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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
BRD4 23476 bromodomain containing 4  19HUNKI, MCAP, CAP, HUNK1 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
22120039   2012Cell line : HCT116,CACO2,Co115,HT-29,COLO205,SW48,SW480,SW620, DLD1

Source : -

Sample Type : -

No. of Sample : -

Stage : -

real time RT-PCR,Chromatin immunoprecepetation,Pyrosequencing, immunoflouresenceHypermethylation--

25603177   2015Cell line : -

Source : Southern Medical University, Guangzhou, China.

Sample Type : CRC tumor and adjacent normal tissue

No. of Sample : 45

Stage : -

real time RT-PCR,MTT Assay,Colony Formation Assay, In Vitro Migration and Invasion Assay,Annexin V,PI Assays,Western BlottingUp-regulation--


Gene Details



NC_000019.9 (15348301..15443354, complement)

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Gene Type protein coding
Gene Family -
Description The protein encoded by this gene is homologous to the murine protein MCAP, which associates with chromosomes during mitosis, and to the human RING3 protein, a serine/threonine kinase. Each of these proteins contains two bromodomains, a conserved sequence motif which may be involved in chromatin targeting. This gene has been implicated as the chromosome 19 target of translocation t(15;19)(q13;p13.1), which defines an upper respiratory tract carcinoma in young people. Two alternatively spliced transcript variants have been described. [provided by RefSeq, Jul 2008]  
Chromosome 19
Location 19p13.12
Start 15348301  
End 15443354  
Strand -  
Gene Sequence

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Length 95054  
OMIM ID 608749   
HGNC ID HGNC:13575   
Unigene ID Hs.187763   
Ensembl ID ENSG00000141867   
PharmGKB ID PA25416   

mRNA Information


mRNA ID ?NM_014299.2
Exon  
mRNA Sequence

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Length  



CDS Information


   
Location
CDS Sequence

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CCDS ID CCDS12328.1



Protein Information


      
Protein IDNP_055114.1
Protein Namebromodomain containing 4
Molecular Wt. (Da)0
Protein Sequence

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Length 1362  
Uniprot IDQ9NP99
Ensembl Protein ID ENSP00000244709  



Post-translational Modification Information (Source : HPRD)


Residue Type site
SPhosphorylation470
SPhosphorylation470
SPhosphorylation1117;-
SPhosphorylation795;-
SPhosphorylation1045;-
SPhosphorylation469
SPhosphorylation469
SPhosphorylation601
SPhosphorylation601
KAcetylation1111
SGlycosylation1215
SPhosphorylation325
SPhosphorylation325
TPhosphorylation803

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

                                                                                                         
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
904CCNT13938NP_001231.2in vivo16109376   
905CCNT24839NP_490595.1in vivo16109376   
5981RFC124NP_002904.3in vitro;in vivo12192049   
5984RFC422NP_002907.1in vitro;in vivo12192049   
55660PRPF40A10995NP_060362.3yeast 2-hybrid15231748   
55743CHFR5552NP_001154816.1yeast 2-hybrid16169070   
79020C7orf259861NP_001093328.1yeast 2-hybrid16169070   


Pathway Information


No matching records could be found.

Structure Information


No matching records could be found.

Domain Information




ID Location Description
cd0549758-164  Bromo_Brdt_I_like
cl0255658-164  Bromodomain superfamily
cd05498353-454  Bromo_Brdt_II_like
cl02556353-454  Bromodomain superfamily
cd05499354-452  Bromo_BDF1_2_II
smart0029757-164  BROMO
cd05506354-454  Bromo_plant1
smart00297352-457  BROMO
cd0550962-164  Bromo_gcn5_like
cd0436963-161  Bromodomain
cd0549869-160  Bromo_Brdt_II_like
cd04369355-454  Bromodomain
cd0550671-157  Bromo_plant1
cd05509360-457  Bromo_gcn5_like
cd05497360-457  Bromo_Brdt_I_like
cd0549970-157  Bromo_BDF1_2_II
pfam00439357-445  Bromodomain
cd05500373-451  Bromo_BDF1_2_I
pfam0043970-151  Bromodomain
cd0550062-161  Bromo_BDF1_2_I
cd05504345-457  Bromo_Acf1_like
cd05502354-456  Bromo_tif1_like
cd0549563-164  Bromo_cbp_like
cd05495368-451  Bromo_cbp_like
cd0550366-160  Bromo_BAZ2A_B_like
cd0550466-164  Bromo_Acf1_like
cd0551995-161  Bromo_SNF2
cd05510352-448  Bromo_SPT7_like
cd05503357-453  Bromo_BAZ2A_B_like
cd05511358-460  Bromo_TFIID
cd05496357-457  Bromo_WDR9_II
cd0550268-164  Bromo_tif1_like
cd05505353-450  Bromo_WSTF_like
cd0551576-160  Bromo_polybromo_V
cd05529333-450  Bromo_WDR9_I_like
cd0551071-165  Bromo_SPT7_like
cd05512376-448  Bromo_brd1_like
cd05507372-448  Bromo_brd8_like
cd0552959-164  Bromo_WDR9_I_like
cd0551180-165  Bromo_TFIID
cd0551895-160  Bromo_polybromo_IV
cd0551660-157  Bromo_SNF2L2
cd05528375-460  Bromo_AAA
cd05515389-450  Bromo_polybromo_V
cd0552862-167  Bromo_AAA
cd0550570-147  Bromo_WSTF_like
cd0551263-140  Bromo_brd1_like
cd05513369-446  Bromo_brd7_like
cd0551363-143  Bromo_brd7_like
cd05520389-449  Bromo_polybromo_III
cd0550770-165  Bromo_brd8_like
cd0549668-161  Bromo_WDR9_II
cd05524389-451  Bromo_polybromo_I
cd0552191-161  Bromo_Rsc1_2_I
cd0552095-160  Bromo_polybromo_III
cd0552295-157  Bromo_Rsc1_2_II
cd05518389-433  Bromo_polybromo_IV
cd05519389-454  Bromo_SNF2
cd0551791-160  Bromo_polybromo_II
cd05522389-447  Bromo_Rsc1_2_II
cd05501389-454  Bromo_SP100C_like
cd0550196-157  Bromo_SP100C_like
cd05508375-446  Bromo_RACK7
cd05516387-450  Bromo_SNF2L2
cd0550860-156  Bromo_RACK7
cd0552591-159  Bromo_ASH1
cd0552495-164  Bromo_polybromo_I
cd0549469-115  Bromodomain_1
cd05525389-451  Bromo_ASH1
cd05521389-448  Bromo_Rsc1_2_I
cd05494357-423  Bromodomain_1
cd05517389-453  Bromo_polybromo_II
COG507622-173  COG5076
COG5076323-463  COG5076
COG507680-167  COG5076
PRK03427809-922  PRK03427
pfam138681230-1271  Trichoplein


Ontology Information


   
HPRD ID7649
Molecular ClassCell cycle control protein
Molecular FunctionMolecular function unknown (GO:0005554)
Biological ProcessBiological_process unknown (GO:0000004)  



SNP Information


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Drug Information


No matching records could be found.

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO