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General Information
- Evidence
- Gene
- mRNA
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- Protein
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- Enzyme
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- Domain
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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 18259822 | 2008 | Cell line : - Source : Department of Surgical Oncology,Medical Institute of Bioregulation, Kyushu University Beppu, Japan. Sample Type : CRC tumor and normal tissues No. of Sample : 65 Stage : - | real-time RT-PCR,immunohistochemistry | Up-regulation | - | Expression of BMP7 in colorectal tumors correlates with parameters of pathological aggressiveness such as liver metastasis and poor prognosis. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Bone morphogenetic proteins, "Endogenous ligands" |
| Description | This gene encodes a member of the transforming growth factor-beta (TGF-beta) family of proteins. The encoded preproprotein is proteolytically processed to generate each subunit of the mature homodimer, which plays a role in bone, kidney and brown adipose tissue development. This protein induces ectopic bone formation and may promote fracture healing in human patients. [provided by RefSeq, Nov 2015] | Chromosome | 20 |
| Location | 20q13 |
| Start | 55743809 |
| End | 55841707 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 97899 |
| OMIM ID | 112267 |
| HGNC ID | HGNC:1074 |
| Unigene ID | Hs.473163 |
| Ensembl ID | ENSG00000101144 |
| PharmGKB ID | PA25384 |
mRNA Information
| mRNA ID | NM_001719.2 |
|---|---|
| Exon | join(1..947,38231..38423,64029..64177,82733..82930, 91645..91721,93342..93452,95544..97899) | mRNA Sequence | Download Select all |
| Length | 4049 |
Protein Information
| Protein ID | NP_001710.1 |
|---|---|
| Protein Name | bone morphogenetic protein 7 |
| Molecular Wt. (Da) | 0 |
| Protein Sequence | Download Select all |
| Length | 431 |
| Uniprot ID | P51511 |
| Ensembl Protein ID | ENSP00000219271 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| C | Disulfide Bridge | 330;396 |
| C | Disulfide Bridge | 359;428 |
| C | Disulfide Bridge | 363;430 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 90 | ACVR1 | 21 | NP_001096.1 | in vivo | 8006002 |
| 92 | ACVR2A | 25 | NP_001607.1 | in vitro;in vivo | 974 822 812 667 445 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Cytokine-cytokine receptor interaction | hsa04060 |
| Hippo signaling pathway | hsa04390 |
| TGF-beta signaling pathway | hsa04350 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| pfam00688 | 34-280 | TGFb_propeptide |
| cl02928 | 34-280 | TGFb_propeptide superfamily |
| smart00204 | 330-431 | TGFB |
| cl02510 | 330-431 | TGF_beta superfamily |
| pfam00019 | 328-431 | TGF_beta |
| PHA02913 | 330-430 | PHA02913 |
Ontology Information
| HPRD ID | 3486 |
|---|---|
| Molecular Class | Ligand |
| Molecular Function | Metallopeptidase activity (GO:0008237) |
| Biological Process | Protein metabolism (GO:0019538) |
Drug Information
No matching records could be found.