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General Information
- Evidence
- Gene
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- Enzyme
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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 23838134 | 2013 | Cell line : - Source : - Sample Type : Population based case control study No. of Sample : Cohort 1 consisted of 99 controls and 97 CRC patients, whereas cohort 2 consisted of 47 controls and 91 CRC patients Stage : - | ELISA | Down-regulation | - | The serum levels of BDNF were significantly lower in colorectal cancer patients when compared to a control population. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Endogenous ligands |
| Description | The protein encoded by this gene is a member of the nerve growth factor family. It is induced by cortical neurons, and is necessary for survival of striatal neurons in the brain. Expression of this gene is reduced in both Alzheimer's and Huntington disease patients. This gene may play a role in the regulation of stress response and in the biology of mood disorders. Multiple transcript variants encoding distinct isoforms have been described for this gene. | Chromosome | 11 |
| Location | 11p14.1 |
| Start | 27654893 |
| End | 27722058 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 67166 |
| OMIM ID | 113505 |
| HGNC ID | HGNC:1033 |
| Unigene ID | Hs.502182 |
| Ensembl ID | ENSG00000176697 |
| PharmGKB ID | - |
mRNA Information
| mRNA ID | NM_170731.4 |
|---|---|
| Exon | join(1..647,63474..67166) | mRNA Sequence | Download Select all |
| Length | 3827 |
CDS Information
| Location | join(645..647,63474..64238) |
|---|---|
| CDS Sequence | Download Select all |
| CCDS ID | CCDS7865.1 |
Protein Information
| Protein ID | NP_001137277.1 |
|---|---|
| Protein Name | brain-derived neurotrophic factor |
| Molecular Wt. (Da) | 25766 |
| Protein Sequence | Download Select all |
| Length | 247 |
| Uniprot ID | P10071 |
| Ensembl Protein ID | ENSP00000379258 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| T | Proteolytic Cleavage | 57 |
| T | Proteolytic Cleavage | 65 |
| T | Proteolytic Cleavage | 57 |
| T | Proteolytic Cleavage | 57 |
| T | Proteolytic Cleavage | 57 |
| T | Proteolytic Cleavage | 57 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 1363 | CPE | 272 | NP_001864.1 | in vitro | 15664176 |
| 6272 | SORT1 | 3910 | NP_002950.3 | in vitro;in vivo | 15987945 |
| 93664 | CADPS2 | 12996 | NP_060424.9 | in vitro;in vivo | 14715936 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Alcoholism | hsa05034 |
| cAMP signaling pathway | hsa04024 |
| Cocaine addiction | hsa05030 |
| Huntington's disease | hsa05016 |
| MAPK signaling pathway | hsa04010 |
| Neurotrophin signaling pathway | hsa04722 |
Structure Information
| PDB ID | 1B8M |
|---|---|
| Resolution | 2.75 |
| Method | X-RAY DIFFRACTION |
| Chains | A |
| Molecule | PROTEIN (BRAIN DERIVED NEUROTROPHIC FACTOR) |
| Model | View |
Domain Information
| ID | Location | Description |
|---|---|---|
| pfam00243 | 130-247 | NGF |
| cl02481 | 130-247 | NGF superfamily |
| smart00140 | 133-240 | NGF |
Ontology Information
| HPRD ID | 756 |
|---|---|
| Molecular Class | Ligand |
| Molecular Function | GTPase activity (GO:0003924) |
| Biological Process | Cell communication (GO:0007154); Signal transduction (GO:0007165) |
Drug Information
No matching records could be found.