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General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| BIRC3 | 330 | baculoviral IAP repeat containing 3 | 11 | cIAP2, hiap-1, MIHC, RNF49, MALT2, c-IAP2 |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 14708638 | 2003 | Cell line : HT 29 (mutated
p53), HCT 116 (wild-type p53), SW 480, and SW 620
(mutated p53) Source : ATCC Sample Type : - No. of Sample : - Stage : - | - | Up-regulation | - | - |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Baculoviral IAP repeat containing, "RING-type (C3HC4) zinc fingers" |
| Description | This gene encodes a member of the IAP family of proteins that inhibit apoptosis by binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2, probably by interfering with activation of ICE-like proteases. The encoded protein inhibits apoptosis induced by serum deprivation but does not affect apoptosis resulting from exposure to menadione, a potent inducer of free radicals. It contains 3 baculovirus IAP repeats and a ring finger domain. Transcript variants encoding the same isoform have been identified. [provided by RefSeq, Aug 2011] | Chromosome | 11 |
| Location | 11q22 |
| Start | 102188181 |
| End | 102210134 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 21954 |
| OMIM ID | 601721 |
| HGNC ID | HGNC:591 |
| Unigene ID | Hs.127799 |
| Ensembl ID | - |
| PharmGKB ID | PA25360 |
mRNA Information
| mRNA ID | XM_011542797.1 |
|---|---|
| Exon | join(1..199,8094..8193,10680..10758,11525..11573, 13627..13869,18594..18848,19388..19429,19537..21950) | mRNA Sequence | Download Select all |
| Length | 3381 |
Protein Information
| Protein ID | XP_011541099.1 |
|---|---|
| Protein Name | baculoviral IAP repeat containing 3 |
| Molecular Wt. (Da) | 42758 |
| Protein Sequence | Download Select all |
| Length | 381 |
| Uniprot ID | P51608 |
| Ensembl Protein ID | ENSP00000301948 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 836 | CASP3 | 2799 | NP_004337.2 | in vitro | 9384571 |
| 2935 | GSPT1 | 753 | NP_002085.2 | in vitro | 12865429 |
| 7185 | TRAF1 | 3418 | NP_005649.1 | in vitro | 11907583 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Apoptosis | hsa04210 |
| Focal adhesion | hsa04510 |
| NF-kappa B signaling pathway | hsa04064 |
| NOD-like receptor signaling pathway | hsa04621 |
| Pathways in cancer | hsa05200 |
| Small cell lung cancer | hsa05222 |
| TNF signaling pathway | hsa04668 |
| Toxoplasmosis | hsa05145 |
| Transcriptional misregulation in cancer | hsa05202 |
| Ubiquitin mediated proteolysis | hsa04120 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd08329 | 441-530 | CARD_BIRC2_BIRC3 |
| cl14633 | 441-530 | DD superfamily |
| cd00022 | 256-322 | BIR |
| cl00035 | 256-322 | BIR superfamily |
| cd00022 | 171-237 | BIR |
| cl00035 | 171-237 | BIR superfamily |
| cd00022 | 32-98 | BIR |
| cl00035 | 32-98 | BIR superfamily |
| cd00162 | 556-595 | RING |
| cl17238 | 556-595 | RING superfamily |
| smart00238 | 254-322 | BIR |
| smart00238 | 168-237 | BIR |
| smart00238 | 28-98 | BIR |
| pfam00653 | 258-323 | BIR |
| pfam00653 | 172-236 | BIR |
| pfam00653 | 32-97 | BIR |
| smart00114 | 441-527 | CARD |
| pfam00619 | 446-528 | CARD |
| cd14394 | 377-411 | UBA_BIRC2_3 |
| cl21463 | 377-411 | UBA_like_SF superfamily |
| pfam13920 | 553-598 | zf-C3HC4_3 |
| cd01671 | 447-525 | CARD |
| cd14321 | 380-410 | UBA_IAPs |
| pfam13923 | 557-591 | zf-C3HC4_2 |
| cd08330 | 447-525 | CARD_ASC_NALP1 |
| cd08323 | 449-514 | CARD_APAF1 |
| cd08325 | 464-525 | CARD_CASP1-like |
| smart00184 | 557-591 | RING |
| cd14396 | 380-410 | UBA_XtBIRC7_like |
| cd08788 | 460-518 | CARD_NOD2_2_CARD15 |
| pfam13639 | 555-592 | zf-RING_2 |
| pfam14634 | 557-593 | zf-RING_5 |
Ontology Information
| HPRD ID | 3442 |
|---|---|
| Molecular Class | Enzyme: Ligase |
| Molecular Function | Transcription factor activity (GO:0003700) |
| Biological Process | Regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism (GO:0019219) |
Drug Information
No matching records could be found.