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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
BAI1 575 brain-specific angiogenesis inhibitor 1  8- 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
9772287   1998Cell line : -

Source : -

Sample Type : CRC tumor

No. of Sample : 49

Stage : -

RT-PCRDown-regulation-BAI1 expression might inhibit angiogenesis and metastasis of colorectal cancer.

10568831   1999Cell line : -

Source : -

Sample Type : CRC tumor

No. of Sample : 62 CRC and 40 extraneoplastic colon mucosa

Stage : -

-Down-regulation--


Gene Details



NC_000008.10 (143545377..143626369)

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Gene Type protein coding
Gene Family -, "GPCR / Class B : Orphans"
Description Angiogenesis is controlled by a local balance between stimulators and inhibitors of new vessel growth and is suppressed under normal physiologic conditions. Angiogenesis has been shown to be essential for growth and metastasis of solid tumors. In order to obtain blood supply for their growth, tumor cells are potently angiogenic and attract new vessels as results of increased secretion of inducers and decreased production of endogenous negative regulators. BAI1 contains at least one 'functional' p53-binding site within an intron, and its expression has been shown to be induced by wildtype p53. There are two other brain-specific angiogenesis inhibitor genes, designated BAI2 and BAI3 which along with BAI1 have similar tissue specificities and structures, however only BAI1 is transcriptionally regulated by p53. BAI1 is postulated to be a member of the secretin receptor family, an inhibitor of angiogenesis and a growth suppressor of glioblastomas [provided by RefSeq, Jul 2008]  
Chromosome 8
Location 8q24.3
Start 143545377  
End 143626369  
Strand +  
Gene Sequence

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Length 80993  
OMIM ID 602682   
HGNC ID HGNC:943   
Unigene ID Hs.194654   
Ensembl ID ENSG00000181790   
PharmGKB ID PA25247   

mRNA Information


mRNA ID XM_011517202.1
Exon join(35..217,14093..15095,25587..25748,26698..26808, 27227..27391,27498..27662,28300..28473,29436..29600, 29806..29907,31367..31473,31630..31824,34090..34158, 34769..34877,38477..38620,39148..39223,39449..39551, 40885..40928,61045..61186,68251..68354,70936..71038, 72078..72228,72754..72823,74351..74417,76655..76740, 83508..83579,87100..87195)  
mRNA Sequence

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Length 3968  



CDS Information


   
Location 403..3888
CDS Sequence

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CCDS ID CCDS64985.1



Protein Information


      
Protein IDXP_011515504.1
Protein Namebrain-specific angiogenesis inhibitor 1
Molecular Wt. (Da)126951
Protein Sequence

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Length 1161  
Uniprot IDQ7Z4N2
Ensembl Protein ID ENSP00000256552  



Post-translational Modification Information (Source : HPRD)


No matching records could be found.

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

               
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
9223MAGI14020NP_001028229.1in vitro;in vivo;yeast 2-hybrid9647739   


Pathway Information


      
Pathway Name Pathway ID
p53 signaling pathway hsa04115


Structure Information


No matching records could be found.

Domain Information




ID Location Description
pfam00002944-1180  7tm_2
cl21587944-1180  7tm_2 superfamily
pfam12003653-875  DUF3497
cl13441653-875  DUF3497 superfamily
smart00209412-462  TSP1
cl15278412-462  TSP_1 superfamily
smart00209525-575  TSP1
cl15278525-575  TSP_1 superfamily
smart00303880-938  GPS
cl02559880-938  GPS superfamily
smart00209359-407  TSP1
cl15278359-407  TSP_1 superfamily
smart00008577-643  HormR
cl02422577-643  HRM superfamily
pfam00090414-461  TSP_1
pfam00090359-401  TSP_1
pfam01825881-933  GPS
pfam00090528-574  TSP_1
smart00209264-314  TSP1
cl15278264-314  TSP_1 superfamily
pfam02793578-637  HRM
PTZ00441410-434  PTZ00441


Ontology Information


   
HPRD ID392
Molecular ClassIntegral membrane protein
Molecular FunctionMetallopeptidase activity (GO:0008237)
Biological ProcessPeptide metabolism (GO:0006518)  



SNP Information


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Drug Information


No matching records could be found.

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO