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General Information
- Evidence
- Gene
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- Protein
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- Enzyme
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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 21809033 | 2011 | Cell line : - Source : - Sample Type : CRC tumor and Normal tissue No. of Sample : 320 colorectal cancer and 30 normal tissue Stage : - | RT-PCR,immunohistochemistry | Up-regulation | - | Bag-1 protein was found to be overexpressed in colorectal cancer. They might be regarded as a biomarker for the diagnosis of the early stages of colorectal cancer. Using RT-PCR, Bag-1 was observed to be expressed in colorectal cancer tissues, but not in normal colorectal tissues. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | |
| Description | The oncogene BCL2 is a membrane protein that blocks a step in a pathway leading to apoptosis or programmed cell death. The protein encoded by this gene binds to BCL2 and is referred to as BCL2-associated athanogene. It enhances the anti-apoptotic effects of BCL2 and represents a link between growth factor receptors and anti-apoptotic mechanisms. Multiple protein isoforms are encoded by this mRNA through the use of a non-AUG (CUG) initiation codon, and three alternative downstream AUG initiation codons. A related pseudogene has been defined on chromosome X. | Chromosome | 9 |
| Location | 9p12 |
| Start | 33252471 |
| End | 33264761 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 12291 |
| OMIM ID | 601497 |
| HGNC ID | HGNC:937 |
| Unigene ID | Hs.377484 |
| Ensembl ID | ENSG00000107262 |
| PharmGKB ID | - |
mRNA Information
| mRNA ID | NM_004323.5 |
|---|---|
| Exon | join(1..538,1932..2060,3593..3675,5729..5842,7854..7961, 8835..8897,9454..12291) | mRNA Sequence | Download Select all |
| Length | 3885 |
CDS Information
| Location | join(88..538,1932..2060,3593..3675,5729..5842,7854..7961, 8835..8897,9454..9543) |
|---|---|
| CDS Sequence | Download Select all |
| CCDS ID | CCDS35004.1 |
Protein Information
| Protein ID | NP_001165886.1 |
|---|---|
| Protein Name | BCL2-associated athanogene |
| Molecular Wt. (Da) | 25858 |
| Protein Sequence | Download Select all |
| Length | 230 |
| Uniprot ID | P08151 |
| Ensembl Protein ID | ENSP00000228682 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| S | Phosphorylation | 223 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 367 | AR | 2437 | NP_000035.2 | in vitro;in vivo | 1 127 876 314 517 280 |
| 596 | BCL2 | 1045 | NP_000624.2 | in vitro | 9305631 |
| 598 | BCL2L1 | 2497 | NP_612815.1 | in vivo | 10467399 |
| 1839 | HBEGF | 526 | NP_001936.1 | in vitro;yeast 2-hybrid | 11340068 |
| 2099 | ESR1 | 589 | NP_000116.2 | in vivo | 8524784 |
| 2908 | NR3C1 | 679 | NP_001019265.1 | in vitro;in vivo | 96 039 791 110 152 300 000 000 |
| 3303 | HSPA1A | 774 | NP_005336.3 | in vitro;in vivo | 11 101 523 930 563 100 000 000 |
| 3304 | HSPA1B | 6784 | NP_005337.2 | in vitro;yeast 2-hybrid | 11231577 |
| 4233 | MET | 1280 | NP_001120972.1 | in vivo | 8947043 |
| 5159 | PDGFRB | 1423 | NP_002600.1 | in vivo | 8947043 |
| 5894 | RAF1 | 1265 | NP_002871.1 | in vitro;in vivo | 8692945 |
| 5925 | RB1 | 1574 | NP_000312.2 | in vitro;in vivo;yeast 2-hybrid | 12845674 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Protein processing in endoplasmic reticulum | hsa04141 |
Structure Information
| PDB ID | 1HX1 |
|---|---|
| Resolution | 1.9 |
| Method | X-RAY DIFFRACTION |
| Chains | B |
| Molecule | BAG family molecular chaperone regulator 1 |
| Model | View |
Domain Information
| ID | Location | Description |
|---|---|---|
| cd01812 | 144-220 | BAG1_N |
| cl00155 | 144-220 | UBQ superfamily |
| smart00264 | 246-326 | BAG |
| cl02539 | 246-326 | BAG superfamily |
| pfam02179 | 249-326 | BAG |
| cd01769 | 170-220 | UBL |
| pfam00240 | 170-220 | ubiquitin |
| cd01809 | 144-218 | Scythe_N |
| cd00196 | 170-220 | UBQ |
| cd01796 | 144-217 | DDI1_N |
| pfam14560 | 144-215 | Ubiquitin_2 |
| smart00213 | 156-220 | UBQ |
| PTZ00121 | 64-138 | PTZ00121 |
| PTZ00121 | 73-291 | PTZ00121 |
| PTZ00121 | 23-140 | PTZ00121 |
| PRK12678 | 2-138 | PRK12678 |
| PTZ00121 | 74-146 | PTZ00121 |
| PTZ00121 | 67-141 | PTZ00121 |
| PTZ00121 | 49-138 | PTZ00121 |
| PTZ00121 | 64-133 | PTZ00121 |
| PTZ00121 | 20-137 | PTZ00121 |
| pfam14728 | 139-295 | PHTB1_C |
| pfam01865 | 233-329 | PhoU_div |
| PTZ00121 | 64-140 | PTZ00121 |
Ontology Information
| HPRD ID | 759 |
|---|---|
| Molecular Class | Transcription factor |
| Molecular Function | GTPase activity (GO:0003924) |
| Biological Process | Cell communication (GO:0007154); Signal transduction (GO:0007165) |
Drug Information
No matching records could be found.