTCTGTCCTGGTGTGTATGGCATGGCCTTCTGCC CTCCATGGTGAGCACTGTGAGGGCAGAGGTTGAGTTGGGTTTGCTGTATTTCTCAGGTGCCTAGGTTTGT GCTTGACAGGTAGATGGAAGGCACACAATGTGGTCATCAAACCTCAGTCAACCATATAAGGAAGGTAGAA GTGAAAAGTCCCATAGGTACCCAACTAATGTCACCAGTTTCCTGGATACCTTTCCTGGAGTTTATTTATA GTGTGTATAAATAAATGATGTATGTGTTTAAATGCCTTTTTCACCTTTCCTTTTAGAGCTGCCTCTTTTT AACAGTTCCATTCCATTGTATGGATGTACTATGATTTATTGAACCAGTTCCCTACTGATTATTCTGTTTT TTGCAGTCTTTTGTTATGATGAACATTCCACAGTGACAATGTTGTTCATAGTCATTCACACACATGCAAG TCCTTCTGCAGGATATATTTCTAGAGGGGAATTGCTGACTCAGAGGTTTTGGTACTCTGTGTTGATTGTA GAGTGACGGCAGAAAAGTGAGGCCCAAGAGTTTCCTAGTGACCATGTGTAGTGGACAAGTCACCAGTCCC TGTGAGTGTTTGGCCCAAAGGCTTTAAGGCATTTGATATCACTGTTTTTGTTTCTGCACCAGGCGGGAGA CACTATATTCAATCGTGCTAAGCTCCTCAATGTTGGCTTTCAAGAAGCCTTGAAGGACTATGACTACACC TGCTTTGTGTTTAGTGACGTGGACCTCATTCCAATGAATGACCATAATGCGTACAGGTGTTTTTCACAGC CACGGCACATTTCCGTTGCAATGGATAAGTTTGGATTCAGGTAAGAGATACTCAGTCAGAATCTGTGGTA AACATGTCTCTCTCATGTGTTGACTAGGAAATGCAGTCCTGGCAGCTCAAGAGTGCCTCTTTAAGCTCTG GAGCAGAATGCCTCCTCTGAGAAATGGGTGCTTTGTATTAGTTGAGATGGAAAGAAGAGACCAGAAATGC CTGTAGTCTCTGCACATCCAGACAAAAACAAATTTTCCCCCCTTTTTTTTTTTTGTTTGTTTTTTGAGAC AGGGTCTGGCTCTGTCACCCAGGCTGGAGTGCAGTGCCGTGATCTTGGCTCACCGCAACCTCTGCCTCCC GGGTTCATGCCATCCTGTCACCTCAGCCTCCTGAGTAGCTGGGACTACAAACACTTGCCACCATGCGCAG CTAATTTTTGTATATTTTGTAGAGATGGGGTTTTGCTGTATTGCCCAGTCTGGTCTCGAACTCCTGAGCT CAAGCAATCCATCTGCCTTGGCCTCTCGAAGTGCTGGATTATAGGCATGTGGCACCATGCCTGGCCTAAG AACAGTTTTTAGCATTTGGGAGGGGCTCTCATCTTTAAGCTCCAAATGATACTGTATTTTCTTGCTTTTT TCTTTCTCTTGCCCCACAAGTTTTGGAAAGTAAATTGGAATAGTTTTCCCCCACTGAATTATTTAGCTTG TATACCTCAGCAGATGTTCCTTGGCCTGTTTTGTTTTGTTTTTGAGACAGGGTCTTGCTCTGTCACCCAG GCTGGAGTGCAGTGACACAATCATGGCTCACTGCAGCCTTGACTGCCTGGGCTCAATCCATCCTGCAGCC TCAGCCTCCTGAGTAGTTGGGACTACAGGCATGAGCCAGCATGTCCAGCTAATTTTTTATTTTTAGTGGA GATGAGGTCTGGCTATGTTGCCCAAGCTGGGCTTGAACTCTTGGGCTCAAGTGATCCTCTCACCTCAGCC TTCCAAAGCATTGGGATTACAGGTGTGAACCACTGCTCCCGCCCTTGGCCCTATAAGAAGGAATGTGATT CTGTTTTCCAGCAGGGCACAAACTTCTGCTTAAATACAAAGCCCAAATTTTTCCACCAAAATGCCCCTAG TGAAGTGGCCAGCCCAGATGCCCGACTAGCGTATTATCCAAAGCATATTGTCATTGGTGGAAAATGGCCT TATAGTCCATTGTTTTGTCTTAAAAGTAAATATATAAATAAACTTGTATATTGTTTCCTAATTCCGTGTT TATATTAACATAAAAGTGTTTTAAATTACCTGTCAGTGGCCAGGTGCAGTGGCTCGTGCCTGTAATCGCA GCACTTTGGGAGGCCGAGGCGGGCAGATCACCTGAGGTCAGGAGTTCGAGACCAGCCTGACCAGCATGGT GAAACCCTGTCTCTACTAAAAATACAAAAATTAGCCAGGTGTGGTGGCAGGTGCCTGTAATCCCAGCTAC TCGGGAAGCTGAGGCAGGAGAATTGCTTGAACCCGGGAGGCAGAGGTTGCAGTGAGTTGAGATCGCGCCA TTGAACTTCAACTTGGGCAACAGAGCAAGACTCTGTCTCAGAGAAAGAAAAAAAAAAACCTATCAGTTGA ATAACAAAACCCTTTCCTTCCTTGCTTTAAGTGAATCTGAAGATCCAGGAGCTGTGCTGCAGGTACCCTC TATGTTGGGTACCCCTGGTTTAGGCTGACTAGTACAGTGTGGTTGGCTCATGTAGACAGCAGACCCTTTA TTTTAGATACAACTTTTTTTCTTTTTCTTTTATTTTTTTTGAGACAGAGTCTTGCTTGTCACCCAGCCTG GAGTGCAGTGGCGTGATCATGGCTCACTATAGCCTTAAACTCCCTGGCTCAAGTGATCCTCTCACCTCGG CTTTCCTAGTAGCTGGGACCACAGGTGTGGGCCAGCACCCCTGGCTGATTTAAAAAAAAAAAAATTTTTT TTTTTAGAGATGTCTCACTATGTTACCCAGGCTGGTCTTGAACTCCTGGGGGCTCAAGCAATCCTCCTGC TTTGACCTCCCAAAGTGCTGGGATGACAGGCATGAACTACTGCACCTGCTGAGATGCAACAGCTTTCTGT CAGACTCATTTTATTCTCATCATTTCTTCCTGTCCTCCCTTGCTGGGAGCATGAGAGCTGTGATGGGAAT ATAGGAATGTATGAAGTCCTTCTCCCAGATCAAAAATCCTAACTTCTTGTCTTAAAGGGAGGAAAATTTG AATGTAACCTTACTTTTAGACTCTTCAGAAATCCTTCTATACCCTTCCGTCCCCGCTTTCACCCTTCCTC CCTCTCCGTGTGTGTATCTTCTTCTCTTGAAACACACAGGTTTATACCCTGACCCCTCTTGATTCATCCC TTGAAGCACAGTGGTGAACAAGGAAGGGGCCCGTGATGCCCTAATTCTTTGCCACAGCACCATGTTTGTT TCACAAGGAGCCTGGCAGGTTTGGGCTTGGGGCAGATAGGGGAGAGAAAGCAGCAGAGACAGCAAAACCA AATCATGTCAGCTTGGCATGTACTTCCCTCTGAAATAGCTAAGAATCCATTTCTGTAAAAGCACTGATTA TCAGAAAACCTTATTGGCCTGGCCACCTTTGGTTCAAACCCTCACATTAATAATGTGGACAGTAGTATGA GGTGTGCCAAAGGTGGATGACTCAGCACCTAAGTGATGACACCTAATTACGAATAGGTTCATTAAAGCAG ACCCCCTGGGGACCTTTGCTTGAGGATCCTTACAGTCAGAATTCCTGAATATATTTGAAAATAATAATTG CATCTTTATTTTCATATGTTCTGTATGGTTTGGCTGACTTCCCCCTCAAAGTCTGAGTTAGAGTTTTCCT TAATTTATGTGATGGGTTTGGTCTTTTTGGATTCCAGAAAGAGCTGGGTGTGGTTTGGAGCTGCACTCAG AGTCACACAAAACCACAGCCTTTAGAGAACCCACAGGAAGGCTTTGGGGCACGTCCTGATTCTTGACATT TCTCATCAGTGCTGACTTTGTATCCCTTAGGAGTTCACAATTCATAACCACTGAAATATTAAAATACAAA AAGTTTTGGAAGGATGAGAGCCCAGATGCTCTACTACTTGAAAATATGTTAAAACATAAGTTCATCATTA TACATTTTGCTAAATCAGGATAAAGTCTGAAGTTTCAAAGAAGTTTTATTTTAGCAAATTTTCAGAAACA CTGCCTCAACTGTTAGGGCCAGTGTTCTAGTCAGTATGCCTTTGGAAGCATGAAAGCTGGATTGGTCGAT AGGATGGGTGTGGAAGGGGGGCTGTGACTGGGTGGGTACAGAGAGGCTCTGAAACAATCTCAGATTCCAG GAGTTCCTGGATAAGGACTTCATGTGCGGGAACAGAGCACAGGAGAAGCAGATTCCTGAGCCACTCAGGA AGAACTGGGCCTAGGCCTGCTCTTGTCACTGACTGGCTTTCTACATAACCACAGAAACAGCACTGTGTTG TAGAAAGAGGAAGATCATACTTTTTGATATCTGTGTCTAATTTAAGGTCATCTGAGCCCTGATAGAAAAG CAAAACAGACAAAACCCTTGTAACTGCTCCCTCCCACCCCACCCACCATCAAAAAAGCTTTAGAGAGGCT GGACATGGTGGCTCTTGCCTGTGATCCCAGCACTTTGGGAGGCTAAGGTGGGTGGATCACCTGAGGTCAG GAGTTCGAGACCAGCCTGACCAATATGGTGAAACCCCATCTGTACTAAAAATACAAAAATTAGCCAGGTG TGGTGGCACACGCCTGTAGTCCCAGCTACTTGGGAGGCTGAGACAGGAGAATTACTTGAAAACCTGGGAG GCGGAGGTTGCAGTGAGCCGAGATCACGCCATTGTACTCCAGCCTGGGCTACAGAGCGAGACTCCTTCAA AAAAAAAAAAAAAAAAAGATCCGGTTTGGTGTCTTACAACTGTAATCCCAGCACTTTGGGAGGCCGAGGC CGGTGGATCACGAGGTTAAGAGATCAAGACCATCCTGACCAACATGGTGAAACCCTGTCTCTACTAAAAA TTAGCTGGGCGTGGTGGCAGGCGCCTGTAGTCCCAGCTCCTCAGGAGGCTGAGGCAGAAGAATCGCTTGA ACCCGGGAGGCGGAAGTTGCAGTGAGCCTAGATCGCGCCCCTGCACTCCAGCCTGGCAACAGAGCAAGAC TACGTCTCAAAAAAAAAATAAATAAAAACTCTAGAGAAGCAAAAAGAATAACTTTAAAAGTGTTTATGTT CTCAGCAAGCTTTATTTTGGGGATGTCAGAACTTAACTAACCACTGCTCCTTCTGTGTGTATGTTTTTCC TCCAGCCTACCTTATGTTCAGTATTTTGGAGGTGTCTCTGCTCTAAGTAAACAACAGTTTCTAACCATCA ATGGATTTCCTAATAATTATTGGGGCTGGGGAGGAGAAGATGATGACATTTTTAACAGGTAATGGTCATA ACTTAGATATCTTTCTCCTCTGTCAACCTTCACTTCCAGTTTTTTAACCAATGCTTGGTTGTTCCCCAAG GACTGACCCTCAGATGGGATGCACCCCTAGTCAGCCCACATTCTTAGGTGTGGCTTCCTACAGGTCCTGC AGGTGCTAAAAGGGATCTGTAGGAAAATGAGTTTCTGAGATTTTTGTATTGGCCTGGAAAAATGTCAAAT GGGAACCAAGTGACGGGGCAAGTTTACTTTGACTTGCTGCATGCCGTTTTGTACTCAAGGAGTAAACCAA TGTCCTTTGTAAAAATCCCTCCTTTCATTATGGTCCCCTTTCACTGTGAAACAAGTTTCCTTGAGCAGAA TCCTAACTGTCTTCACAGAAGCTTTGTGTTATATTTTTATTTTGGAGTATTTTCACATATACAAAAGAGA TACTGTAGTATAATAAACCTTTGAGGACCTATCCAGCCCCAGCAACCATTATGGCCTGGTCAGTTCTGTC CCATCCACATCCTGGGGCTCTTTTTAAGCTGGTAAATCATTATGATGTGGGTTGTCATTTACAGTGGTAA AAAACATCTATCAGTAGCATTTGAAAGAACATTCTGCTCAGTCCTCTGGCTGTAGAGGCTTCAACCCCAC CAGCCACCGATGAGCACCTTCTCCCTCCAGGAGCCAGTCTGAGCTCATTACTGAGTTTAATATCAGAATA CACCCTGGTGCAGCCTTTCTAAATTGCAGTACCAGTTAACAGAAGGTGTCTGTCAGAGCAACACCCAAGT CATTCAAGTTACCATTGTGTGCAAACTTAACAGAGACCCACGTCTTCAATATAAGCCTTGAAGGAAACTC CAGTTTTAGTATGTAGATGGGGTATCAAGTGTGTGCACATTGAACATCTGCTGCATACAGAGCACTGTGC CAGGCAGGCCCAGGACACTGAAAACCTGGACATAGGGTCCAGACAGAAGCAAGCCTGCTTCCACAGAGGC ACTCCTGGGCAGACACTCTGGACTGATATGACAGTGTGCAGGGCCGACAGGATACCACAGGTCTGAATGG TCAGAACAGCTGGGGAGGGAGGGAGCATCCGCAGGCATCTAGTCCCATGCTAACGCAGTGGCACTAGAAG GATGGGTGGTGTGTGGAGCAACTTTCTTGAAAGATAAAGGACCTAACACTTTCTATGCACCACTTACTGT GTGCCAGGCAAGGCCAGGAATGTTTAAGTGGTCTGGGATCAGCCAGTTCTGCCTCTTAACTAACTTTGCT GTCCTGCTCTCCAGGCTTTCATTTTGGTCCTCATTCCTTTTCCTTGGACCAACACAGAATCCTCCACCCT GTTCTGGCTGCCTCTAGTCTTGTTCTCAGCCCTCCATTTGTTTTTTTCTGCCTTTTCCCACATGTTCTGA AGCCCTCCATTCGTATACTACTTTCCAGAGACTTCCCCATGGCTAAAAGCATTTTGGAAATACTGTATAT TAGGCCCCTTTCAGATACTGGCAACCGTTTGTGGGATGCTCTGAGAAGGCCTCTGTGACTTAGCCTGGCC CTTTTCAGCCCATCACCTGCCACGTCCTACCCCAGACCCTTGTCACCAGTCCCCAGGAGCTTACGTTGCT CCCTGAGGGCACTAGGCTTGCTCTCACTTCCATGCCTTTGCCTGTGCCATCCTGGCTGCCCAAAATGCTA TGGCAGATACCTGTTCATCCTCAACTGGGCTCTGCCTAGGCTTGCTCCAGCAGAGGTTACAAACTCTATG CTTCTTCCTCTGTGTCTCCAACCTCATCTTCCTCTTCTCACCTCCATCCTGGCCCTAAAGGCCCTATGTT TGAAGCATTCACACTGTATATTCTGTGGGGCACACGGCCCCAGTGTCTGGCACATGGTAGTCAACACCAC AAACCGCAGAACCAGTTGTAAAAGGACATGGAGTCGGAATGTGAGTTTTAACCAGGGTCATGCTGGGCTG GGTTCTGGCATGATGCTGGGTTGTGGGCTGAGTGAGAACAGCAAGGGTGATGGTGGATGGAGCAACAGTC TTGCAGCCGGGGCTCTCAGGCCAAGTGTATGGCAGCTCTGTGATAATGACTTTCCCTTTACTCTTTGCAG ATTAGTTTTTAGAGGCATGTCTATATCTCGCCCAAATGCTGTGGTCGGGAGGTGTCGCATGATCCGCCAC TCAAGAGACAAGAAAAATGAACCCAATCCTCAGAGGTGCATTCTTTGTTTATTCATACTCCTTCCCCCTT TAGGATGAGGTAGGCTGCAGGTCCGAGGCTCTGGGCCTAGAGGGAAATTGAGGTGGTCAGGTTACAGTGG AGAGGGAGGAGGAAGTACGTGTGATGATTTCTTCTTAAGATTTTTGTTTTAAGACAATCTCCTTGTGCTC TTTTCCTTGTAGGTTTGACCGAATTGCACACACAAAGGAGACAATGCTCTCTGATGGTTTGAACTCACTC ACCTACCAGGTGCTGGATGTACAGAGATACCCATTGTATACCCAAATCACAGTGGACATCGGGACACCGA GCTAGCGTTTTGGTACACGGATAAGAGACCTGAAATTAGCCAGGGACCTCTGCTGTGTGTCTCTGCCAAT CTGCTGGGCTGGTCCCTCTCATTTTTACCAGTCTGAGTGACAGGTCCCCTTCGCTCATCATTCAGATGGC TTTCCAGATGACCAGGACGAGTGGGATATTTTGCCCCCAACTTGGCTCGGCATGTGAATTCTTAGCTCTG CAAGGTGTTTATGCCTTTGCGGGTTTCTTGATGTGTTCGCAGTGTCACCCCAGAGTCAGAACTGTACACA TCCCAAAATTTGGTGGCCGTGGAACACATTCCCGGTGATAGAATTGCTAAATTGTCGTGAAATAGGTTAG AATTTTTCTTTAAATTATGGTTTTCTTATTCGTGAAAATTCGGAGAGTGCTGCTAAAATTGGATTGGTGT GATCTTTTTGGTAGTTGTAATTTAACAGAAAAACACAAAATTTCAACCATTCTTAATGTTACGTCCTCCC CCCACCCCCTTCTTTCAGTGGTATGCAACCACTGCAATCACTGTGCATATGTCTTTTCTTAGCAAAAGGA TTTTAAAACTTGAGCCCTGGACCTTTTGTCCTATGTGTGTGGATTCCAGGGCAACTCTAGCATCAGAGCA AAAGCCTTGGGTTTCTCGCATTCAGTGGCCTATCTCCAGATTGTCTGATTTCTGAATGTAAAGTTGTTGT GTTTTTTTTTAAATAGTAGTTTGTAGTATTTTAAAGAAAGAACAGATCGAGTTCTAATTATGATCTAGCT TGATTTTGTGTTGATCCAAATTTGCATAGCTGTTTAATGTTAAGTCATGACAATTTATTTTTCTTGGCAT GCTATGTAAACTTGAATTTCCTATGTATTTTTATTGTGGTGTTTTAAATATGGGGAGGGGTATTGAGCAT TTTTTAGGGAGAAAAATAAATATATGCTGTAGTGGCCACAAATAGGCCTATGATTTAGCTGGCAGGCCAG GTTTTCTCAAGAGCAAAATCACCCTCTGGCCCCTTGGCAGGTAAGGCCTCCCGGTCAGCATTATCCTGCC AGACCTCGGGGAGGATACCTGGGAGACAGAAGCCTCTGCACCTACTGTGCAGAACTCTCCACTTCCCCAA CCCTCCCCAGGTGGGCAGGGCGGAGGGAGCCTCAGCCTCCTTAGACTGACCCCTCAGGCCCCTAGGCTGG GGGGTTGTAAATAACAGCAGTCAGGTTGTTTACCAGCCCTTTGCACCTCCCCAGGCAGAGGGAGCCTCTG TTCTGGTGGGGGCCACCTCCCTCAGAGGCTCTGCTAGCCACACTCCGTGGCCCACCCTTTGTTACCAGTT CTTCCTCCTTCCTCTTTTCCCCTGCCTTTCTCATTCCTTCCTTCGTCTCCCTTTTTGTTCCTTTGCCTCT TGCCTGTCCCCTAAAACTTGACTGTGGCACTCAGGGTCAAACAGACTATCCATTCCCCAGCATGAATGTG CCTTTTAATTAGTGATCTAGAAAGAAGTTCAGCCGAACCCACACCCCAACTCCCTCCCAAGAACTTCGGT GCCTAAAGCCTCCTGTTCCACCTCAGGTTTTCACAGGTGCTCCCACCCCAGTTGAGGCTCCCACCCACAG GGCTGTCTGTCACAAACCCACCTCTGTTGGGAGCTATTGAGCCACCTGGGATGAGATGACACAAGGCACT CCTACCACTGAGCGCCTTTGCCAGGTCCAGCCTGGGCTCAGGTTCCAAGACTCAGCTGCCTAATCCCAGG GTTGAGCCTTGTGCTCGTGGCGGACCCCAAACCACTGCCCTCCTGGGTACCAGCCCTCAGTGTGGAGGCT GAGCTGGTGCCTGGCCCCAGTCTTATCTGTGCCTTTACTGCTTTGCGCATCTCAGATGCTAACTTGGTTC TTTTTCCAGAAGCCTTTGTATTGGTTAAAAATTATTTTCCATTGCAGAAGCAGCTGGACTATGCAAAAAG TATTTCTCTGTCAGTTCCCCACTCTATACCAAGGATATTATTAAAACTAGAAATGACTGCATTGAGAGGG AGTTGTGGGAAATAAGAAGAATGAAAGCCTCTCTTTCTGTCCGCAGATCCTGACTTTTCCAAAGTGCCTT AAAAGAAATCAGACAAATGCCCTGAGTGGTAACTTCTGTGTTATTTTACTCTTAAAACCAAACTCTACCT TTTCTTGTTGTTTTTTTTTTTTTTTTTTTTTTTTTTTTGGTTACCTTCTCATTCATGTCAAGTATGTGGT TCATTCTTAGAACCAAGGGAAATACTGCTCCCCCCATTTGCTGACGTAGTGCTCTCATGGGCTCACCTGG GCCCAAGGCACAGCCAGGGCACAGTTAGGCCTGGATGTTTGCCTGGTCCGTGAGATGCCGCGGGTCCTGT TTCCTTACTGGGGATTTCAGGGCTGGGGGTTCAGGGAGCATTTCCTTTTCCTGGGAGTTATGACCGCGAA GTTGTCATGTGCCGTGCCCTTTTCTGTTTCTGTGTATCCTATTGCTGGTGACTCTGTGTGAACTGGCCTT TGGGAAAGATCAGAGAGGGCAGAGGTGGCACAGGACAGTAAAGGAGATGCTGTGCTGGCCTTCAGCCTGG ACAGGGTCTCTGCTGACTGCCAGGGGCGGGGGCTCTGCATAGCCAGGATGACGGCTTTCATGTCCCAGAG ACCTGTTGTGCTGTGTATTTTGATTTCCTGTGTATGCAAATGTGTGTATTTACCATTGTGTAGGGGGCTG TGTCTGATCTTGGTGTTCAAAACAGAACTGTATTTTTGCCTTTAAAATTAAATAATATAACGTGAATAAA TGACCCTATCTTTGTAACTGCA Download Select all
Length	56722
OMIM ID	137060
HGNC ID	HGNC:924
Unigene ID	Hs.272011
Ensembl ID	ENSG00000086062
PharmGKB ID	-

mRNA Information

mRNA ID	XM_005251440.3
Exon	join(33..601,31935..32170,46753..46940,53481..53585, 53773..56722)
mRNA Sequence	>2683 GCGCCTCGGGCGGCTTCTCGCCGCTCCCAGGTCTGGCTGGCTGGAGGAGTCTCAGCTCTCAGCC GCTCGCCCGCCCCCGCTCCGGGCCCTCCCCTAGTCGCCGCTGTGGGGCAGCGCCTGGCGGGCGG CCCGCGGGCGGGTCGCCTCCCCTCCTGTAGCCCACACCCTTCTTAAAGCGGCGGCGGGAAGATG AGGCTTCGGGAGCCGCTCCTGAGCGGCAGCGCCGCGATGCCAGGCGCGTCCCTACAGCGGGCCT GCCGCCTGCTCGTGGCCGTCTGCGCTCTGCACCTTGGCGTCACCCTCGTTTACTACCTGGCTGG CCGCGACCTGAGCCGCCTGCCCCAACTGGTCGGAGTCTCCACACCGCTGCAGGGCGGCTCGAAC AGTGCCGCCGCCATCGGGCAGTCCTCCGGGGAGCTCCGGACCGGAGGGGCCCGGCCGCCGCCTC CTCTAGGCGCCTCCTCCCAGCCGCGCCCGGGTGGCGACTCCAGCCCAGTCGTGGATTCTGGCCC TGGCCCCGCTAGCAACTTGACCTCGGTCCCAGTGCCCCACACCACCGCACTGTCGCTGCCCGCC TGCCCTGAGGAGTCCCCGCTGCTTGTGGGCCCCATGCTGATTGAGTTTAACATGCCTGTGGACC TGGAGCTCGTGGCAAAGCAGAACCCAAATGTGAAGATGGGCGGCCGCTATGCCCCCAGGGACTG CGTCTCTCCTCACAAGGTGGCCATCATCATTCCATTCCGCAACCGGCAGGAGCACCTCAAGTAC TGGCTATATTATTTGCACCCAGTCCTGCAGCGCCAGCAGCTGGACTATGGCATCTATGTTATCA ACCAGGCGGGAGACACTATATTCAATCGTGCTAAGCTCCTCAATGTTGGCTTTCAAGAAGCCTT GAAGGACTATGACTACACCTGCTTTGTGTTTAGTGACGTGGACCTCATTCCAATGAATGACCAT AATGCGTACAGGTGTTTTTCACAGCCACGGCACATTTCCGTTGCAATGGATAAGTTTGGATTCA GCCTACCTTATGTTCAGTATTTTGGAGGTGTCTCTGCTCTAAGTAAACAACAGTTTCTAACCAT CAATGGATTTCCTAATAATTATTGGGGCTGGGGAGGAGAAGATGATGACATTTTTAACAGATTA GTTTTTAGAGGCATGTCTATATCTCGCCCAAATGCTGTGGTCGGGAGGTGTCGCATGATCCGCC ACTCAAGAGACAAGAAAAATGAACCCAATCCTCAGAGGTTTGACCGAATTGCACACACAAAGGA GACAATGCTCTCTGATGGTTTGAACTCACTCACCTACCAGGTGCTGGATGTACAGAGATACCCA TTGTATACCCAAATCACAGTGGACATCGGGACACCGAGCTAGCGTTTTGGTACACGGATAAGAG ACCTGAAATTAGCCAGGGACCTCTGCTGTGTGTCTCTGCCAATCTGCTGGGCTGGTCCCTCTCA TTTTTACCAGTCTGAGTGACAGGTCCCCTTCGCTCATCATTCAGATGGCTTTCCAGATGACCAG GACGAGTGGGATATTTTGCCCCCAACTTGGCTCGGCATGTGAATTCTTAGCTCTGCAAGGTGTT TATGCCTTTGCGGGTTTCTTGATGTGTTCGCAGTGTCACCCCAGAGTCAGAACTGTACACATCC CAAAATTTGGTGGCCGTGGAACACATTCCCGGTGATAGAATTGCTAAATTGTCGTGAAATAGGT TAGAATTTTTCTTTAAATTATGGTTTTCTTATTCGTGAAAATTCGGAGAGTGCTGCTAAAATTG GATTGGTGTGATCTTTTTGGTAGTTGTAATTTAACAGAAAAACACAAAATTTCAACCATTCTTA ATGTTACGTCCTCCCCCCACCCCCTTCTTTCAGTGGTATGCAACCACTGCAATCACTGTGCATA TGTCTTTTCTTAGCAAAAGGATTTTAAAACTTGAGCCCTGGACCTTTTGTCCTATGTGTGTGGA TTCCAGGGCAACTCTAGCATCAGAGCAAAAGCCTTGGGTTTCTCGCATTCAGTGGCCTATCTCC AGATTGTCTGATTTCTGAATGTAAAGTTGTTGTGTTTTTTTTTAAATAGTAGTTTGTAGTATTT TAAAGAAAGAACAGATCGAGTTCTAATTATGATCTAGCTTGATTTTGTGTTGATCCAAATTTGC ATAGCTGTTTAATGTTAAGTCATGACAATTTATTTTTCTTGGCATGCTATGTAAACTTGAATTT CCTATGTATTTTTATTGTGGTGTTTTAAATATGGGGAGGGGTATTGAGCATTTTTTAGGGAGAA AAATAAATATATGCTGTAGTGGCCACAAATAGGCCTATGATTTAGCTGGCAGGCCAGGTTTTCT CAAGAGCAAAATCACCCTCTGGCCCCTTGGCAGGTAAGGCCTCCCGGTCAGCATTATCCTGCCA GACCTCGGGGAGGATACCTGGGAGACAGAAGCCTCTGCACCTACTGTGCAGAACTCTCCACTTC CCCAACCCTCCCCAGGTGGGCAGGGCGGAGGGAGCCTCAGCCTCCTTAGACTGACCCCTCAGGC CCCTAGGCTGGGGGGTTGTAAATAACAGCAGTCAGGTTGTTTACCAGCCCTTTGCACCTCCCCA GGCAGAGGGAGCCTCTGTTCTGGTGGGGGCCACCTCCCTCAGAGGCTCTGCTAGCCACACTCCG TGGCCCACCCTTTGTTACCAGTTCTTCCTCCTTCCTCTTTTCCCCTGCCTTTCTCATTCCTTCC TTCGTCTCCCTTTTTGTTCCTTTGCCTCTTGCCTGTCCCCTAAAACTTGACTGTGGCACTCAGG GTCAAACAGACTATCCATTCCCCAGCATGAATGTGCCTTTTAATTAGTGATCTAGAAAGAAGTT CAGCCGAACCCACACCCCAACTCCCTCCCAAGAACTTCGGTGCCTAAAGCCTCCTGTTCCACCT CAGGTTTTCACAGGTGCTCCCACCCCAGTTGAGGCTCCCACCCACAGGGCTGTCTGTCACAAAC CCACCTCTGTTGGGAGCTATTGAGCCACCTGGGATGAGATGACACAAGGCACTCCTACCACTGA GCGCCTTTGCCAGGTCCAGCCTGGGCTCAGGTTCCAAGACTCAGCTGCCTAATCCCAGGGTTGA GCCTTGTGCTCGTGGCGGACCCCAAACCACTGCCCTCCTGGGTACCAGCCCTCAGTGTGGAGGC TGAGCTGGTGCCTGGCCCCAGTCTTATCTGTGCCTTTACTGCTTTGCGCATCTCAGATGCTAAC TTGGTTCTTTTTCCAGAAGCCTTTGTATTGGTTAAAAATTATTTTCCATTGCAGAAGCAGCTGG ACTATGCAAAAAGTATTTCTCTGTCAGTTCCCCACTCTATACCAAGGATATTATTAAAACTAGA AATGACTGCATTGAGAGGGAGTTGTGGGAAATAAGAAGAATGAAAGCCTCTCTTTCTGTCCGCA GATCCTGACTTTTCCAAAGTGCCTTAAAAGAAATCAGACAAATGCCCTGAGTGGTAACTTCTGT GTTATTTTACTCTTAAAACCAAACTCTACCTTTTCTTGTTGTTTTTTTTTTTTTTTTTTTTTTT TTTTTGGTTACCTTCTCATTCATGTCAAGTATGTGGTTCATTCTTAGAACCAAGGGAAATACTG CTCCCCCCATTTGCTGACGTAGTGCTCTCATGGGCTCACCTGGGCCCAAGGCACAGCCAGGGCA CAGTTAGGCCTGGATGTTTGCCTGGTCCGTGAGATGCCGCGGGTCCTGTTTCCTTACTGGGGAT TTCAGGGCTGGGGGTTCAGGGAGCATTTCCTTTTCCTGGGAGTTATGACCGCGAAGTTGTCATG TGCCGTGCCCTTTTCTGTTTCTGTGTATCCTATTGCTGGTGACTCTGTGTGAACTGGCCTTTGG GAAAGATCAGAGAGGGCAGAGGTGGCACAGGACAGTAAAGGAGATGCTGTGCTGGCCTTCAGCC TGGACAGGGTCTCTGCTGACTGCCAGGGGCGGGGGCTCTGCATAGCCAGGATGACGGCTTTCAT GTCCCAGAGACCTGTTGTGCTGTGTATTTTGATTTCCTGTGTATGCAAATGTGTGTATTTACCA TTGTGTAGGGGGCTGTGTCTGATCTTGGTGTTCAAAACAGAACTGTATTTTTGCCTTTAAAATT AAATAATATAACGTGAATAAATGACCCTATCTTTGTAACAAAAAAAAAAAAAAA Download Select all
Length	4214

CDS Information

Location	join(190..601,31935..32170,46753..46940,53481..53585, 53773..53905)
CDS Sequence	>lcl\|XM_005251440.3_cds_XP_005251497.1_1 [gene=B4GALT1] [protein=beta-1,4-galactosyltransferase 1 isoform X1] [protein_id=XP_005251497.1] [location=158..1231] ATGAGGCTTCGGGAGCCGCTCCTGAGCGGCAGCGCCGCGATGCCAGGCGCGTCCCTACAGCGGGCCTGCC GCCTGCTCGTGGCCGTCTGCGCTCTGCACCTTGGCGTCACCCTCGTTTACTACCTGGCTGGCCGCGACCT GAGCCGCCTGCCCCAACTGGTCGGAGTCTCCACACCGCTGCAGGGCGGCTCGAACAGTGCCGCCGCCATC GGGCAGTCCTCCGGGGAGCTCCGGACCGGAGGGGCCCGGCCGCCGCCTCCTCTAGGCGCCTCCTCCCAGC CGCGCCCGGGTGGCGACTCCAGCCCAGTCGTGGATTCTGGCCCTGGCCCCGCTAGCAACTTGACCTCGGT CCCAGTGCCCCACACCACCGCACTGTCGCTGCCCGCCTGCCCTGAGGAGTCCCCGCTGCTTGTGGGCCCC ATGCTGATTGAGTTTAACATGCCTGTGGACCTGGAGCTCGTGGCAAAGCAGAACCCAAATGTGAAGATGG GCGGCCGCTATGCCCCCAGGGACTGCGTCTCTCCTCACAAGGTGGCCATCATCATTCCATTCCGCAACCG GCAGGAGCACCTCAAGTACTGGCTATATTATTTGCACCCAGTCCTGCAGCGCCAGCAGCTGGACTATGGC ATCTATGTTATCAACCAGGCGGGAGACACTATATTCAATCGTGCTAAGCTCCTCAATGTTGGCTTTCAAG AAGCCTTGAAGGACTATGACTACACCTGCTTTGTGTTTAGTGACGTGGACCTCATTCCAATGAATGACCA TAATGCGTACAGGTGTTTTTCACAGCCACGGCACATTTCCGTTGCAATGGATAAGTTTGGATTCAGATTA GTTTTTAGAGGCATGTCTATATCTCGCCCAAATGCTGTGGTCGGGAGGTGTCGCATGATCCGCCACTCAA GAGACAAGAAAAATGAACCCAATCCTCAGAGGTTTGACCGAATTGCACACACAAAGGAGACAATGCTCTC TGATGGTTTGAACTCACTCACCTACCAGGTGCTGGATGTACAGAGATACCCATTGTATACCCAAATCACA GTGGACATCGGGACACCGAGCTAG Download Select all
CCDS ID	-

Protein Information

Protein ID	NP_001488.2
Protein Name	UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1
Molecular Wt. (Da)	43789
Protein Sequence	>2683 MRLREPLLSGSAAMPGASLQRACRLLVAVCALHLGVTLVYYLAGRDLSRLPQLVGVSTPLQGGS NSAAAIGQSSGELRTGGARPPPPLGASSQPRPGGDSSPVVDSGPGPASNLTSVPVPHTTALSLP ACPEESPLLVGPMLIEFNMPVDLELVAKQNPNVKMGGRYAPRDCVSPHKVAIIIPFRNRQEHLK YWLYYLHPVLQRQQLDYGIYVINQAGDTIFNRAKLLNVGFQEALKDYDYTCFVFSDVDLIPMND HNAYRCFSQPRHISVAMDKFGFSLPYVQYFGGVSALSKQQFLTINGFPNNYWGWGGEDDDIFNR LVFRGMSISRPNAVVGRCRMIRHSRDKKNEPNPQRFDRIAHTKETMLSDGLNSLTYQVLDVQRY PLYTQITVDIGTPS Download Select all
Length	398
Uniprot ID	P16402
Ensembl Protein ID	ENSP00000244534

Post-translational Modification Information (Source : HPRD)

Residue	Type	site
S	Phosphorylation	74
S	Phosphorylation	64

Enzyme Information

EC	2.4.1.22
Name	lactose synthase UDP-galactose---glucose galactosyltransferase N-acetyllactosamine synthase uridine diphosphogalactose-glucose galactosyltransferase lactose synthetase UDP-galactose:D-glucose 4-beta-D-galactotransferase UDP-galactose:D-glucose 4-beta-D-galactosyltransferase
Class	Transferases; Glycosyltransferases; Hexosyltransferases
Sysname	UDP-alpha-D-galactose:D-glucose 4-beta-D-galactosyltransferase
Substrate	UDP-alpha-D-galactose [CPD:C00052]; D-glucose [CPD:C00031]
Product	UDP [CPD:C00015]; lactose [CPD:C00243]
Reaction (IUBMB)

PPi Information

(Click to view network : Source STRING) View

Interactant Gene ID (Source: HPRD)	Gene Symbol	HPRD ID	Ref Seq ID	Technique	References
985	CDC2L2	308	NP_277073.1	in vitro	11506180
7277	TUBA4A	1851	NP_005991.1	in vivo	7744867
203068	TUBB	1852	NP_001060.1	in vivo	7744867

Pathway Information

Pathway Name	Pathway ID
Galactose metabolism	hsa00052
Glycosaminoglycan biosynthesis - keratan sulfate	hsa00533
Glycosphingolipid biosynthesis - lacto and neolacto series	hsa00601
Metabolic pathways	hsa01100
N-Glycan biosynthesis	hsa00510
Other types of O-glycan biosynthesis	hsa00514

Structure Information

PDB ID	2AE7
Resolution	2
Method	?? X-RAY DIFFRACTION
Chains	A, B,
Molecule	Beta-1,4-galactosyltransferase 1
Model	View

Domain Information

ID	Location	Description
cd00899	175-393	b4GalT
cl11394	175-393	Glyco_tranf_GTA_type superfamily
pfam13733	130-262	Glyco_transf_7N
cl15817	130-262	Glyco_transf_7N superfamily
pfam02709	267-337	Glyco_transf_7C
cd06420	219-325	GT2_Chondriotin_Pol_N
cd00761	180-330	Glyco_tranf_GTA_type
TIGR04440	177-241	glyco_TIGR04440
pfam10111	212-331	Glyco_tranf_2_2
pfam15449	42-135	Retinal
PTZ00118	162-197	PTZ00118

Ontology Information

HPRD ID	3889
Molecular Class	Enzyme: Galactosyltransferase
Molecular Function	Molecular function unknown (GO:0005554)
Biological Process	Carbohydrate metabolism (GO:0005975)

SNP Information

View SNP Geneview Report

Drug Information

Uniprot ID DrugBank ID Name Type
P15291 DB00141 N-Acetyl-D-glucosamine SmallMoleculeDrug

External Links

ArrayExpress GO
ICGC GO
Cancer3D GO
COSMIC GO
NCG GO
TSGene GO
Tumor Gene Family of Databases GO
CCDB GO
G2SBC GO
Osteosarcoma Database GO
RCDB GO

ArrayExpress	GO
ICGC	GO
Cancer3D	GO
COSMIC	GO
NCG	GO
TSGene	GO
Tumor Gene Family of Databases	GO
CCDB	GO
G2SBC	GO
Osteosarcoma Database	GO
RCDB	GO