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General Information
- Evidence
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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 23747338 | 2013 | Cell line : - Source : - Sample Type : CRC tumor and normal tissue No. of Sample : 208 Stage : - | Genome-wide and targeted copy number and mutation analyses | Mutation | - | Mutations in BUB1 and BUB3 cause mosaic variegated aneuploidy and increase the risk of colorectal cancer at a young age. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | WD repeat domain containing |
| Description | This gene encodes a protein involved in spindle checkpoint function. The encoded protein contains four WD repeat domains and has sequence similarity with the yeast BUB3 protein. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008] | Chromosome | 10 |
| Location | 10q24 |
| Start | 124913760 |
| End | 124924886 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 11127 |
| OMIM ID | 603719 |
| HGNC ID | HGNC:1151 |
| Unigene ID | Hs.418533 |
| Ensembl ID | ENSG00000154473 |
| PharmGKB ID | PA25467 |
Protein Information
| Protein ID | NP_001007794.1 |
|---|---|
| Protein Name | BUB3 mitotic checkpoint protein |
| Molecular Wt. (Da) | 0 |
| Protein Sequence | Download Select all |
| Length | 328 |
| Uniprot ID | O94953 |
| Ensembl Protein ID | ENSP00000371178 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| S | Phosphorylation | 211 |
| S | Phosphorylation | 211 |
| Y | Phosphorylation | 194;- |
| Y | Phosphorylation | 194;- |
| K | Acetylation | 179 |
| K | Acetylation | 179 |
| T | Phosphorylation | 154 |
| T | Phosphorylation | 154 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 142 | PARP1 | 1435 | NP_001609.2 | in vivo | 12011073 |
| 699 | BUB1 | 3907 | NP_004327.1 | in vivo | 112 836 199 660 858 |
| 701 | BUB1B | 4176 | NP_001202.4 | in vitro;in vivo | 9660858 |
| 3065 | HDAC1 | 3143 | NP_004955.2 | in vitro | 15388328 |
| 3066 | HDAC2 | 5521 | NP_001518.2 | in vitro | 15388328 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Cell cycle | hsa04110 |
| HTLV-I infection | hsa05166 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd00200 | 14-296 | WD40 |
| cl02567 | 14-296 | WD40 superfamily |
| cd00200 | 14-124 | WD40 |
| cd00200 | 95-296 | WD40 |
| pfam00400 | 95-124 | WD40 |
| smart00320 | 95-124 | WD40 |
| pfam00400 | 236-262 | WD40 |
| smart00320 | 236-262 | WD40 |
| pfam00400 | 14-43 | WD40 |
| smart00320 | 14-43 | WD40 |
| COG2319 | 11-296 | WD40 |
| COG2319 | 11-297 | WD40 |
| COG2319 | 4-296 | WD40 |
| COG2319 | 80-296 | WD40 |
| pfam04762 | 231-320 | IKI3 |
Ontology Information
| HPRD ID | 19416 |
|---|---|
| Molecular Class | Cell cycle control protein |
| Molecular Function | Transcription factor activity (GO:0003700) |
| Biological Process | Transcription (GO:0006350); Organogenesis (GO:0009887) |
Drug Information
No matching records could be found.