Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| CACNA1G | 8913 | Calcium channel, voltage-dependent, T type, alpha 1G subunit  | 17 | NBR13; Cav3.1; Ca(V)T.1  |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 20028768    | 2009 | Cell line : - Source : Nurses Health Study and the Health Professionals Follow-up Study Sample Type : - No. of Sample : - Stage : - | Real Time RT- PCR (MethyLight), Pyrosequencing,Immunohistochemistry | Methylation | - | Quantified DNA methylation in eight CIMP-specific promoters (CACNA1G, CDKN2A, CRABP1, IGF2, MLH1, NEUROG1, RUNX3, and SOCS1) by MethyLight. |
| 20077021    | 2010 | Cell line : - Source : Asan Medical Center, Seoul, Korea. Sample Type : - No. of Sample : 285 patients with CRC Stage : - | - | Methylation | - | CIMP markers (MLH1, MINT1, MINT2, MINT31, p16 ( INK4a ), p14 ( ARF ), and CACNA1G) and four genes (COX2, DAPK, MGMT, and APC) frequently methylated in colorectal cancer. |
| 22655257    | 2012 | Cell line : - Source : The Institute of Pathology, University Hospital of Basel, the Institute of Clinical Pathology, Basel, Switzerland, and the Institute of Pathology, Stadtspital Triemli, Z?rich, Switzerland. Sample Type : - No. of Sample : 1420 CRC patients Stage : - | DNA isolation,mutation,MSI analysis, DNA bisulfitetreatment and Pyrosequencing | Methylation | - | - |
Gene Details

| Gene Type | protein coding |
|---|---|
| Gene Family | Calcium channel subunits, Voltage-gated ion channels / Calcium channels |
| Description | Voltage-sensitive calcium channels mediate the entry of calcium ions into excitable cells, and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division, and cell death. This gene encodes a T-type, low-voltage activated calcium channel. The T-type channels generate currents that are both transient, owing to fast inactivation, and tiny, owing to small conductance. T-type channels are thought to be involved in pacemaker activity, low-threshold calcium spikes, neuronal oscillations and resonance, and rebound burst firing. Many alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Sep 2011]   | Chromosome | 17 |
| Location | 17q22 |
| Start | 50561068   |
| End | 50629625   |
| Strand | +   |
| Gene Sequence |    Download   Select all |
| Length | 68558   |
| OMIM ID | 604065    |
| HGNC ID | HGNC:1394    |
| Unigene ID | Hs.591169     |
| Ensembl ID | ENSG00000006283    |
| PharmGKB ID | PA381    |
mRNA Information
| mRNA ID | NM_001256325.1 |
|---|---|
| Exon | join(1..634,7803..7914,8098..8231,8639..8736,10811..10970, 11487..11787,11954..12046,14476..15259,17121..17497, 29404..29555,30368..30553,30672..30786,30870..31025, 33926..33994,35495..35579,35663..35856,38361..38792, 39659..39759,39984..40107,41753..41821,41948..42132, 43088..43214,44831..44956,45833..45922,46760..46973, 48815..48868,54294..54445,55208..55317,56371..56504, 56792..56862,56981..57059,57155..57276,57588..57941, 62840..63008,63293..63462,64950..66407)   | mRNA Sequence |    Download   Select all |
| Length | 8006   |
CDS Information
| Location | join(393..634,7803..7914,8098..8231,8639..8736, 10811..10970,11487..11787,11954..12046,14476..15259, 17121..17497,29404..29555,30368..30553,30672..30786, 30870..31025,33926..33994,35495..35579,35663..35856, 38361..38792,39659..39759,39984..40107,41753..41821, 41948..42132,43088..43214,44831..44956,45833..45922, 46760..46973,48815..48868,54294..54445,55208..55317, |
|---|---|
| CDS Sequence |    Download   Select all |
| CCDS ID | - |    
Protein Information
| Protein ID | NP_001243253.1 |
|---|---|
| Protein Name | Calcium channel, voltage-dependent, T type, alpha 1G subunit |
| Molecular Wt. (Da) | 255895 |
| Protein Sequence |    Download   Select all |
| Length | 2314   |
| Uniprot ID | P20827 |    
| Ensembl Protein ID | ENSP00000357391   |    
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| T | Phosphorylation | 735 |
| T | Phosphorylation | 735 |
| T | Phosphorylation | 735 |
| T | Phosphorylation | 735 |
| T | Phosphorylation | 735 |
| T | Phosphorylation | 735 |
| T | Phosphorylation | 735 |
| T | Phosphorylation | 735 |
| T | Phosphorylation | 735 |
| T | Phosphorylation | 735 |
| T | Phosphorylation | 735 |
| T | Phosphorylation | 735 |
| T | Phosphorylation | 735 |
| T | Phosphorylation | 735 |
| T | Phosphorylation | 735 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING)      View   
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 56893 |    UBQLN4 |    5670 |    NP_064516.2 |    yeast 2-hybrid |    16713569    |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Aldosterone synthesis and secretion |    hsa04925 |    
| Calcium signaling pathway |    hsa04020 |    
| Circadian entrainment |    hsa04713 |    
| MAPK signaling pathway |    hsa04010 |    
| Type II diabetes mellitus |    hsa04930 |    
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| pfam00520 | 777-963  | Ion_trans |
| pfam00520 | 1314-1536  | Ion_trans |
| pfam00520 | 1645-1850  | Ion_trans |
| pfam00520 | 130-394  | Ion_trans |
| pfam08016 | 1648-1851  | PKD_channel |
| PHA03307 | 1947-2377  | PHA03307 |
| pfam08016 | 838-969  | PKD_channel |
| pfam03154 | 1956-2373  | Atrophin-1 |
| PHA03247 | 1882-2356  | PHA03247 |
| PHA03247 | 1960-2377  | PHA03247 |
Ontology Information
| HPRD ID | 549 |    
|---|---|
| Molecular Class | Voltage gated channel |
| Molecular Function | Transcription factor activity (GO:0003700) |
| Biological Process | Regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism (GO:0019219)   |
Drug Information
| Uniprot ID | DrugBank ID | Name | Type |
|---|---|---|---|
| O43497 | DB00347 | Trimethadione | SmallMoleculeDrug |
| O43497 | DB00421 | Spironolactone | SmallMoleculeDrug |
| O43497 | DB00568 | Cinnarizine | SmallMoleculeDrug |
| O43497 | DB00593 | Ethosuximide | SmallMoleculeDrug |
| O43497 | DB00661 | Verapamil | SmallMoleculeDrug |
| O43497 | DB00909 | Zonisamide | SmallMoleculeDrug |
| O43497 | DB04841 | Flunarizine | SmallMoleculeDrug |
| O43497 | DB05246 | Methsuximide | SmallMoleculeDrug |
External Links
| ArrayExpress | GO |    
|---|---|
| ICGC | GO |    
| Cancer3D | GO |    
| COSMIC | GO |    
| NCG | GO |    
| TSGene | GO |    
| Tumor Gene Family of Databases | GO |    
| CCDB | GO |    
| G2SBC | GO |    
| Osteosarcoma Database | GO |    
| RCDB | GO |    
