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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
BRD8 10902 bromodomain containing 8  5SMAP, p120 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
19787264   2009Cell line : DLD 1, HCA 7, HCT-116

Source : -

Sample Type : -

No. of Sample : -

Stage : -

Western Blotting,real time RT-PCR,siRNAUp-regulation-BRD8 gave growth advantage and resistance to taxol when stably overexpressed in HeLa cells. Targeting BRD8 would improve therapy outcome against aggressive/metastatic colorectal cancers.


Gene Details



NC_000005.9 (137475455..137514358, complement)

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Gene Type protein coding
Gene Family -
Description The protein encoded by this gene interacts with thyroid hormone receptor in a ligand-dependent manner and enhances thyroid hormone-dependent activation from thyroid response elements. This protein contains a bromodomain and is thought to be a nuclear receptor coactivator. Multiple alternatively spliced transcript variants that encode distinct isoforms have been identified. [provided by RefSeq, Jul 2014  
Chromosome 5
Location 5q31
Start 137475455  
End 137514358  
Strand -  
Gene Sequence

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Length 38904  
OMIM ID 602848   
HGNC ID HGNC:19874   
Unigene ID Hs.519337   
Ensembl ID ENSG00000112983   
PharmGKB ID PA134923194   

mRNA Information


mRNA ID ?NM_001164326.1
Exon  
mRNA Sequence

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Length  



CDS Information


   
Location
CDS Sequence

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CCDS ID CCDS34241.1



Protein Information


      
Protein IDNP_001157798.1
Protein Namebromodomain containing 8
Molecular Wt. (Da)0
Protein Sequence

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Length 1235  
Uniprot IDQ9HC35
Ensembl Protein ID ENSP00000320663  



Post-translational Modification Information (Source : HPRD)


Residue Type site
TPhosphorylation264;-
SPhosphorylation268;-
SPhosphorylation128;-
TPhosphorylation124;-
SPhosphorylation284;-
SPhosphorylation144;-
SPhosphorylation641;-
SPhosphorylation637;-
SPhosphorylation714;-
SPhosphorylation710;-
SPhosphorylation531;-
SPhosphorylation535;-
SPhosphorylation1152;-
TPhosphorylation1151;-
KAcetylation481
KAcetylation554
KAcetylation375
TPhosphorylation569
TPhosphorylation642
TPhosphorylation463
SPhosphorylation579
SPhosphorylation652
SPhosphorylation473
SPhosphorylation136
SPhosphorylation136
TPhosphorylation175
TPhosphorylation175
TPhosphorylation35
SPhosphorylation621
SPhosphorylation694
SPhosphorylation515
SPhosphorylation924
SPhosphorylation919

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

                                             
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
5468PPARG3288NP_056953.2yeast 2-hybrid10517671   
6256RXRA1577NP_002948.1in vitro;yeast 2-hybrid10517671   
7465WEE11907NP_003381.1in vivo15070733   


Pathway Information


No matching records could be found.

Structure Information


No matching records could be found.

Domain Information




ID Location Description
cd05507709-812  Bromo_brd8_like
cl02556709-812  Bromodomain superfamily
cd055071105-1208  Bromo_brd8_like
cl025561105-1208  Bromodomain superfamily
smart00297709-811  BROMO
smart002971107-1205  BROMO
cd04369726-808  Bromodomain
cd043691122-1204  Bromodomain
pfam00439725-799  Bromodomain
pfam004391112-1195  Bromodomain
cd05509725-811  Bromo_gcn5_like
cd055091121-1196  Bromo_gcn5_like
cd05506726-800  Bromo_plant1
cd05499725-801  Bromo_BDF1_2_II
cd05498727-807  Bromo_Brdt_II_like
cd055101123-1207  Bromo_SPT7_like
cd055111125-1205  Bromo_TFIID
cd05513732-797  Bromo_brd7_like
cd05497707-810  Bromo_Brdt_I_like
cd055041119-1208  Bromo_Acf1_like
cd05504726-809  Bromo_Acf1_like
cd054991121-1193  Bromo_BDF1_2_II
cd05510727-809  Bromo_SPT7_like
cd05500732-802  Bromo_BDF1_2_I
cd05511732-800  Bromo_TFIID
cd054951110-1203  Bromo_cbp_like
cd054981123-1203  Bromo_Brdt_II_like
cd05495714-797  Bromo_cbp_like
cd055051119-1189  Bromo_WSTF_like
cd055031121-1197  Bromo_BAZ2A_B_like
cd055061117-1196  Bromo_plant1
cd05502732-812  Bromo_tif1_like
cd055281115-1204  Bromo_AAA
cd055001125-1198  Bromo_BDF1_2_I
cd05528717-812  Bromo_AAA
cd05519713-808  Bromo_SNF2
cd05515725-810  Bromo_polybromo_V
cd05512729-803  Bromo_brd1_like
cd055151122-1202  Bromo_polybromo_V
cd055021121-1193  Bromo_tif1_like
cd05503732-802  Bromo_BAZ2A_B_like
cd05516715-811  Bromo_SNF2L2
cd055201114-1198  Bromo_polybromo_III
cd055121128-1199  Bromo_brd1_like
cd055161123-1190  Bromo_SNF2L2
cd054961118-1204  Bromo_WDR9_II
cd055081125-1193  Bromo_RACK7
cd055221120-1199  Bromo_Rsc1_2_II
cd05496712-800  Bromo_WDR9_II
cd05522742-803  Bromo_Rsc1_2_II
cd054971115-1204  Bromo_Brdt_I_like
cd055191128-1204  Bromo_SNF2
cd05508732-797  Bromo_RACK7
cd05520729-802  Bromo_polybromo_III
cd055131128-1193  Bromo_brd7_like
cd05505726-793  Bromo_WSTF_like
cd05518717-808  Bromo_polybromo_IV
cd055241128-1202  Bromo_polybromo_I
cd05521742-808  Bromo_Rsc1_2_I
cd055181128-1204  Bromo_polybromo_IV
cd05517739-802  Bromo_polybromo_II
cd055211138-1204  Bromo_Rsc1_2_I
cd05525742-793  Bromo_ASH1
cd05492741-810  Bromo_ZMYND11
cd05529732-812  Bromo_WDR9_I_like
cd055251115-1183  Bromo_ASH1
cd05526742-802  Bromo_polybromo_VI
cd05524742-812  Bromo_polybromo_I
cd055171128-1197  Bromo_polybromo_II
cd054941117-1163  Bromodomain_1
cd054911148-1200  Bromo_TBP7_like
cd055261138-1198  Bromo_polybromo_VI
cd055011112-1186  Bromo_SP100C_like
cd055291126-1189  Bromo_WDR9_I_like
COG50761088-1230  COG5076
COG5076707-811  COG5076
COG5076725-794  COG5076
TIGR03835302-681  termin_org_DnaJ
PRK13108511-668  PRK13108


Ontology Information


   
HPRD ID5957
Molecular ClassTranscription regulatory protein
Molecular FunctionCalcium ion binding (GO:0005509)
Biological ProcessCell communication (GO:0007154); Signal transduction (GO:0007165)  



SNP Information


View SNP Geneview Report   

Drug Information


No matching records could be found.

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO