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General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| BTG1 | 694 | B-cell translocation gene 1, anti-proliferative | 12 | - |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 25449431 | 2015 | Cell line : SW620,RKO Source : - Sample Type : - No. of Sample : - Stage : - | real time RT-PCR,Immunoblotting, immunohistochemistry, immunofluorescence, Cell viability and apoptosis assays,Luciferase reporter assay | Down-regulation | - | B-cell translocation gene 1 (BTG1) was identified as a new target of miR-22, which could reverse the inhibition of autophagy induced by miR-22. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | This gene is a member of an anti-proliferative gene family that regulates cell growth and differentiation. Expression of this gene is highest in the G0/G1 phases of the cell cycle and downregulated when cells progressed through G1. The encoded protein interacts with several nuclear receptors, and functions as a coactivator of cell differentiation. This locus has been shown to be involved in a t(8;12)(q24;q22) chromosomal translocation in a case of B-cell chronic lymphocytic leukemia. [provided by RefSeq, Oct 2008] | Chromosome | 12 |
| Location | 12q21.33 |
| Start | 92534054 |
| End | 92539673 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 5620 |
| OMIM ID | 109580 |
| HGNC ID | HGNC:1130 |
| Unigene ID | Hs.255935 |
| Ensembl ID | ENSG00000133639 |
| PharmGKB ID | PA25450 |
Protein Information
| Protein ID | |
|---|---|
| Protein Name | B-cell translocation gene 1, anti-proliferative |
| Molecular Wt. (Da) | 0 |
| Protein Sequence | Download Select all |
| Length | 0 |
| Uniprot ID | P13640 |
| Ensembl Protein ID | ENSP00000369139 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| S | Phosphorylation | 159 |
| T | Phosphorylation | 158 |
| T | Phosphorylation | 158 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 3219 | HOXB9 | 852 | NP_076922.1 | in vitro;yeast 2-hybrid | 10617598 |
| 3276 | PRMT1 | 4257 | NP_001527.3 | in vitro;yeast 2-hybrid | 14 734 530 866 314 600 000 000 |
| 5914 | RARA | 6769 | NP_000955.1 | in vitro | 15674337 |
| 7067 | THRA | 7185 | NP_003241.2 | in vitro;in vivo | 15674337 |
| 7068 | THRB | 7521 | NP_000452.2 | in vitro | 15674337 |
| 9337 | CNOT8 | 7225 | NP_004770.4 | in vitro | 11136725 |
| 29883 | CNOT7 | 5370 | AAH60852.1 | in vitro;in vivo | 98 208 261 113 672 500 000 000 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| RNA degradation | hsa03018 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| smart00099 | 11-118 | btg1 |
| cl15439 | 11-118 | BTG superfamily |
| pfam07742 | 11-126 | BTG |
Ontology Information
| HPRD ID | 1134 |
|---|---|
| Molecular Class | Cell cycle control protein |
| Molecular Function | Phosphorylase activity (GO:0004645) |
| Biological Process | Metabolism (GO:0008152); Energy pathways (GO:0006091) |
Drug Information
No matching records could be found.