CoReCG

Search results:

General Information

Gene_Symbol	Gene_ID	Gene_Name	Chromosome	Alias
BCL6	604	B-cell CLL/lymphoma 6	3	ZBTB27, LAZ3, BCL5, BCL6A

Evidence
Gene
mRNA
CDS
Protein
PTM
Enzyme
PPi
Pathway
Structural
Domain
Ontology
SNP
Drug
External Links

Evidence Information

Pubmed ID	Year	Sample Information	Techniques	Mechanism	Fold Change	Remark
25973304	2015	Cell line : - Source : - Sample Type : CRC tumor and normal tissue No. of Sample : 22 normal colorectal mucosa, 22 microadenoma,22 colorectal cancer Stage : -	real time RT-PCR, methylation specific PCR, Flow cytometry and western blotting	Methylation	-	Methylation of BCL6B is a prognostic and chemo-sensitive marker in colorectal cancer. BCL6B suppresses colorectal cancer growth by activating P53 signaling.
24220798	2014	Cell line : RKO, HT 29, DLD1, LOVO, HCT116, SW480, SW620 Source : AJCC and Paiteint sample from Chinese PLA General Hospital. Sample Type : CRC tumor No. of Sample : 102 Stage : TNM Stage I-IV	Immunohistochemistry, immunofluorescence coupled with confocal microscopy and western blotting.	Up-regulation	-	The increasing expression of BCL6 in human colorectal cancer development suggests the involvement of BCL6 in tumor progression, from the earliest stages of carcinogenesis with significant increase in cancer.

Gene Details

NC_000003.11 (187439165..187463513, complement)
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Gene Type	protein coding
Gene Family	-, "Zinc fingers, C2H2-type", "BTB/POZ domain containing"
Description	The protein encoded by this gene is a zinc finger transcription factor and contains an N-terminal POZ domain. This protein acts as a sequence-specific repressor of transcription, and has been shown to modulate the transcription of STAT-dependent IL-4 responses of B cells. This protein can interact with a variety of POZ-containing proteins that function as transcription corepressors. This gene is found to be frequently translocated and hypermutated in diffuse large-cell lymphoma (DLCL), and may be involved in the pathogenesis of DLCL. Alternatively spliced transcript variants encoding different protein isoforms have been found for this gene. [provided by RefSeq, Aug 2015]
Chromosome	3
Location	3q27
Start	187439165
End	187463513
Strand	-
Gene Sequence	>gi\|568815595:c187745725-187721377 Homo sapiens chromosome 3, GRCh38.p2 Primary Assembly ACCATCGTCTTGGGCCCGGGGAGGGAGAGCCACCTTCAGGCCCCTCGAGCCTCGAACCGGAACCTCCAAA TCCGAGACGCTCTGCTTATGAGGACCTCGAAATATGCCGGCCAGTGAAAAAATCTTGTGGCTTTGAGGGC TTTTGGTTGGCCAGGGGCAGTAAAAATCTCGGAGAGCTGACACCAAGTCCTCCCCTGCCACGTAGCAGTG GTAAAGTCCGAAGCTCAAATTCCGAGAATTGAGCTCTGTTGATTCTTAGAACTGGGGTTCTTAGAAGTGG TGATGCAAGAAGTTTCTAGGAAAGGCCGGACACCAGGTGATTATTGCTGTTGCTGCCGCCGCTGCTGCTG CTACTGCCGCCGCCGCCGCTGTTGCCGCTGGTGCCGCTGCCGCCGCCGCTGCTCATGATCATTATTTTAC CTTTTAATTCTTTTTTTTTCCGCTCTTGCCAAATGCTTTGGCTCCAAGTTTTCTATGTGTATCTATTGAT ATAAATGTATATATTTATTTATTCTAGCTGTCAGGTGTTAAAATAAATGCCGAAGATTAGTCCCACGTCT CTCCCACCATAGGATATAGATTGTTATGTATTTATTATTATTATTGTTGTCTTTGAGTGAATCGGCCGGT TTGGGGAGGCTTTTGCCACCCTCCCTTGTGTTGTTTTGGTTTTTGGAAAGGAGGTGGAGGAGAGGAAGGA GGGGAATTAGGGGGCGGCCGGAGCAGAGAGGACGAGACAGTGCTTGGGGGGTGATTCGGGCTAGTCTGGG GGCTGTCTGGCCCCAGACCGCGGAGAGGACGCGCGCTCGCGCTCTCGCTCTTTCTGCTGCTGCTTGCGTA CGGCTTGTGATCTCTCTGGATTCGTGCGGCTGTGTTTTTTCCCTCTTTTCTCGCTTGCAAACTGCTTTCC TTGCTCCGTCGCTCCTGGCCTCCGCTTCCCTCCCTCCTCTTTTTCCTCGCCTCTTCTTCCTTCCCTTCCC CTGTCCTTCTGGGTAACTCCGGGAGGCAAAAAGGGAGGCTGCCCGCTCGCTCGCCCCGCTGGCTCTCTTC CATCGGCCTCGGTCTTTTAGATTCCCTGCCTTCGAGCCGAACCGAGATTTGGAAGGAAAAAATGCAAGCG AACTCTTTGGGTTTTTGTTTTTGTTTTTTTGGTCATAAATCCAGATGAGATGAAGTATCGTGTCTACTAT TTCCTTTCAGAGCCGTGATCTTCCTAATGAGAGCCGAGTGTTTTGGTGTTCCCTGCCCCTGTGTTTTGGG GAGCTTGGGGGCGGGGATGTTGAACACTTTGAAAATTATTCTTTCTTGGTTGTAGTCGAGGGAGTCGGGA ACCTCCGCGCGCTCTCCCTGCTCATCCCGAGGAGAGAGACTGATGGCGGGACAGGGCTTCTTGGGGTGGG TGGGAAAGGGGTGCGCACTGCACCTGCGATGCCTTTCAGTGTGCGGGGGGACTCAGGGAACCTCGACAGG ACAGCCTGGGAGAACGAGAAAGGTGGCGGGATTTCTGGCCGCTGCGGTGTTTGTATTTTGGGCGCTGCGT GACTCTGTGTTGGCTCCCAATGGCTGTTGCCTCCCTTTCCTAAATTTTATTTTATTTTTTCCCATGGTGC AAGCTCTGTAAAAAGGGAACTGCGGGCCTGAGCGTAGTGGACGCCAGGCTTCAGATTCCCGAGGTCCTTA CCTTGGGCGAGGAGAAAGACGAACAGAGCCCCAGCCCGCGTTCCTTATGTGCAAGACTCAGGAGGAGAGA AGGGCACTTTGTGGCCGTGGCTGAGGGGACCCGGCGCGGGAGGAGCGGGCGCGGGCGCGAAAGGGAGATC TTTGTGAGTGATTTTGCAAAAATAGATTGCGAGGTTGGTTGGATTTGCAACCTGTGGCTCTCCTCGAGGG AGTAAGAATGGGGGAAGGCGCGGCGGCGGCGGCCCGGGGAGGGAGTGGGTAGAGTTGGAGCCTCAGAAAT CGGCTGAGCTCCGGGGGCGGGCGGGGAGAAAGGGCGGGGGGGCAGCAGGAGCTAGGGGCCACCCCGCTGC CGGATGTAGTGACCGTGGTAAATGTCTTGAGAACTGTGGGTTGCGTTGCCTTTATGATGCCGTGTTATTG GAACCCTGGCGAAAAATGGAACTAGTGTTGCAATAATGAGTTTTAAAGCTCCCCCATGGAAAACAAAAAC ACAACCAAACCGATTTTTTAAAAAAATGAAAAAAGACCCTCTGTGTTGTGTTCCCTTCTACGATGGTTGT GTTGGTGGCTGGGGTTTGGGGGTGGGGGGTCCTGACAGTTGAGCAGATAAATGACCCCAAACCAGGTGCT GAAAGTCCCAAGCTGTCACAGGGCCCCTGACCACCTCAGAGAGCCAATCTCCACTCCGCGCCCCCTCCCC GCCGGCCCCCGCCACCCCACAACCCGCCAGGATTTAATCTTTTATGGATTTTTTTTTCAGTTTATAGTTT CCAGGAGGAAAGTCTTGTAACGCTTTACTTTTTCTCTTCTTTTTTTAAAGTAAAGTGAGTGTCAGTAGAT GTGTTTTTTACAGTCTGGATTTTAAAAAAAGTGGGGCAGGAGAGAGGGAACCAGGGAAAGGGCTGTTTAG AAATACAGTTTGTGGCTCTGAGCGATGCCACCGGCTTCCTCTACAGAGACTGCCAGTTTCCCTTTTTCTT TGCAAGGTGTGTGTGGTTTTAATAAATAACTTAAAAAAAAAAAGAGGGGGCGGCAAGATCCATCAGGAGA CAGGTATCTATTTTGCTCACTATTTACTACCAAGAGCCTTTGGCACTAGAACAGAACCTCGTAAATCTGC AGCCCAAGTTGAAGTTCATCTGGCCCTAGTCCACACGCTATTCCTGGAGGTAGCAAACATGAGCTCAAAG AAGAGAGATGAAATCACATTCTTGCTTTAAAATATATACTTTTTTAAAAAAGACGAAAAGATATTTGTCT CTGGGGGAGGAGGAAATGGCGAACAAGTACCAGGAGATGGGCATTCCCTTACTCTAATGACTGCAGTTGA GTCTTCAGGCCAAAATAGAAACCTGTAGATGGCAACTCTCTCTCCACCTCCCCGCCCCGCCCGCCACCCC AAGCTTATAAATAGAAGTTTCCAGTATCCTATTTGGAAGACTTTCCAATACTAGAGGCCGAAGCATTGGC TAGTTTTAAGGGTTGTTGATAGTGACAGTAAGGCTAGATGCTGTTCATAAAAACTGGGCGACTTGAAGGA GACAGCCAGAAAAAGTGGGAATTCTCCAATTGCCCCTTTCTTCTTTTCAGTTTTGAAGGGTTTTATACCA ATGCTTTCTTGAAAAGACTAACTTATTCTGGGTTTGGTGGATAGGGATGGGACTCTAAATGCTTAAGTTG TCGTTTGCTGAGCCCTTGAAGAGTTCCAGTTATTGGTTGAGTAAATGGTAGCCACGGCTAGATGTCAAAA CCCTTCCTTCCCTCTATCCCCTACAGGGTAATGACACTCACAACCCACTTTGTTGTGAAAAACTTAAGAG ATATAGAGGAGGCGGTGCAGCAGCGCCACCCCTCGGTGGGTGAAACTATTGGCAAAAGTCAATTTTTGAA AAATATTGGGAAGTGAACTTATGAAACATTTTTCCCCCAGAGATTTAAAAAAAATAGGGGAGATAAAACT AACGGATAAAAAGGACTTTGAAGTTTATCAAGTAGGGAAGAAAAATGTTGCTTTCCAACTAGGATGGTGT TATAATAGGCAACGTGGTTCTAAGGTTTTTTTTTTTGGTGGGGGGAGGGTGCCTGGTTGATTTTAAGTAG AAGAGTTCTCCAGGCGGAGGTAGCCCGGCCTTCCCCTTGGATTGACTTCTCAGGGCATCTTAATTCTGCT GCCTGTCTGATACCGAGATAGTGAGGGATGTTTTGGTGTAAAACACCATAGTGGCTGGAAATGCTGTAGT TTTGCCGGCGGTGGCAGGACGTATGTGTAGGGGGTGTGTTGAGGAGGTTTGTGGATGGCGTGGAGCAATG GTAGGCTGGTCTGTAGCCCTCTGTGAATCAACATCGAATGGCGCGTGCCGGTTTCCAGCACTGCGCAACA AGTGGGACCGCCGCTGCCGCCGCGAGCACAGCGAGGGTGCAGCGTGGTGGCAGAACTGGCTGGTTTCTCT TTGCCCCAGTGGAAACCAGGAACGGCCCCTCCCAACCCTCCCGATGTCCACTCCGAGACCCACAACTTCA CCAAAAGACCATACCCGACTCCCCACTCCCCCGCTTTGCCAGGCGCAGTGAGCCTGAGTGGGATCCAGCA CTCGGCCCCCAGCGCCCCTTTCCTCCGAGAAGATCAGGAGTTTATTCCCGACTTTCTTTGCTGGATGACC AGTGTTTGGCAAGAATCTCTGCCAATACTGTCGAGTGCCATTCTGCCTTTTGAAGACAAGTGCACCTTCT TTCCCTTCCCAGTACATAAAGCTTTTCGGAGGCTGGGGGAGAAATCAACTTATGATACATGAAACCAGCT CCAGATACCGCGTTGTGGTTGCTAGAGGCGGGAGCATCGGGAGGAACGGAATTACATACACTAAATTAAA TGTTTTCTAGCTTTGCTTTTAGAGGCAATCACACCCCCAACCCTCGCCCCCACCAGACAGAAAATAAAGA GGGGCGGGTAGGGATCGGTGTGGAAGCTGCGGCCGCGCGGCGATTCTCGGACGGGCTGGCCTGCCACCTA GCGGTGGGCTGAGATCGAGTTCGCGGCCATGGGCGGTGGGCTCGCCGTTCCACCTCCCGGGCGGCGGTAC CCTGACCAGATGCTAGGACTGACAGAAGGAGGGCACCCTCCAATGGGGATGGCATACAACCTCCAAAGTT TTGGCAAGAGGGATGAAAATCAGAAAGGCCTCGCTGCTTGCCCATCACTCAGCGATGAGCATCTATTTGC ACTAAGAAAAACCACAAATAACCCGCTTCGAACACACCATCTTCCTGTCCCTGTGGCCCCTCTTAGGGGA AGTCGGTAGTGGAAGGATGCCACCTAGGAGCTCAGGGGCTTTGGGACGTACAACTCTGTTTTGCAGTTGA GGAAACAGGCCCGACGAGGAGGCTTGTTAGTGGTGAGTTAGTGACTTAACCAGGACCAGATTTTAAGCTT CTGAATTTCATGTCAGTGACTGAAAGCCAAAGGCGGGTTTATCTCAGCTCCTTAGAAGTATTTATGAGAA AGGAGCGGCTGCCAGAACCATGAGTTTAACCTCTTAGGTCACCTTTGTTGCCAGTGTTCATTGGAAACCG CTCCCCAGCAGTCTTGGAGGATTTTTTTTAAAGAAAATATGGCCTAAGATTTTCGGTAATGACACGAAAA GCCCAGATGGTGCTGAAGGGTGTGGGTCTCGGAGCTCGGGGGTTTGCGTGTTAAGAGGGGGGTTAAGGCC TGGACCAAAGACTTGCAGGGCGAGCCTCGATTCTGAAATCGCTCTCTTCCCCTTCCTAACATCCTCTGCA TAGTAGCCTGGCGAGAAACCGGGTGTGTGTGTGTGAGGGGGTGGGGGTCATGTGGATAGGCCAGAATTTG TGCCACAACAGTTCCTCCGTAAAGTTTTCTTTCTCCGAGCTCGTGACTTAAGATGGCAAACGCGCGTCCG CATGCTGGCGGCCCCTAGCGGCAGCAGGCGCGCTCTGCAGGGGGAGACAGCGCCGTCGCCCCCGCCCGGG TCGGCGGGGATCGAGTTCGGCCCCTCCCACTGCGGGAGCCGTCGGAGGCCGCGTCGGAGAAACGCGCCTC TGTTCGGACTGGAAACGAATCTGGGAACGAGTTTGAAGCGCGGTCAAGTTTGACTCATCGCTTTCCAAGG ACAGTTAGTGCCTTCCATCTTCATTAACGTGAATAAGGACCTTGGCTGACTTCTTTCCAGATCGGATTTT TAAAGGCATTGTTTGCTTGAGGAGATCATGCTTCTCCCCTCCCCCGCCAGCCTTTTTGCAAAGGCTGAGC CCAGTCCAGCCAGGACGGCCGAGGGATCTCTGCTCCGGGACGCGATTTGCTGGCATTGTCTTCGGGCCCT TCTGGAAGGCTGTCTCGCGCTGAGCGTATGGGGAACGTCCCTTCTGCAACTCCTCTTCAGATCTTGATGA TAAAACACATCCCTCTGTTTTATTGCATTTCCTAGAAGCTTGCAGGCTTGCAAGAGCACTGTTGGCAGGA AACGTGATAGAAATGAAAGTCAGGACACAATGTCCCCGAACACCTCGGTTATCCAAAGCGGCTGTCGAGG CCATCGCGTTATCAAATTCGCTTTTATTTACTGTCGTCTCCTGCACCCTCCCGTTCCCCAGCCAAGAGGG CGAAGAGTGTTTTCCCCCAAGAATAAAAACAGCTCCGCGATTTGACCTCACCCCCTGCCGCCGGACCACG GTGGTGTCTGCAGCCGTGCAGCTAGTTGGCTGAAACACTGCTGAGACCGGGAGCCCCACGGCAGGGCCCC TGATGCGGGGTTCACTACGGCAGTTGCAGCCTTATTAAAATTCCTTGTCCTTGTCCCTAAACAGTGCTTT ACACTTTCAGATTTCCCTTTGGATTTTTCAGCGGGTTATTGGAGTTATTAGATTACCAATAATCCAACAG CCTCTGTAGCCTCTCTGGCTGGAGAGGAGGGGGGAAGGGCGGAAGGCATTCTCCAAATCGGGAGGCTCTG GCCAAACTAGGTCAATGGGAAGGAGGGGAGGGGCGAGAAAGGGGTTGACGGTTTCAAACCTTGATGGAGG GCTCTCTCTAGCGTTAGGCAGCGGTAAAAACACCATTCGGTTTGAGCTCCCGGAACCACGGGACTCCTAA TTTCCAATAAATGCACTTACTTCATTTTAACTTCCCAGATTCTCATCCCTACCCCTTATTAAATCCCAAC CGTCTCTTTCACCTTTATCCCACCGGGCGAAGGGGTGAGAAAGCCTCAATGTAGGATTTTGAGGCCAAAG GCTCGTTCTTTGCAGACCGACTCTGACCCTTCCGCTTGCCGCAGAAGGGATGAGCGGCGCAGTGTGACGC CACTGGCTAGTTTTAGGACCAGACTGCGGCCTTTGTGGCTGAGTCTTTCGCTGTCCCCTAGCCCCCGAAA GCGCACCCCGGAGCCTGCTACCGAGACCAATTAGGACATGGCACCCGGGGGTTATAATTCCCGGGAGGGC CACAGGAAGGCGAGGCAACTTTGGAGAGTGCCAGTGCGCGCGCAGGGGTCGGGGCCCCGGCCTTTGCCGA GTCCAAGCTGTGTCTCTACGGTTTCGGGGAAATCGGATTCGGAAATCCTTACGGCTTGGCAGCTCCTGTT CTAAAGACTTTGGGCGGAAACCAAGTGGAGCTGGGTTCCCGTTCTTGCCAACGTAGGCGGAAGGGGCTTT CTGTTTAGTTTTTCTCCAACCTTGCCTGGGGCGCCTATGATGGAGACCCTCAGCCCCTAGGGACTCCATC TTTTGACCTTGAAGTCTCGCTCAAACATTCCCCTAAAAGAACGGGGGTGAGGGAGAATGGAAGGCAAAAA GAGGGAAAAAAGCAAATAAACTTCGGAATCGGACAACTTAAAGTCTCGATATGAGCCTCGGATTGTATTC GAACTCCTGGGTTCTAGACCCAGCTCTGCTACTAACTTGTCTGACCTTCCCCATTTATAAACTGTTGTGG GTGAGAGGTGGGACTAGGTGAACTCTGAGAGCCCTGCACTCGGCGCGGACGAGGGATTTAGGGGAAAGTG TGCTGTATTCCCCGCGAGCCTTCCCCAGCGGCCCCGCCTCCCTGGGTGAATCCCCGGCGGCCAGCGCAGC GCAGGCAGCGATCCTGGCGGCTGCCGGGGCCGGCAGCTTCCTGGAAAGTTACTTCTTGTTGGAGCCGGCA ATAGGCAAAGTGTGTTCTGTGAAATCCGCAGAGCCGAGATTGACTACGTTCCGGGAATGAGAGGGCTGTG TCATTCCCCTCATTGCCTGCTGCATTGACGGCGTAACAGGAAAAAAAAAAAAAAAAAAAAAAAGGCATAC ACACAATGTTAGCTACCGAGGTGCACCAAAAGTTTTATTTGAATGTAACTAAATTAAGGGCCGCCACGGT CATACCACAAAGCCTCCGTCGCGCCTTGCGGGGGGCTTCGAGGTGGATCGCCCAGGGGCGGGCAGTCCCT GGAAGACAGGTACGGAGTGGTCGGGGTGGGGTAGCGAAGTCTGCCTAGGCTTGCCCCGGCGCGCAGGGCT GGTGTTTGTGCTCTTATGTGTGAGCGAGAAAATGGGGCTTTCTGGTGCCAGCCCAGGGGAGGAGGGAGGA AAAGGATGGGGTCTTTTGTATTGGCTTGCTCTCTGGCTCTTAACCTCGCCTCTCCCTCTTCTCTCATTTT CTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTGTCGTTTCTGCTGTCTTCTCTC TCTCTTTGCTTTTTTTTTTTTTTGGTTCCTGTTTTCTTCTTCAATGGAAAGCTCTTTTAAAGGATCTGTC TTCTCAAGGAGCCTAGTTGGCTATGCACAAGGAAAGCGCCAAAAGAGCTAAAGGGAGGAAGGGAAGAGAA AACATTTAACTCTCCCATGGTGGTTACTGACCCAGCGTGGGTGCGGGGAGATTGGGATGGGAAGTCCAGG TCTGGGGGCAGCCAGCAGTTGTCAGTTTCTCATTGACAGCCCTGCTCCTTGGAGATTGTTTTTGTGGGTA GTCTTGTGTGTGGCATTGGTGGAATGGCTGAATCTAGGAGACGCGGCGTGTCCAGAACTTGCTGGAAATT GGTTTTGAGATTTTGGGCAAGGCCTCTCACCCGGAGCCTCAGTTCCCTCCCTAATAAAGCAGGGCTGTTA TAAGGATAAGATGCAATCTTGAGGGGGTGGGAAAGGACTAAGAGCTCTGTAAAAATACAAACCAAATGCT GGTGGTGCTTCCACACCTGCGGCATTTGGGGTGGGGGTGGTGACAACATTGCCCACACTCAACCCACACA CTCAGGAGTTGGGGGGGGCTGGTTCTTAAGACGAGTTGGCTTGCAAAGGAGTGAACTTGAGAAGGACCTG CGCCTCGTGTATGTACATTTGTTTTTGGCCAGGCAGAGGCTTACGGTGAAAAGCCCAAGGCCCAGCTGAC AGTGGACACAGGGGAATTTGTTTGTTTGTTTCAATCCGCATCTGGAGTGAGTCATTGCCACTTGTCATGG TGAAATGGCAAATCTGGGCTTCCTGTGGTTCCAGAAGCCTGCGACTGGAAATCCACAAGCGAGCTGGTGG TTGAAGCTGGTTAAAGAACAGCCTAGGTATTCCAGAAGTGTTTGAGGATCCCTTCCATGAAGGAAGAGAG GAAAGTTTTTAAGTAAACCTCCCACTCCCATGTGTCTTCAGCTTTCTTTTGCAAAGGAGAAAATCCTTGA AGTTTGGTAAAGACCGAGTTAGTCTATCTCTCTTTGCCTATCTCGAGTTGGGCTGGGGAGAGGAGGAGAT AGGTTCTTTTGTCTTTTTCTGTCTTCTCCCTTCCCCACTTCCTTCCCTCCAGTCCCCACTCACTCACATG CACACACTAACCTTGGAGCCGATGGGATTGAGTGACTGGCACTTGGGACCACAGAGAAATGTCAGAGTGT TTGGTTACAGACTCAAGGAAACCTCTCATTTTAGAGTGCTCATTTGGTAAGACTCAGCAGCCTGGAATGG GGCAAAGTGTTTGTGTGGGGGAAGGAACTTAAAAATGAGATTCACCCACATCAGGGTGCTGTCTTGCATG TTCTACAGCACGTAGGCTGATTTGGAAAGGGGACAGGAATTTGAGCCAGAAGACCTAGGGCCGGGTCACC AACCATGTACATGGCCCAACATGACCTTGTTGGCCTCAGGCCTCTTTACCCAGAAAATAGCTCTAAAAGG TTCTGCTTTTTTTTTTTTAAAGGGGGGAAGACAGTTCAAATATTGTTTTATTTTGCAGCCCACATTTGAT CATAAATGAGGGTCTTACACCTGTGCTTTTAATGATTTTGTTTTAGAGAAGCCGGTTTGGAAGGAGGTAC ATATTTCATTAAATCTCTTCAAGGTTTAGTGCTCCCTGGCCAGTTCTCAGCTAAATCACATAGTTAAGTC TTTTACCAGCAGGGAGAAGCACAAACTTAGAAGCAATGGCATTCTGTCTGGTCTTAGACCCAGTAGGGAA GGGAGAGAACACTTTGAAAAAGAAGACAAAGGTTTTCAAGGAATACGTAGACATGACATCTCAGGCTGTG TTCTGCAGAGTCTATATTCAGTCTTAATGTTTCAGATGGGCAGGAAATACTGCCTAGCTGTTTGTCTTGA GCAAGCCACTTGAACCCCTAAGTCTCAGTTTCATCGCCAGTGAAATAAGGATAAAGATATTGGCCCTATC GTCCTTGCGGAATCATTCTAAGGCTTGAAAGATAATATTTTAGCAGGTTTTGAATGACGTCCAGTGGTTT TAGGCCACGGACGAATCGTTATTGTTAATGTTGACAGAACCATTTTTCTTATTTTTTCTTTCCCATAAAC TCTAGTGGCCTTTGGATAGTATAAATTTTTTCTTTGAAGAAGGAAATATATGTATGTATGTATGTATAAC TAATTAATGTATGCAATTGTACTCCCAGTACTCTGGATAAAAACATTATTATCTCATAGCTTCGGGTGCC TGTTGTTTCCGTAAGAGCAGAGCTGGAAAATGTTTGTTAGCTTGTGGTAAAACCACACCAGCTGGCAAGC TGCAACTATCAAAGCAAAACTAAATGTGTATGTCCTAAAATAAGACTATAGTGGACAATCTTACATTCGT TAAATCAATTTCTGTTTGCTTTCTTCTCTTCTCTGTAGGTTTTGAGCAAAATTTTGGACTGTGAAGCAAG GCATTGGGTAAGTAAATAAAATTATATGCTTTAAAATGTTGGGACAAACTGTTTCTTTTGAATTTGCCAA TACATGTGTCTCTGTGAACTTTGCCACTGTTCATTATATGAGACAAGGATAACCAGTTCCCTCTACATCA CTCCTAGTCCTCATCCTTCACCTCTGTATTAGACTGTCTTACCACTTGCATGGTCAATCATTGTTACTCT TTCTTTGTACAAACTAATTTAGCCAGCTAATGTTCACCAACAATATGCTAGCTCCTCGAGGTACAAAAGT CAAGCAACTCTAAAGCCTAACAGTAGAGAGAGACCAATGGTGACTGAGATGATGAAATAAGATACCTATG AGAATAGCTATGAGTTTTGAGAGCCTCCTATGAACGAGGAATGTATTTCTAACTTTTATAACCACATAGG TATTACTACTTCCATTTGGGGAAACCAAAGCCCCAAACCAGTAAACAACCTGCTTAAAGTCCCACAGCTA GCAAAAGGCAAGTCTAGCCTGATAATCTTAAAACACAGTGTCTTGACTGGGCGCGGTGGCTCATGCCTGT AATCCCAGCACTTTGGGAGGCCAAGTTGGGCAGATCACGAGGTCAGGAGTTTGAGACCCAGCCTGGCCAA CATAGTGAAACACTATCTCTACTAAAAATACAAAAAAATTAGCTGGGCATGGTGGCAGGCACCTGTAATC CCAGCTACTCGGGAGACCGAGGCAGGAGAATCACTTGAACCTGGGAAGGCGGACTTGCAGTGAGCTGAGA TTGCACTATTGCACTTCAGCCTGGGTGACAGTGTGAGACTCCATCTCAAAAAACAAAAACAAAAACAAAA AACACGGTGTCTCTCCATTGCAACATACTCACTACCTGTCAGTGCTTGGCAGAGTATTTGGTATGTGGGA AAAACACTCAACAAATATTCATTCCCTTTGCTTTTCCCCTAAAGGGCTTTCTATCCCAACTTGTTGGATA AAAGTTATTCTCCCCATTTTAAAACTATGAAGAATAATGGCCAGAGTTGGACTATGAATTGTTCAAAGAT CAAATACAAGGGACCTGAGTTGCATTCTGTACCTTAGCAGGCTAAGCCACCTGCTCTGATACCTGTGGCA AGCAGGAAACAGGTTCTGGAGGACTAACAGGATTTTGGCCTCTTTTTTCAAGTGAAGACAAAATGGCCTC GCCGGCTGACAGCTGTATCCAGTTCACCCGCCATGCCAGTGATGTTCTTCTCAACCTTAATCGTCTCCGG AGTCGAGACATCTTGACTGATGTTGTCATTGTTGTGAGCCGTGAGCAGTTTAGAGCCCATAAAACGGTCC TCATGGCCTGCAGGTGAGGGATCTGAAAGGAAAGGGTGGGTAAGTCAAAGTGGGGTGATGGTGCTGGCAG CCAAGCAAGGCAGAACATGTGGGCCTTTTACTGCATCTGGGATGACGTCTCGCTTTGTCTCCAGATCTCA GCACCATGGCGTGGCACAGTAGGCTCCCAAGTGAATGAATGAATGAATGGATGAATGCACTTTTAGAAAA GAAAGAGCCACGTTCTGTGGGCATAGAGGGAGAAAAATTATATACTGCCCCAAGAAAGGATGTGTTTGGG GCAGACATGGAGAATAACTTCAGTTAACCAGTGAAAAAATGAGAAAAGATTTCAAATGAACTTTCTTTGT CTTTAAGTAGCTTAAGCAAGTTAATTTGAAATGTTTTGCTCTTTTATGCTATAAATGTATTTATTTTTTG CTACAACTGAATTTCCATGGGTGTTCAGAGTATATGCAAGAGTTAGTGAGAGTGAACTAGCTGATTCTTC ATGTTTATCAAGTATTTCGAGTTTTCAGAGCAATTTTATATTACATGATATCATCTTCCTGGATCTTTTT AGTAGTCTTCAGTGTTATGCATTACACTATTGCCTTCATTTTATAGATGGTAAAAGGAAAGCACAGGGAG GTTAAATGATACAGAATCAGGGATCTCTATTGCTATTTGAAAACTTATCCAACATCTACTCTAAGCACCT GATTTTTAATAGTGGAAATAACAGAGGCTTATGGAGATATAAAAATAATAGATAATGTTTAGTGAATGCT TACTATATGCCAGGCATCATTCTATATCCTTTACATTTTTATTCTTGCCACAACACTATAAGGTAGACAT GATTGTTCCTCCTACTTTGAAGATGAGTAAAGCAAGATGCAGAGAAGCTAAATATCTTACCCAAAGTTGC ATAGCTACTTGGTGGAAGTCTGGCTCACTTCTGGCAACCCACTCAGAAAAAGTAGAATCAAGAATCAAGA TGATAGCTCAGAATTCTTCTTTACAATTGAGTACTCTTTCCACCACCAGACAGCATGGCACCTGGAGGCA TTGCTTGGGGTTTGAGTTGGGTCTTCAAGGAATAACAGACCCTCTGTTAATCTATGGACTTTGATAAAAG CAGTAGAGTATAGATGTAGGCATATTTTTATTTATTTGTCATTCATAGCCAAATTCTAAAAAGAGATAGA ATTTTAAAAATAAGTGTAAATGCAATGGAACAAGAAGGAATGCTTATGACAAAGGTAGACTAAGAATAGT TACTGCAAAGGGGCTAAATTTAACTCTGGTAATCTGTACAGTTAAGACTAAAAGGAAAACAGGCCCTGTG ACTTTAAGAATATTCACTTAACCCCCCTGATCTTAGTTCCCCTATTTGTAAAGGCAGAGAGTGATAGTAC CTACCTTGCAGCGTTGTAAGGAGCAAACGATAATGTATGTAAGGTGCTTAATGACTCCTGACATTTGGTA AGCTCTCCATAAATAGCAGCTATTATTAATTACCGTAGAAGTTCTGGAGGTAGGCCCAGGGGAAAGGGGC TGAGTATCAGTGCTGACTGTAAGGGATCACAGATTCGATATGTCTACTATAGTGGGACATTTGTTTGTTT TACAGTGGCCTGTTCTATAGCATCTTTACAGACCAGTTGAAATGCAACCTTAGTGTGATCAATCTAGATC CTGAGATCAACCCTGAGGGATTCTGCATCCTCCTGGACTTCATGTACACATCTCGGCTCAATTTGCGGGA GGGCAACATCATGGCTGTGATGGCCACGGCTATGTACCTGCAGATGGAGCATGTTGTGGACACTTGCCGG AAGTTTATTAAGGCCAGGTGAGTTGCTACCCGGGTGGAAGCGTCGGAGATGGAAGAGATAGTCCCCGATC AGAAACCTTTGATAATTCATGCATACAGAAAAAATACTCCTCTATGATATGCTGCAACCCACATTTCCAC TCTTGTTGCACACTTCTGCTCTTCTTAACTCTTGTGCCCCAGGCAGACTTAACTCCTGTGGCTATACAGG TATGTCCTATGCATTACCGCATCTTGCTTTCTTCCATTCACTTAATATACCCTCTCCTCCCACCCATCCT GCAAGGCTAATCTTGGATGCCAGCTCTTCCATGGAAGTGTTTCTGATTAACACTTTTCCTCCCTCAGCTC TTCCTCTGTGTTGTGAAGCATTTTGCTGGTGCTTTAAACTTTCCTTCTATTTTAATATTTGCATATGTAT TTTAGTTCTCCTTTAGACTTCTATTATAACTATTTACATATGTGCCTTAGTTCCCGACCAGACTGTGAGC TACTCAAGGTTATAGGGGCTATCTTACTCACCTTTTATGTCACGCTGCTCCTACTAGGCAGGACATTTAT TGAATTGAATGGAGTTCACTGAGTTTAATCTCCTACCTGAGGGGTGATAAGACATGACCTTCATTTAAAG ATGAGGAACTTGAGATCCAAAGAAGTGAAGAGCTTCACTAAGTGCAACAGAGACTCAGAGCTTAACTTCT TTAGAACCTTTTGATCCAGCCATGCTAGGGTGATTGCATCCTCGCTCAAACAGAAGGGTTTTCCAGGCTG TGTTTGAAAACCTCCAGGAGCCAGGAACTCAGTGTTCCCAGAACCACACAGCATACCTTGGACAGTTAGA AAGCTTCTCTTTTTGGCTTCTCTTTAACCTTCTTATGGGTTCTAGCTCCGTTAACTGTGATCATGGTGAG CTTGCCTATTTATTTCACCCACATGATGTTCCTTCAGGTATATACAGCTAGAGTTCTTTGTCTCCTGTGA GTGATGACGGTGGCAAGATCATCATTGCTGTCATTTACAAGTACTTTCAGTGGCTCAGGCCTTGTGCTTA GAATGGCTGAGTAACTGGCTCCATGTCACCAGCTGCTAAGTGGCACAGCTAGGTTTGCAAACCAGGTCTG GCTGCTCTAGACCAGGGATTCATACATTGGCATTTGCTGCCTGTTCTTTATGTAAACTTTCATCAGCATC TGGGACAAGTTCTTTCTTCAGTAGGCTACTCGTTTGTGTATGATCCTCCAAAAGTGTCATACCAACATTG TATAAATTCTTTTCCTGTTTCCCTATGTGTAAAATGGAGATAATAATAACCACCTTTCCTTCCTTTCAGG ATTTTGCATGGGTGAAGTGAGATAAGGGCTTTGAAAGTTTTATGTGAGCTATAAAATTTCATAACATCAG AAGAGCTATAGATTCACACACATGCATAGATATGTGCCTTAAACATACAAGATTATGTCTAATCAGGCAT AGATCATGCCGGAAACTCACTTCCCTTCTCTGGGACTCAGTCTTCCCAATTTCAGGCTGGATTTCCAGGC TTCTAGCATAAATGCGTTGTAATTGTGGTTCCCTGCTCCAGAGCCACGTCACCTATGTCTAGCTAATTCA AACACAGATGTGGTTATATAAGTGTCACTGGAAGGTCATCTATTTAACAGTTCTGATTTGGGGCCGGTGT CTTTCCTCTTTTTTTCTTTCACAGTGAAGCAGAGATGGTTTCTGCCATCAAGCCTCCTCGTGAAGAGTTC CTCAACAGCCGGATGCTGATGCCCCAAGACATCATGGCCTATCGGGGTCGTGAGGTGGTGGAGAACAACC TGCCACTGAGGAGCGCCCCTGGGTGTGAGAGCAGAGCCTTTGCCCCCAGCCTGTACAGTGGCCTGTCCAC ACCGCCAGCCTCTTATTCCATGTACAGCCACCTCCCTGTCAGCAGCCTCCTCTTCTCCGATGAGGAGTTT CGGGATGTCCGGATGCCTGTGGCCAACCCCTTCCCCAAGGAGCGGGCACTCCCATGTGATAGTGCCAGGC CAGTCCCTGGTGAGTACAGCCGGCCGACTTTGGAGGTGTCCCCCAATGTGTGCCACAGCAATATCTATTC ACCCAAGGAAACAATCCCAGAAGAGGCACGAAGTGATATGCACTACAGTGTGGCTGAGGGCCTCAAACCT GCTGCCCCCTCAGCCCGAAATGCCCCCTACTTCCCTTGTGACAAGGCCAGCAAAGAAGAAGAGAGACCCT CCTCGGAAGATGAGATTGCCCTGCATTTCGAGCCCCCCAATGCACCCCTGAACCGGAAGGGTCTGGTTAG TCCACAGAGCCCCCAGAAATCTGACTGCCAGCCCAACTCGCCCACAGAGTCCTGCAGCAGTAAGAATGCC TGCATCCTCCAGGCTTCTGGCTCCCCTCCAGCCAAGAGCCCCACTGACCCCAAAGCCTGCAACTGGAAGA AATACAAGTTCATCGTGCTCAACAGCCTCAACCAGAATGCCAAACCAGAGGGGCCTGAGCAGGCTGAGCT GGGCCGCCTTTCCCCACGAGCCTACACGGCCCCACCTGCCTGCCAGCCACCCATGGAGCCTGAGAACCTT GACCTCCAGTCCCCAACCAAGCTGAGTGCCAGCGGGGAGGACTCCACCATCCCACAAGCCAGCCGGCTCA ATAACATCGTTAACAGGTGATTTCAGAGACTGTCTGGGTCTGAGGTCAGGGGTTACCTGGGCAGGGTTCC ATGTCGTTTCTTCTTTTCTTGCCTGAATTGCTGAGCCTATTAGAGGTGTGGAATCAGTGCCTATAGATTG AGTTAGTCTGAGTAAGGAAGTATTTTACACTTAAGTAGTGTATATTTTTTCATAGCAAGAGAGATAATTC CCTTCTGGGGCAGAATAGCATTCTGTAAATCCCACAGGCACTTCCTGTGGTCTTGATGTAGCAGGGGACC ATCCTACTACCCTTGGACTGAGAGAGATTGTGGGCTGCGGGGAAGCTCTGGCTCAGTTTGACCCTGGTCA GTGATCTTTCTGCAGATACTGTTTGGAGATAAACTTGAGGACAACTCTGGGGTCTCAGAGCTTGAGTGGG CAGCCCAGCTCTGGCCTCTGGGCTTGCCTACACACAGGGAGGAGAGGGTGGTCTTGAGGCCCTGCCCCAG GTGCTGAGGCTGTTTTTACTCCTGTCCATAGGTCCATGACGGGCTCTCCCCGCAGCAGCAGCGAGAGCCA CTCACCACTCTACATGCACCCCCCGAAGTGCACGTCCTGCGGCTCTCAGTCCCCACAGCATGCAGAGATG TGCCTCCACACCGCTGGCCCCACGTTCCCTGAGGAGATGGGAGAGACCCAGTCTGAGTACTCAGATTCTA GCTGTGGTGAGTCCTTTTCCCTCCCTCCTCTTGTCAGGGAGAAGGAAGGCCCCTCTGCTCCATAGGTTTT GTGCTCCATTTTACTTATGCTGTTGTCTCTGATTGGAGCAGTCCTCAATTGGAAGTCCACTGGCACTCCA AGTCACCAGCCGTTCATCCCACGCTTCGCTTCTTGGGGAACTGGGTTAACCAAAGCAAGGGATGGGGTTT TAGAGTTGATCTGGGGTAATCAAGACTTACCATACAGTCATTTTAGCTTCATGCCAGCAAAAGTAGCTTG TGGGGCTGGCTGTAACTCCCAGAGCTTTCTCCATTCCTCTATACCAAAATGACTAGGACTGACCTGTGTG CATGTTATTCTCTGCCAGGCTGTACATTCTGTAAGGAGAAGCATCTGACCTTATTCATTCTCACATCCCC CATAGGTAGTAGTAAGTCCCTAGCATGGGGTAGGAACTCAGTAATATTAGTCGAGTTAAAAGAGTTGAAG AGAATTATTAAATTGCAGTTTCTGGATAGTTGGTGGTTGGCATTCCCAGTTTTTACCAGACAAAAAAGTC TAAATCTTCGCCCAGCTCTGGCTACAGTAATAGAGCCCAGTAGTACCTAATCAGGGTAAAATCACCGTGA CTTCTCATTTTCAAATTGTTACAACAAATGAAAAAATAAATCAGCTGCTTACACCAAGAGATTTGGCACA GGGTCATGGACCCATAGATGGGAGAGCGGGGACTGTCCCCTCCTGCACCCTGGCTAGTTTGCCTTTGCTC TGCACTCCAGTTCTTTTTCTCTGGGCCTCTGTTCCCACTTCCACCATCAGCTTCGGTCTCCCAGTCTCAC AGGAGGATTTGGAGACATGAAATCCAAATAGGTGCAAGGGTGACCACAGAGTGTTCGTCATTGATTCCTC CTTCAGTGACCTCAAAGTAGAATTGAATTTGACCTATATCTTACATTCCTGGAATGCTTTGTGTTTTATT TTGTGTAATATAATATCCTCCTGTGAGGTAGGCAGGACAGGGATTTATTATCTGACTTTGAAGACAGAGA TACAGAGAGAGGCTCAGAGGTAAAGGGTCTTGCCCTAGGGCTTCTGTGTATAAATGTAAATAAAACTGTA AACTTATTTTTAAAAATCAATTCTCAGAGCTCTTGGGGAAAGAAAATCTCTGTTGAGCTTTCCTCAAACT GGCGCAGGCCCTCTGAGCACCTGTTGGTTTGAGCTTCCCTTCTGTACCTTAATTCAGTCCATCTCCTTTC TCCCTTCTCTATGGCTAAGACTCTGAATGATAAGAAAAATAAAGTCCCCACAGATCCTTTGCTCCGAGCT CCCATGAATGTCGGGTGGGTGAGTGAGGGACTGAGAGTTCAGTTTGGCACAAGGGGTAGCTACAGAGGAG AGCGGCCTTAGAGCCCTACCTCCCTTCCTCGTGCTGACTTTGGTGTCCCCCTACCACCCTCCAACAGAGA ACGGGGCCTTCTTCTGCAATGAGTGTGACTGCCGCTTCTCTGAGGAGGCCTCACTCAAGAGGCACACGCT GCAGACCCACAGTGACAAACCCTACAAGTGTGACCGCTGCCAGGCCTCCTTCCGCTACAAGGGCAACCTC GCCAGCCACAAGACCGTCCATACCGGTATGGCCCTGCCCCACACGACCCGAACTCTCCACAATTATTGGG GCAGGACAGGGAGAGGATCCTAGAGAAAGCTGTGTGGGGCCTGGAGACCTGGTGGGGCAAGGCAGGAGGC AGGCCCCATCCTGGCCTGAACGAGGGGTCTAACCCTGTCTTGTCTTTGCTTAGTGACTCGACTCATCTAC TCCCTGTATCCTTTGTCTTTCCTCTGAGATGCTCTATCCTGCTTTTCTGCCTTTGCTGGGGTCAGAAGTG TTAATCCCACTGTACAGGTGAAGAGACTAAGTCTGGGAAAGACAAATAGATTCAATTTTTGTAAAGCCAG AAAAAAAAGCCTGTTGATTTGTTTCAATGACTTGTTCCTTATCAACTCACATTCCTTTACCAGGTAGCTT CTCATGACCTGCTTGTTGTTTAAAATCTACTCTCTTAGTACCGTAAATGGCCCTATTATCCCAAAAACTT TCCATGAAGGAAGGTTCAGCCATTCTATTGGTTTCCTCTGCTGAGCATCTACTCAGGCCCAAGCCCCACC CCTCTTGCAAATGGAATCCAGCTGTAGTTGCCACAAGCGGAAAAATCTGTTTGTTCTAAAAGAGAGAAAC TAGAGCAGCCTGATTGTGTCTCCCTGGTGAATGAGTTGATGAGTGAATCTGTCTTATCCAAGGGAAAAGC TAGAAGAACCTTCCCAGGTAATCTGAAGTAGCCCCTCAGGTTCCAGAGAGGGAAACTGAGGCCCAGAGAA GGAGAGTGACTTGTCCAGGTTCCGCAGGCAGATAATCCTAATGACAAAGCTGGTTCTAAAGCCCAGGCTT CCTGGAATCTCCCCCTCTCCTATCCCACACCTGGCATTGTTGCTACTCCGTGCCACCACTTGTTTCTTGG CCCTGGTCCCCTGCGAGGTATGCAGGTGCGTGTGTGAGAGAGGGCTGACAGATGTGGGGGCAGGCCCCTG GATTCTCTCTCTCACATTCCCTAAGGGAAAGGAAAACACAAGTGGCCTCAGGGAGGAGCAGGCTGCTTAG AAATCCAGGAGCCACGGACTGCAGAGACCTTCCTTATTGAATATGGCTTTTCTTTTTCCCTTTTTCTTGG TAATAGGTGAGAAACCCTATCGTTGCAACATCTGTGGGGCCCAGTTCAACCGGCCAGCCAACCTGAAAAC CCACACTCGAATTCACTCTGGAGAGAAGCCCTACAAATGCGAAACCTGCGGAGCCAGATTTGTACAGGTG AGCAGAGTGGGCAGGCGAGCGGAGCGGGCAGGCGAGCGGAGCGGGCAGGCGAGCGGAGGAGTGGGCAGGC AAGCGGAGGAGTGGGCAGGCAAGTGGAGCGGGCAGGCAAGCGGAGCGGGCAGGTGAGCAGAGCGGGCAGG AGAAAGTCCCACTCAGTCCCCGTGTGCAGGTGAGCAGAGCGGGCAGGTGAGCAGAGCGGGCAGGTGAGCA GAGCGGGTAGGTGAGCAGAGTGGGCAGGTGAGCAGAGGAGTGGGCAGGTGAGCAGAGTGGGCAGCAGAAA GGCCCACTCAGTCCCTGTGTGCAGGTGAGCAGAGTGGCCTGGAGAAAGGCCCACTCACTGGCTGTGTGCT AATGAGGGGCTGCCCAGAGGCCTGCAGCCCACCCCAGAAGACCTCTCATGCCTTCTTCTTCGTTCAGGTG GCCCACCTCCGTGCCCATGTGCTTATCCACACTGGTGAGAAGCCCTATCCCTGTGAAATCTGTGGCACCC GTTTCCGGCACCTTCAGACTCTGAAGAGCCACCTGCGAATCCACACAGGAGAGAAACCTTACCATGTACG TAAGCCTCTTGAGGCCGCTCTCTGACCTGCGGGGATGTGGAGGGCAGGGAAGGAGGTGGAGCGCAGGGAA GGAGGTGGAGCAGGGAGGCAGTGGAACTGTTTGCTCCCATCTCAAGCACACAGTGGGGCAACCACTACGC TAATGGTTGGAAGACCTAGATCTGGGCCCAATGGCCAGACACCCTGCTTGACCTTGGCCCAAGCATTAGG GGACTCATCTTTAAAATGAGGGTATGGGACTAGGTGATCTGGGCCTTAGGAGAGGAGTCTAGACTGTGGA TACATAGACTTGATTCACTCCACCTAGATTCATTCATTTCACAAATACTTATTGATTGCCTCCTGGACAC CCCATACTGGGCTAGATGCACATTTAAGAGGAGCTAAGGTGTTTGAGAAGGAACAGTCTTAGGAGGAGGA GAACAAAAAGAATGTTATAAGAATTAATGATGTTACAGGAAAAAATTAAAAAAAAACATAAAGAAGGTCA TTTTAAGAAAGAGGAGGCGGCCAGCCATGCAGCACGACACTGTGGATAGGTTCACTGGGATTGGAATGTT CTAGGGCGGGGTCTCGGCAGCTATAGCCTGTGTGCCAATGTTTGAACATTCCATGAACTAGGAATGGTTT TTACAGTTAAAAAGTAAAAGAATATTTTGTGCCATATGCAAATTATATGAAATTTAAATTTCATTGTCCC TAAGTAAAAGGTTATTGGAACACAGCCACGCTCATCTGTGTACGTTTTGCCTATGGTTGCTTTGAGGAGT TGATGACATTCTTCTAGGTGGTGATGGGGACAAGAAGTAATCAATGAATGGTTAACCTACATACCGGAGG TTAACCTGCAAAACATGGTTATTTTTGTTCACTTGTTGATCAAGCTGTGAGTGAATATCTTCTTACTTGC TGTTTGGGCAAATTCGTTATCCTCTTAGTACCTTAATTTCCTAATCTGTAAAGTGAGTTTGAAAATAGTA TCTACTTCATGGAGTTGTAGTATTAACTAATGATTAAAGTGTTGAGGATAGCACATGCACATAGTAATAG TAAAATAAATATCTGCTATCATGATTTGCTAGAATTTTAGATGCCTAGGATATCAGAGTTGAGAATGACT TTCAGCCTGTATTGACCCAGGCCATTCAGAAGGGAGATCCAAGGCCCGGAGAGTGAAATGACATGCTGGG GACACACAGCGGTGAATGGCATAGATACAGTAGATTCTCTATGTCTCCCAAGACCAGAGAGTTTACACAT GGCCCTGCTCATTTTTTATTTGTCTTCATCTATTTCCATTTTCACTTGAAAACATATACTCTATCTGAAC ATATTTTATTACCCTTTTTGTTTTAGGATAGTTTTAGATTTATAGAAAAGTTGCAAAGATTGTACTGAGG GCTCCTACCCGCACCCATTTTATCCTATTGTTAACATCTTACGTTAGTTCCATACATTTGTCACAACTAA TGAACCAATACTGATAATATAATTATAAGCTAAAGTTCGTACTTTACTTACATTTTCTTTGTTTTTATCT AAGAATGTCCTTTCTCATTCAAGATCTCATCTAGATTACCCCATTACATTTAGTCATCCATTTTACTTTT AAGTAACTTTTATCTAAACTAAAGCGCTTATTACCCATTCATTGAATTAAATCAAGAAACGGCTCCACTT GCTAATGTTTAGTTAGCTTATCTAGGATATATACCCTAGGAAAGAATATAACTGCATTTAAAAAAATTTA CCCTAGACTCCAGAATTTCCGTGAATTCAGACTGATCTAGTCCATTTGTCCAGATGTGTTCAGATTAATT GCATAATTTGAATAAGAGGTATATTCTGTGAGGTCCTAGGAAGATTATAAAGTTTAGGAAAAAAATAGCC ACTGCCCTCAAAGTGTTACCCACTGAAGAAGGATCCATGCACACGGAGGGCTGTGTGGTAAAGGTAGAAA TCTTACAGAGGCTCAAAGGAAAACAAGGATTATTTTCATCCTTGAGAGATTCAGAAATGCCTTAATCATT AGAAGAGTTTGCATCTAACTGCACTTTTGGATAAGACTCAAACTTGTGGAGTTAAGGCAGGGAAGGACGT CTCTAGCAAGGGAGAGGCAGAAGCAACACTTGGGAAAGCAGGGAACGGACATTTGCACAACGCTAGCTTA TCTGTCGGCAGAAGCCCGGATGCATATGGGTTCTTCACCTGGCCTTGGAGAGGCAAGAGCTGCCCCAGTC CCTCGTAGGGAGAATCTTCCTCTCTGGGTCTTTGAGCAATGACATCTTTCTTGGGTTGATGACAGCTAAC AGTTTGCCTCTGATATCCCTGCAGTGTGAGAAGTGTAACCTGCATTTCCGTCACAAAAGCCAGCTGCGAC TTCACTTGCGCCAGAAGCATGGCGCCATCACCAACACCAAGGTGCAATACCGCGTGTCAGCCACTGACCT GCCTCCGGAGCTCCCCAAAGCCTGCTGAAGCATGGAGTGTTGATGCTTTCGTCTCCAGCCCCTTCTCAGA ATCTACCCAAAGGATACTGTAACACTTTACAATGTTCATCCCATGATGTAGTGCCTCTTTCATCCACTAG TGCAAATCATAGCTGGGGGTTGGGGGTGGTGGGGGTCGGGGCCTGGGGGACTGGGAGCCGCAGCAGCTCC CCCTCCCCCACTGCCATAAAACATTAAGAAAATCATATTGCTTCTTCTCCTATGTGTAAGGTGAACCATG TCAGCAAAAAGCAAAATCATTTTATATGTCAAAGCAGGGGAGTATGCAAAAGTTCTGACTTGACTTTAGT CTGCAAAATGAGGAATGTATATGTTTTGTGGGAACAGATGTTTCTTTTGTATGTAAATGTGCATTCTTTT AAAAGACAAGACTTCAGTATGTTGTCAAAGAGAGGGCTTTAATTTTTTTAACCAAAGGTGAAGGAATATA TGGCAGAGTTGTAAATATATAAATATATATATATATAAAATAAATATATATAAACCTAAAAAAGATATAT TAAAAATATAAAACTGCGTTAAAGGCTCGATTTTGTATCTGCAGGCAGACACGGATCTGAGAATCTTTAT TGAGAAAGAGCACTTAAGAGAATATTTTAAGTATTGCATCTGTATAAGTAAGAAAATATTTTGTCTAAAA TGCCTCAGTGTATTTGTATTTTTTTGCAAGTGAAGGTTTACAATTTACAAAGTGTGTATTAAAAAAAACA AAAAGAACAAAAAAATCTGCAGAAGGAAAAATGTGTAATTTTGTTCTAGTTTTCAGTTTGTATATACCCG TACAACGTGTCCTCACGGTGCCTTTTTTCACGGAAGTTTTCAATGATGGGCGAGCGTGCACCATCCCTTT TTGAAGTGTAGGCAGACACAGGGACTTGAAGTTGTTACTAACTAAACTCTCTTTGGGAATGTTTGTCTCA TCCCATTCTGCGTCATGCTTGTGTTATAACTACTCCGGAGACAGGGTTTGGCTGTGTCTAAACTGCATTA CCGCGTTGTAAAATATAGCTGTACAAATATAAGAATAAAATGTTGAAAAGTCAAACTGG Download Select all
Length	24349
OMIM ID	109565
HGNC ID	HGNC:1001
Unigene ID	Hs.478588
Ensembl ID	ENSG00000113916
PharmGKB ID	PA25312

mRNA Information

mRNA ID	NM_001706.4
Exon	join(1..316,10819..10857,12023..12193,13796..14017, 15705..16676,17182..17366,18828..18995,20097..20227, 20648..20785,23125..24349)
mRNA Sequence	>gi\|299115782\|ref\|NM_001706.4\| Homo sapiens B-cell CLL/lymphoma 6 (BCL6), transcript variant 1, mRNA ACCATCGTCTTGGGCCCGGGGAGGGAGAGCCACCTTCAGGCCCCTCGAGCCTCGAACCGGAACCTCCAAA TCCGAGACGCTCTGCTTATGAGGACCTCGAAATATGCCGGCCAGTGAAAAAATCTTGTGGCTTTGAGGGC TTTTGGTTGGCCAGGGGCAGTAAAAATCTCGGAGAGCTGACACCAAGTCCTCCCCTGCCACGTAGCAGTG GTAAAGTCCGAAGCTCAAATTCCGAGAATTGAGCTCTGTTGATTCTTAGAACTGGGGTTCTTAGAAGTGG TGATGCAAGAAGTTTCTAGGAAAGGCCGGACACCAGGTTTTGAGCAAAATTTTGGACTGTGAAGCAAGGC ATTGGTGAAGACAAAATGGCCTCGCCGGCTGACAGCTGTATCCAGTTCACCCGCCATGCCAGTGATGTTC TTCTCAACCTTAATCGTCTCCGGAGTCGAGACATCTTGACTGATGTTGTCATTGTTGTGAGCCGTGAGCA GTTTAGAGCCCATAAAACGGTCCTCATGGCCTGCAGTGGCCTGTTCTATAGCATCTTTACAGACCAGTTG AAATGCAACCTTAGTGTGATCAATCTAGATCCTGAGATCAACCCTGAGGGATTCTGCATCCTCCTGGACT TCATGTACACATCTCGGCTCAATTTGCGGGAGGGCAACATCATGGCTGTGATGGCCACGGCTATGTACCT GCAGATGGAGCATGTTGTGGACACTTGCCGGAAGTTTATTAAGGCCAGTGAAGCAGAGATGGTTTCTGCC ATCAAGCCTCCTCGTGAAGAGTTCCTCAACAGCCGGATGCTGATGCCCCAAGACATCATGGCCTATCGGG GTCGTGAGGTGGTGGAGAACAACCTGCCACTGAGGAGCGCCCCTGGGTGTGAGAGCAGAGCCTTTGCCCC CAGCCTGTACAGTGGCCTGTCCACACCGCCAGCCTCTTATTCCATGTACAGCCACCTCCCTGTCAGCAGC CTCCTCTTCTCCGATGAGGAGTTTCGGGATGTCCGGATGCCTGTGGCCAACCCCTTCCCCAAGGAGCGGG CACTCCCATGTGATAGTGCCAGGCCAGTCCCTGGTGAGTACAGCCGGCCGACTTTGGAGGTGTCCCCCAA TGTGTGCCACAGCAATATCTATTCACCCAAGGAAACAATCCCAGAAGAGGCACGAAGTGATATGCACTAC AGTGTGGCTGAGGGCCTCAAACCTGCTGCCCCCTCAGCCCGAAATGCCCCCTACTTCCCTTGTGACAAGG CCAGCAAAGAAGAAGAGAGACCCTCCTCGGAAGATGAGATTGCCCTGCATTTCGAGCCCCCCAATGCACC CCTGAACCGGAAGGGTCTGGTTAGTCCACAGAGCCCCCAGAAATCTGACTGCCAGCCCAACTCGCCCACA GAGTCCTGCAGCAGTAAGAATGCCTGCATCCTCCAGGCTTCTGGCTCCCCTCCAGCCAAGAGCCCCACTG ACCCCAAAGCCTGCAACTGGAAGAAATACAAGTTCATCGTGCTCAACAGCCTCAACCAGAATGCCAAACC AGAGGGGCCTGAGCAGGCTGAGCTGGGCCGCCTTTCCCCACGAGCCTACACGGCCCCACCTGCCTGCCAG CCACCCATGGAGCCTGAGAACCTTGACCTCCAGTCCCCAACCAAGCTGAGTGCCAGCGGGGAGGACTCCA CCATCCCACAAGCCAGCCGGCTCAATAACATCGTTAACAGGTCCATGACGGGCTCTCCCCGCAGCAGCAG CGAGAGCCACTCACCACTCTACATGCACCCCCCGAAGTGCACGTCCTGCGGCTCTCAGTCCCCACAGCAT GCAGAGATGTGCCTCCACACCGCTGGCCCCACGTTCCCTGAGGAGATGGGAGAGACCCAGTCTGAGTACT CAGATTCTAGCTGTGAGAACGGGGCCTTCTTCTGCAATGAGTGTGACTGCCGCTTCTCTGAGGAGGCCTC ACTCAAGAGGCACACGCTGCAGACCCACAGTGACAAACCCTACAAGTGTGACCGCTGCCAGGCCTCCTTC CGCTACAAGGGCAACCTCGCCAGCCACAAGACCGTCCATACCGGTGAGAAACCCTATCGTTGCAACATCT GTGGGGCCCAGTTCAACCGGCCAGCCAACCTGAAAACCCACACTCGAATTCACTCTGGAGAGAAGCCCTA CAAATGCGAAACCTGCGGAGCCAGATTTGTACAGGTGGCCCACCTCCGTGCCCATGTGCTTATCCACACT GGTGAGAAGCCCTATCCCTGTGAAATCTGTGGCACCCGTTTCCGGCACCTTCAGACTCTGAAGAGCCACC TGCGAATCCACACAGGAGAGAAACCTTACCATTGTGAGAAGTGTAACCTGCATTTCCGTCACAAAAGCCA GCTGCGACTTCACTTGCGCCAGAAGCATGGCGCCATCACCAACACCAAGGTGCAATACCGCGTGTCAGCC ACTGACCTGCCTCCGGAGCTCCCCAAAGCCTGCTGAAGCATGGAGTGTTGATGCTTTCGTCTCCAGCCCC TTCTCAGAATCTACCCAAAGGATACTGTAACACTTTACAATGTTCATCCCATGATGTAGTGCCTCTTTCA TCCACTAGTGCAAATCATAGCTGGGGGTTGGGGGTGGTGGGGGTCGGGGCCTGGGGGACTGGGAGCCGCA GCAGCTCCCCCTCCCCCACTGCCATAAAACATTAAGAAAATCATATTGCTTCTTCTCCTATGTGTAAGGT GAACCATGTCAGCAAAAAGCAAAATCATTTTATATGTCAAAGCAGGGGAGTATGCAAAAGTTCTGACTTG ACTTTAGTCTGCAAAATGAGGAATGTATATGTTTTGTGGGAACAGATGTTTCTTTTGTATGTAAATGTGC ATTCTTTTAAAAGACAAGACTTCAGTATGTTGTCAAAGAGAGGGCTTTAATTTTTTTAACCAAAGGTGAA GGAATATATGGCAGAGTTGTAAATATATAAATATATATATATATAAAATAAATATATATAAACCTAAAAA AGATATATTAAAAATATAAAACTGCGTTAAAGGCTCGATTTTGTATCTGCAGGCAGACACGGATCTGAGA ATCTTTATTGAGAAAGAGCACTTAAGAGAATATTTTAAGTATTGCATCTGTATAAGTAAGAAAATATTTT GTCTAAAATGCCTCAGTGTATTTGTATTTTTTTGCAAGTGAAGGTTTACAATTTACAAAGTGTGTATTAA AAAAAACAAAAAGAACAAAAAAATCTGCAGAAGGAAAAATGTGTAATTTTGTTCTAGTTTTCAGTTTGTA TATACCCGTACAACGTGTCCTCACGGTGCCTTTTTTCACGGAAGTTTTCAATGATGGGCGAGCGTGCACC ATCCCTTTTTGAAGTGTAGGCAGACACAGGGACTTGAAGTTGTTACTAACTAAACTCTCTTTGGGAATGT TTGTCTCATCCCATTCTGCGTCATGCTTGTGTTATAACTACTCCGGAGACAGGGTTTGGCTGTGTCTAAA CTGCATTACCGCGTTGTAAAATATAGCTGTACAAATATAAGAATAAAATGTTGAAAAGTCAAACTGGAAA AAAAA Download Select all
Length	3575

CDS Information

Location	366..2486
CDS Sequence	>lcl\|NM_001706.4_cds_NP_001697.2_1 [gene=BCL6] [protein=B-cell lymphoma 6 protein isoform 1] [protein_id=NP_001697.2] [location=366..2486] ATGGCCTCGCCGGCTGACAGCTGTATCCAGTTCACCCGCCATGCCAGTGATGTTCTTCTCAACCTTAATC GTCTCCGGAGTCGAGACATCTTGACTGATGTTGTCATTGTTGTGAGCCGTGAGCAGTTTAGAGCCCATAA AACGGTCCTCATGGCCTGCAGTGGCCTGTTCTATAGCATCTTTACAGACCAGTTGAAATGCAACCTTAGT GTGATCAATCTAGATCCTGAGATCAACCCTGAGGGATTCTGCATCCTCCTGGACTTCATGTACACATCTC GGCTCAATTTGCGGGAGGGCAACATCATGGCTGTGATGGCCACGGCTATGTACCTGCAGATGGAGCATGT TGTGGACACTTGCCGGAAGTTTATTAAGGCCAGTGAAGCAGAGATGGTTTCTGCCATCAAGCCTCCTCGT GAAGAGTTCCTCAACAGCCGGATGCTGATGCCCCAAGACATCATGGCCTATCGGGGTCGTGAGGTGGTGG AGAACAACCTGCCACTGAGGAGCGCCCCTGGGTGTGAGAGCAGAGCCTTTGCCCCCAGCCTGTACAGTGG CCTGTCCACACCGCCAGCCTCTTATTCCATGTACAGCCACCTCCCTGTCAGCAGCCTCCTCTTCTCCGAT GAGGAGTTTCGGGATGTCCGGATGCCTGTGGCCAACCCCTTCCCCAAGGAGCGGGCACTCCCATGTGATA GTGCCAGGCCAGTCCCTGGTGAGTACAGCCGGCCGACTTTGGAGGTGTCCCCCAATGTGTGCCACAGCAA TATCTATTCACCCAAGGAAACAATCCCAGAAGAGGCACGAAGTGATATGCACTACAGTGTGGCTGAGGGC CTCAAACCTGCTGCCCCCTCAGCCCGAAATGCCCCCTACTTCCCTTGTGACAAGGCCAGCAAAGAAGAAG AGAGACCCTCCTCGGAAGATGAGATTGCCCTGCATTTCGAGCCCCCCAATGCACCCCTGAACCGGAAGGG TCTGGTTAGTCCACAGAGCCCCCAGAAATCTGACTGCCAGCCCAACTCGCCCACAGAGTCCTGCAGCAGT AAGAATGCCTGCATCCTCCAGGCTTCTGGCTCCCCTCCAGCCAAGAGCCCCACTGACCCCAAAGCCTGCA ACTGGAAGAAATACAAGTTCATCGTGCTCAACAGCCTCAACCAGAATGCCAAACCAGAGGGGCCTGAGCA GGCTGAGCTGGGCCGCCTTTCCCCACGAGCCTACACGGCCCCACCTGCCTGCCAGCCACCCATGGAGCCT GAGAACCTTGACCTCCAGTCCCCAACCAAGCTGAGTGCCAGCGGGGAGGACTCCACCATCCCACAAGCCA GCCGGCTCAATAACATCGTTAACAGGTCCATGACGGGCTCTCCCCGCAGCAGCAGCGAGAGCCACTCACC ACTCTACATGCACCCCCCGAAGTGCACGTCCTGCGGCTCTCAGTCCCCACAGCATGCAGAGATGTGCCTC CACACCGCTGGCCCCACGTTCCCTGAGGAGATGGGAGAGACCCAGTCTGAGTACTCAGATTCTAGCTGTG AGAACGGGGCCTTCTTCTGCAATGAGTGTGACTGCCGCTTCTCTGAGGAGGCCTCACTCAAGAGGCACAC GCTGCAGACCCACAGTGACAAACCCTACAAGTGTGACCGCTGCCAGGCCTCCTTCCGCTACAAGGGCAAC CTCGCCAGCCACAAGACCGTCCATACCGGTGAGAAACCCTATCGTTGCAACATCTGTGGGGCCCAGTTCA ACCGGCCAGCCAACCTGAAAACCCACACTCGAATTCACTCTGGAGAGAAGCCCTACAAATGCGAAACCTG CGGAGCCAGATTTGTACAGGTGGCCCACCTCCGTGCCCATGTGCTTATCCACACTGGTGAGAAGCCCTAT CCCTGTGAAATCTGTGGCACCCGTTTCCGGCACCTTCAGACTCTGAAGAGCCACCTGCGAATCCACACAG GAGAGAAACCTTACCATTGTGAGAAGTGTAACCTGCATTTCCGTCACAAAAGCCAGCTGCGACTTCACTT GCGCCAGAAGCATGGCGCCATCACCAACACCAAGGTGCAATACCGCGTGTCAGCCACTGACCTGCCTCCG GAGCTCCCCAAAGCCTGCTGA Download Select all
CCDS ID	CCDS3289.1

Protein Information

Protein ID	NP_001697.2
Protein Name	B-cell CLL/lymphoma 6
Molecular Wt. (Da)	78716
Protein Sequence	>lcl\|NM_001706.4_prot_NP_001697.2_1 [gene=BCL6] [protein=B-cell lymphoma 6 protein isoform 1] [protein_id=NP_001697.2] [location=366..2486] MASPADSCIQFTRHASDVLLNLNRLRSRDILTDVVIVVSREQFRAHKTVLMACSGLFYSIFTDQLKCNLS VINLDPEINPEGFCILLDFMYTSRLNLREGNIMAVMATAMYLQMEHVVDTCRKFIKASEAEMVSAIKPPR EEFLNSRMLMPQDIMAYRGREVVENNLPLRSAPGCESRAFAPSLYSGLSTPPASYSMYSHLPVSSLLFSD EEFRDVRMPVANPFPKERALPCDSARPVPGEYSRPTLEVSPNVCHSNIYSPKETIPEEARSDMHYSVAEG LKPAAPSARNAPYFPCDKASKEEERPSSEDEIALHFEPPNAPLNRKGLVSPQSPQKSDCQPNSPTESCSS KNACILQASGSPPAKSPTDPKACNWKKYKFIVLNSLNQNAKPEGPEQAELGRLSPRAYTAPPACQPPMEP ENLDLQSPTKLSASGEDSTIPQASRLNNIVNRSMTGSPRSSSESHSPLYMHPPKCTSCGSQSPQHAEMCL HTAGPTFPEEMGETQSEYSDSSCENGAFFCNECDCRFSEEASLKRHTLQTHSDKPYKCDRCQASFRYKGN LASHKTVHTGEKPYRCNICGAQFNRPANLKTHTRIHSGEKPYKCETCGARFVQVAHLRAHVLIHTGEKPY PCEICGTRFRHLQTLKSHLRIHTGEKPYHCEKCNLHFRHKSQLRLHLRQKHGAITNTKVQYRVSATDLPP ELPKAC Download Select all
Length	706
Uniprot ID	P08254
Ensembl Protein ID	ENSP00000299855

Post-translational Modification Information (Source : HPRD)

Residue	Type	site
S	Phosphorylation	308
S	Phosphorylation	308

Enzyme Information

No matching records could be found.

PPi Information

(Click to view network : Source STRING) View

Interactant Gene ID (Source: HPRD)	Gene Symbol	HPRD ID	Ref Seq ID	Technique	References
2033	EP300	4078	NP_001420.2	in vitro;in vivo	12402037
5467	PPARD	2679	NP_006229.1	in vitro;in vivo	12970571
5594	MAPK1	1496	NP_002736.3	in vitro	9649500
23683	PRKD3	6151	NP_005804.1	in vivo	16147992
65266	WNK4	3505	NP_115763.2	in vivo	16147992

Pathway Information

Pathway Name	Pathway ID
FoxO signaling pathway	hsa04068
Transcriptional misregulation in cancer	hsa05202

Structure Information

No matching records could be found.

Domain Information

ID	Location	Description
pfam00651	22-128	BTB
cl02518	22-128	BTB superfamily
smart00225	33-126	BTB
pfam13465	588-613	zf-H2C2_2
cl22375	588-613	zf-H2C2_2 superfamily
pfam13465	616-641	zf-H2C2_2
cl22375	616-641	zf-H2C2_2 superfamily
pfam13465	645-669	zf-H2C2_2
cl22375	645-669	zf-H2C2_2 superfamily
pfam13465	560-585	zf-H2C2_2
cl22375	560-585	zf-H2C2_2 superfamily
PHA03098	34-125	PHA03098
PHA02713	13-126	PHA02713
COG5189	543-648	SFP1
COG5048	572-636	COG5048
PHA03247	172-426	PHA03247

Ontology Information

HPRD ID	1525
Molecular Class	Transcription factor
Molecular Function	Metallopeptidase activity (GO:0008237)
Biological Process	Protein metabolism (GO:0019538)

SNP Information

View SNP Geneview Report

Drug Information

No matching records could be found.

External Links

ArrayExpress GO
ICGC GO
Cancer3D GO
COSMIC GO
NCG GO
TSGene GO
Tumor Gene Family of Databases GO
CCDB GO
G2SBC GO
Osteosarcoma Database GO
RCDB GO

Mechanism	Methylation/Up-regulation
Biomarker	25973304
Drug Target	-
Biological Process	Apoptosis

ArrayExpress	GO
ICGC	GO
Cancer3D	GO
COSMIC	GO
NCG	GO
TSGene	GO
Tumor Gene Family of Databases	GO
CCDB	GO
G2SBC	GO
Osteosarcoma Database	GO
RCDB	GO