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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
BPTF 2186 bromodomain PHD finger transcription factor  17FAC1, NURF301 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
25716692   2015Cell line : -

Source : -

Sample Type : CRC tumor and normal tissue

No. of Sample : 20 pairs of CRC and non-tumor adjacent tissues,105 cases of paraffin-embedded primary CRC specimens

Stage : -

Real-time PCR and Western blotting, immunohistochemistryUp-regulation-High BPTF expression was significantly correlated with tumor progression and may be a potent prognostic marker of CRC.


Gene Details



NC_000017.10 (65821644..65980494)

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Gene Type protein coding
Gene Family Zinc fingers, PHD-type
Description This gene was identified by the reactivity of its encoded protein to a monoclonal antibody prepared against brain homogenates from patients with Alzheimer's disease. Analysis of the original protein (fetal Alz-50 reactive clone 1, or FAC1), identified as an 810 aa protein containing a DNA-binding domain and a zinc finger motif, suggested it might play a role in the regulation of transcription. High levels of FAC1 were detected in fetal brain and in patients with neurodegenerative diseases. The protein encoded by this gene is actually much larger than originally thought, and it also contains a C-terminal bromodomain characteristic of proteins that regulate transcription during proliferation. The encoded protein is highly similar to the largest subunit of the Drosophila NURF (nucleosome remodeling factor) complex. In Drosophila, the NURF complex, which catalyzes nucleosome sliding on DNA and interacts with sequence-specific transcription factors, is necessary for the chromatin remodeling required for transcription. Two alternative transcripts encoding different isoforms have been described completely. [provided by RefSeq, Jul 2008]  
Chromosome 17
Location 17q24
Start 65821644  
End 65980494  
Strand +  
Gene Sequence

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Length 158851  
OMIM ID 601819   
HGNC ID HGNC:3581   
Unigene ID Hs.444200   
Ensembl ID ENSG00000171634   
PharmGKB ID PA162377557   

mRNA Information


mRNA ID XM_005257150.2
Exon join(1..810,28413..29235,40937..41160,49290..49493, 50029..50217,60601..60789,66317..66507,67843..68198, 68507..68638,78262..78391,79175..79313,84055..84234, 85350..87660,93187..93311,94488..94616,97313..97463, 99020..99062,102828..103074,103432..103593,103809..103960, 106384..106492,114912..115129,118623..118845, 119882..120798,122199..122281,122554..122779, 134014..134348,137806..137979,138685..138877, 141045..141129,150245..150431,156725..158849)  
mRNA Sequence

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Length 11762  



CDS Information


   
Location 198..9674
CDS Sequence

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CCDS ID CCDS11673.1



Protein Information


      
Protein IDXP_005257207.1
Protein Namebromodomain PHD finger transcription factor
Molecular Wt. (Da)350137
Protein Sequence

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Length 3158  
Uniprot IDQ16647
Ensembl Protein ID ENSP00000244043  



Post-translational Modification Information (Source : HPRD)


Residue Type site
SPhosphorylation216
SPhosphorylation637
SPhosphorylation216
SPhosphorylation763
SPhosphorylation691;-
SPhosphorylation817;-
SPhosphorylation572;-
SPhosphorylation572;-
SPhosphorylation1171;-
SPhosphorylation1297;-
TPhosphorylation1177;-
TPhosphorylation1303;-
TPhosphorylation938;-
TPhosphorylation1064;-
SPhosphorylation2244;-
SPhosphorylation2370;-
SPhosphorylation1707;-
SPhosphorylation1701;-
SPhosphorylation1833;-
SPhosphorylation1827;-
SPhosphorylation2483
SPhosphorylation2491
SPhosphorylation1174
SPhosphorylation1300
SPhosphorylation1972
SPhosphorylation2098
SPhosphorylation1105
SPhosphorylation1231
TPhosphorylation1586
TPhosphorylation1589
TPhosphorylation1590
TPhosphorylation1712
TPhosphorylation1715
TPhosphorylation1716
KAcetylation754
KAcetylation880
KAcetylation2737
KAcetylation2720
SPhosphorylation601
SPhosphorylation601
SGlycosylation1623
TGlycosylation1627
SGlycosylation1749
TGlycosylation1753
TGlycosylation1968
TGlycosylation2094
SGlycosylation1955
SGlycosylation2081
TGlycosylation1977
TGlycosylation2103
SPhosphorylation1184
SPhosphorylation1310
TPhosphorylation1637
TPhosphorylation1763
SPhosphorylation1145
SPhosphorylation1271
TPhosphorylation1545
TPhosphorylation1671
SPhosphorylation2241
SPhosphorylation2367

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

                              
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
4150MAZ2999NP_001036004.1in vitro;in vivo;yeast 2-hybrid10727212   
9817KEAP112079NP_036421.2in vitro;in vivo;yeast 2-hybrid15379550   


Pathway Information


No matching records could be found.

Structure Information


No matching records could be found.

Domain Information




ID Location Description
cd055092931-3031  Bromo_gcn5_like
cl025562931-3031  Bromodomain superfamily
cd155602869-2915  PHD2_3_BPTF
cl228512869-2915  PHD_SF superfamily
cd15559392-434  PHD1_BPTF
cl22851392-434  PHD_SF superfamily
cd043692936-3028  Bromodomain
smart002972928-3029  BROMO
pfam004392936-3018  Bromodomain
cd054982936-3027  Bromo_Brdt_II_like
cd055032939-3024  Bromo_BAZ2A_B_like
pfam02791240-300  DDT
cl02674240-300  DDT superfamily
cd055042936-3029  Bromo_Acf1_like
cd055102930-3021  Bromo_SPT7_like
cd054992940-3024  Bromo_BDF1_2_II
cd055002938-3028  Bromo_BDF1_2_I
cd155542869-2915  PHD_PHF2_like
cd054972936-3029  Bromo_Brdt_I_like
cd055062940-3024  Bromo_plant1
cd055112949-3021  Bromo_TFIID
smart00571240-299  DDT
cd055022928-3029  Bromo_tif1_like
cd15532393-434  PHD2_CHD_II
cd055122936-3017  Bromo_brd1_like
cd160392869-2915  PHD_SPP1
cd055282936-3012  Bromo_AAA
cd155532869-2915  PHD_Cfp1
cd155522869-2915  PHD_PHF3_like
cd156402869-2916  PHD_KDM7
cd156412869-2918  PHD_PHF2
cd055182952-3028  Bromo_polybromo_IV
cd055052932-3028  Bromo_WSTF_like
cd156422868-2918  PHD_PHF8
cd15541393-434  PHD_TIF1_like
cd055152946-3030  Bromo_polybromo_V
cd054952919-3028  Bromo_cbp_like
cd156392867-2915  PHD_DIDO1_like
pfam00628393-437  PHD
cd054942932-2980  Bromodomain_1
cd15533393-434  PHD1_PHF12
cd15523393-434  PHD_PHF21A
cd15539392-434  PHD1_AIRE
cd055192952-3027  Bromo_SNF2
cd055132934-3020  Bromo_brd7_like
cd15535393-434  PHD1_Rco1
cd154892869-2915  PHD_SF
cd15544393-434  PHD_BAZ1A_like
cd054962951-3040  Bromo_WDR9_II
cd15567393-434  PHD4_NSD
cd055222935-3024  Bromo_Rsc1_2_II
cd156132872-2915  PHD_AL_plant
smart00249393-434  PHD
smart002492869-2915  PHD
cd156102872-2915  PHD3_KDM5A_like
cd15623393-434  PHD_TIF1beta
cd15489392-434  PHD_SF
cd15531392-434  PHD1_CHD_II
cd155222869-2915  PHD_TAF3
cd15627393-434  PHD_BAZ1A
cd055072939-3010  Bromo_brd8_like
cd15543393-434  PHD_RSF1
cd15537393-434  PHD_BS69
cd156382871-2915  PHD_PHF3
cd15595393-434  PHD2_KMT2D
cd055292935-3021  Bromo_WDR9_I_like
cd15536393-434  PHD_PHRF1
cd15545393-434  PHD_BAZ2A_like
cd055212960-3023  Bromo_Rsc1_2_I
cd155562870-2915  PHD_MMD1_like
cd15562393-434  PHD2_PHF14
cd15519393-434  PHD1_Lid2p_like
cd055202948-3021  Bromo_polybromo_III
cd15510393-434  PHD2_KMT2C_like
cd15622393-434  PHD_TIF1alpha
cd15624393-434  PHD_TIF1gamma
cd155172871-2915  PHD_TCF19_like
cd15628393-434  PHD_BAZ1B
cd055082951-3020  Bromo_RACK7
pfam006282869-2917  PHD
cd15625390-434  PHD_TIF1delta
cd15513393-435  PHD5_KMT2C_like
cd155502870-2915  PHD_MLL5
cd15617393-434  PHD_UHRF2
cd15525393-434  PHD_UHRF1_2
cd055162948-3025  Bromo_SNF2L2
cd15524392-434  PHD_PHF21B
cd15527393-434  PHD2_KAT6A_6B
cd15538393-434  PHD_PRKCBP1
cd15658393-434  PHD4_NSD3
cd155182869-2915  PHD_Ecm5p_Lid2p_like
cd055012963-3029  Bromo_SP100C_like
cd055172962-3027  Bromo_polybromo_II
cd15594393-434  PHD2_KMT2C
cd15530402-434  PHD2_d4
cd155422869-2915  PHD_UBR7
cd15602393-436  PHD1_KDM5A
cd15604393-434  PHD1_KDM5C_5D
cd15605393-434  PHD1_Lid_like
pfam15612339-388  WHIM1
cl21411339-388  WHIM1 superfamily
cd155202870-2915  PHD3_Lid2p_like
cd055252962-3027  Bromo_ASH1
cd15515393-434  PHD1_KDM5A_like
cd15629393-435  PHD_BAZ2A
cd15603393-434  PHD1_KDM5B
cd055242962-3026  Bromo_polybromo_I
cd15626393-434  PHD_SP110_140
cd15656393-434  PHD4_NSD1
cd15568393-431  PHD5_NSD
cd155492870-2915  PHD_PHF20_like
cd156342870-2915  PHD_PHF20
cd11726389-434  ADDz_ATRX
cd156062869-2915  PHD2_KDM5A
cd04718412-438  BAH_plant_2
cl02608412-438  BAH superfamily
cd15657393-434  PHD4_NSD2
cd15563392-434  PHD3_PHF14
cd15648393-434  PHD1_NSD1_2
cd15509392-434  PHD1_KMT2C_like
cd15504393-434  PHD_PRHA_like
cd15616393-434  PHD_UHRF1
cd155472870-2915  PHD_SHPRH
cd15497393-434  PHD1_Snt2p_like
cd15534393-431  PHD2_PHF12_Rco1
cd156332870-2916  PHD_PHF20L1
cd15502393-434  PHD_Phf1p_Phf2p_like
cd15630392-436  PHD_BAZ2B
cd155082869-2915  PHD3_KMT2A_like
cd155162869-2915  PHD2_KDM5A_like
cd15564393-434  PHD1_NSD
cd155052869-2915  PHD_ING
cd15501392-434  PHD_Int12
cd155142870-2915  PHD6_KMT2C_like
cd156152869-2915  PHD_ARID4_like
cd054922959-3020  Bromo_ZMYND11
cd155852869-2915  PHD_ING3
cd15522393-434  PHD_TAF3
cd155482870-2915  PHD_ASH1L
cd155802869-2917  PHD2_MTF2
COG50762925-3029  COG5076
COG50762904-3029  COG5076
pfam096062163-2544  Med15
pfam031572120-2500  Glutenin_hmw
pfam096062112-2492  Med15
pfam096062175-2502  Med15
pfam097702221-2494  PAT1
TIGR028132105-2307  omega_3_PfaA
pfam072232365-2506  DUF1421
pfam138682615-2788  Trichoplein
pfam096062214-2632  Med15
pfam031572105-2333  Glutenin_hmw
COG52531410-1669  MSS4
PRK149712154-2272  PRK14971


Ontology Information


   
HPRD ID1348
Molecular ClassTranscription regulatory protein
Molecular FunctionPeptide hormone (GO:0005180)
Biological ProcessCell communication (GO:0007154); Signal transduction (GO:0007165)  



SNP Information


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Drug Information


No matching records could be found.

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO