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General Information
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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 23553442 | 2013 | Cell line : Colo201, Colo205, DLD-1, HCT-15, HCT-116, HT-29, KM-12, SW480, SW620, and WiDr Source : - Sample Type : - No. of Sample : - Stage : - | Immunohistochemistry, In situ hybridization on tissue microarrays,RT-PCR, Western blotting, immunofluorescence | Up-regulation | - | Aberrant Bag-3 expression might be involved in colorectal adenoma-adenocarcinoma sequence and subsequent progression. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | BAG proteins compete with Hip for binding to the Hsc70/Hsp70 ATPase domain and promote substrate release. All the BAG proteins have an approximately 45-amino acid BAG domain near the C terminus but differ markedly in their N-terminal regions. The protein encoded by this gene contains a WW domain in the N-terminal region and a BAG domain in the C-terminal region. The BAG domains of BAG1, BAG2, and BAG3 interact specifically with the Hsc70 ATPase domain in vitro and in mammalian cells. All 3 proteins bind with high affinity to the ATPase domain of Hsc70 and inhibit its chaperone activity in a Hip-repressible manner. [provided by RefSeq, Jul 2008] | Chromosome | 10 |
| Location | 10q25.2-q2 |
| Start | 121410859 |
| End | 121437331 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 26473 |
| OMIM ID | 603883 |
| HGNC ID | HGNC:939 |
| Unigene ID | Hs.523309 |
| Ensembl ID | ENSG00000151929 |
| PharmGKB ID | PA25239 |
Protein Information
| Protein ID | NP_004272.2 |
|---|---|
| Protein Name | BCL2-associated athanogene 3 |
| Molecular Wt. (Da) | 0 |
| Protein Sequence | Download Select all |
| Length | 575 |
| Uniprot ID | Q9Y6E7 |
| Ensembl Protein ID | ENSP00000202967 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| S | Phosphorylation | 275 |
| S | Phosphorylation | 279 |
| S | Phosphorylation | 377 |
| Y | Phosphorylation | 240 |
| Y | Phosphorylation | 247;- |
| S | Phosphorylation | 264;- |
| S | Phosphorylation | 283;- |
| S | Phosphorylation | 377;- |
| S | Phosphorylation | 289;- |
| T | Phosphorylation | 285;- |
| S | Phosphorylation | 171;- |
| S | Phosphorylation | 274;- |
| S | Phosphorylation | 386;- |
| S | Phosphorylation | 381;- |
| S | Phosphorylation | 173 |
| S | Phosphorylation | 177 |
| S | Phosphorylation | 291 |
| S | Phosphorylation | 385 |
| T | Phosphorylation | 406 |
| S | Phosphorylation | 284 |
| S | Phosphorylation | 136 |
| S | Phosphorylation | 194 |
| S | Phosphorylation | 7 |
| S | Phosphorylation | 195 |
| S | Phosphorylation | 198 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 596 | BCL2 | 1045 | NP_000624.2 | in vitro;in vivo | 11513873 |
| 3303 | HSPA1A | 774 | NP_005336.3 | in vitro;in vivo | 987 301 610 980 614 |
| 5335 | PLCG1 | 1398 | NP_002651.2 | in vitro;in vivo | 10980614 |
| 9413 | FAM189A2 | 16255 | NP_004807.3 | yeast 2-hybrid | 16189514 |
| 9802 | DAZAP2 | 8463 | NP_001129738.1 | yeast 2-hybrid | 16189514 |
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd00201 | 23-53 | WW |
| cl00157 | 23-53 | WW superfamily |
| pfam02179 | 424-498 | BAG |
| cl02539 | 424-498 | BAG superfamily |
| smart00264 | 421-498 | BAG |
| smart00456 | 21-53 | WW |
| pfam00397 | 22-52 | WW |
| PHA03247 | 257-417 | PHA03247 |
| PRK07003 | 257-421 | PRK07003 |
Ontology Information
| HPRD ID | 5415 |
|---|---|
| Molecular Class | Adapter molecule |
| Molecular Function | Molecular function unknown (GO:0005554) |
| Biological Process | Cell development (GO:0048468) |
Drug Information
No matching records could be found.