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General Information
- Evidence
- Gene
- mRNA
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- Protein
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- Enzyme
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- Domain
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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 23001810 | 2012 | Cell line : - Source : - Sample Type : Mouse model No. of Sample : - Stage : - | Gene expression profiling | Methylation | - | Low folate increased Ppara and Aldh1a1 expression, and decreased Bcmo1, Sprr2a, and Bmp5 expression in BALB/c, compared to BALB/c on control diets. Bcmo1, Ppara, and Bmp5 showed differential DNA methylation related to strain, diet, and/or Mthfr genotype. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Bone morphogenetic proteins |
| Description | This gene encodes a member of the bone morphogenetic protein family which is part of the transforming growth factor-beta superfamily. The superfamily includes large families of growth and differentiation factors. Bone morphogenetic proteins were originally identified by an ability of demineralized bone extract to induce endochondral osteogenesis in vivo in an extraskeletal site. These proteins are synthesized as prepropeptides, cleaved, and then processed into dimeric proteins. This protein may act as an important signaling molecule within the trabecular meshwork and optic nerve head, and may play a potential role in glaucoma pathogenesis. This gene is differentially regulated during the formation of various tumors. [provided by RefSeq, Jul 2008] | Chromosome | 6 |
| Location | 6p12.1 |
| Start | 55753653 |
| End | 55875593 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 121941 |
| OMIM ID | 112265 |
| HGNC ID | HGNC:1072 |
| Unigene ID | Hs.296648 |
| Ensembl ID | ENSG00000112175 |
| PharmGKB ID | - |
mRNA Information
| mRNA ID | XM_011514816.1 |
|---|---|
| Exon | join(1..1218,55747..55939,81167..81315,101351..101545, 115061..115137,119912..121941) | mRNA Sequence | Download Select all |
| Length | 2207 |
CDS Information
| Location | join(729..1218,55747..55939,81167..81315,101351..101545, 115061..115137,116479..116589,119912..120061) |
|---|---|
| CDS Sequence | Download Select all |
| CCDS ID | CCDS4958.1 |
Protein Information
| Protein ID | NP_066551.1 |
|---|---|
| Protein Name | Bone morphogenetic protein 5 |
| Molecular Wt. (Da) | 51606 |
| Protein Sequence | Download Select all |
| Length | 454 |
| Uniprot ID | P03950 |
| Ensembl Protein ID | ENSP00000336762 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| T | Phosphorylation | 4 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View (Click to view network : Source STRING) View
No matching records from HPRD source could be found.
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Hippo signaling pathway | hsa04390 |
| TGF-beta signaling pathway | hsa04350 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| smart00204 | 353-454 | TGFB |
| cl02510 | 353-454 | TGF_beta superfamily |
| pfam00019 | 350-454 | TGF_beta |
| pfam00688 | 28-304 | TGFb_propeptide |
| cl02928 | 28-304 | TGFb_propeptide superfamily |
| PHA02913 | 353-453 | PHA02913 |
Ontology Information
| HPRD ID | 105 |
|---|---|
| Molecular Class | Ligand |
| Molecular Function | Ribonuclease activity (GO:0004540) |
| Biological Process | Regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism (GO:0019219) |
Drug Information
No matching records could be found.