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General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| BNIP2 | 663 | BCL2/adenovirus E1B 19kDa interacting protein 2 | 15 | Nip2, BNIP-2 |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 21242194 | 2011 | Cell line : SW620, SW480 Source : - Sample Type : - No. of Sample : - Stage : - | real time RT-PCR, western blotting, Fluorescence reporter assays | Down-regulation | - | Endogenous BNIP2 mRNA and BNIP2 protein levels were inversely related to miR-20a levels . |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | This gene is a member of the BCL2/adenovirus E1B 19 kd-interacting protein (BNIP) family. It interacts with the E1B 19 kDa protein, which protects cells from virally-induced cell death. The encoded protein also interacts with E1B 19 kDa-like sequences of BCL2, another apoptotic protector. [provided by RefSeq, Mar 2011] | Chromosome | 15 |
| Location | 15q21.3 |
| Start | 59951345 |
| End | 59981728 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 30384 |
| OMIM ID | 603292 |
| HGNC ID | HGNC:1083 |
| Unigene ID | Hs.592515 |
| Ensembl ID | ENSG00000140299 |
| PharmGKB ID | PA25393 |
mRNA Information
| mRNA ID | XM_011521955.1 |
|---|---|
| Exon | join(1..395,7016..7122,9222..9289,11443..11619, 16791..16893,18216..18347,20168..20254,20540..20638, 21392..21427,25410..30384) | mRNA Sequence | Download Select all |
| Length | 6179 |
Protein Information
| Protein ID | XP_011520257.1 |
|---|---|
| Protein Name | BCL2/adenovirus E1B 19kDa interacting protein 2 |
| Molecular Wt. (Da) | 43959 |
| Protein Sequence | Download Select all |
| Length | 388 |
| Uniprot ID | Q99966 |
| Ensembl Protein ID | ENSP00000246139 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| S | Phosphorylation | 235;- |
| T | Phosphorylation | 237 |
| T | Phosphorylation | 240 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 392 | ARHGAP1 | 4108 | NP_004299.1 | in vitro;in vivo;yeast 2-hybrid | 1 095 471 110 551 880 |
| 596 | BCL2 | 1045 | NP_000624.2 | in vitro;yeast 2-hybrid | 129 018 807 954 800 |
| 998 | CDC42 | 309 | NP_001782.1 | in vitro;in vivo;yeast 2-hybrid | 109 547 111 079 952 000 000 000 |
| 2260 | FGFR1 | 634 | NP_000595.1 | in vitro;in vivo | 10551883 |
| 10488 | CREB3 | 7339 | AAC04325.1 | yeast 2-hybrid | 16189514 |
| 149428 | BNIPL | 16557 | NP_612122.2 | yeast 2-hybrid | 12901880 |
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd00170 | 147-290 | SEC14 |
| cl15787 | 147-290 | SEC14 superfamily |
| pfam12496 | 47-163 | BNIP2 |
| cl13877 | 47-163 | BNIP2 superfamily |
| smart00516 | 147-295 | SEC14 |
| pfam13716 | 165-305 | CRAL_TRIO_2 |
| pfam00650 | 188-290 | CRAL_TRIO |
Ontology Information
| HPRD ID | 389 |
|---|---|
| Molecular Class | GTPase activating protein |
| Molecular Function | DNA repair protein (GO:0003685) |
| Biological Process | Regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism (GO:0019219) |
Drug Information
No matching records could be found.