Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| BAI1 | 575 | brain-specific angiogenesis inhibitor 1  | 8 | -  |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 9772287    | 1998 | Cell line : - Source : - Sample Type : CRC tumor No. of Sample : 49 Stage : - | RT-PCR | Down-regulation | - | BAI1 expression might inhibit angiogenesis and metastasis of colorectal cancer. |
| 10568831    | 1999 | Cell line : - Source : - Sample Type : CRC tumor No. of Sample : 62 CRC and 40 extraneoplastic colon mucosa Stage : - | - | Down-regulation | - | - |
Gene Details

| Gene Type | protein coding |
|---|---|
| Gene Family | -, "GPCR / Class B : Orphans" |
| Description | Angiogenesis is controlled by a local balance between stimulators and inhibitors of new vessel growth and is suppressed under normal physiologic conditions. Angiogenesis has been shown to be essential for growth and metastasis of solid tumors. In order to obtain blood supply for their growth, tumor cells are potently angiogenic and attract new vessels as results of increased secretion of inducers and decreased production of endogenous negative regulators. BAI1 contains at least one 'functional' p53-binding site within an intron, and its expression has been shown to be induced by wildtype p53. There are two other brain-specific angiogenesis inhibitor genes, designated BAI2 and BAI3 which along with BAI1 have similar tissue specificities and structures, however only BAI1 is transcriptionally regulated by p53. BAI1 is postulated to be a member of the secretin receptor family, an inhibitor of angiogenesis and a growth suppressor of glioblastomas [provided by RefSeq, Jul 2008]   | Chromosome | 8 |
| Location | 8q24.3 |
| Start | 143545377   |
| End | 143626369   |
| Strand | +   |
| Gene Sequence |    Download   Select all |
| Length | 80993   |
| OMIM ID | 602682    |
| HGNC ID | HGNC:943    |
| Unigene ID | Hs.194654    |
| Ensembl ID | ENSG00000181790    |
| PharmGKB ID | PA25247    |
mRNA Information
| mRNA ID | XM_011517202.1 |
|---|---|
| Exon | join(35..217,14093..15095,25587..25748,26698..26808, 27227..27391,27498..27662,28300..28473,29436..29600, 29806..29907,31367..31473,31630..31824,34090..34158, 34769..34877,38477..38620,39148..39223,39449..39551, 40885..40928,61045..61186,68251..68354,70936..71038, 72078..72228,72754..72823,74351..74417,76655..76740, 83508..83579,87100..87195)   | mRNA Sequence |    Download   Select all |
| Length | 3968   |
CDS Information
| Location | 403..3888 |
|---|---|
| CDS Sequence |    Download   Select all |
| CCDS ID | CCDS64985.1 |    
Protein Information
| Protein ID | XP_011515504.1 |
|---|---|
| Protein Name | brain-specific angiogenesis inhibitor 1 |
| Molecular Wt. (Da) | 126951 |
| Protein Sequence |    Download   Select all |
| Length | 1161   |
| Uniprot ID | Q7Z4N2 |    
| Ensembl Protein ID | ENSP00000256552   |    
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING)      View   
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 9223 |    MAGI1 |    4020 |    NP_001028229.1 |    in vitro;in vivo;yeast 2-hybrid |    9647739    |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| p53 signaling pathway |    hsa04115 |    
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| pfam00002 | 944-1180  | 7tm_2 |
| cl21587 | 944-1180  | 7tm_2 superfamily |
| pfam12003 | 653-875  | DUF3497 |
| cl13441 | 653-875  | DUF3497 superfamily |
| smart00209 | 412-462  | TSP1 |
| cl15278 | 412-462  | TSP_1 superfamily |
| smart00209 | 525-575  | TSP1 |
| cl15278 | 525-575  | TSP_1 superfamily |
| smart00303 | 880-938  | GPS |
| cl02559 | 880-938  | GPS superfamily |
| smart00209 | 359-407  | TSP1 |
| cl15278 | 359-407  | TSP_1 superfamily |
| smart00008 | 577-643  | HormR |
| cl02422 | 577-643  | HRM superfamily |
| pfam00090 | 414-461  | TSP_1 |
| pfam00090 | 359-401  | TSP_1 |
| pfam01825 | 881-933  | GPS |
| pfam00090 | 528-574  | TSP_1 |
| smart00209 | 264-314  | TSP1 |
| cl15278 | 264-314  | TSP_1 superfamily |
| pfam02793 | 578-637  | HRM |
| PTZ00441 | 410-434  | PTZ00441 |
Ontology Information
| HPRD ID | 392 |    
|---|---|
| Molecular Class | Integral membrane protein |
| Molecular Function | Metallopeptidase activity (GO:0008237) |
| Biological Process | Peptide metabolism (GO:0006518)   |
Drug Information
No matching records could be found.
External Links
| ArrayExpress | GO |    
|---|---|
| ICGC | GO |    
| Cancer3D | GO |    
| COSMIC | GO |    
| NCG | GO |    
| TSGene | GO |    
| Tumor Gene Family of Databases | GO |    
| CCDB | GO |    
| G2SBC | GO |    
| Osteosarcoma Database | GO |    
| RCDB | GO |    
