Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| BIK | 638 | BCL2-interacting killer (apoptosis-inducing) | 22 | NBK |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 15180185 | 2004 | Cell line : SW620-MDR Source : - Sample Type : - No. of Sample : - Stage : - | Northern hybridization,real time RT-PCR | Down-regulation | - | In the SW620-MDR cell line the pro-apoptosis genes, CASP4, BIK, PDCD2, and TACE were expressed with decreased levels. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | The protein encoded by this gene shares a critical BH3 domain with other death-promoting proteins, such as BID, BAK, BAD and BAX, that is required for its pro-apoptotic activity, and for interaction with anti-apoptotic members of the BCL2 family, and viral survival-promoting proteins. Since the activity of this protein is suppressed in the presence of survival-promoting proteins, it is suggested as a likely target for anti-apoptotic proteins. [provided by RefSeq, Sep 2011] | Chromosome | 22 |
| Location | 22q13.31 |
| Start | 43506754 |
| End | 43525718 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 18965 |
| OMIM ID | 603392 |
| HGNC ID | HGNC:1051 |
| Unigene ID | Hs.475055 |
| Ensembl ID | ENSG00000100290 |
| PharmGKB ID | PA25354 |
mRNA Information
| mRNA ID | NM_001197.4 |
|---|---|
| Exon | join(1..56,13269..13436,16950..17048,17749..17878, 18466..18965) | mRNA Sequence | Download Select all |
| Length | 966 |
Protein Information
| Protein ID | NP_001188.1 |
|---|---|
| Protein Name | BCL2-interacting killer (apoptosis-inducing) |
| Molecular Wt. (Da) | 17885 |
| Protein Sequence | Download Select all |
| Length | 160 |
| Uniprot ID | P09238 |
| Ensembl Protein ID | ENSP00000279441 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 596 | BCL2 | 1045 | NP_000624.2 | in vitro;in vivo | 128 534 739 525 867 000 000 000 000 000 |
| 597 | BCL2A1 | 3034 | NP_004040.1 | in vivo | 10381646 |
| 598 | BCL2L1 | 2497 | NP_612815.1 | in vitro;in vivo | 1 134 261 912 853 470 000 000 000 000 000 |
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Ontology Information
| HPRD ID | 1705 |
|---|---|
| Molecular Class | Adapter molecule |
| Molecular Function | Metallopeptidase activity (GO:0008237) |
| Biological Process | Protein metabolism (GO:0019538) |
Drug Information
No matching records could be found.