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General Information
- Evidence
- Gene
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- Enzyme
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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 25196438 | 2014 | Cell line : Colo201, Colo205, DLD 1, HCT 15, HCT 116, HT 29, KM 12, SW 480, and SW 620 Source : Affiliated Hospital of Kanagawa Cancer Center Sample Type : CRC tumor No. of Sample : CRC 589, norma ltissue 550, adjacent adenoma 139, lymph nodes 195 and livers 48 with metastasis Stage : TNM Stage I-IV | RT-PCR ,Western blotting, Immunohistochemistry and in situ hybridization | Up-regulation | - | Beclin 1 expression is closely linked to colorectal carcinogenesis and distant metastasis of colorectal carcinoma. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | This gene encodes a protein that regulates autophagy, a catabolic process of degradation induced by starvation. The encoded protein is a component of the phosphatidylinositol-3-kinase (PI3K) complex which mediates vesicle-trafficking processes. This protein is thought to play a role in multiple cellular processes, including tumorigenesis, neurodegeneration and apoptosis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015] | Chromosome | 17 |
| Location | 17q21 |
| Start | 40962150 |
| End | 40976310 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 14161 |
| OMIM ID | 604378 |
| HGNC ID | HGNC:1034 |
| Unigene ID | Hs.716464 |
| Ensembl ID | ENSG00000126581 |
| PharmGKB ID | PA25337 |
Protein Information
| Protein ID | NP_001300927.1 |
|---|---|
| Protein Name | beclin 1, autophagy related |
| Molecular Wt. (Da) | 0 |
| Protein Sequence | Download Select all |
| Length | 450 |
| Uniprot ID | Q13007 |
| Ensembl Protein ID | ENSP00000294984 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| T | Phosphorylation | 62 |
| S | Phosphorylation | 64 |
| T | Phosphorylation | 57 |
| T | Phosphorylation | 38 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 596 | BCL2 | 1045 | NP_000624.2 | in vitro;in vivo;yeast 2-hybrid | 9765397 |
| 598 | BCL2L1 | 2497 | NP_612815.1 | in vitro;in vivo;yeast 2-hybrid | 9765397 |
| 7514 | XPO1 | 3975 | NP_003391.1 | in vitro;in vivo | 11309306 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Regulation of autophagy | hsa04140 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| pfam15285 | 105-129 | BH3 |
| cl21133 | 105-129 | BH3 superfamily |
| pfam12777 | 196-269 | MT |
| cl15084 | 196-269 | MT superfamily |
| pfam04111 | 135-450 | APG6 |
| COG1196 | 145-266 | Smc |
| COG1196 | 137-266 | Smc |
| TIGR02168 | 145-266 | SMC_prok_B |
| pfam13851 | 196-275 | GAS |
| COG1196 | 141-266 | Smc |
| TIGR02169 | 166-266 | SMC_prok_A |
| TIGR02168 | 145-308 | SMC_prok_B |
| COG4942 | 208-266 | EnvC |
| COG1196 | 142-265 | Smc |
| pfam04156 | 142-254 | IncA |
| PRK11448 | 112-247 | hsdR |
| TIGR02169 | 144-265 | SMC_prok_A |
| COG4372 | 196-264 | COG4372 |
Ontology Information
| HPRD ID | 6440 |
|---|---|
| Molecular Class | Adapter molecule |
| Molecular Function | Molecular function unknown (GO:0005554) |
| Biological Process | Signal transduction (GO:0007165) |
Drug Information
No matching records could be found.