CoReCG

Search results:

General Information

Gene_Symbol	Gene_ID	Gene_Name	Chromosome	Alias
BCMO1	53630	Beta-carotene 15,15'-monooxygenase 1	16	BCO; BCDO; BCMO; BCO1; BCDO1

Evidence
Gene
mRNA
CDS
Protein
PTM
Enzyme
PPi
Pathway
Structural
Domain
Ontology
SNP
Drug
External Links

Evidence Information

Pubmed ID	Year	Sample Information	Techniques	Mechanism	Fold Change	Remark
23001810	2012	Cell line : - Source : - Sample Type : Mouse model No. of Sample : - Stage : -	-	Methylation	-	Decreased expression of Bcmo1 and increased expression of Aldh1a, which upregulate the peroxisome proliferator-activated receptor alpha (PPARA) pathway. Bcmo1, Ppara, and Bmp5 showed differential DNA methylation related to strain, diet, and/or Mthfr genotype. BALB/c and C57BL/6 mice-fed low folate were used to study.

Gene Details

Chromosome: 16; NC_000016.9 (81272296..81324747)
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Gene Type	protein coding
Gene Family	-
Description	Vitamin A metabolism is important for vital processes such as vision, embryonic development, cell differentiation, and membrane and skin protection. The protein encoded by this gene is a key enzyme in beta-carotene metabolism to vitamin A. It catalyzes the oxidative cleavage of beta,beta-carotene into two retinal molecules. [provided by RefSeq, Jul 2008]
Chromosome	16
Location	16q23.2
Start	81238642
End	81291142
Strand	+
Gene Sequence	>gi\|568815582:81238642-81291142 Homo sapiens chromosome 16, GRCh38.p2 Primary Assembly AACCTTTAACCAAACATCTTATAAGTAACGCCAGCGCAGCTTCCCTTGTGAATGTAAAGAGATCCAGGGC TCTTGGAGAGGGACAAGTGAGAGCCAGCCAAAAAGGAAAAAGCAAAGGCAGAAACGGCATCAGGAGAGAC AGAGATGTGAAGGAGGGAAGGAGCAGGAGAGCAGGAAGGAAACGCAGGAGGAGGGAGCAGCATCTCCTGT GAACACAGAGGAGCACCTGTTTGCTGTTAAAATCGATCTCCCTCGGCACCCTGAGCAATGGATATAATAT TTGGCAGGAATAGGAAAGAACAGCTGGAGCCTGTGAGGGCCAAAGTGACAGGTGAGCATTCTGATAAACA CTGGGCTCTTTCTTCTATTTATTTTATTATTTTTTTTTTTTTTGAGGCGGAGTCTCGCTCTGTCGCCCGG GCTGGAGTCCAGTGGCTTGATCTCGGCCCACTGCAACCTCTGCCTCCTGGGTTCAAACGATCCTCCCACC ACAGCCTCCCGAGTAGCTGAGATTACAGGCACCCACCACCAAGCCCGGCTAATCTGTGTGTTTTTAGTAG AGACGGGGTTTCAGCATGTTGGCCAGGCTGGTCTCGAACTCCTAGCCTCAAGTGATCCACCCACCTCGGC CTCCGAAAGTGCTAGGATTACAGGGGTGAGCCACTGCACCTGGCTTCTTCCTTGTGTTTAGATGGACACT ATTTTTTCCTGATGATATAAGTAATACTAATTGTAAATTACTTTTGGAAAGTCTGGAAAACAGTACAGAG AGGGGACACATTTTCTGTGAAAATCTAGGTATTCTTTTACACATTATAACTCCGTTTGCAAAGGGAGGAG AGTCAGTCTCACTGTTCCCAGGAAAAAAGCATTGGAATGCCCCAGTGGGTACATAGACAATGGGATTAAT CTGCAAACTGCTGCCTGTCTCAGATGCATGATGTATTTGTGCAAATGTATGCATTCTAAATTAGTTTCAA AATGCTTAGAGGGGCGTGCATGAGCTCCCACGCATGCACATCCACCACGCACACTTGCAGGGGATTGCAG AGTCTGATGTGATTTTCTCTCAGGAACTCACAGGTGTGAGCTCCTGCAGAGCCTATAGGAGTAGGACCTT CTATCCTTTAGAGGCTCTGTGTTTCGCTTAATCTTTTATATCTCTTTTTCCTCCTCTTTTGAGTTGCCAC TTTCCTGGTACCATTTCGACTCTAAAGGGCAGTTCCTGGTTCTGGACTCCCGGGTCCCCAGAGTGGTGCT CGCTCAGTTTTAAGAACAGCTGAGTCAGCTCAGGCCTGCAGGCATTTTCATCTGCTAGATGGACTGGAAT TGTTCATAAGGAGAGGACAACTGTGAGTGATTTTCGTGAGAACATCAGATTGAAGCTTTTCAACTGAGCA ATTGCCTTGGGAGTCTTTTGAAACAAAAAAAAAATAGCTTTTATGTATATATTTTCCTGGTTACAAAGGT AAGGCACAATCTATAGCTATCAATCTGTATATATATATAGCTGTATGTATATTAAATTATATATAAATTA ATTAGGAGTGCAAATGAGAACATGGAAGGAAATAAAATCAGCTGTATTTTGAAATCTCTTAACCACTATT AATATTTGGGTCTATTTCCTTTAACTTTTTAAAACATAGGTAGATCAATTGATAGATTACTATATTTGTA AACAGTTTTTCAAAAAGCAAATGTATACTATTACATTTTTATTTTTTTTCTCAATTTGACTGTTCATCTG TACATATTTTATTTTTTAAAAAGACACCCCACGGCCAGGTGCGGTGGCTCACGCCTGTGGTCCCAGCACT TTCGGAGGCCAAAGAGGGTGGATCACTTGAAGCCAGGAGTTTGAGACCAGCCTGGCTAACATGGCGAAAT CCCTCTCTACTAAAAATACACAAATTAGCCAGGGGTGGTGGCATGCACCTGTAGTCCCAGCTACTCAGGA GGATGAGGTAGTAGAATTGCTTGAACCCCGGAGGCAGAGGTTGCAGTGAGCTGAGATCGTGCCACTGCAC TCTGGCCTTGGCAAGAGTGAGACCCTGTCTCAAAAATAAATAAATAAAAAAAAACCAGGCACCCCAGCCT GGCCAACCTGGTATGGTGAAACACTGTCTTTATTATTTGGTTGGTGCAAAAATAATCGCGGTTTTTGCCA TTACTTTCAATGCATTTAATTTTAATTTTTTTTTTTTTTTGAGAAGGAGTTTCACTCTTGTTGCCCAGGC TGGAGTGTAATGGCGCGATCTCGGCTCACCACAACCTCTGCCTCCTGGGTTCAAGCGATTCTTCTGCCTC AGCCTCCCAAATAGCTGGAATGACAGGCATGCACCACCACACCCGGCTAATTTTGTATTTTTAGCTGAAA CAGGGTATCTCCATGTTGGTCAGGCTGGTCGCAAACTCCCAACCTCAGTTGATCCGCCCGTGTTGGCCTC CCAGAGTGCTGGGATTATAGGCGTGAACCACCATGCCCGGCCTGAAATTTTATTTTAAATAAAAATACAA AAATTAGCCAGGCATGGTGGTGCATATCTATAAGCCCAGCTCCTCAGGAGACTGGGCATGAGAATCACTT GAACCCAGGAGGCAGAGGTTGTAGTGAGCCAAGATCGCACCACTGTACTCCAGCCTGGGCAACAGAGTGA GACTCTGTCTCCAAAAGAAAACAAAAAGGCACCTATGATACCTACCTTTTCGTGCCCTGGAATATTTTGT ACCCTTTACACCTCATGTTTAATGACTGCATGAAATCCTTGGAAATGTTAGAAAACATGAATTCTAGAAC ACGAGAGGCTGAGTGAGCCCCAAAGATCAGCAGCGGTTCTCAAAGGGGTGGCCCCGGACCTGCAGCATAA GCATCACCTGGGTGCTGGGTAGAAATAAACATCCTTGGGCCCTACCCAGACCCACGGGGTCAGACACTTG GGGGGTGGAGCTCAGCAAGCTGTGTGTTCACAAGCCCTCAGGCGATTCCAAAGGTAAGAACCATTCCTCT ACATCAAGCCTCCCTATTGACAGATGGGAAACTGAGGCAGAGGGGCAGTGACTTGCCAAGGCCAGGCAGC CTGCAGAGAACAGGCCTCCTGACTCTCCGTCCAGGCCTGGGTTGAGCCTAATCAGTTGGTGACATCCATG GGCAAACAGCTAACTAAAAACTGTGCCTGGGTTGACACGTCCATGCAGGGAGCACATGCAAAGGTTTTGG CTTTGTAACTGGCTGTGCCGACACACGTGTGTTCTGAGACCTCTTTGGCAACTTAAGCATTTCCTGCCTC AGTGTTCTTTTCTGTTTGATGAATGTAGCCTGGCACCTCCCACATAGGGTTGCTGCAACGATTAAGTGGT TTAATCCACCTAGAACACAGTGGCTGGTGTATGAATGCATGTAAGTGTTCTTGTCCTATCTAGGGCTTTA ATTATATTCTCAGATGCCTCTCTCCCTGCTCTTTCTCAAGCCTGCCCCCTCTCCTGTGCCCTGGGTGCCT GTGCCTGGCGCCACGATTATGTAGGTGCCCAAGGCAAGAGACTTGGCTGTCTTTTTTTTTTTTTTTTTTT TTTTTTGAGGCGGAGTTTCACTCTGTCGCCCAGGCAAGAGTGCAATGGCGCAATCTTCGGCTCACTGCAA TCTCCTCCTCCTAGGTTCAATCGATTCTCCTGCCTCAGCCTCCCCAGTAGCTGGGATTACAGGCACCCAC CACCACACCCAGCTAATTTTTGTATTTTCAGTAGTGACGGGGTTTCACCATATTGGCCAGGCTAGTCTCA AACTTCTGACCTCGAGTGATCCATCCGCCTTGGCCTCCCCTAGTGCTAGGATAACAGGCCTGAGCCACCG CGCTGGCCTCGGCTGTCATTTTTCAGTGCTCCACTGCACATCCCCCTGTATTTAGTCAAATAGAGGCCCA TCAGTTCTGTGTGTTCCATCTATCTTTGTTCATCCATTTCTCTCCATCCCTGTGGAATCCCCGGGTCCTC TCTCTGGTCTTCCTGCCTCTCTCAGGGAATTTCCCAGTCCACAATCCACACCATGGGTGGAGACAACCTT CGAAGCTCCAAGTTCCTATTCCATTTATAACAGGGGTCCCCGACCCTCGAGCCGTGGACCAGTACCAGTC TGTAGCCTGTTAGGAACCGGGCCGCACAGCATTACGGCCCGAGTTCTGCCTCCTCTCAGATCGGTGGCAT TAGATTCTCATATGAGTGCAAACCCTACTGTGAGCGTGAACCCTGTCGTGAACTGCACATAGGAGGGATC TAGGTTGTGCGCTCCTTATAAGAATCGACCCCTCAACCCCACCATCCATGGAAAAATTATCTTCCACAAA ACCAGTCCCTGGTGCCAAAAAGTTTGGGGACCACTGATCTATATGGAATCCAGAACAGGCAAATCCATAG GAAAGAAGATGGGTGCCTGCCAGGGGCTGGGGTAAGGGGAGAAGGGGGAGTGACAGCTAATGCATAAGGG AGATGGCTTTTTGGAGTGATGAAATGTTCTGGAATTAGGTGATGGTTGCGCAACATTGTGAATACACTAG AACCCCCTGAACTGTACATTTTAAAATGATGAGTTTTATCTCAAATTTTTTTAAATTGCAGAAAATATCT GGTCCTGTCCTTCCCTATTATAACCATCAAAGGTGCCCCATTCTTCTGAGGATTAGATCAGGACCCTTAG TGTGATCCTGTTGACCTTTGTCCCCTGGCCCCCGTTATTTCTGCAGTTTCATTGCTTACAGTTTTCTTGC TTGAAAATGACGGTCCAGTCTTACTAAACAGCTTGCCCGTCTCCTGGTCTTGATCATTCATTCATTCATT CATTCATTCATTTATGAGACGGAGTCTTGCTCTGTCACCCAGGCTGGAGTGCAGTGGCGTGATCTCAGCT CACTGCAACCTCCCCCTTCCGGGTTTAAGCAATTCTCCTGTCTCAGCCTCCAGAGTGGTTGGGATTACAG GCACCCGTCATCACACCTGGCTAATTTTTGTATTTTTGGTGGAGGCGGGGTTTCACCATGTTGGCCAGGC TTGTCTCCAGCTCCTGACCTCAAGCGATCTGCCTGCCTCACCTCCCAAAGTGCTGGGATTCAGGTATGCC TCGGCATGCCCAGCCTCCTGGTTTTGGTCTTCTTGTTTTGGGTTCCTCCAGAGGCAAGAATTCAAGGCTA AGTGGTTTATTTGGCACGTGATCCCAAGAAACATCAGGAGGAACTCAGGGAAACAGAGAGAAGGAAACCA ATAAATGGGGCATTGTCGAGCCATTGGCTGCTGAGGCCATTGGAGCTAAATCCTCTGGGTATGACGTAAA ACATGCCTCTCGTGATCCCAACTGAGGGCAAGGCAACGGCGGGATTTGTCCCCCAATTCTGCATCCATCA CTGGGTGAGAGCAGCTTCCAGGGGCATTACCTATCCGAGGTGCTTCCTGCTCTTCCTGCATGTAGGCAAA GCCTGCCCCACCCGCAGTCAGAACCAAGCACTCAGGCAGGGAGCTGCAGGCATTTGCAGAAAGCAGCCTG TAGGAAGGGACGAACGCTGAGAGGACTTGGGTGGAGGCACCAACAGCATTTTCTGCAGCACCCTGCCTCT AGAGCAGGGCTGTCCCCTAGAAAGAGAACCTATGCCACACGTGCACTTTTAAATTTTCTGGTAGAAACAT TGAAAAAAGTCAAAAGAAGCAGGTGAAATTATTTCAGTGGTATATTTTAACACAACAAATCCAAGATATT ATCAGTTCAACATGAAATCAATATTTAAAAAATTGCTAATGAGATGGTTCACTTTTGTTCATACTAAGTC TTTGAAATCTGGTGTATATTTCATTCTTATAGCACATGTCATTTCAGACCAACCACATTTCAAGTGCTGA TAGCTACCATATTGGACAGTACAGCTCTAGAATGTTCTTTCCTTTTGCCTTTGTGAGGCGAATACCTACT CTCCCTCAAGACTTAGCCAGGTTGCCTCCTCTAGGAAGCTGACCACACCCTCCTGCTCTCAGCCCACCCG AGGGCTGTTCTGTTTCACAAAGAACCTTTTTCTACGTCTGTAGCGTTGCCCCTATCTTTTTTTTTTTTTT TTTTTAATTTTTTGAGACAAGGTCTTGCTCTGTTGCCCAGGCTGGAGTGGAGTGGTGTGATCACTGCAGC CTGGAGCTCCCAGGCTCAAGCGATCCTCCCACCTCAACCTCCCAAGCAGCTGGGACTACAGGCATATGCC ACCACAATGAGCTATGTTTTTTTGGGGGGTTTTTTTGACACAGAGTTTCGCTCTTGTTGCCCAGACTTTA GTGCAGTGGTACAATCTCGGCTCGCTGCAACCTCTGCCTCCTGGGTTCAAGTGATTCTCCTGCCTCAGCC TCCCGAGTAGCTGGGATTACAGGCGCTCACTATGACGCCCAGCTAATGTTTTGTATTTTTAGTAGAGGTG GGATTTCATCATGTTGGCCAGGCTGGTCTTGAACTCCTGACCTCAGGTGATCCACCCACCTAGGCTTCCC AAAGTGCTGGGATTACAGGCGTGAGCCAACACACAACCAGCATTGCCTTGACCACAGTGGATCTTGGGTG TCTGTTTATTCATCTGTCTCTTAATGGTCAGTAGGCAGTTTGAGGACAGGGACAGTGTCTCCATCTTGGT ATCCTCAGTGCTAGCCAACTGCCCAACACATTATACACTTTCTGGAAATGACTGTAGAATAAACGAACAG ATGCAAGGAGTGGTACTGGGACCACAACTCTCAAATTCCTTTCCATGACCATTTCTTCCAGCATTTTGGT TTGCAGGTGGAAACGGGAAACTAAACATTCTCTCTTTTCTCAGGCAAGATTCCAGCATGGCTGCAGGGAA CCCTGCTCCGCAATGGGCCTGGGATGCACACAGTTGGGGAGTCCAGATACAACCATTGGTTCGACGGCCT TGCCCTGCTCCACAGCTTCACCATCAGAGACGGTGAGAACACCCACGAGTGTGCTGCCACTGCTGCAGCA AAGGACCCCAAATGCAGTGCCTTAAAACAGCACAAATTTATTCTTTTAGGGATTGGAGGTCAGAAGTCTA AATCGGGTCTCACTGAACTGAAATCAAGGTGTTCATAGGGCCACATTCAGTTCTGGAGGCTCTAGGAAAA ATATCCACGTTCTTCCGTTTTCTATCTTCTAGAAGCCGCTTTCCTTGACTTGTGGCTCCATCTCTGTCTT TTTTTTTTTTTTTTTTTTTTTTTTCTCTGAGACGGAGTTTTGCTCTTGTTGCCCAAGCTGGAGTGCAATG GTGCAATCTTGACTCACGGCAACCTGCATCTCCCAGGTTCCAGTGATTCTCCTGCCTCAGCCTCCTGAGT AGCTGGGATTACAGGCATGTGACACCATGCCCAGCTAATTTTTGTACTTTTGGTCTCAAACTCCTGACCT CAGATGATCCGCCCACCTCGTGCTCCCAAAGTGCTGGGATTACAGGCATGAGCCACTGCGCCCGGCCTCC ATCTCTATCTTTAAAGCAGCAGCAGAGCATCTTGTCTTGCAATCTCTCTCTCTCTCCTTCCATCCTCACA CCTCCTCCTCTGACTGACTTTCCTGCCTCCCTCTTATAAGGACCCTTGTGATTACATTGAATCCACTCAG ATAATCCCTAGATAATCTCCCATCTCAAAATCCTTATTCACATCTACAAAGTCCATTTTGATATGTCAGG TCACACATTCAACAGGTTCTAGGGATTTGGATGTGGAGATATTTGTCAGGGGTGCATTATTCAGCCAACC GCAAGCACAGACTTTCCTAAAAAGGAGGCCAAGGTTCTTTTTCAAATAGTTAATCTTGCAAAATAATATA CATCCTCAATCAGGTAGGCAAGAGCAGGTGGAAGAGTACAGGAATCAGACATGCCTAAAGTTGAAACAGG AAATGGACAGAGCTGGTAGCTGGGCGCAGTGGCTCATGCCTGTAATTCCATCACTTTGGGAGGCCAAGGC AGGCAGATCATTCAGGGTCGGGAGTTTGAGACCAACCTGGCCAACATAGCGAAACCCCATCTCCACCAAA AATACAAAAATTAGCTGGTCATAGTGGCACACACCTGTAATCCCAGCTACTAGGGAGGCTGAGGCACGAG AATTGCTTGAACCCAGGAAGCAGAGGTTGCAGTGAGCTGAAATTGTGCCACTGCACTCCAGCCTGGGAGA CAGAGCCAGACTTTGTCTCAAAAAAAAAAAAAAAAAAGAAGAGTACAGAGCTGGAAAGAGCAAAGCTGCA TATATTGCCCATTAAGCAAGACAGAGCCAGACCACTTACACAATAAGCCGAGGGATCTCCCTGAGTGGAA AGGGAAATGGATAAATATAGGGCATCACAAATAAGGCGAATTCTGAGTTCAGGTGTCTGGCTCATGAGGT GGGATGTAAATTCTTTGCTGTTGGCCATTGAGCCAGTTTATGCTACAAAATCAAGAGCCGAGTTCTTAAA GAGGTCCAGGATGGATTTAGCGGGCTTCGGGTCACACAGTGGACAGATTTGTGTCCAAATGCTCCAGGCT TTCCAAAATTTTTCTTTAATTCCTGTGTTCTAATGTGGTCAAACTGGGATTACGTTAAGTCTCTCAGCCT CAGTTTCCTCATCAGTAAAATGAGCTTGTTCATCCTCCCCTGGAGAGCTGTTGGGATCATTGGAAGTATT GGACGTTCTAGCAAGGGCCTGACACCTGGTAGATGCTTAAGAGATTAAAAATCACCATTGACCAGGCACA GTGGCTCATGCCTGTAATCCCAACACCTTGAGAGGCGGAGGCAGGAGTGTTGCTTGATCCCAGGAGTTCC AGACCAATCTGTGCAACATAGTGAGACCCCATTTCTATTTTATTTTATTTTATTTTTTATTTTTATTTTT ATTTATGTTTTTGAGACAGAGTTTCGCTCTTGTTGCCCAGGCTGGTGTGCAATGGTGCAATCTCAGCTCA CCACAGCCTCCACTTCCTGGGTTCAAGTAATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGGATTACAGGG ATGCGCCACCATACTCAGCTAATTTTGTATTTTTAGTACAGATGGGGTTTCTCCATGTTGGTCAGGCTGT TCTCGAACTTCCAACCTCAGGTGATCTGCCCACCTCGGCCTCCCAAAGTGCTGGGGTTACAGGCATGAGC CACCACGCCCGGCCCATCCCATTTCTATTTTAATTTATTTTAAAAAAATAATTAAACATAAAAATAAAAC CACTATCTGTGGCTTTGAATCCCAGCTCCACCATCCTAGCTAACATGCACCTAAACTGTGTAACTTTGGC CAAGGTACTGACCCTGTCTGTCTCAGTCTCTTCTGTAAAATGGACATATCAATAGCGTATCTCATGGAGC TGCTATTAGATCTAAACGAATGTGTAAACAGCTCTGTATTATGTCTCGTGCACAACACCTGCTCAATAAG CATTTGTTCTTAATTTCATATAACTACTGGCCAGTCGCGATGGCTCACACCTGTATTCCCAGCACTTTGG GAGGCCGAGGCGGGTGGATCACCTGAGATCAGGAGTTCGAGACCAGCCTGGCCAACATGGTGAAACCCCG TCTCTACTAAAAATACAAAAAATTAGCTGAGCGTTGTGGTGAGCACCTGTAATCCCAGCTACTTGGGAGG CTGAGACAGGAGAATCGCTTGAACTCGGGAGGCAGCGGTTGCAGTGAGCTGAGATTGCACCATTGCACTC CAGCCTGGGCAACAAGAGCGAGGCTCCCTCTCACAAAAAAAAAAAAAAAAAAAAATTATATAACTATTAA TTTCTTTTGAGCTAGTCAGCAATTATTTTTTGAATGTGTACTCTATGCCAGTGCCTTGCTCTAACATTTA CACATGAATAGAGACACGATGGGTGAAAAGCGCGAGCTCTGAGTCTGCAATACCTTGCAGATTTTACTGT GACTCAGCTACAGAATGGGTGGTTCCATATTTTGCTGACAGCACTAAATCTTAATGATTCCTTTCTTTTC TAAACAGAAGTTCCCAATGATTCTTGGAAATAAATACTGTTCTGGATGAGGAACATAGAAGGTAAATGCA CCAGTGGTGGCCGGGCGCGGTGGCTCACGCCTGTAATCCCAGCACTTTGGGGAGCCAAGGTGGGCAGATC ACCTGAAGTCGGGAGTTCAAGACCAGCCTGGCCAACATGGGAAAATCCTATCTCTACTAAAAATACAAAA ATTAGCCGGATGTGGTGGCAGGCAACTGTAATCCCAGCTACTTGGGAGGCTGAGATAGGATAATTGCTTG AACTCAAGAGGCAGAGGCTGTGGTGAGTTGAGATCATGCCACTGCACTCCAGCCTGGGTGACACAGTGAG ACTCCGTCTCAAGAAAAAAAGCACCAGTGGTTTTCCTTCCATGAGGCCTTGCTTCCCCAGGCTGCCAGCT CCTCCATGGTCTCTTTCTTTCTTTTTTTTTTTTTTTTGAGATGGAGTCTCACTCCGTTACCCAGGTTGGA GTGTGGTGGCGCAATCTCGGCTCACTGCAACCTTCGCCTTCCAGGTTCAAGTGATTCTCATGTCTCAGCC TCCGGCGTAGCTAGGATTACAGGCACATGCCACCACATCTGGCTAGTTTTTTTTTCTTTTTTTGAGACAG AGTCTGGCTCTGTCACCCAGGCTGGAGTGCAGTGGCACGATCTCGGCTCATTGCAAACTCCACCTCCCGG GTTCACGCCATTCTCCTGTGTCAGCCTCCCGAGTAGCTGGGACTACAGGCTCCCACCACCACGCCTGGCT AATTTTTTGTATTTTTAGTAGAGACGGGGTTTCACCGTGTTAGCCAGGATGGTCTTGATCTCCTGACCTC GTGATCTGACCGCCTCGGCCTCCCAAAATGCTGGGATTACAGGTGTGAGCCACTGTGCCCGGCCCCGGCT AGGTTTTTTTGTATTTTTAGTAGAGATGGGGGTTTCATCATGTTGGCCAGGCCGGTCTCGAACTCCTGAC CTCAGGTGATTCACCAGCATGGGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACCGCGCCCGGCCG AGTCAGTTTTATTCACAATCTGGCATTGGCTGGGAAAATAGGAAACCCAGGAATTACACCCAATGATTTG TTTTCCCTCCATCTTTCTCTTAGACCTAGGCCAGCGTCTGAGGGTTCATGCCCCATTCTGCTTGGCAGGC ATCATTTTGCCAATCTGTGGCATAGGGTGGGAAGGCCCAGAGTGCGGGGAGCCTGCCTGAATTGTGGTGT CTTCATCATCTAGCATGGGGCCTGGCCCAGAGGGGCGCTTGGAAACTGTATATGGAGCTGAGATGGTACA GTGAGGCAGTCATTGTTTTGGTAGACAGAGGCAATACTTTCCCAGTCAAACTCTTCAATATTTACTACAA AGAGGGTTTGCTGGGCCCTGCCCCAAGTGTTTCATGTCCATCCACAACTCAGCCCTCCCCGTCACTCCTG AGGAGGATAGCCTGGGGACTACCACAGTTTTAGAGATAAGGAATGAAGTCCCAGAGAGGCCAAGTCACTT ACCCAGAAGCACACAGCTAAGAGTTGGTAAAGCTCAGACATAGACGCAATACTCTCTAACTTCAGAATCC CAAGTCCTAACCATTGTGCAATTCAGCCCTGTTTCCCCTTCCCACCAGCTCCTGCCTCCCCATCTCTCCA TCCCAATCCTCTCAGTGCTGCCAGCTTGCCAATGCTGGTGTGGCATAGCCTGGCTTCATCTCTCCTCTCC TCTAGGACTCTCCGTGGCACCCCATTGTCTAATGGTGGGAAGATACACCAGAAATGTTCAGTTCCACTCT AGCGGGTTCAGAAGAGAACACGTGGGGAAGTTGGGGTCCCTGATAAGCTGAAAACAAAGCCAATAACTCT CAAAAAGTGGTTTGTGTGCCTCCTTTCTCAATAAAGCTTTTTTTTTTTTTTTTTTTTGAGATGGAGTCTC ACTGTGTTGCCCAGGCTGGAGTACAGTGGCACGATCTCAGCTCACTGCAGGCTCTGCCTCCCAGGTTCAA GCGATTCTCGTGCCTCGGCCTCTGGAGTAGCTAGGATTACAGGCATGAGCCACCATGCCCAGCTAATTTT TGTATTTTTAGTAGAGATAGGGTCTCGCCATGTTGGCCAGGTTGGTCTCGACCTCCTGACCTCAGGTGAT CCACTTGCCTGGGCCTTCCAAAGTGCTGGGATGACAAGTGTGAGCCACCGCGTCTGGCCATTCAGTAAAG CTTTGAATCCTGAAAGCTGCACAGGGCTTGAGTGCATCATAGTCCTCAAAGATAGCGTTTGTGTTTCTAA CACACTTCCCAGGTGACCCCGAGCCCTCTGAGGTTTGACAATCCCTCCACAATGGGCCTCTAGCCTGGCT GCCCAGGCCTAACCAAAACCATGTTATTAATACTAATAATCAGAAGAACCATGGGCTAGTGAATAGCCTT CTGTACCTTTTTAAAGCACCCAGGTGATTCCAGTGTAGATGCAGGTTAGGTGCTTAAGACCAAACATCTA ACTTAGAGAAAAGACTTTGGAGCAAGAAACAAAAAGGCAGAAAATAGCTTGTGGCCTTCAGCAGAGGCCA GTAGAAATTAATGCTCTAAAAAAAAAACAAAGAGGGACCAGAGGTTGTGGTTCATGCCTATAATCCCAGC ACTTTTAGAGGCTGAGGTGGGAGGATCCCTTGAGCCCAGGAGTTCAAGACAAGCCTGGGTAACATAGTGA GACCTGGTACCTACCAGAAAATCAAAAAGTTATCCAGGCGTGGTGGTATGCACCTATAGTCCCAGCATCT TAGGAGACTGAGGCAGGAGGATCACTTGAGCCTTGGAGGCAGAGGCTGCAGTGAGCCGAGATCACACCTC TGCACTCCATCCTGGGTGACAGAGTGAGACTTCATCTAAAAAAAATTAAAAAAGAAAAACATGTAAAAAA TAACAAAGATATGAACAAAAAAAGCAGAGTACAGAGGGAGAAGCTGGGTGAAGGGTACAAGAACACTCCT TTCTGTACATCTAAAATTATTTCAAAGCAAAAAGTTTTTACAAAGCACGCATAGAAATGAGTGATTCCAA GTCTCCCTCATTAATGATATCTGTTAATTTTCCGATAAAATTAACAGGCAAAGTCATTGTCCCACCAGGA TTTGAACATTGGAAAGTTTCTTTTATATATACCCACACACACACACACACGCACACACACACACACACAT ATATGTGTGTGTGTGTGTGTATATATATCTATATCTTCCCTTCTTCCCCAAAATATCAAACTTGACCTAG TTCTAGAAGATCCCAGGCAGGAGCACGTCTGTTGGCGTATGTCCCTTCAGAAGGAATGTGGCTAATTGGG CTCTCCTGAAAGCAGACTGCTGGGGAATGCATGGAGGCTCCTTCTGTAATCTCAACCTCAAAGTCCAGGG TCAGCCTTGAGTAATTCCAGACACCTACTTTCCTGTGGTCACCAGGCACTCCATGCTCTGGGGCTGGATG TTTATAGGAAATGGGCAGCCTGTTCACTACCCAGCCTGGGTGTTTATATTTCTTTCTTTCTTTTTTTTTC TTTTCTTGTGTGTGTGGGTGTGTGTTTTTGTTTTGTTTTGTTTTGTTTTGTTTTTTGAGATGGAGACTTG CTCTGTCACCCAGGCTGGATTGCGGTGGCATGATCTCAGCTCACTGCAACCTCTACCTCCCAGGCTCAAT TCTCCTGCCTCAGCCTCCCGAGTGGCTGGGATTACAGACACCCGGCACCATGCCCAGCTAATTTTTATAT TTTCAGTAGAGACGGGGTTTCACCATGTTGGTCAGGCTGGTCTTGAACTCCTGACCTCAGGTGATCCACC TGCCTCGGCCTCCCAAAGTGCTGGGATTATAGGCGTGAGCCACAGCACCCAGCCAATATTTCAAGTGAAC ATAATTCAACATTTCAGGTCAAGCACCTTAGCCAATGCCTTGTGGGTGGTGACTCCCAGCAACAGTAACC AGTGAAAGACAGGCTGGCTCAAAGGGGAGATCAGGGTGGCCTTAAGTGGGCCTCTGTCTCCATGTAGCAT GTAGCTGAGGACCAGTGAGTATGTGTGGCCTTGCTCACCCACAGATGAGTCCGCCTGCCACCCGGATTTT CTTGGACAATGCAGTTTCAACAGCCTTTGTTTACGAAGTGCATGCTGGGAGTCAATGCGCAGGACCCCTT ACATTACCACATCTCATTTAAAACTGCCCACCTCACCACTTGAGGTCAGGAGTTCAAGACCATCCTGGCC AACATGGTGAAACCCCCTCTCTAGTAAAAATACAAATATTAGCCAGGCATGGTGGCAGGCACCTGTCATG CCACCTACTCAGGATGCTGAGGCAGGAGAACTGCTTGAACCCAGGAGGTGGAAGTTGCAGTGAGCCGAGA TCGCACTACTGCACTCCAGCCTGGGTGACGGAGCAAGATGTTGTCTCAAATATAAAAAATAAAGATAATA AAACTGCCCACCTAGAAGGGGAGGACTATGTGATTCCCAGCTTCCAGTCAAGGAGACTGAGGCTCGATGA GATTAAGAGACCTGCCCAAGGTCACCCAACCTGGATGAGATGAAACCTAGAGCCGAAGCCTTGATCACTC TGTCTACTGCATCTCAATACTCTACGCAGCTTTTCTTGAGCACCTACTATGTGCACAGTGCTTTGCAAGC CTCAAATGTCACGTGACTCTGCAAGGACTGTGTCACGATCCTCATGTCATAGTGGAGGGGACAGATTCTT GACTGTTACCAAGGTCAAGTGCATGGTTGGTACATGATGAAGCCAGGATTCATATCCATGTGGAGATTGA GCCTCCTTAGCAACAGGAATCCTGGCCATTCTGCTCATTGTTATATTTTCACTCCTGGCCCATCAGGGCA GTTAATAAATAATGGTTGAAAGCATGAACTCAGGGCCTGGTCAGCCCCAAAGCTCAGGCTCCTAACCGTT CCTCCATATTTCTTTCTGCTGCCCAGGAATAAATCTCCCCCTACAGAAATATCTCAGTGAGGCTGGGCAC CGTGCCTCACACTTGTAATCCCAGCACTTCAGGATGCCAAGGCGGGAGGATCGCTTGAGTCCAGGAGTTC AAGACCAGCCTAGGCAATATAGCAAGATCCCATCTCTACAAAAAATAAAAAATTAGCCAGGCATGGTAGC ACGCACCTATAGTCCCAGTTACTTGGGAAACTGAGGTGGGAGGATCACTCGAGCCTGGGAGATTGAGGCT GCAGTGAGCTGTAATTGCGCCACTGCCCTTAGCCTGGTGACAGCAAGACCCTGTCTCACAAAGAAAGGAG AAAGAAATATCTCAGTGACACTTATTCACACAGTAACCACCCCTGAAAAGATGTTTGCATAAAGGCTAGA TGATTGTCTCTTAGGAACACAAATAACCTCCTGAAGACTGGAGGAGGAACTAGCAGGTCTTTCATGATCT CCCTCAATTTTATTTTATTGTATATTTTTTTCTTTGAGATAGAGTCTCCCTCTGTCACCCAGGCAGGAGT TCAATGGCACAGTCTCAGCTCACTGCAACCTCTGCCTCCTGGGTTCAAGCAATTCTCCTGCCTCAGCCTC CTGAGTAGCTGGGACTATGGGTGCGTGCCACCACGCCCGGCTAATTTTTTTTTTTTTTTTTTTTTTTTTT TGTATTTTTAGTAGAGACAGGGTTTCACCATGTTGACCAGGCTGGTCTCGAACTCCTGACCTCAGACGAT CCGCCCATCTTGGCCTCCCAAAGTGCTGGGATTACAGGCATAAGCCACCACACCAAGCATTTTTTTTTTT TTAATAGATAAGGGCTTCCTACATTGCCCAGGCTGATCTCGAACACCTAGCCTCACCTTTTTATGTGCCA GGACAACAAGCCTGAGCCACCACGCCTCCCCTCAATTTTCTTATAATTAGTGTTACTATTATTGTCATTA TGTCCATCCAAGTGCACAGGTGGGAGTCATTGCCACTGGAATGTACATTCAAATCCTTTGGCAATGGACA TGGAAACACAACCCCAAGGGCAAAACAAGTTGAAACTCTTCAAAGTCAAGATAGCGGTTACCCTGGAGGG GGAAGAGGTTAGTGACAAGGTGGATATATGAGGCTAGCGTTCAGGGGGCTGCTCTGGTCCTGTTTCTCTT TTTGAGGCAGGGTCTTGCTCTGTTGCCCAGGCTGAAGTGCAGTAGTGCGATCTTGGCTCACTGTAGCCTT GACCTCCCAGGCTCAAGTGATCCTCCCGCCTCAGCCTCCTGAACAGCTGGGACTACCATACCCATCTGAT TTTTGTATTATTTGTAGAGATGGGGTCTCGCCATGCTGCCCAAGTAGTCTTGAACTCCTGGGCTCAAGCG ATCCTCCCCTCTGGGCCTCTCAAACTGCTGGGATTACAGGCATGAGCCATTGCACCTGGCCCCAGGTCCT GTTTCTTGATCAGGATGTAGTTTGCGTGGGTAGCTCCCCTTTGTGAAACCTCAGCAGGCTGGATGTCATC AAGCTGCACATCTCTGTAGGAGTGATTTTAATTGGAAGGTGCAGACAGAACACTCAAACTGATTGTTCTT GCTGTGTTAGGATCTTGGTTAAGAGGGCCAGCTTTAGATGCCCATTGCTGGCCTTCGACTCCAGATTACC ACTCGCTAGCTGTGTGGCTTAACACAAGCTGCTTAACCTCTCTGTGCCTCAATTTTATTAGCTGGGAAAT AAGTCTGCAGGGCTGTGAGTACCCAAGCCCTTTGTACTTCATTTGGTAAAAAAGTTGGAACCTTTAAGCA CTGTTTAGATCTTGCTTTATTTTGCTATTAATTAACAAATGACATTATGTTATTTTTTTTTATTTTTTAT TTTTTTGAGATGGAGTCTCGCTCTGTTGCCCAGGCTGGAGTGCAGTGGCGTGATCTCAGCTCACTGCAAC CTCTGCCTCCTGGGTTCGAGCGATTCTCCTGCCTCAGCCTCCCAAGTAGCTGGTAGCTGGGACTACAGGT GCCTCCCACCACACCCAGCTAATTTTTGTATTTTTAGTAGAGACAGGGTTTCACCGTATAGGCCAGGCTG GTCTCAAACTCCTGACCTTGTGATCCGCCTGCCTCAGCCTCCCAAAGTGCTGGGATTATAGGAGTGAGCC ACCATGCCCAGCCTTTCTTTCTTTCTTTTTATTTATTTATTTATTTATCTTTGACATTGAGTCTCGCTCT GTTGCCCAGGCTGGACTTCAGTGGCACGATTTCGGCTCACTGCAAGCTCCGCCTCCCAGGTTCAAGCAAT TGAACCTCCCGAGTAGCTGGGACCACAGGTGCCCAGTACCCCGGCTAATTTTTTTTGTATTTTTAGTAGA GATGGAGTTTCCCCATGTTGGCCAGGCTGGTCTTGAACTCCTGACCTCAAATGATCCACCTGCCTCTACC TCCCAAATTGCTAGGATTACAGGCATGAGGCACTGCGCATGGCCGATTTTTTTTTTTTTCCAGCGAATGC ATTTCTGGTTGGAGTATTCTACTTGCTTCCAGTGTTGTGAGTATGAAACCAGATAACACACATCAAGTGC CCAGCACAGTGTTTAGCATGCTGGTGCTCAATCGATGCTGGCTGTTAGTACTAGTTTCCTTTTCCTAAGA TATCAAAAGGCACTGGGCGAGAATTTCTTGGAAACATGTTTTCTCCTCTAAGCCCATCCTGTGGCAGTCA ACATATGATGGGCGTTTCTGAGGTCAACTTTTTGCTTATTGGAATGCAATGTCACTGTGTCCCAGGCTTG GCTTTTCCGTGTGTTGTAATTGTAGCAACACTGGAAGCACATACTATACCACGAAAATGAAATGCGTTCT GTAAAAGGAAAAAATCTTAATGTCATTTGCGAATTAACAGCAAAATAAAATAAAACACTGCCTCTTTCAG GCCCCTCCCCGAGGTTTCAAACTGCCCAGGAAATAAAGTTCTCAGGGCTGGTGCGGTGGTTCATGCCTGT AATCCCAGCACTTTGGGAGGCCGAGGCAGGCAGTTCACCCGAGCTTAGGAGTTTGAGACCAGCCCGGCCA ACAGAGTAAAACCTCGTCTCTACTAAAAATACAAAAATTAGTCGGACATGGTGGCACATGCCTGTAGTCC CAGCTATTTGGGAAGCTGAGGCAGGAGAATCGTTCGAACCTGAGACGTGGAGGTTACAGTGAGCCAAGAT CGTACCACTGGACTCCAGCCTGGGCGACAGAGTGACTCCATCTCAAAAAAAGAAAAAAAAAAAGTTATCA GGCCTGCAAACCTAGTAGGACCCCTCAACCCATTTCCCAATTTCATTTCACTCCTGTCCTCCAAATCCCT CTCTAATGTTCCAGCCCAGCCGAACTCAACGCCTGCAAGAAGGGTTCTGCATTTTCCCAACTCCAGGCCT TTGCTTACAGACCTCTTAGCGGGTGAACAGGACAGCTCTGCCCTCTCTCCCCAGCATATTGCAGTCAAAT TCTACTCATCCTTTAAGAGCTGTTTCATGCACCACCTCCTCCCTGAAGCTTCTCCTGACTTATTCCCAGC TGGGAAGGACCTCCTCTCACCCCTGCCCCAGGAGGAATCCATGGATGTGGGTTTTTTGTTGTTGTTGCGT TTTTTTGTTTATTTGTTTTTTGAGACGGGGTCTCGCTCTGTCGTCCAGGCTATAGGGCAGTGGCGCGATC TCGGCTCACTGCAGCCTCTGCCTCTTGGGTTCAGGCAATTCTGTCTCCTCAGCCTCCTGAGTAGCTGGGA TTACAAGGGTGTGCCACCACACCCAGCTAATTTTTGCATTTTTAGTAGAGATGGGGTTTCACCATGTTGG CCAGGCTGGTCTCAAACTCCTGACCTCAGGTGATCCACCCACTTTGGCCTCCCAAAGTGCTGGGATTACA GGCGTGAGCCACCGCACCTGGCCTAGATGTGTTATTTTACATAGCAAAAGAAACTTCGCAGGCTAGGCAA ACGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGCAGGTGGGTCTCCTGTGGTCAGGAGTTCGAGACCAG TCTGACCAACATGGCAAAACCCTGTCTCTACTAAAAATATTTTAAAAATTAGCTGGGCATGGTGGCACAT GCCTGTAATACCAGCTACTCGGGGAGGCTGAGGCAGGAGAATCTTTTGAACCAGAGAGGCTGAGCTTGCA GTGAGCCAAGATTCCACCATTGCACTCCAGCCTGGGTGACAGAGTGAGACTCCATCTCAAAAAAAAAAAA AAAAAGAGAGAGACTTTGTAGATGTGATTAGATGAAGGATCTTGAGATGGGGGAGGTGATCTGACATTAG GGATGGGCCCAGTGTAATCTCAAGAGAGAAGCAGGAGCGTCAGCCTCAGAGGAGATGTGATACCGGGACA GGAGACAGGGGTCACAGTGACGCAGCCATGACCAGGGAAGGCAGCAGCTTCTCAAAGCTAGAAAAATCAA GGAACAGACCTCCCCTGGAGCCTCCAAAAGGAACTAGCCCTGTGGACACCTTGATTTTAGCTCTGTAATC CCCATTTCAGACTTTCTTCCAAACTCTGAGATAATGACTGTATGTTGTGTGAAGCCACTAAGTGAGGGGT AAGTCGTTACAGCAGCCGTAGAAAACTAACACGGGTCTAGAACCATCTGGTATATTTTGAGGTTGGTCTC AATGGACTGGTCAAGAGATTTATGCCATGAGTTAGACTCTCTGCAGAATTTGGATGAATTAGACATTGAA CACAGGTCTGACCCTCTATTGCTATGCAGGATTGGGCATCAGGTCACCTCCTGGTTGTGTTCAATATCAA ACGTTACTCCAGGGAGACTGAAGTGATCAACTGGGCTTCTGGAGGCAGCGCTCCCAGGACTGAACGGGGC CCTGGGGAAAACCACCCCACATATGCAGCCTTCTAGATTAGTCCTCCAGCTCTGCTCCTTCCCTGGAGGG ACACAAACAGGGTGGAAGGGATGACTGATTCTGGTCAGCACTCTCAGATGGGTGACCCTGGGCAAGGTGA AAGAATGTTTCTGAGCCTGAGTTCCTTCCTATGGAAAATGGAGCTAAGAACAGACATATTTTGCATTGAC ATATTTTGCATTATCACATTTTGCATTGCTATAAAGGAATACCCAAGACCGGGTAATTTATAAAGAAAAG AGGTTTATTTGGCTCACGGTTCTGCAGGCTGTACAGGAAGCAAGCCACCAGCATCTGTTTGGTTTCTGGC GAGGGCCTCAAAAAGCTTTGGCTCATGGCAGAAGGCAAAGGGGGAGCAGGCATGTCACATGGTGAAAGAG AGAGAGAGAGAGGAGGGAGGGATCTTTTAAACAACCAGATGTTGCATGAACTAATAGAGTGAGAACTCAC TCATCACCAGAACAACACTAAGCCATTCATGAGGGACCCACCCCCATCACCCAGACACCTCCTCCTAGGC CCACCTGCAACATCACAGGCTTCAACATGAGATTTGCAAGGAACAAAACATTCAAACCGTAACACATACT TATCCAGCCATACTGTTGTGAGTCAGGAGTGAGAAAATGTGTGTCTAAAATTATATTCCAGGCCGGGCAT GGTGGCTCACGCTTGTAATTTCAGCACTTTGGGAGGCTGAGGCGGGTGGATCACCTGAGGTCAGGAGTTC AAGACTAGCCTGGCCAACGTGGTGAAACCCCATCTCTACTAAAAATACAAAAATTTGCTGGTCGTGGTGG CGCATGCCTATAATCCTAGCCACTCAGGAGGCTGAGTCAGGAGAATCACTTGAACCCAGGAGGCGGAGGT TGCAGTGAGCCGAGATCGCACCATTATATTCCAGCCTGGGCAACAAGAGCAAAACTCAAAAAAATAATAA TAATAAATAAAATTATATTTAAAATGCGAATTGTATCGGCCCTGTGTACTAAAGGAGCTTGTCCTAGTGA AATAACCACCTTCTTCTCCCAGTAAAACCCATACAAGGACTGACATTGATTTTAAAGCCCTGTGAAGGCG TCAGCCTGAGATTATGCTGGTTCTTCTCTTGCAGGTGAAGTCTATTACAGGAGCAAATACCTGAGAAGCG ATACCTACAACACCAATATTGAGGCAAACAGGATTGTGGTGTCTGAGTTTGGAACAATGGCCTATCCGGA CCCCTGCAAAAACATATTTTCCAAGTAACTGCCTATTTTAAATCTGAGCAAATTTCATGCTTTTTGCTAT CCTTGATGGCTGAAATAACCAGCATTTGCTCCTCTGACAATTCTCTTTAGGGTAGATGAAAACTCCACAT GACTGCCCTTTAACCAGAGGTGCTACACAGTTCTTGATCACTGATTGCCAGAGAGACTAAGAGCATTTGA CAAATTATTAGAAGCCCTCCCACATGGCTGGTGGGAAAGCGATTTGGAATCATCTGTCAAAATTATAAAT GCGTATTCCCTTCAGCCTAGAGATCTGCTTACTTGCATAGAAAATGACACATGCACCAGGTATTTGTCAT TTATGGCTGCATCATTTGTTATAACAAGTAGCTGAAAACAACCCAAATGTTCATTAAAAGAGGACTGGTT AAATCCGTAACAGTAAAACTGTACGAGAAAATGCCATGTAGAAGTAAAAAGGAATGAGGATGTTCTCTTT GCACTCTACAGAAGCTTTTCCAAGATAGACTAAGTGGAAAAAAAAAAAAAAAGGAAGGTGTAGAAAGAGC ATGTTATAAGCTGTACTTTGTGTGAAAAAGCAGTAAGAAATCTAAATTAAATTTTGCTTGTACATGCATA AAGAAACTAGGAAAGGATGCACAGGGGCAGATGGATGTTGAGGAGAGGGAGAGATTTTTTGCTGTATATA TTTTATTTCATTTCATTTCATTTTATTCATTTATTTATTTATTTAAGATGGAGTTTCACTCTTCTTGTCC AAGCTGGAGTGCAATGGCGCAATCTCAGTTCACCGCAACCTCTGCCCCCCAGGTTCAAGTGATTCTCCTG CCTCAGCCTCCCAAGTAGCTGGGATTACAGGCACCCACCACCACGCCCGGCTAATTTTTATATTTTCAGT AGAGACGGGGTTTCACCATGTTGATCAGGCTGGTCTTGAACTCCTGATCTTAGGTGATCCACCCACCTTG GCATCCCAAAGTGCTAGGATTACAGGCATGAGCCACTGCGCCTGGCCACTGTATACATTTTAAATCATCT GGATTAGTATCCATATGAATGTGTTACATATCTGACAGTTAAATTCTTGGCCAGGGAATCAGGCCTGCCA TCAGTATCTTCTTTCTGAAACTCTCTAGATGTAGAAGAGTTATGAAAGAGTTGAAGGGTGGACTGGCCCA GAGATGGAAGATTGCTTCTGCTTTTTTGAGAACTGAAGTCATCTCTCCCATTCCAGTATCCAGCTCTAGG GCTAGCTCAGAGCAAGCACTGAATTCACATTTGCAAATAGGAGGTGTGGAGTAGGAGCCAGTGAGAAAGG AGGAGGAAAGAGCAAAGGAATTTAAAACCACCATACTTACCTGGTAGGGGAGATAGCAGGATCACGAATT TGAAACCACGACCTGGAGGTCCTGGAACCAAGCCTCCTTTTTGTTCCAGTGTTTGCCAGTAGGAGGAGCA CTCCCCAATACACCGATACAGGATTTGCCAATTTCATCACCCATAAACCCCTCTGGTTTTTCTTTCTTCT TGCTTTGAGTATACCTTCTGATCAAATGAGCTATGTGTTCTTAACTCATAATTAGTTTGTTTTCCTTTTT AAATTAAAAACTAATTTCCTGGATAAATTCGAGATAACCAGTGTGGACTCACATTCCTGGCAAAGCAGAT ATCAGCTACGTTGTTAGGCTTTGGGAGCCGTTACGGGTTCATATACGATTTCCGTAGAGCTTCTTGACAT ACTTTGGAACAGTATGTCTTGCTGGCTCTGATGTTAGAGACCTTTGGGTTTTGGGGAGCCCAGGAGGATC AGCTGGTGACCATGGCATTCCGGCCGACTCATTTCTTAGCTAACTCAACGTGGAGGTGTCTTTGGGGTGT CTGAGTTCTTAGGATTCCTCAGGTGACCCATTGGGACCCAGTTGCTTTTTCTTCCTTAGTTGAAGTAAAG CATTTTTTTTTTTTCTTTGAGACAGAGTCTCGCTCTTTCGCCCAGGCTGGAGTGTAGTGGCGCCATCTCG GTTCACTGCAAGCTCCGCCTCCCGGGTTCACGCCATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGGACTA CAGGCGCCTGCCACCACGCCCGGCTGATTTTTTGTATTTTTTAGTACAGACGGGGTTTCACCGTGTTGGC CAGGATGGTCTCAATCTCCTGACCTCGTGATCCACCTGCCTCGGCCTCCCACAGTGCTGGGATTACAGGC ACCCGGCCGAAGTAAAGCATTTTTAAGTGGTAGGAAAACTAAAGCCATCAAGGATAGACTTCTCTGGCTG GGTGGACATAGCCACTGACTCTGTTGATTTGCTTTTCTCCCCAGAGCTTTCTCCTACTTGTCTCACACCA TCCCCGATTTCACCGACAACTGCCTGATCAACATCATGAAGTGCGGAGAAGACTTCTACGCGACCTCAGA GACCAATTACATCAGGAAAATCAACCCACAGACTCTGGAAACCCTGGAGAAGGTATCAACACATATGTAA CCAGCATCACTTCCTGACTCAAGAAAGGGAGAGTCGGCGACGGCCGGGGTGAGGTTGCTCAGCCTGCAAG CAGCTTACCAGGGGAGCCCCTCCTCTAACACCGTTGGATCCCGTGCCCTAGCGCCACACTTACTGCTAGA TGCTAGGCAGGGACTGTGTTGTTTTTATCTTCGTGTCTGTATCAGTTTCCTGGGGCTGATGTAACCAAGT CCTACAAAAAAGATTGCTTTAAACAACAGAAATTGGCTGGGTGTGGTGACCTACACCTGTAATTCCAGCA CTTTGGGAGGTCAAGGTGGGCAGATCACCTGAGGTCAGGAGTTTGAGACCAGCCTGGCCAACATGGTGAA ACCCCATCTCTACCAAAAATACAAAAATTAGCCAGGCGTGGTGGCATGTGCCTGTAATCCCAGCTACTCT GAGGCTGAGGCAGGAGAATCGCTTGAACTCAGGAGGGGGAGGTTGCAGTGAGCCCAGATTGCACCACTGC ACTCCAGCCTGCATGACAGAGTGAGACTCTGTCTCAAACAAAAACAAAAAAAAAAAAAAAAAAAACAAGA CAAACAAATAAAAAAACAGAAATTTACTCTCTCACAGTTCTGGAGGTTAAAAGTCTGAAACCAAGGTGTC AGCCCGGCCATGCTCTCTCTGAAGACTCTAGAGGAGGGTCCTCCCTGGCCCCTTCCTGGCTTCTAGCGGT TGCCGGCAACCCCTGGTGTTCCTCAGCTTGTAGATGCATCCCTCCAGCCTCTGCCTCAGTCTTCACACTG CCTCTCCTTATGGGGCTATGTGTCCAAATGTTCTGCCTTTTTTTTTTTTTTTTTTTTGAAAAAGTGTCTT GCTCTGTCGCCCAGACTGGAGTGCAGTGGTGCGATCTCAGCTCACTGCAACCTCCGCCTCCTGGGTTCAA GCGATTCTTCTGCCTCAGCCTCCTGAGTAGCTGGGACTACAGGCACGTGCCACCACACTTCACTAATTTT TTGTATTTTTGGTACAGATGGGGTTTCACCGTGTTAGCCAGGCTGGTCTTGATCTCCTGACCTCATGATT GGCCCTCATGATTACAGGCGTGAGCCATTGCACCCAACCATGTTCTGCCTTTTATAGAGACACAAGTCAT TGCATTAGGGCCCACCCCAGTGCAGTATGACCTCATCTTAACTTAATGACATCTATAAAGACCTTATTTC CAAGTAAGGTCACATTCACAGGTACCCAAGGTGAGGACTTCAACCTATCTTTTTTGCAAGACACAATTCA ACCCATAACTCTGTTCATAATTCTTGGCACTGAGGGAGTTCACTGAGAATTTGAATGAATGACTGTTGAA ATGCCTGCGATTCTCAGCAATCCTACCTTCTATTGACCTGAAGAGGGAGGCATTAGGCAAAAAGCTAGGG CACAAAAATCAGTGCCCAAGCACATACCTTTCCTGGGAAGAATCAAGTCAACATTTTGGTGGGAATCAAT AGACCCACTTTCAATTTTCTCCAGCTGGCTGTTCAAAATTCCGATGTCTCTGCAATACGTTTTAACGATC TGTTAAAGAGATGAGGCTTTTCTTAGCTGTGAAATTATGTCCAGCTCCTTTTAAGCTAGACGGCATCGGT CCAACTGATGATGCTTTCCACAGGGCTACAGAGAGGAAATGCTGGAAGAGAAAGGAGTTATCTGACTCTG GGCTGGAGGTTGTGTTTTTCTAGGGGAGGAAGCGCAGACGGTTGGTCTGCGGCCACTCCATCATTCTGCA GCTGTGGACTGCAGAGTGAGGGTCATTATTCAGCTCGTTGATCAAACTTCACTTTGACCAAATGTTTTTG TAACCTCTCCATTCCCAGAATAATCGTCTAAGAGAGGCCTAGAGATTTATGCTTCTGTGCAATGCAAAAG GGCAGAATTTAAGCCAGAATGACAGAACTGTGGCCAAGATTAGCTCGAAGGCTACCTCTCTGCCCAGGTC ATTGCTCAGAGCTTTCTGCAGTGAGGAATCTTGTTTCCATGTTGAGGATTCCAGCAAGGTCAGGCAACAG GATTGGAACGATAGCCACAGAAGCACACCAGCTCCCTAACTCCCCTGCAACCTATTAGCTGTCTGAGTCC CTCAAATCCCCATGTGAGGTTGTATAAGGTCACAAGAGTGAAAGTCTTCTTTAAAAGCAAATTCTGTATC GTTTTCAGATCAACAGAGTGCAAAAATATCCCTCATCTCTCTGAACCTAGAATCAGTCACGTTTTCATAG GACTTCAACCTTTCTCCTTTGAAAAACCAGATGATGTCATATCTTGCAGGTTGATTATCGTAAATACTTT AAAAAACAGGAGGTGTCATATCTTGCAGGTTGATTATCGTAAATACGTGGCGGTAAATCTGGCAACGTCA CATCCCCATTATGATGAGGCTGGAAATGTTCTAAACATGGGCACATCCATTGTGGAAAAGGGGAAGACAA AGTATGTGATTTTTAAGATCCCTGCCACAGTACCAGGTAGGCCACTCTGGGGAATTGAATAAAACACAAA CAACCAAGTGTGGCTTCTTCTGAAGAGTTCTGTTTTTCGTTGATGACACAAGATCCAGTGTGGTACTTTC TCCCGTAGATTATTGAGGTGGACCATGAAGTCAGTACTTTCCTTTAGAAGAGAAGAGGAGATGCTGGGAT TCCTCTTGGAAGAAAGAAATCCCTTTACTATTCTAATTTCCTTTTATTTAGGCTCCAGTTTATTATTTTA TTAATTTATCTACCCATCTACCATCCATCCATCCATCATCTATTTACCATCCAACCATTCCTTCATCTAC CATCCATCCATTCATGCATCTACTCACCGTCCATCTATCCACCATTCATTCAGCTACTCACTATCCATCC ACCCACCTACCCACCATTCATCCACCTATCCATCACCCATCCACCATCCGTCCACCCATCCACCTATCCA CCCCTTATCTAGCCAGCCACTCACCATCCATCCATTCATCCATTCACCCACCTACCCATCCACCCACACA CCATCCCTCCATCCATCCATCTACCCACTATCCATCTACCCACCCATCCACCCATCCACCCACCATGAAT CCATTCAACCATCTACCCATTCTCCCATCCATCCACCCATCCACCATCCATCCATTCATCCATCCACCCA CCACCCATCCACCATCTATCTACCCACCCACCCGCCCACCCATCATGAATCCATTTATCCATCTACCCAT TCTCCCATCCATCAACCCATTCACTTACCCACCATCCATCCATCCATTGAGCTTCCCACCCACCCATCCA TCCATCATTCATCCATCCATCCACCCACCCATCCACCATCCATCCATTCATCCATCCACCCACACACCAT CTACCCATCCATCCGTCCACCCACCATCCATCCACCATCCATCTACCTACCCATCCACCCACCCACCATG AATCCATTCATCCATCTACATGTTCTGCCATCCATCCACTCATCCACTTATCCACCATCCATCCATTGAG CCACCCACCTGCCCATCCATCCATCATTCATCCATCTACCCACCATCTATACACCCACCATTCATCCATC TATCCATCTACCATCCATCCATCCACCCACCCAACATCCATCTACCATGTGCATCTACCACCCATCTATT CACTCACCATCCTTCCATCCACCATCTATCCATCCACCCACCATCCATCTGTCTACTATCCACCGATTCA TGCATGCACCCACCCACCCACCTATCGATTCATCCTTCCATCCATTCAGTTTTTCAGTCTCCTGACAAAA CTTTCTATGACAAGGTTATGCCACCTACTTTCATTCCTAGCCCCTGCAGCCAAGTTTCCAGGGCTGTTTA GGGAGCTCAGTCCTGCTGGGATCCACTCCAGATCCCTGCCCTGTTCTCCAGGCCTTCTGGACCTTCTCCA TGTGGGGCTGGGATCTTGGAGCAAAGCCCAGGCTGACTGTGATTGCATGATCCTGAGGGGGAGGAGGCGG AGGCTCTTAGCCCATGTTTGTCCAGGACCCTCCTGGGAACCACACCCAGGAGACCTAGGCCTGTGAGGAC AGCTGACAGGACTCAGGAGACAGTGCAGAACTACAACGGTGCTTCCTCTGACCTTCTAGTTTAAAAAAAA CTAGTTTCTGCCTGTGATCCTTGCTGCTCCCCCATCCCCCACTGTCTTGTAGAGCCCCCTGAGCAAACTA CCAGGCACTGCCTGGAGATATGAGCCTTCGAGGTCAGAAGGTACACGGAGTGTACTTGCTAAATAGAACT CTCATTAATTAAGCCAGTAAAGGGATATAGGGGTCAAGCTCAGAATCCTAGAATGCCATACCTGGGGATT GTCTAGGCATTTGAGTTTGCCACCTTGTATTACAGAGGAGGACTGTGAGGCTCAGGGGATCAGATGACAC ACCCCAGTCACACAGCTCCCAGGAGCCACTGACATCCTGCAAGCAGAGATCCTCTGAGCACCTGCTCCAT GCTGGCGGTGGCACTGCGACTCATGCCCCATCCTGCTCCTCCCAGGCCACAGTGCTTTTCGTTTCAGTTT GCATTGTGTTCCATTTGTTTTATAAAGACGATAACTATCCCACAACCCCACAGCATCCCTCCCACCAGCC AGCTGTTTACAGGGTGCACAGGTGGCCACAAGAGAGGTGGGGAAGTTTGCAGATAACTCATTATAAGCCA GCCGTAGGCCTGGGTGGGGAGGCCTTTTGACCAGCGAGTGACTCATGCTTGCAGAGGAATAAGAAAACTG AACACGTATTGAGCACCTTCCATGTTTGGGTGCAGGGCGAGGCACATGGATGACTGCTTTATTTCATTCT GTTCTCTACCTTCACTGTATGAGAGTCGTAATCCCTGATAAAAGAGGAGGAAGGCGAAGGGGGCTGTGTT TTCTTGGCTTAACCCTATGACTCTGACCATAATGATAGCCCATTCCACTAAGCCTCAGTTTCCCATCTAT AAAATGGCCATTCTACAGCCCCGCTTGACTATCTGCATTTATATAAAACCCCTAATTATGGCCGGGCGCA GTGGCTCACACCTGTAATCCCAGCACTTTGGGAGGCCGAGGCGGGCAGATCACCTGAGGTCAGGAGTTCG AGAACAGCCTGGCCAACATGGCAAAACCCCATCTCTACTAAAAATGCAAAAATTAGCCAAGCATGGTGGC GTGAGCCTATTGTACCAGCTACTCGGGAGGCTGAGGCAGGAGAATTGCTTGAACCTGGGAGGCGGAGATT GAAGTGGGCTGAGATCGTGCCCCTACATTCCAGTCTGGGCAGCAGAGGGAGACTCTATCTCAGACAAACC GGTGGAGGCAGGATTTAGCCCCCAGGCTATAGGTGAAGACCCCTTACCTGGAGGGCTCCCTCTTGGTTCA GTGGTTTTCAGATTGTATATGGGGTGGGTGCTGAGTGGAAGGTCTCAGCCTGGCCCCCTGCAGCAGCTGC AGCAACCTTGTTGTCTGTCTACACGTTGCTGTTTAATGTAAAGGTTTTTTTCAGCAATCAAGTCAGTTTG TAGGTGATGGTGGTGTGGTCTTGGGGGGGCAGCCAGATCCTGCACAATTCCTGAGGCTTGCTTTTTGTCT TGCTAGAGGGCAAGAAGCAGGGGAAGAGCCCCTGGAAGCACACAGAGGTGTTCTGCTCCATCCCATCCCG CTCCCTGCTCTCCCCAAGCTACTACCACAGCTTTGGAGTCACCGAGAACTATGTCATCTTCCTTGAGCAG CCTTTCAGGTTGGATATTCTCAAGATGGCAACCGCATACATCCGGAGAATGAGCTGGGCCTCCTGCCTGG CTTTCCACAGGGAGGAGAAGGTGAGGTCTGGCTGGACTCTAGCCCAGTGGGTGCTGGCTGACCATGGAGG GAGGCTGGTGTGCAGGAGGGTGAAGTTTAAGGCAAGGAAGTGGCATGGAAGAGGGAGGAGGCTACCAGAG GCATCTACCCACCTTCCAGCAAGTTCTGAAGCTGGATGGTCCTTCAGAATGGCCCCCAGGCCTTTGTACC CCCACGGTGATGAGTTATTGGATGAGGCTGTCCAGGCAAGGGGGTGCCATCTTGGGCAAACATGGAAGCC CTGGCAGTCCCCATATGCCCAGCAGCAAAAGGAGTGAGTCCTCAGTCCTTATGGAGAGCTGGGCTCCTCC CCACCTCCGCCCTGTTGACAAGACCCCTTAACCATGTCTGCTACCAGTGTGTAGCGTTGGGGCGGTAGCG GCCAGAGGTTTAGACATTGTAATGACAGTATGTTCCACCAGACAGTTCAATAGAAACCTCTCCTTCCATT CAGGTACACCTGAGTGCTCAAAGTATGTATGCACGTATTGCATGCTTGTATATGCACATATGCATGTATA TGTGTACATGTATATGTGCATGTATGTGCATATGTGTATGAATACATGTACGTGTGCATGGGTGTATGTA TGTATTACTAGTGTTTATTTACTTGTTGGGTTTTTATTGTGGGGGGGTTGTTTTTGAGACAGAGTGTTGC TCTGTCACCCAGGCTGGAGTGCACTGGTACAATCACAGCTCAGTGCACCCTCAACCTCCCAGGCTCAAGT GATCCTCCCAAGTAGCTGGAACCAGAGGCACATGTCTCTATGCCTGGCTAATTTTTTGTTGTTTTGTAGA GATTGGGGTCTTGCTATGTTGCCCAGGCTAGCCTCAAACTCTGGACTCAAGTGATCCTCCTCCCTTCCCC TCCCAAAGTACTGGGATTACATGTGTGAGCCATTGCACCTGGTCTTTTTTTTTTTTTTTTTTTTTTTGCG TTGTCACTTCACTTTTGTAAAATATCCAGTAGTTCTCAGTGTTACCTATTCAAAGAATATACAAGTATAG AAAGCCATGTATAAAATCCTCCCCAACTCACTTCCCCCCTCCTGCCTCCCATCCACCCCCACGTCTGAAG GGAGCCACTGCTACCCACTGACACTGTGTTACTCCACCATCTCTGCCTTCACGTGCACTTTTAGTTTTTC TTTTTTTTTTTTTTCAGATAGAGTCTCACTCTGTCACCCAGGCTGGAGCGCAGTGGTGCGATATCAGTTC ACTGTAACCTCCGCCTACGTATCAAGCTATTCTCCTCTCTCAGCCTCCTGAGTAGTTGGGATTATAGGCA CACGCCACAATGCCTAGTGAATTTATTTATTTATTTATTTTTTGAGATGGAGTTCCATGCTTGTCGCCTA GGCTGGAATGCAATGGCACATTCTTGGCTCACTGCACCCTCCACCTCCTGGGTTCAAGCGATTCTCCTGC CTCCACCTCCTGAGTAGTTGGGATTACAGGCAAGTGCCACCATGCCTGGCTAATTTTTTGTATTTTTAGT AGAGATGGGGTTTTGCCATGTTGGCCAGGCTAGTCTTGAACTCCTGACCTCAAGTGATCCACCTGCCCGG CCTCCCAAAGTGCTGGGATTACAGCATGAGCCACTGTGCCCTGCCAAGGCTCCAGTCTTAGATGGAGCCT GGCACCTGGCAGATTCTCCCCAACTTGGTCATTGCCAGGGAGCTGGGATGTCAGGACAATGGAACAAGGG GACCGTGCACACTGGAGCGTCTCTCCAAACACTGTCCTCCTAGTGACTGCAAAGACTCTGGCAGCAAAGC ATCCCTCCTCTCCATCTGAAAGATATACTTATGGAAGTACAATAAACAGCTCTCATTTTGGGGGGCACTT TTGCCTGTCTGGTGTTGTGGAGCACACACAGAATGCAGAATGGGGACATAGTCCTGAGCCTAGCTCCTGG CGGGGCTGGGTTTTGTTCAGCCCCCAGATGCCACAGTGCCAGGCTGAGAGAGGGTGAGCTGAGCCCTTGA TATGTGTCCTTTTTCAGACTTATATCCACATCATCGACCAAAGGACCAGGCAGCCTGTGCAGACCAAGTT TTACACAGACGCCATGGTGGTCTTCCATCACGTCAACGCCTACGAAGAGGACGGCTGCATCGTGTTTGAC GTCATTGCCTACGAGGACAACAGCCTCTACCAGCTCTTCTACCTGGCCAACCTGAACCAGGACTTCAAGG AGAACTCCAGGCTCACCTCGGTCCCCACCCTCAGGAGGTTTGCCGTGCCCCTCCACGTGGACAAGGTAAT GGCTTCCAAGGAGGTCCCTTTTCTTTCTAGAGAGATATCGGCCCAGGTGGGAAGTTACTTTGGCCCTTAT TTGATTGACATTGAAATCCAAATGAACTGTTCTTGAAAAAAAAAAAAGTTTTCATTGTTTTTCCCAAAGT AGTACCGATTCATAATAAAAACTTTAGAAAATATAGATAAGTAAAAAGGAGAAAAAAATCCCTATAAACC TACCACCGAAGATGATCACTGTGGATATATATGTTTGTCTCCCAGTCTCTCTCTCTGTGTCTGTGTGTGT GTGTGTGTGTGTGTGTGTGAATCTTCATTTTAATCATATTGTACATAATTTTTTTTTTTTTGAGACGTAG TCTCGCTCTGTCACCCAGGCTGGAGTGCAGTGTTGCGATCTCTGCTCGCTGCAAGCTCCACCTCCCAGGC TCACGCCATTCTCCTGCCTCAGCCTCTGGAGTAGCTGGGACTACAGGTGCCCGCCACCATGCCCAGAGAA TTTTTTGTATTTTTAGTAGAGACGGGGTTTCACCGTGTTAGCCAGGATGGTCTGGATCTCCCGACCTCGT GATCCACCCGCCTCGGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACTGCACCTGGCTGTCTTACA TAATTTTTAACAGCTTTATTGAGATGTAATTGACACAGCATACAATTTGCCCTTTTATTTATTTTTTTTT TTATTTTTTTTGAGACAGAGTCTTGCTCTGTCACCCAGGCTGGAGTGCAGTGCCATGATCTAAGCTCACT GCAACCTCTGCCTCCTGGATTCAAGCGGTTCTCCTGCCTCGGCCTCTCAAGTACCTGGGATTACAGGCGC CTGCCACCACGCCCAGCTAATTTTTGTATTTTTAGAAAAGACGGGGTTTCACCATGTTGCTCAGGCTGTT CTCGAACTCCTGACCTCAGGTGATCCACCCACCTTGGCCTCCCAAAGAGCTGAGATTACAGGCGTGAGCC ACCATGCCTGGCCTAATTTGCCCATTTAAAGTGTTTGACAGCCTTTGGTATGTTTTCACAGTTGTGCATC CACCACCACGATAAATTTTAGAACATTTTCATCACCTCCAAAACACACCCCACACCCCTTAGCCATCACC TCCTAGTCTTCCCCTCCCTGCCCCAGGCAACCTGTCATCTGCTCTCTGTCTCTGCAGACTTGCCCTTTCT AGACATCACGTATAAATGGAGTCTTACAATACGTGATCTTTTGTGTCCGGCTCCTTTCACACAGCACAGT GTTGTCAAGGCTCATCTGTGTTGTAGTCCGTATAAGTGCTTCATTTCTTTTTGTTGTTGTTGTTGGTTTT TGCTTGTTTGTTTGTTTTGAGACAGTCTCGCTCTGCCGCCCAGGCTGGAGTGCAGTGGTGTAATCTCGGC TCATTGCAACCTCTGCCTCTGAGGTTCAAGCAATTCTTGTGCCTCAGCCTCCTGAGTAGCTGGGATTACA GGTGCCCACCACCATGCCTAAGTTTTTGTATTTTTAGTAGAGGTGAAGTTTCGCCATGTTGCCCAGGCCG GTCTTGAACTCCTGAACTCAGGCAATCTGCCCCCCTACGTCTCCCAAAGTGCTGGGGTTTCAGGTGTGAG CCACAGTGCCCGGCCAGTACTTCATTTCTTTTTATGGATTAATAGGTACATACTATCTTACAGACTGCTT TTCTTTTCTTTCTTTTTTTTTTTTTTTTTTGAGAAGGAGTCTCGCTCTGTGGCCCAGGCTGGAGTGCAGT GGCGCAGTCTCAGCTCACTGCAAGCTCCGCCTCCCAGGTTCAAGCCATTCTCCTTCCTCAGCCTCCCAAG TAGCTGGGACTACAGACACCTGCCACCACGCCTGGCTAATTTTTTTTTTGTATTTTTTAGTAGAGACAGG GTTTCACCGTGTTAGCCAGGATGGTCTCAACCTCCTGACCTCATGATCCGCCCGCCTTGGCCTCCCAAAG TGCTGGGATTACAGGCGTGAGCCACCGCGCCCGGCCCAGACTGCTTTTCTACCTATTTATGTATCGAAAC ATCTCTCCATGACATTAAATATTCTTTGAAACATCACTTTAAACATTTGCCTAATCGTTCATGGCAGGGA TTCATCACCATTTGCTTACACAATTCTCTGATGTTGGAAGTTCCGTTCTTGCACTAAGAATGACCACCAG GCCAGACATTATCCCCAATTAGGGTGATGTGGCCCAGGCTCTGGGCTTTACTTACAGAGACTTACAAAGG CTTCTGGCTCCAGAACTCACTGACTTCATGACTTAATTAATTTAAGTGAAACCAAATTCAATTCAATTAA ATGTTGATGGCTTACATTGACTAAATGCAAGTTATGTGCCAGGTACTTTGCTAAGCATTTTGTTTTTCTT ACCTCACTTAATGATCAAAACAACCTGTGGGAAACGTCCCTGTAGAAGCCTCATTTTACAGATGAACAAA CTGAGGCTCAGAGAAGTTAAGAAATGTGGGCAAGGTCACAGCCCAGAGTGGCAGAGCCAAGACTGGAACC TGCCCCAGTCTGTCTCTAAACCCCCATTTTTTTTTTCTTTTTGTGGGGGATGGAGTCTTGTTGTGTCACC CAGGCTGGAGTGCAGTGGTTTAATCTCGGCTCACTGCAATCTCCGCCTCCTGGGTTCTAGCGATTCTCCT GTCTCAGTTTCCCAAGAAGCTGGGATTACAGGCATGTGCCAGCACACACAGCTCATTTTTTGTTTGTTTG TTTGTATTTTTAGTAGAGATGGGGTTTCACCATGTTGGCCAGGCTGGTCTTGAACTCCTGACCTCAAGTT ATCCACCCACCTCGGCCTTCCAAAGTGCTGAGATTACAGGCATGAGCCACCGTGGCCGGCCCTAAACCCC TGTTTGTAACTACGAAGGAGGAGGAACTCTGCTATTCTCCCCAGTAGCCCTAAGTCCTAGGAAAGAGCCT CAGATGGGCCACACTTGGCACTCTGCAGGCCTGGCAGACGGTCCTACAGTGTCCAGGGAGCCTTTTCCCA CCCTTACCGCCCAGTTTCTCAGTGCAGGAATTCAGCCACCCTCCCAGCCAGCGGGCAGGGGAGCTGGCGT TTGAACTGAGGTTTGTCTGACTCCAGAGCTGGGGTCCTCTCCCATCTCTCCAGCATTTTCCCACCCATGG CCATTTGTGTGTCTCTGCCATGGTTTTTGTCATATTTTATATCACCTCTACTTAACATTTAAAAATCCTT TTTTTTTTTTCATTTCAATCAATTCACTCTCTACTTAGCTCATTTGAAAGGAAACACATCACTACCCAGT AGAAAGCTGGCAATGCTTGCTGCACAGAGAAGACAAGCATGAGAATAAAATAGTGGAAATAAAGCAGAGG TCTTGAGCTCCAGCCAGAGGGCTGTGGCTTACCAAGACCTGATCTCTCTGTGAAAAAGCCAAGTTTTAAA AGTATTAGGCATTAAAGACATCGTGGCACCGCACTGAGACTCTCCTTGACCTAGTCAGAACAACTGGAAG AGAAAAAGGCATTGATTTTCTCCCCTATGTGACTCAGGGCTATTGGATGAACAGCCACGTCCCATGAAAT CAGCACATGAGCCCTGGGCGCCTGCACCCCTTGCTCCAGAAGCACCGCAGTGCAGCCCCTCAGACTTTCT CCTGGTTCCAGGAAGTACTGAGGAGTAACAAGGCACAAAGGTAGTAAGTCTCAAGGCTGACCTCAGCCTA GGGATAGTACACAGAGAGGAACATACTCCCTCCCACTGCCACACCTTACAAGATTTTATAACCTTTTGTC ATGCTCGAGAATGCTTTGCTGCCTTGGAACCAAGCTAAGAATGTTAGCTTGTGTATCTTTTTTTTTTTTT TTTTTTTTTTGAGACAGAGTCTCGCTCTGTCGCCCAGGCTGGAGTGCAGTGGCGTGATCTCGGCTCACTG CAAGCTCCGCCTCCCGGGTTCACGCCATTCTGCTGCCTCAGCCTCCCTAGTGGCTGGGACTACAGGCGCC CGCCACTACACCTGGCTTATTGTTTTGTATTTTTGGTAGAGACGGGGTTTCACCGTATTAGCCAGGATGG TCTCGATCTTCTGACCTCGTGATCCGCCTGCCTCAGCCTTCCAAAGTGCTGGGATTACAGGCGTGAGCCA CTGCGCCCAGCCCCCTAGCTTGTGTATCTTTAAAAGCCATCAGGTGTTCAGGCACAGTGGCTCACGCCTG TAATCCCAACACTTTAGGAGGCCCAGGCAGGTGATCACCTGAGGTCAGGAGTTCAACACCAGCCTGGCCA ACAAGGTGAAACCCTGTCTCTGCTAAAAATGTAAAAATTAGCTTGGCGTGGTGGCCCCTGCCTGTAATCT TAGCTACTCAGGAGGCTGAGGCAGGAGAATTGCTTGAACCCAGGAGGTGGAGGCTGCAGTGAGCTGAGAT CCCACCACTGCACTCCAGCCTGATCCCGCCACTGCACTCCAGCATGGGCAACAGAGTGAGACTCCATCTC AAAAAAAAAAAAAAAGAAAGCTGTCATATGAACCATCTGCTGCTTTGAAACTAGCAAAGGAAAGCAAGCC CTGGGATGGGTAGCTCCAGCCACGCTTTTTAATTGCTACTTATTGTCCCTTAAATATGTCTTCTTACTGC ACTTTCAATGGCTCCGCCTGCATAGTGAAATCAGAAAGTCAGGCAGGTGGACAGAGCCTTACATGCCCTG ATCCAGCAGCTTTGGCTCCACCCCATCCAGAGGTTTACTGGAGAAGCGACTTCAGGAAGATGCTGCCCTT ACTCAGATGCCCTCTGGGCCTGAGGCCTTTGCAGGACATTGCTTTCCCCTCTGTCTGAAACCCTGTCCTC CTGGGCTGACACTCCTGCTCCCCCTGGCTGGCTGCACATTGGGATCCCCTGGAGAGCCCTGAGACCCCCA TGTCCGGGCCTTGGCTTCCGCCCAGACCGGGGAAGCCCAGGCCCGGGTGTGGTCTCAGAAACCCCCAGTG ATTCTGCAGTGCAGCCGTGGCAGAGAACCTCCAAGGTCAGGGATCAGCAGCATGACCCCGCAGCTGAGTC CGTATCCTCTAATGGCGCCTTGTAACTCTTTGTCAACATTTATCTCAAGTGTAAGTAACTTGTTCATTTC CCTCTTCCTGTTCAAGCCTAAGTTCTGGGAGGACAGGGACTCTGTCTCATCAGCAGTTCATCTGCTGCAC TCAGAGGGTGCTCTTAAATATTTGAAATGAATGAATGAATGATGAATACATGAAAAATGGGAAGCAAGTT CTCTAAAAGGGCGCAGCATCTTCCTTCAGCCTTTGGAACCCGTCCCAAGTGAAAAGTGCTTCCCACATAG AACAGGCAATAGCAAATTCTATTTAAAAGGCCAGGAGGTCCTGAATGTCCCAGATTCTCTTGCTTTGGGA CCAGCTGGGGTCAAAGGAAGGCAGGGCTGGCAGGGCCTCTGGGCACCGTGGGCCTGTTTACGCAGGGCGG TGTGGGGGTGCCTGAGGCAGGGCTTAGCAGTGGCGGGGTGTGGCTGGGAGGGGTGTGGGCAGGGGTGGGT CATCTGGACCTTGGCCCTGCCCTGGTGCTGCAGGGCGCTGTGTGAGGCCCGAGGTTCGTGTGCACCCACG CCTAAGGGGCATTCACAGGAGGAAGCACTGTGGACCTGGAAGGGATGGCTTTGATGACTGGATCAGTGGG TTTGGTTTCTGTCTCCAAATGCACAAATGCAGACACTCCAGTAAGAGAAGCACCATTCATGGAGGACCCG CTAGGTGCCAGGCTCTGTGTTCAATGCCTTTTCTGCTCTTAGACCCTGGCAAGAGGGGCCCCTGCTCTGG GTTTGGCACTTTGGAGGACTGTGGTCCAGGCTTTCTTTCTCTAGCAGGACCCGTACTCCACAGGGTGAGT TCACAGGGCCAAGGCATTCTGACTACCCAGAGGGGTGCTTCCACCCCCACCCCAACCATGTGCTGGACAC CTGGGATCCCAGAAGCTCCTGAAGGGCCCAGCCTTGCTTCCAATACCCGTCTTCCTAAGGGCAGACTGCC ACTCTGCTGTTCCTGCCACAGGCCCATGAGGTGGCCAGGGCTGGCTGTTGCCTTGGTTGTGCTGGCTAGG GCATCCACGCAGTGAGGGATGGAGCCTGGGATGAGGCAGGAAGGAGCCAAGGGCCAGAGACTGCCTTATT CCAGCTCAGAACTCTAAGGAGTCCTGGGGTTCTCAATTCACAGTCATCCTTTCAGACCAGCACAGTGCAT TGCTGGAACATTCTGTCTGTCCAACACAGTAGCTACTAACTACGAGTTGTTATTGTACACTTGAAATGTG GCTGGTGCAGCTAAGGAATTGAATTTTTAATTTTACTTAAGCTTATTTTAAAATTAAATTTAAGGCCAGG CATGGTGGCTCACGCGTGTAAACCCAGCACTTTGGGAGGCCAAGCCAGGCAGATCACTTGAGGTCAGGAG TTCAAGACCAGCTTGGCCAACATGATGAAACCCCATCTCTACTAAAAATACAAAACTTAGCCAGGCATGG TGGCTCATGCCTGTAACCTCAGCTACTCAGGAAGCTGAGGCAGGGGAACTGCTCGAACCCGGGAGGCGGA GGTTGCAGTGAGCTGAGATCGTGCCACCGTATTCCGCCTGGATGACAGAGTGAGACTCGGTCTCAAAAAA AAAAAAAAAAAAAGTAAAATAAAATAAAATTAAATTTAAATCGCAACATATGGCTAGCGATTGCCGTTTG GGACAGCCTGTTCCACGCCATCATGAAGGGCTGCGTGTCAAGGCAGGGAGAGAGATGGTGTTGGACTTAA TTTGCTTGGTGTATTTAGACAGAAGGTTGGTGGGCCTCCACTTGTACTCTCCTCCTGGCTCCTGTGAATT TTAGGGGCTGTGAAGTGCTTTGCTAATCTTCATCACAATGTTCTAAGTTATTTATGATCCCCCACGTCTA CAGATGAGAAAGTAACTTGCCCAACTTTTTAGAATCATCCCCAGGACTTGAGCTGGAACTGGAATGTACG CCTGTCTGCCTGCACGATGTGTGTGGCCCTGGACCAGCCTATTTTTCTCAACCATTATTTAATTTAATCC TAACATAATGCTCAGATGCAGGTGGAAACCGCCTCACTTATACCCAGCACCACACTAAAAGTTATGAATC ACCACCCCGATTTTACACAGTGGAGGAAACTAGCTCTGAGAAAAAGAGGTCTGCTCGAATCTGCATGGAA AACCACAGCGTTGAATTTCATATGGCAGGCAGCATTCTAGGGGATGACAGTGATGACTGCTTCTTATGAG AGTTCCCTTAAGTGTCGGGATTTCAATGTAAGCTTGCAAGATGGTGCTGGATTCTGGCTGGAAAGTGATG TCTTCCTAAAACTGAGCATGCTGGCCACTGAAAGCAGCCAAGTCATGTTTGTTATTGCTGTGTGTGGAAA AATTCACAGTTTATTCCTCAACCAGTCCGACCAGTTTGGGGCTGGAGTTATAAGATGTCTGTGCAGACCA ACTCCCTAAGAATCAAGGCTGGAATGTGCCCAGAGGTCTCTTGCTGTCACATGCTTAGCAAGGTACCAGG AAGGGCCTCCCACCAGCTTGCAGAGCCATGGAGGTGGAGGCATTGAAAGTTTCTGTTTATTTTATTTTAT TTTTTTTTGAGACAGAGTCTCGCTCTGTCGCCCAGGCTGGAGTGCAGTGACGCGATCTCGGCTCATTGCA ACCTCCGCCTCCCAGGTTCAAGCGATTCTCCTGCCTCAGTCTCCTGAGCAGCTGGGACTACAGGCATGTG CTACCACGCAGGGCTAATTTTTACATTTTGAGTAGAGATGGGGTTTCACCATGTTAGCCAGGCTGGTCTC GAACTCCTGACCTCAGATGATCCACCCACCTCGGCCTCCCAAAGTGCTGGGATTACAGGCATGAGCCCCC GCACTCAGCTAAATGTTTCTAAGAAGCCACCGATGTGCCAGGTGCTGGGCTCCTTTGTCTCTGCATTTCC TCTCATTTGATTCTTACAGCCACCGTGCAAAACAAGTCTTGCCCCTTGACAGCCCAAAGAAAAGCTTATT GAGTTGTGCATTCACTCATTAATTCAGCGATTACTTCCTGGGCACTAGGTGCCAGGCACTGAGCAAAATC TGGTCCCTGGCTTCATGCGGCAGACAAGCTAAAATAAGGAAAAGAGCTTCATAAAGGAGATAATTACAGC TCAGGGCCAGTGCCTTGGAGACACTGCAGATTCCAATGGAGTTGTTAGGGAAGGGGTGTTTCTTCTGAGA CCTCAGGGTTTGGGGAAGAACCAGCCTCAGGGCCTTTGCACTGCCTTCACCCTCTACCAGCAATGCTCTT GCTTCTGGGCCAAAGAATCAATGCAAAGGCCCCAGGCACAGGGTCTGCTTCTCTCCATGTGACTTTGGAC CAGTCCCTTTCCTTCTCTAGGCCTCAGTTACTTCTACAAATCGAGACTGAATTAAACAAATTTCCGAGGA CCCTTGCGGTTCAGCTGCTAAGTTGCAGTAAACTTTTCATGCTCTCCAACAAAAATGCTGCTATCCCTAA AATAGGTTGGTTTTAATTATAAAAGCCATTTTGAGCCAGGTGTACTGGCTCATGCTTGTAATCCCAGCAC TTTGGGAGGTCAAGAGAGGAGGATCACTTGAGCCCAGGAGTTCGAGACCAAGCTGGGCAACATAGTGAGA CCCTGTCTCTACAAAAAATACAAAAATTAACCAAGGATGGTGACGCATGCCCGTAGTCCCCCAGCTACTC AGGAGGCTGAGGTGGAAGGATCACTTGAGCCTGGGAGTTTAAGGCTACAGTGAGCTGTCATCACACTACT GTACTCCAGCCTGGGCGACAGAGCAAGACCCTGTCCCAAAATAAAATAGAAGCTATCTTAGAAAATGTAG AAAGTAGAGAAAAGTTTAAATGAGAAGTCAGCCATAACAATAATGTTCCATCCTCTTGTTCCTCAATATC TTCCAGAGCCTAACCCGTAGTCACCTCCAGTAGTGGTGGCAGCAATATAATAATAATAAGTGATAGTAGT AGTAGTATGGTAATAATAGTAATAATAATATAACAACGTCATCAATAGAAGCAGCTGACATTCATCTAGC ACTTATTGTGAAGCAGGCATTCTTGTGAATCATTTGTGCAGATGATGTCATTCAGTCTGCACAATAACTC AAAGATGCATATGCTATTAATATACACATAAGGAAACGGAACTATAGAGAGGCCAACTGACTTGCTCAAG GCCCCACGGTTAGTACATGAGGGAAACAGGGAGTAGTAGATGCTCAATAAATATTTAATCATGCTAAATC CCTCCCCTTGCTTATACTGATGACAGTAAGATACTGAACACAGCAAAATCTGACTGTAAATTGAGACCAA GAAATGTCCTTGAAGGCTGTTTTGCCACCAAATAATTTTTATTGCATGTTTGTTTTCATTTCTGCAGTGA TAACTTTTCCTAGAAGAAAATACTGAAAATACAGAGAGGCATACAAAAAAGAAATTAAAGTCCCCCCAAT CCCATCATCTGTTGTATTTTTAATATTTAGTATATTTCTGGCTGGGCGTGGTGGCTCACGCCTGTAATCC CAGCACTTTGGGAGGCCGAGGCGGGTGGATCACTTGAGGTCAGGAGTTCAAGACCACCCTGGCCAACATG ATGAAACCCCATCTCCACTAAAAATATAAAAATTAGCCAGGCATGGTGGAATGAACCTGTAATCCCAGCT ACTCTGGAGGCTGAGGCAGGAGAATCGATTGAACCTGGGAGGCAGAGGTTGCGGTAAGCCAAGATCACAC CACTGCACTCCGGACTCCAGTCTGGGCAACAGAGTGAGACTCCATCTCAAAAAAAAAAAAAAAAAAAAAA AAAAAAAAAAAAAAAAATTACACACACACACAGACACACACACACACACACACACACACATTTAGTATAT TTCTCTGTCTCTTCTCCGTGTAACTTTTTTAATGTGGTTGAGCTCAGACTGCATACGCAATTTGTCCTGT TGCTGCTTTTACTCAGTGTTATGTGATAAGCATTTCCCATGTTGTTGTAAACTCTTTAGAAGCATCCTTT TAACGACTGATGCAGCTTTTTATAGGTGAATCATCTAGTACTTTAAAAGTGAGAACTTACTCTCAGAAGC ACATTAATTTTCCCTGTGAGGGATAAGGCAGGCTCAGAGTAAGAGAAAAGAGTCCTATCACCTACCAGGT ATGTGACCTTGGAGGAGTCACCTTAAATGGCCAATCCTCATTTTTTAAACTGAGACTAAGGATAACAACA GGAAACGAGCTGCTTCCTATGATTAATGTGAGGCTAAGCCAAGATGACATGTATTCAAGCATTTTAAAAA ATATATACACTAAAGCAAATGTTTGCTCTGGATTACACGTTTTTATTTTACTTTTTGAAAACTGAATTTT TTCAGAATGCAGAAGTGGGCACAAATTTAATCAAAGTGGCATCTACAACAGCCACGGCCCTGAAGGAAGA AGATGGCCAAGTCTACTGCCAGCCGGAATTTCTTTATGAAGGTAAAATGCATCCTCTTGTCCTGAGTTTA GGAAAGGGGCAGATTTTCACAGGGAGCCCAGAGGCCTCTTTACATAATAATTCCCTCCTGTGCATGGACA AGGGCCAAAAAGGAAAGGGTCTTGGGATGCCCTGGTGAAAAGCATCTGGGGACATTTCTCTTTTCTCTAT CTTCAAATGCTTCCTAGGAAGGCAATGGGTGAGGCCAGGCACGGTGGCTCCCACCTGTAGTCTCAGCACT TTGGGAAGCTGAGGGAGGCAGATCACTTGAGGCCAGGAGTTCAAGACCAGCCTGAGCAACATGGCGAAAC CCCATCTCTACTAAAAATACAAAAATTAGCCGGGTGTGGTGGCGCATGCCTGTGGTCCCAGCTACTCAGG AGGCTGAGGCATGAGAATCACTTGAGCCCAGGAGGTGGAGATTGCAGTGAGTTGAGATTGTGCTATTGTA CTCCAGCCTGGGCAACAGAGCAAGACACTGTCTCACAAAAATAAAAATAAAAATAGGAAGGCAGTGGGTG GTTGTTGGGCCAGATGACTTCTGCAAATGCTGTCCCTTACTGAACATGGGCTTACTGAACAGGCACAATA CATTTCCATTTCTTCCTCTCAACATCCACAATATCCTGCAAAAATAGGTGTTATCGGCCCCGTAATATAG CGAAGAAAACTAGGCCTGGGAGTCCTTGAGGTACACACAGAAAGCAGACCCTCTAGAACAGGAGTCACAC CCGTGGAGCAGGGCTCCTCAATCTGGGCACCATCGCCATCTGGGGCTGGGTCATTCTTTGCAGTGGGTGC TGTCCAGGGAATTGTAAGATGTTTAGCCACATCCCTGGCCTCTACCCACTGGAAGCCAGGAAGACCCCCA TCCTGAATTGGAGCAGCCAAATATGTCTCCAGACATTGCCAGCATCTCATGGGAGCACCATTGCCATGAT GGAGAACTTCTGCCCCAGAATATAAGCCCGTGAGGCGAGAATTGTGTTGCTGTGCTCACAGCGTATCAGC AGCACATGACACAAAGGCTGGCATAGAGAGGTCTGTGTTCCATACGCCAAAGTGCAGAATGAATGGACTT GTCCAAGGAGACTCAGCTAGAGAGTGGGACAGAGTGCATTTCAACTGAGCGCATTGGCTGGGCACGGTGG CTCACGCCTGTAATCCCAGCACTTTGGGATGCTGAGGTGGGCAGATCACTTGAGGCCAGGAGTTTGAGAC CAGCCTGGCCAACATGGCGAAAACACATCTCTACCGAAAATACAAAAATTAGCCGGCATGGTGGTGCACG CTTGTAATCCATAATCCCAGCTACTCAGGAGGTTGTGGCAGGAGAATTGCTTGAACCCCGAAGGCAGAGC AGAGAGCTGAGATTGCGCCACTGCACTCCAGCCTGGGCAACAGAGACTTTGCCTCAAAACAAAAAACAAA AAACAAAAACAAAAACAAAAAACCCTGAGAGCCTTGTTCCATCAGCTGCCCCATGCCAGGAGGTTTGGGC ATCTGGAAGAGCACATAGACTTGGGGACTCTTTTAGGATGACCCTTGGATTTGACCTAAGAATCCACTTC TGTAAAAGGCATCCCATGCATCCCATAACCGGTTCTGTGATGCAACTCATTCCCCTGGAGTCTTTAGAAA TGAATCAATAGATGATGCCAGGTCTGAAGGCATCAACCCCCAACCCCCATCCCTGCTCACCCACCACATC CCTTTTTTTTTTTTCCTGAGAAGACCACGCTTGTTTATTGTTGCAATATTGTCCACACTAAAAAGTGTAA CAATAAAGAAACCACCCGTAATCCCTGCCCCCGTGACAGCGCTTTGGGCTACCCATCCAATCCTCCCATC ATGCATGGATTGTGTGACATAGGCCGGGTCCCTTCTGGCGAGTTCTCAGACTCTCTCATTTCATCCCGGC AGTGTCATTCTTTTATTGTTGACATTAGATTTGTTCACGTACATCAAGGGCTTAGTGTGGGGTCTGGCCT ATAGGGAGAGTCCAGCCATTGGCAGCAATATTAGAACAGTCCTAAGAAGCAGGCTCAGACAATCTCAAAA CTTGCCAAAAGGCAGGCAGCAGAGCCAGGTTCTGACCCCAGCAGTCTCTTATCCCAGAGCCCATTGCCTC TGCATTTGTACTTTTGCAAAATGCATTCCATATCATCTAGAATGTTCCGAAGCTGCCTCTTGCACTTAAT GTATGTAACCTGAGTATTTTCCCACATCCTGAAGATTCTTCAAGAACATGGCTGTTAAGGACCGGGCATG GTGATTCACACCTATAATCCCAGCACTTTGGGAGGCCAAGCCTTAATTTCATGTAACTACTGGCCAGGCG CAATGGCAATTACAGGCATTACTCATGCCTGTAATCCCAGCACTTTGGGAAGCTGAGACAGGTGGGGCAT CTGAGGTCAAGAGTTTGAGACCAGCCTGGACAACATGGCAAAACCCCATCTCTATTTAAAAAAAAAAATA CAAAAATTAGCCGGGGGTAGTGGTGCACACCTGTAGTCCCAGCTACTTGGGAGGCTTAGGCAGGAGAATC GCTGGTCTGAGAGGGGCCCAGGAACATCTTGGAAGTCTCAGGCCTACTTTGAGGTCAAGGGCAGGCACCT TCTTCTTATCTAAGTATGGGAGTGTTCCCTCTGCCTCACCTTCATCTGGGCCTGTCCCTTGGAAGTTTCA TGCTTTCTCATTTGTGGGATTGGACATCTGCTTCCCATCTCAATACTTCATTCCCCTTCCCGCCCCACTG AGCCTAATCAGCATTTATCCATGGATGTATCTCTGCTTCCTCTTTTCTTGGACATTATATCTTCACCAGC AGTTGGCGGCAACCACCTAGAATATTTCCTAAGAGTTGAACATCCATTTCAGTATTCAGACTTAGAAATT CAATTTGATGCAATAGGCATATATACATATATACACATTTACGGCCAAGCACGGTGGCTCACACCTGTAA TCCCAGCACTTTGGGAAGCTGAGACGGGCGGATCATGAGGTCAGGAGATCGAGACCATCCTGGCTAACAT GGTGAAACCCTGTCTCTACTGAAAATACAAAAAAAAAAAAAAGTAGCCGGATGTGGTGGCACGCACCTGT AGTCCTAGCTACTTGGGAGGCTGAAGCAGGAGAATTGCTTGAACCTGGGAGGCGGTGGTTGCAGTGAGTT GAGATTGAGCCACTGCACTCCAGCCCAGGCGACAGAGCTAGACTCCATCTCAAAACAACAACAACAAACA AACTATATATATATATATTTTTATATATTTATATATTTATATATAAATATATATTTATATATTTATATAT AAATATATATTTATATATACACACACATTTACAGAGAAAAAATAATATTTTTGATTATGTAAAAATAATA AGCATGATGAAAATTTCACATAATGAGAAACTTAGATTCTATCATAGAAAATGTAAACTGTAAGGCAGTT AGAACCCCAGCAATGCTTCCAAATTTTTTCTCTTCATTTGTAACCTAGCGGAGATACAATAATTCTATAA CCAGCATTTTACACTTAACCTTATGGTATGGACACTTGCCCATGTTATTAAAATCATTTGTAAATGTTGT TTTTCCATAATGTTATTATAGAATTCACCAGATTTAATTAACTGTTCTCCATTGACACCCTTTTCCACAG CTTCCCATTCTGTTTTATTTTTTAGTTTTTATTTTAGAGATGGGGTTCTTGCCATGTTGAGCAGGTTGGT CTCAAACTCCTGGCCTCAAGCGATCCTCCCATCTCAGCTTCCCAAAGTGCTGGGATTACAGGCATGAGCC ACCATGCCTAGCACAGCTTCCTATTTCTTTTCTTTTTGTTTTGTTTTGTTTTCTTTTCTTTTCTTTTCTT TTTTTTTTTTTTCGAGACAGAGTCTCACTCTGTGGCCCAGGCTGGAGTGAAGTGGCACGATCTCGGCTCA CTGCAACCTCTGCCTCCTGGGTTCAAGTGATTCTCCTGCCTCAGCCTCCTGAGTAGCTGGAATTACAGGC ATGCGGCACCATGCCTGGCTAATTTTCTTTGTATTTTTAGTAGAGGGAGGGTTTTGCCATGTTGGCCAGG CTGGTCTCAAACTCCCGAACTCAAGTGATCTGCCCGCCTCGGCCTCCCAAAGTGCTGAGATTACAGGCAT GAGCCACTGCGCCCAGCCAGCTTCCCATTTCTCATCACATATGTGCACATGCACGCACACATATATACAC ATCAGCACTTTTTTGAAAAAAAGCTTTAAGAAATTGCAGTAGCCTCTGATTTTAATCATGCAATTCTCTT TGATTTCTATGTTGGATAATTAAAGATGTTTATACACTTAAAACCTAGGTCTGGAGTACCTTGCTCCTGG ACTCTCTAATAGAGCTGGGGTAATTAAATTACCAGAGGCTCCCTCCCCTGCCTTTGACCACCTTTGATCC AATGCAGGCTCTAAATCAAGCTCAAGGATCTTGGTGTGGAAACGGATTCTGAGGAAAGGCTACCCAATCT GACAGGAAGGGTGGATGCTCCCAGCCCCCAATGATAGGGGCTTCATCCACCTCCTCATTTCCTTGTAGGC TTAGAGCTTCCACGGGTCAATTATGCTCACAATGGAAAGCAATACCGATATGTCTTTGCTACAGGAGTTC AGTGGAGTCCAATCCCAACCAAGGTACTGGTCTCTGTGTATTCACAAGCCTTTCCTACAGTGATTGTGTC TATATGCAAAGCTGAATTCTAAGGTTCTGAGACGTTGATTAGAAAAGAGGAGGTCAGAAGGAGTAAGCCT AGGATAAAATAAATTTGAAGTAAGGATGTTCAGCTGGGAGAGGGAGTGGTACCTAATGGGCTAAGGTTCA GGTAAGAGGTTGTGGCTGGAGTTTATTCACTGATTTCTTTATTCAATACATATTTAATGAGCACCAATTA TGGGCTACAATGTGGTAGGCACTGAGGGTAAGGAAGTCAGCAGGGAGATTCCCAATCCCTGACCTAAGGA ACTCACCCTCTCCAGCAGAGAGGGTGTAGCTGAAACTTAGAGGATTTATTTTGCTTCTTTTTTTGTTTTG TTTTGTTTTTTCCTTTTTATTTAAAAAAAAAATACAGAAAGAGACAGAGTCTCATTGTGTTGTCCATGCC TGTCTTGAATTCCTAGGTTCAGGGGATCCTCCTGCCTCAGCCACCAAAAGTGCTGGATTACAGCCTCGAG CCACCATGCCTGGCCCATTTTGCTTCTTAAGCTACCATTTGTCAAACACTTACTGTGTTCTGGGCACTGT GCTAAGTGCTGTGCAGGTGTCACTTCTTTTTAATGTCTTCATTTTTCATAATAAAATGGAAAATCTTTTT TTTAAAATGCAAACAGAGCAGGAATGTACACAGCCAAAAATTAAGCCTCCACCCCTCCATACCCCAAGCC ACTCTCCACTAATCCCAAACCCCAGAGGGAAATAGGCCTATTGGGAGATTAAGAGAGATTCAGGGAATTG CACCCTTAAAGCAACAAAGGGGTTGTATTGTACTTTAAATGTTTGCATTGAATATATTCATTTATTTAAC TCATATAAAATTGCAGTGCAATTTCAAATACAAGATATGTTCGATATTTTTAGGCAGGGTGTGGTGGCTC ACGCCTGTAATCCTAGCACTTTGGGAGGCTGAGGATTGCTTGAGACCAGGAGTTCGAGACCAGCTTGGTC AACAATAGCAAGACCCTGTCTCTATATTAAAAAATAATAATAAATTTTAAAAGATTTTAATTTTTAAAAG AATTCCTTCTACAGTATCAGCTACGTGGTGGCCAGAGGACCCATGTTTAAAACTGGGGGAGGAGGCCGGG CGCGGTGGCTCACACCTGTAATCCCAGCATTCTGGGAGGCTGAGGTGGGCGGATCACCTGAGGTCAGGAG TTCAAGACCAACCTGGCTATGGTGAAACCCCGTCTCTACTAAAAATACAAAAAATCAGCCAGGTGTGGTG GCACACGCCTGTAATTCCAGCTACTCAGGAGGCTGAGGCAGGAGAATCACTTGAACCCGGGAGGCCGAGG TTGCAGTGAGCCAAGATCACGCCATTGCACTCCAGCCTGGGCAACAGCCTGGAAACTCCGTCTCAAAAAA CAAACAAACAAACAAAAAACTGGGGGAGGAGAGTTAGCTCCTGTCCTTTCTTGGCTGTGCTCACCAGAGG TAGCTGTCATTGGGAGACTACGTCAAAAGTCTACATCCGATGGGCTTCATCTCCTCTGTGTGGATCTTCA TGCACTCCTATTTGCAGAGAATAGTATTCTCTCAAACAAGTCATTTATGTGTTTTTCCTCGTTGGATGTA CAGATAATAAAATATGACATTCTCACAAAGTCATCCTTAAAATGGAGAGAGGACGACTGCTGGCCAGCGG AACCCCTGTTTGTGCCCGCGCCAGGTGCCAAGGATGAGGATGACGGTAAGACTCTAAGAAGCCACGCCTA GTTGCTGCACGTTACTGCAGATCGCCCTCCAACAGAGACACCATCTGGGGGCAGCTGACCCCCCCAGGTC ATAAAGGGGGTGGATTGGTGCTTTGAAGTGTACATCTGTCTGGGTCAAAGCTAAAGGGTGAGGGAGTCCC CAAGACCACCTTTACTTCTGATACCAATTGCAAAGTTTGAGGGTCCCCAAGATAGCCTTCAGCTTCAATA ATTCATTAAATCACCAACCTCACTGCAAGTGCTTATGTTCACAGTTCTGGTTTGTGGCAATGAAAAGATA CAGACTAAAATTAGCACAGGGAAGAGATGCACAAGACAGAGCCCAGCAGGGACCAGGCAGGAGCTTCCAG GTGCCTCTCCAAGTAGAGTCACAGATAGCACTGACTTCTCCCGACAATGACGTATGACAATACTCACCGA GTATTACTGCCAGCCAGGAAGCTCCCCTGAGACTCAGTATGGAGAGTTTTTATTGGGACTCAGTCATGTA AACATGGTTGACTGCCTGTGTGTCTGACCTTTATTTAGTCTTCAGTCCTCCTGGAGATCAAGTTCATACC ACACGGCACAAGGCCCCACCATAAATCCCACTGTAAGGGTAGACTGCCTGATGTGGCCCAAGGCCCCCAG GTATACAAAGATACTTGTATCAAGCAGGACATTCGACGGGTATAGAGGTGACCTCCCAGAAGCTGAGGAC AAAAGCCAGCCCCCTCTTTAGACAAGTTTAAGTTTTTTACCGCACAAAGTCCATCTCCTTTCCACTCAGT GACATTAAACTCTCTCAGAATGCAGAATCTTGGTTTTAAAATTGATTGCAGTGGCTGGATCCCAAACAAA TGTTTTTAAGAAATGGAGTCTTGCTCTGTTGCCCAGGCTGGAGTGTAGTGGCATGATCATAGCTCACTGC AGCCTCAAACTCCTGGGCTCAAGTGATCCTCCTGCCTCAGCCCACCAAGTAGCTGGAGCTACAGGGGCAC ACCACCATGCCTAGCTCATTCTTTTTATTTTTTTGTAAAGAAAGGGTCTCACTATGTTTCCCAGGCTGGT CTCAAACTCTTGGGCTCAAGCGATCCTCCCATCTTGGCCTCCCAAAGTGCTGGGATTACAGGTGTGAGCC AGTGCACCTGGCCTGGATCCCGGATCCAAATTTTTAACAATGTATAAGCATGTAAATGTTTCACAGAGCC GCTGGAAATGTGTATTTGTGGCCCACCTCTATTTTCTAGGTTTCCACTTGACTGAATGATGCTTTCCCTC TTCCATTCTCAGAAATGCTTCAGAAATGCCCTGCCCACAGCCCTGAGGAGGCTAAGGAGGGTAACTAGAA CCATAGGTGGGGATGCCACCTGGCCACACCAGCAATGGGGCTGCCACACCTGCAAGGAGGGCAGGCTGCC CCACTTGAGCCTGCCAGCTTCTTCCCTCAGGTCACAAGGGAGTGGTTTTCCACCTGGGCCTTGTCTTCCT ACTGATCATGGCATGGCACGCCAGGCCAGCAACCCTGTGTCACTGTCATCTCCAAGGCGGGGGACCACAG GCCTTGCCTCCTGTTCAGGTCGTTCTCCCACTCAGTGGGACACTTCCTTTACATTCTCTGTGAGGAGGGA GTATCGTTGTCTTCATTTTACCAATGGGATGCTCAGAGAGTGACCTTTTTGCCCAAGGTCACACACCCCT TACATTCAGAGGTAAGATTTAAATCCAGGCCAATCTGACCTCAACGATGCTCAACTGCTCTTCCACCTGG GACCCTCTGGAGGCATTGAGAGTATTTGCAGGAAGTTGATATGCATTATTTCATTTAACTCTCTATCCCT TCAGAGTGAGTATTGAGAGTATTTCCATTTTACAGAGGGGAAGGATGAGTTTAGTAGCACTGCTACATGT GCAAGAGATGAATTGGGCCCATTGAAATGCCATTCTTCAAGCCAGGTGCGGTGGTTCATGCCTGTAATCC CAGCACTTGGGAGGTCAAGGTAGGCAGATCGCTTGAGCCCAGGAGTCCAAGACCAGCATGGGCGATATAG GGAGACCCCATCTGACAAAAAATACAAAAATTAGCCAGACGTGGTGTCATGTGCCTGTAGTCCCAGCTAC TTGGAGGGCTGAAGTGGGAGGATAGCTTGAGCCCAAGAGATCGAGATTGCAGTGAGCTGTGATCACACCA CTGCACTCTAGCCTGGGCAACAGAGTAAGACCCTGTCTCAAAAAAGCAAAACAAACAAACAAAAAACCGA ATACCACTCTTCGATGCCTGCAATAATTTACAGAGTGCTTTCAAAATCCATCATTCAGGAGATACTCTCG GCAACCCTGTGGAGTGTAGGTGAGATTATCGCATCTCTACAGATGAAGAGACTGAGGCTCCGAGAGGTCA AGGGACTGGCCCAGCCAAGGGTAGAACCAGGTTTTCTGGTTTGTTCATTCGTTTGTTTGTTCGTTTGTTT TGAGGCCGTGTTTCACTCCGTCACCCAGGCTGGAATGCAATGGCACGATCTCGGCTCACCGCAACCTCCA CTCCCAGGTTCAAGTAATTCTCTGGCTTCAGTCTACTGAGTAGCTGAGATTACAAGCACCCACCACCACA CCCAGCTAATTTTTGTATTTTTAGTAGAGATGGGGTTTCACCACGTTGGCCAGACTGGTCTCAAACTCCT GATCTGAAGTGATCCGCCCACCTCTGCTCCCAAAGTGGCGGGATTACAGGCGTGAGCCACCGCGCCCGGC CTAGAACCAGGTTTTCTGATGCCTAGTTGCCAGGCCTTTCCCTTCTGTTACAGTGTCTCAAATTCACTCC CTCCTGTTTTGGTTAGATACATATGTTTAAAGAGGGCAGAGAGACATGCTGAGAAATTCATCCCTCCGAC TGAAGCCTGCACTTTTACGAAGTGTTTTTTTTCTGTTTCCCTAAAGGAGTAATCTTATCAGCCATTGTCT CTACTGATCCCCAAAAGCTGCCTTTTCTGCTCATTCTGGATGCCAAAAGCTTTACGGAATTGGCCCGTGC CTCTGTTGATGTCGATATGCACATGGATCTCCATGGATTATTCATTACAGACATGGACTGGGACACAAAA AAGCAGGCCGCTTCTGAGGAACAGCGGGACAGGGCTTCCGACTGCCACGGGGCTCCTCTGACCTGATGGT GTTGGGGTTTGGGTAGGGGAGGGGAGCTCGGCTGTCAGAACTCCATGGATATGTTTCTTTGGATGGAGGG GAGGGCCTTTGTTACCTTTTGCACTTATTCTTTCTGTGGGTGCTTTGACAAGGGCATGGCAAGAGAGCTT GTCAGTATCATTTCTTTCATTTTATTTTGGCTGTAAAAATTTTGTTTGAAAGTCAAACATTTGAACATCA AATATGTATTGATTAGATCCAGTCCTTCTAAGAAACCTCCTTTCCTTTAACAAAAAGACCTTGACCATGA ATCAGAGATTGTATTCAATGACATTATCATCATTTTTAGAACGAGCCACTAACCTATTAGAGAAGAGGCA GATAATTATTTATCATTGTGCCTTCCTCTGTCTCTTTCTCTTTCCTTTGCTCCCTCCCATGTTTCTGGTG GACTAAATTGTGTATCTGGGAGTTCTCACTTTCTAGCCAGGCCTGATGAGTTAAGTTACATGACCAGGAA GGTTATGCCACTTTGTGGTCATTCCATGCAAGTCATGGCGTAATATAAAATAATAAAAACTTTAAAGTCT G Download Select all
Length	52501
OMIM ID	605748
HGNC ID	HGNC:13815
Unigene ID	Hs.212172
Ensembl ID	ENSG00000135697
PharmGKB ID	-

mRNA Information

mRNA ID	XM_011523109.1
Exon	join(1..331,6834..6962,21035..21164,23495..23642, 25999..26146,29267..29490,31518..31775,48654..48765, 51707..52501)
mRNA Sequence	>53630 AACCTTTAACCAAACATCTTATAAGTAACGCCAGCGCAGCTTCCCTTGTGAATGTAAAGAGATC CAGGGCTCTTGGAGAGGGACAAGTGAGAGCCAGCCAAAAAGGAAAAAGCAAAGGCAGAAACGGC ATCAGGAGAGACAGAGATGTGAAGGAGGGAAGGAGCAGGAGAGCAGGAAGGAAACGCAGGAGGA GGGAGCAGCATCTCCTGTGAACACAGAGGAGCACCTGTTTGCTGTTAAAATCGATCTCCCTCGG CACCCTGAGCAATGGATATAATATTTGGCAGGAATAGGAAAGAACAGCTGGAGCCTGTGAGGGC CAAAGTGACAGGCAAGATTCCAGCATGGCTGCAGGGAACCCTGCTCCGCAATGGGCCTGGGATG CACACAGTTGGGGAGTCCAGATACAACCATTGGTTCGACGGCCTTGCCCTGCTCCACAGCTTCA CCATCAGAGACGGTGAAGTCTATTACAGGAGCAAATACCTGAGAAGCGATACCTACAACACCAA TATTGAGGCAAACAGGATTGTGGTGTCTGAGTTTGGAACAATGGCCTATCCGGACCCCTGCAAA AACATATTTTCCAAAGCTTTCTCCTACTTGTCTCACACCATCCCCGATTTCACCGACAACTGCC TGATCAACATCATGAAGTGCGGAGAAGACTTCTACGCGACCTCAGAGACCAATTACATCAGGAA AATCAACCCACAGACTCTGGAAACCCTGGAGAAGGTTGATTATCGTAAATACGTGGCGGTAAAT CTGGCAACGTCACATCCCCATTATGATGAGGCTGGAAATGTTCTAAACATGGGCACATCCATTG TGGAAAAGGGGAAGACAAAGTATGTGATTTTTAAGATCCCTGCCACAGTACCAGAGGGCAAGAA GCAGGGGAAGAGCCCCTGGAAGCACACAGAGGTGTTCTGCTCCATCCCATCCCGCTCCCTGCTC TCCCCAAGCTACTACCACAGCTTTGGAGTCACCGAGAACTATGTCATCTTCCTTGAGCAGCCTT TCAGGTTGGATATTCTCAAGATGGCAACCGCATACATCCGGAGAATGAGCTGGGCCTCCTGCCT GGCTTTCCACAGGGAGGAGAAGACTTATATCCACATCATCGACCAAAGGACCAGGCAGCCTGTG CAGACCAAGTTTTACACAGACGCCATGGTGGTCTTCCATCACGTCAACGCCTACGAAGAGGACG GCTGCATCGTGTTTGACGTCATTGCCTACGAGGACAACAGCCTCTACCAGCTCTTCTACCTGGC CAACCTGAACCAGGACTTCAAGGAGAACTCCAGGCTCACCTCGGTCCCCACCCTCAGGAGGTTT GCCGTGCCCCTCCACGTGGACAAGATAATAAAATATGACATTCTCACAAAGTCATCCTTAAAAT GGAGAGAGGACGACTGCTGGCCAGCGGAACCCCTGTTTGTGCCCGCGCCAGGTGCCAAGGATGA GGATGACGGAGTAATCTTATCAGCCATTGTCTCTACTGATCCCCAAAAGCTGCCTTTTCTGCTC ATTCTGGATGCCAAAAGCTTTACGGAATTGGCCCGTGCCTCTGTTGATGTCGATATGCACATGG ATCTCCATGGATTATTCATTACAGACATGGACTGGGACACAAAAAAGCAGGCCGCTTCTGAGGA ACAGCGGGACAGGGCTTCCGACTGCCACGGGGCTCCTCTGACCTGATGGTGTTGGGGTTTGGGT AGGGGAGGGGAGCTCGGCTGTCAGAACTCCATGGATATGTTTCTTTGGATGGAGGGGAGGGCCT TTGTTACCTTTTGCACTTATTCTTTCTGTGGGTGCTTTGACAAGGGCATGGCAAGAGAGCTTGT CAGTATCATTTCTTTCATTTTATTTTGGCTGTAAAAATTTTGTTTGAAAGTCAAACATTTGAAC ATCAAATATGTATTGATTAGATCCAGTCCTTCTAAGAAACCTCCTTTCCTTTAACAAAAAGACC TTGACCATGAATCAGAGATTGTATTCAATGACATTATCATCATTTTTAGAACGAGCCACTAACC TATTAGAGAAGAGGCAGATAATTATTTATCATTGTGCCTTCCTCTGTCTCTTTCTCTTTCCTTT GCTCCCTCCCATGTTTCTGGTGGACTAAATTGTGTATCTGGGAGTTCTCACTTTCTAGCCAGGC CTGATGAGTTAAGTTACATGACCAGGAAGGTTATGCCACTTTGTGGTCATTCCATGCAAGTCAT GGCGTAATATAAAATAATAAAAACTTTAAAGTCTG Download Select all
Length	2275

CDS Information

Location	join(268..331,6834..6962,21035..21164,23495..23642, 25999..26146,29267..29490,31518..31775,42216..42321, 46899..46993,48654..48765,51707..51936)
CDS Sequence	>lcl\|XM_011523109.1_cds_XP_011521411.1_1 [gene=BCO1] [protein=beta,beta-carotene 15,15'-monooxygenase isoform X1] [protein_id=XP_011521411.1] [location=268..1710] ATGGATATAATATTTGGCAGGAATAGGAAAGAACAGCTGGAGCCTGTGAGGGCCAAAGTGACAGGCAAGA TTCCAGCATGGCTGCAGGGAACCCTGCTCCGCAATGGGCCTGGGATGCACACAGTTGGGGAGTCCAGATA CAACCATTGGTTCGACGGCCTTGCCCTGCTCCACAGCTTCACCATCAGAGACGGTGAAGTCTATTACAGG AGCAAATACCTGAGAAGCGATACCTACAACACCAATATTGAGGCAAACAGGATTGTGGTGTCTGAGTTTG GAACAATGGCCTATCCGGACCCCTGCAAAAACATATTTTCCAAAGCTTTCTCCTACTTGTCTCACACCAT CCCCGATTTCACCGACAACTGCCTGATCAACATCATGAAGTGCGGAGAAGACTTCTACGCGACCTCAGAG ACCAATTACATCAGGAAAATCAACCCACAGACTCTGGAAACCCTGGAGAAGGTTGATTATCGTAAATACG TGGCGGTAAATCTGGCAACGTCACATCCCCATTATGATGAGGCTGGAAATGTTCTAAACATGGGCACATC CATTGTGGAAAAGGGGAAGACAAAGTATGTGATTTTTAAGATCCCTGCCACAGTACCAGAGGGCAAGAAG CAGGGGAAGAGCCCCTGGAAGCACACAGAGGTGTTCTGCTCCATCCCATCCCGCTCCCTGCTCTCCCCAA GCTACTACCACAGCTTTGGAGTCACCGAGAACTATGTCATCTTCCTTGAGCAGCCTTTCAGGTTGGATAT TCTCAAGATGGCAACCGCATACATCCGGAGAATGAGCTGGGCCTCCTGCCTGGCTTTCCACAGGGAGGAG AAGACTTATATCCACATCATCGACCAAAGGACCAGGCAGCCTGTGCAGACCAAGTTTTACACAGACGCCA TGGTGGTCTTCCATCACGTCAACGCCTACGAAGAGGACGGCTGCATCGTGTTTGACGTCATTGCCTACGA GGACAACAGCCTCTACCAGCTCTTCTACCTGGCCAACCTGAACCAGGACTTCAAGGAGAACTCCAGGCTC ACCTCGGTCCCCACCCTCAGGAGGTTTGCCGTGCCCCTCCACGTGGACAAGATAATAAAATATGACATTC TCACAAAGTCATCCTTAAAATGGAGAGAGGACGACTGCTGGCCAGCGGAACCCCTGTTTGTGCCCGCGCC AGGTGCCAAGGATGAGGATGACGGAGTAATCTTATCAGCCATTGTCTCTACTGATCCCCAAAAGCTGCCT TTTCTGCTCATTCTGGATGCCAAAAGCTTTACGGAATTGGCCCGTGCCTCTGTTGATGTCGATATGCACA TGGATCTCCATGGATTATTCATTACAGACATGGACTGGGACACAAAAAAGCAGGCCGCTTCTGAGGAACA GCGGGACAGGGCTTCCGACTGCCACGGGGCTCCTCTGACCTGA Download Select all
CCDS ID	CCDS10934.1

Protein Information

Protein ID	NP_059125.2
Protein Name	Beta-carotene 15,15'-monooxygenase 1
Molecular Wt. (Da)	62506
Protein Sequence	>53630 MDIIFGRNRKEQLEPVRAKVTGKIPAWLQGTLLRNGPGMHTVGESRYNHWFDGLALLHSFTIRD GEVYYRSKYLRSDTYNTNIEANRIVVSEFGTMAYPDPCKNIFSKAFSYLSHTIPDFTDNCLINI MKCGEDFYATSETNYIRKINPQTLETLEKVDYRKYVAVNLATSHPHYDEAGNVLNMGTSIVEKG KTKYVIFKIPATVPEGKKQGKSPWKHTEVFCSIPSRSLLSPSYYHSFGVTENYVIFLEQPFRLD ILKMATAYIRRMSWASCLAFHREEKTYIHIIDQRTRQPVQTKFYTDAMVVFHHVNAYEEDGCIV FDVIAYEDNSLYQLFYLANLNQDFKENSRLTSVPTLRRFAVPLHVDKNAEVGTNLIKVASTTAT ALKEEDGQVYCQPEFLYEGLELPRVNYAHNGKQYRYVFATGVQWSPIPTKIIKYDILTKSSLKW REDDCWPAEPLFVPAPGAKDEDDGVILSAIVSTDPQKLPFLLILDAKSFTELARASVDVDMHMD LHGLFITDMDWDTKKQAASEEQRDRASDCHGAPLT Download Select all
Length	547
Uniprot ID	P11487
Ensembl Protein ID	ENSP00000334122

Post-translational Modification Information (Source : HPRD)

No matching records could be found.

Enzyme Information

EC	1.14.99.36
Name	beta-carotene 15,15'-monooxygenase beta-carotene 15,15'-dioxygenase (misleading) carotene dioxygenase (misleading) carotene 15,15'-dioxygenase (misleading) BCMO1 (gene name) BCDO (misleading)
Class	Oxidoreductases; Acting on paired donors, with O2 as oxidant and incorporation or reduction of oxygen. The oxygen incorporated need not be derived from O2; Miscellaneous
Sysname	beta-carotene:oxygen 15,15'-oxidoreductase (15,15'-epoxidizing, bond-cleaving)
Substrate	beta-carotene [CPD:C02094]; O2 [CPD:C00007]; AH2 [CPD:C00030]; beta-carotene 15,15'-epoxide; H2O [CPD:C00001]; 15,15'-dihydroxy-beta-carotene [CPD:C20332]; A
Product	all-trans-retinal [CPD:C00376]; beta-carotene 15,15'-epoxide; H2O [CPD:C00001]; A [CPD:C00028]; 15,15'-dihydroxy-beta-carotene [CPD:C20332]; AH2
Reaction (IUBMB)

PPi Information

(Click to view network : Source STRING) View

No matching records from HPRD source could be found.

Pathway Information

Pathway Name	Pathway ID
Metabolic pathways	hsa01100
Retinol metabolism	hsa00830

Structure Information

No matching records could be found.

Domain Information

ID	Location	Description
pfam03055	5-520	RPE65
cl10080	5-520	RPE65 superfamily
COG3670	20-521	COG3670
PLN02491	10-520	PLN02491
PLN02969	4-517	PLN02969
PLN02258	15-529	PLN02258

Ontology Information

HPRD ID	3665
Molecular Class	Enzyme: Oxygenase
Molecular Function	Growth factor activity (GO:0008083)
Biological Process	Cell communication (GO:0007154); Signal transduction (GO:0007165)

SNP Information

View SNP Geneview Report

Drug Information

No matching records could be found.

External Links

ArrayExpress GO
ICGC GO
Cancer3D GO
COSMIC GO
NCG GO
TSGene GO
Tumor Gene Family of Databases GO
CCDB GO
G2SBC GO
Osteosarcoma Database GO
RCDB GO

ArrayExpress	GO
ICGC	GO
Cancer3D	GO
COSMIC	GO
NCG	GO
TSGene	GO
Tumor Gene Family of Databases	GO
CCDB	GO
G2SBC	GO
Osteosarcoma Database	GO
RCDB	GO