Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| BRMS1 | 25855 | breast cancer metastasis suppressor 1 | 11 | DKFZP564A063 |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
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- Ontology
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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 24748145 | 2014 | Cell line : Lovo Source : Shandong cancer prevention and control institute. Sample Type : CRC tumor No. of Sample : - Stage : TNM Stage I-IV. | real time RT-PCR | Up-regulation | - | High expression of BRSM1 in rectal cancer plays an essential role in tumor progression. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | This gene reduces the metastatic potential, but not the tumorogenicity, of human breast cancer and melanoma cell lines. The protein encoded by this gene localizes primarily to the nucleus and is a component of the mSin3a family of histone deacetylase complexes (HDAC). The protein contains two coiled-coil motifs and several imperfect leucine zipper motifs. Alternative splicing results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008] | Chromosome | 11 |
| Location | 11q13-q13. |
| Start | 66104804 |
| End | 66112596 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 7793 |
| OMIM ID | 606259 |
| HGNC ID | HGNC:17262 |
| Unigene ID | Hs.100426 |
| Ensembl ID | - |
| PharmGKB ID | PA164741342 |
Protein Information
| Protein ID | NP_056214.1 |
|---|---|
| Protein Name | breast cancer metastasis suppressor 1 |
| Molecular Wt. (Da) | 0 |
| Protein Sequence | Download Select all |
| Length | 246 |
| Uniprot ID | Q709C8 |
| Ensembl Protein ID | ENSP00000249837 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| S | Phosphorylation | 209 |
| S | Phosphorylation | 209 |
| S | Phosphorylation | 237 |
| S | Phosphorylation | 237 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 3065 | HDAC1 | 3143 | NP_004955.2 | in vivo | 15451426 |
| 3066 | HDAC2 | 5521 | NP_001518.2 | in vivo | 15451426 |
| 3308 | HSPA4 | 9025 | NP_002145.3 | in vivo | 16919237 |
| 3320 | HSP90AA1 | 777 | NP_001017963.2 | in vivo | 16919237 |
| 3337 | DNAJB1 | 5198 | NP_006136.1 | in vivo | 16919237 |
| 3621 | ING1 | 3337 | NP_005528.3 | in vivo | 15451426 |
| 3841 | KPNA5 | 5179 | NP_002260.2 | yeast 2-hybrid | 16919237 |
| 5204 | PFDN5 | 5359 | BAA14006.1 | in vivo;yeast 2-hybrid | 16919237 |
| 5928 | RBBP4 | 4232 | NP_005601.1 | in vivo | 15451426 |
| 5931 | RBBP7 | 4231 | NP_002884.1 | in vivo | 15451426 |
| 6525 | SMTN | 3675 | NP_599032.1 | yeast 2-hybrid | 16919237 |
| 6605 | SMARCE1 | 4382 | NP_003070.3 | in vivo;yeast 2-hybrid | 16919237 |
| 6872 | TAF1 | 2436 | NP_004597.2 | yeast 2-hybrid | 16919237 |
| 8819 | SAP30 | 4540 | NP_003855.1 | in vivo | 15451426 |
| 9759 | HDAC4 | 5610 | NP_006028.2 | in vivo | 16919237 |
| 10013 | HDAC6 | 2228 | NP_006035.2 | in vivo | 16919237 |
| 10014 | HDAC5 | 9246 | NP_001015053.1 | in vivo | 16919237 |
| 10049 | DNAJB6 | 7107 | NP_490647.1 | in vivo;yeast 2-hybrid | 16919237 |
| 55791 | C1orf103 | 17975 | NP_060842.3 | yeast 2-hybrid | 16169070 |
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Ontology Information
| HPRD ID | 7896 |
|---|---|
| Molecular Class | Unclassified |
| Molecular Function | Molecular function unknown (GO:0005554) |
| Biological Process | Cell proliferation (GO:0008283) |
Drug Information
No matching records could be found.