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General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| BCL11A | 53335 | B-cell CLL/lymphoma 11A (zinc finger protein) | 2 | BCL11A-XL, BCL11A-L, BCL11A-S, CTIP1, HBFQTL5, ZNF856 |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 20145154 | 2010 | Cell line : DLD 1, MKN74, H1299, SBC3, U251 Source : National Cancer Center Hospital. Sample Type : CRC tumor No. of Sample : 36 Stage : - | Microarray,reporter assay, chromatin immunoprecipitation,real time RT-PCR | Up-regulation | - | - |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Zinc fingers, C2H2-type |
| Description | This gene encodes a C2H2 type zinc-finger protein by its similarity to the mouse Bcl11a/Evi9 protein. The corresponding mouse gene is a common site of retroviral integration in myeloid leukemia, and may function as a leukemia disease gene, in part, through its interaction with BCL6. During hematopoietic cell differentiation, this gene is down-regulated. It is possibly involved in lymphoma pathogenesis since translocations associated with B-cell malignancies also deregulates its expression. Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] | Chromosome | 2 |
| Location | 2p16.1 |
| Start | 60678302 |
| End | 60780633 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 102332 |
| OMIM ID | 606557 |
| HGNC ID | HGNC:13221 |
| Unigene ID | Hs.370549 |
| Ensembl ID | ENSG00000119866 |
| PharmGKB ID | PA25300 |
Protein Information
| Protein ID | NP_060484.2 |
|---|---|
| Protein Name | B-cell CLL/lymphoma 11A (zinc finger protein) |
| Molecular Wt. (Da) | 0 |
| Protein Sequence | Download Select all |
| Length | 835 |
| Uniprot ID | Q9H2X9 |
| Ensembl Protein ID | ENSP00000243964 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| S | Phosphorylation | 608 |
| S | Phosphorylation | 608 |
| S | Phosphorylation | 608 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 7025 | NR2F1 | 584 | NP_005645.1 | in vitro;yeast 2-hybrid | 10744719 |
| 7026 | NR2F2 | 139 | NP_066285.1 | in vitro;yeast 2-hybrid | 10744719 |
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| pfam13465 | 756-781 | zf-H2C2_2 |
| cl22375 | 756-781 | zf-H2C2_2 superfamily |
| pfam13465 | 391-416 | zf-H2C2_2 |
| cl22375 | 391-416 | zf-H2C2_2 superfamily |
| pfam00096 | 743-764 | zf-C2H2 |
| cl23491 | 743-764 | zf-C2H2 superfamily |
Ontology Information
| HPRD ID | 11376 |
|---|---|
| Molecular Class | DNA binding protein |
| Molecular Function | Receptor binding (GO:0005102) |
| Biological Process | Cell communication (GO:0007154); Signal transduction (GO:0007165) |
Drug Information
No matching records could be found.