Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| B4GALT3 | 8703 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 3 | 1 | beta4Gal-T3 |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 24403309 | 2014 | Cell line : HCT116, SW480, SW620, colo205 and HT29 Source : Bioresource Collection and Research Center (BCRC, HsinChu, Taiwan). And Tissue array BC051110 and CO2161 (US Biomax, Rockville, MD). Sample Type : Tissue Array No. of Sample : 110 and 208 non-overlapping CRC patient tissues Stage : TNM Stage I-IV. | knockdown cells,Transfection,Immunofluorescence,MTT?assay,Transwell migration?assay,Matrigel invasion?assay,Immunoblotting and lectin pull-down assay,Flow cytometry | Down-regulation | - | B4GALT3 is negatively associated with CRC metastasis and suppresses cell invasiveness through inhibiting activation of ?1 integrin. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Beta 4-glycosyltransferases |
| Description | This gene is one of seven beta-1,4-galactosyltransferase (beta4GalT) genes. They encode type II membrane-bound glycoproteins that appear to have exclusive specificity for the donor substrate UDP-galactose; all transfer galactose in a beta1,4 linkage to similar acceptor sugars: GlcNAc, Glc, and Xyl. Each beta4GalT has a distinct function in the biosynthesis of different glycoconjugates and saccharide structures. As type II membrane proteins, they have an N-terminal hydrophobic signal sequence that directs the protein to the Golgi apparatus and which then remains uncleaved to function as a transmembrane anchor. By sequence similarity, the beta4GalTs form four groups: beta4GalT1 and beta4GalT2, beta4GalT3 and beta4GalT4, beta4GalT5 and beta4GalT6, and beta4GalT7. This gene encodes an enzyme that may be mainly involved in the synthesis of the first N-acetyllactosamine unit of poly-N-acetyllactosamine chains. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Dec 2010] | Chromosome | 1 |
| Location | 1q21-q23 |
| Start | 161141100 |
| End | 161147758 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 6659 |
| OMIM ID | 604014 |
| HGNC ID | HGNC:926 |
| Unigene ID | Hs.321231 |
| Ensembl ID | ENSG00000158850 |
| PharmGKB ID | PA25225 |
Protein Information
| Protein ID | NP_001186802.1 |
|---|---|
| Protein Name | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 3 |
| Molecular Wt. (Da) | 0 |
| Protein Sequence | Download Select all |
| Length | 393 |
| Uniprot ID | O00322 |
| Ensembl Protein ID | ENSP00000222275 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 54622 | ARL15 | 12471 | NP_061960.1 | yeast 2-hybrid | 16169070 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Glycosaminoglycan biosynthesis - keratan sulfate | hsa00533 |
| Glycosphingolipid biosynthesis - lacto and neolacto series | hsa00601 |
| Metabolic pathways | hsa01100 |
| N-Glycan biosynthesis | hsa00510 |
| Other types of O-glycan biosynthesis | hsa00514 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd00899 | 122-341 | b4GalT |
| cl11394 | 122-341 | Glyco_tranf_GTA_type superfamily |
| pfam13733 | 77-212 | Glyco_transf_7N |
| cl15817 | 77-212 | Glyco_transf_7N superfamily |
| pfam02709 | 215-284 | Glyco_transf_7C |
| cd06420 | 160-275 | GT2_Chondriotin_Pol_N |
| pfam10111 | 159-281 | Glyco_tranf_2_2 |
Ontology Information
| HPRD ID | 5717 |
|---|---|
| Molecular Class | Enzyme: Galactosyltransferase |
| Molecular Function | Ubiquitin-specific protease activity (GO:0004843) |
| Biological Process | Protein metabolism (GO:0019538) |
Drug Information
| Uniprot ID | DrugBank ID | Name | Type |
|---|---|---|---|
| O60512 | DB00141 | N-Acetyl-D-glucosamine | SmallMoleculeDrug |