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General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| BAMBI | 25805 | BMP and activin membrane-bound inhibitor | 10 | NMA |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 18756595 | 2008 | Cell line : - Source : - Sample Type : CRC tumor and normal tissue No. of Sample : 183 Stage : TNM Stage I-IV | Immunohistochemistry,Immunoblotting | Up-regulation | - | BAMBI was linked to a potentially aggressive tumor phenotype and predicted tumor recurrence and cancer-related death in CRC. |
| 19328798 | 2009 | Cell line : - Source : - Sample Type : - No. of Sample : - Stage : - | Microarray ,real time RT-PCR,cell motility, and experimental metastasis. | Up-regulation | - | BAMBI regulates CRC metastasis by connecting the Wnt/beta-catenin and TGF-beta-signaling pathways. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | This gene encodes a transmembrane glycoprotein related to the type I receptors of the transforming growth factor-beta (TGF-beta) family, whose members play important roles in signal transduction in many developmental and pathological processes. The encoded protein however is a pseudoreceptor, lacking an intracellular serine/threonine kinase domain required for signaling. Similar proteins in frog, mouse and zebrafish function as negative regulators of TGF-beta, which has led to the suggestion that the encoded protein may function to limit the signaling range of the TGF-beta family during early embryogenesis. [provided by RefSeq, Jul 2008] | Chromosome | 10 |
| Location | 10p12.3-p1 |
| Start | 28966424 |
| End | 28971868 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 5445 |
| OMIM ID | 604444 |
| HGNC ID | HGNC:30251 |
| Unigene ID | Hs.533336 |
| Ensembl ID | ENSG00000095739 |
| PharmGKB ID | PA134909139 |
Protein Information
| Protein ID | NP_036474.1 |
|---|---|
| Protein Name | BMP and activin membrane-bound inhibitor |
| Molecular Wt. (Da) | 0 |
| Protein Sequence | Download Select all |
| Length | 260 |
| Uniprot ID | Q6N021 |
| Ensembl Protein ID | ENSP00000265149 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 11063 | SOX30 | 9461 | NP_848511.1 | yeast 2-hybrid | 16189514 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| TGF-beta signaling pathway | hsa04350 |
| Wnt signaling pathway | hsa04310 |
Structure Information
No matching records could be found.
Ontology Information
| HPRD ID | 12323 |
|---|---|
| Molecular Class | Unclassified |
| Molecular Function | Molecular function unknown (GO:0005554) |
| Biological Process | Biological_process unknown (GO:0000004) |
Drug Information
No matching records could be found.