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General Information
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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 26318832 | 2015 | Cell line : - Source : - Sample Type : Serum samples No. of Sample : 522 Stage : - | ELISA | Up-regulation | - | CA11-19 is a serologic tumor marker for the diagnosis of CRC. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Carbonic anhydrases |
| Description | Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. They show extensive diversity in tissue distribution and in their subcellular localization. CA XI is likely a secreted protein, however, radical changes at active site residues completely conserved in CA isozymes with catalytic activity, make it unlikely that it has carbonic anhydrase activity. It shares properties in common with two other acatalytic CA isoforms, CA VIII and CA X. CA XI is most abundantly expressed in brain, and may play a general role in the central nervous system. [provided by RefSeq, Jul 2008] | Chromosome | 19 |
| Location | 19q13.3 |
| Start | 49141272 |
| End | 49149451 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 8180 |
| OMIM ID | 604644 |
| HGNC ID | HGNC:1370 |
| Unigene ID | Hs.428446 |
| Ensembl ID | ENSG00000063180 |
| PharmGKB ID | PA25986 |
mRNA Information
| mRNA ID | NM_001217.3 |
|---|---|
| Exon | join(1..629,718..792,1626..1768,5915..6100,6312..6407, 6574..6646,6736..6890,7142..7307,8051..8180) | mRNA Sequence | Download Select all |
| Length | 1686 |
Protein Information
| Protein ID | NP_001208.2 |
|---|---|
| Protein Name | carbonic anhydrase XI |
| Molecular Wt. (Da) | 0 |
| Protein Sequence | Download Select all |
| Length | 328 |
| Uniprot ID | Q99707 |
| Ensembl Protein ID | ENSP00000355536 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
No matching records from HPRD source could be found.
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd03121 | 48-304 | alpha_CARP_X_XI_like |
| cl00012 | 48-304 | alpha_CA superfamily |
| cd00326 | 65-297 | alpha_CA |
| smart01057 | 35-297 | Carb_anhydrase |
| pfam00194 | 63-302 | Carb_anhydrase |
| cd03119 | 63-300 | alpha_CA_I_II_III_XIII |
| cd03123 | 48-297 | alpha_CA_VI_IX_XII_XIV |
| cd03118 | 65-300 | alpha_CA_V |
| cd03149 | 65-300 | alpha_CA_VII |
| cd03122 | 48-297 | alpha_CARP_receptor_like |
| cd03126 | 65-297 | alpha_CA_XII_XIV |
| cd03117 | 65-297 | alpha_CA_IV_XV_like |
| cd03120 | 52-301 | alpha_CARP_VIII |
| cd03124 | 48-297 | alpha_CA_prokaryotic_like |
| cd03125 | 52-302 | alpha_CA_VI |
| cd03150 | 48-300 | alpha_CA_IX |
| COG3338 | 11-297 | Cah |
| PLN02202 | 48-314 | PLN02202 |
| PLN02179 | 48-259 | PLN02179 |
Ontology Information
| HPRD ID | 3979 |
|---|---|
| Molecular Class | Enzyme: Carbonic anhydrase |
| Molecular Function | Oxidoreductase activity (GO:0016491) |
| Biological Process | Metabolism (GO:0008152); Energy pathways (GO:0006091) |
Drug Information
| Uniprot ID | DrugBank ID | Name | Type |
|---|---|---|---|
| O75493 | DB00909 | Zonisamide | SmallMoleculeDrug |