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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
CACNA1G 8913 Calcium channel, voltage-dependent, T type, alpha 1G subunit  17NBR13; Cav3.1; Ca(V)T.1 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
20028768   2009Cell line : -

Source : Nurses Health Study and the Health Professionals Follow-up Study

Sample Type : -

No. of Sample : -

Stage : -

Real Time RT- PCR (MethyLight), Pyrosequencing,ImmunohistochemistryMethylation-Quantified DNA methylation in eight CIMP-specific promoters (CACNA1G, CDKN2A, CRABP1, IGF2, MLH1, NEUROG1, RUNX3, and SOCS1) by MethyLight.

20077021   2010Cell line : -

Source : Asan Medical Center, Seoul, Korea.

Sample Type : -

No. of Sample : 285 patients with CRC

Stage : -

-Methylation-CIMP markers (MLH1, MINT1, MINT2, MINT31, p16 ( INK4a ), p14 ( ARF ), and CACNA1G) and four genes (COX2, DAPK, MGMT, and APC) frequently methylated in colorectal cancer.

22655257   2012Cell line : -

Source : The Institute of Pathology, University Hospital of Basel, the Institute of Clinical Pathology, Basel, Switzerland, and the Institute of Pathology, Stadtspital Triemli, Z?rich, Switzerland.

Sample Type : -

No. of Sample : 1420 CRC patients

Stage : -

DNA isolation,mutation,MSI analysis, DNA bisulfitetreatment and PyrosequencingMethylation--


Gene Details



Chromosome: 17; NC_000017.10 (48638429..48704835)

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Gene Type protein coding
Gene Family Calcium channel subunits, Voltage-gated ion channels / Calcium channels
Description Voltage-sensitive calcium channels mediate the entry of calcium ions into excitable cells, and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division, and cell death. This gene encodes a T-type, low-voltage activated calcium channel. The T-type channels generate currents that are both transient, owing to fast inactivation, and tiny, owing to small conductance. T-type channels are thought to be involved in pacemaker activity, low-threshold calcium spikes, neuronal oscillations and resonance, and rebound burst firing. Many alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Sep 2011]  
Chromosome 17
Location 17q22
Start 50561068  
End 50629625  
Strand +  
Gene Sequence

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Length 68558  
OMIM ID 604065   
HGNC ID HGNC:1394   
Unigene ID Hs.591169    
Ensembl ID ENSG00000006283   
PharmGKB ID PA381   

mRNA Information


mRNA ID NM_001256325.1
Exon join(1..634,7803..7914,8098..8231,8639..8736,10811..10970, 11487..11787,11954..12046,14476..15259,17121..17497, 29404..29555,30368..30553,30672..30786,30870..31025, 33926..33994,35495..35579,35663..35856,38361..38792, 39659..39759,39984..40107,41753..41821,41948..42132, 43088..43214,44831..44956,45833..45922,46760..46973, 48815..48868,54294..54445,55208..55317,56371..56504, 56792..56862,56981..57059,57155..57276,57588..57941, 62840..63008,63293..63462,64950..66407)  
mRNA Sequence

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Length 8006  



CDS Information


   
Location join(393..634,7803..7914,8098..8231,8639..8736, 10811..10970,11487..11787,11954..12046,14476..15259, 17121..17497,29404..29555,30368..30553,30672..30786, 30870..31025,33926..33994,35495..35579,35663..35856, 38361..38792,39659..39759,39984..40107,41753..41821, 41948..42132,43088..43214,44831..44956,45833..45922, 46760..46973,48815..48868,54294..54445,55208..55317,
CDS Sequence

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CCDS ID -



Protein Information


      
Protein IDNP_001243253.1
Protein NameCalcium channel, voltage-dependent, T type, alpha 1G subunit
Molecular Wt. (Da)255895
Protein Sequence

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Length 2314  
Uniprot IDP20827
Ensembl Protein ID ENSP00000357391  



Post-translational Modification Information (Source : HPRD)


Residue Type site
TPhosphorylation735
TPhosphorylation735
TPhosphorylation735
TPhosphorylation735
TPhosphorylation735
TPhosphorylation735
TPhosphorylation735
TPhosphorylation735
TPhosphorylation735
TPhosphorylation735
TPhosphorylation735
TPhosphorylation735
TPhosphorylation735
TPhosphorylation735
TPhosphorylation735

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

               
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
56893UBQLN45670NP_064516.2yeast 2-hybrid16713569   


Pathway Information


                              
Pathway Name Pathway ID
Aldosterone synthesis and secretion hsa04925
Calcium signaling pathway hsa04020
Circadian entrainment hsa04713
MAPK signaling pathway hsa04010
Type II diabetes mellitus hsa04930


Structure Information


No matching records could be found.

Domain Information




ID Location Description
pfam00520777-963  Ion_trans
pfam005201314-1536  Ion_trans
pfam005201645-1850  Ion_trans
pfam00520130-394  Ion_trans
pfam080161648-1851  PKD_channel
PHA033071947-2377  PHA03307
pfam08016838-969  PKD_channel
pfam031541956-2373  Atrophin-1
PHA032471882-2356  PHA03247
PHA032471960-2377  PHA03247


Ontology Information


   
HPRD ID549
Molecular ClassVoltage gated channel
Molecular FunctionTranscription factor activity (GO:0003700)
Biological ProcessRegulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism (GO:0019219)  



SNP Information


View SNP Geneview Report   

Drug Information


Uniprot ID DrugBank ID Name Type
O43497DB00347TrimethadioneSmallMoleculeDrug
O43497DB00421SpironolactoneSmallMoleculeDrug
O43497DB00568CinnarizineSmallMoleculeDrug
O43497DB00593EthosuximideSmallMoleculeDrug
O43497DB00661VerapamilSmallMoleculeDrug
O43497DB00909ZonisamideSmallMoleculeDrug
O43497DB04841FlunarizineSmallMoleculeDrug
O43497DB05246MethsuximideSmallMoleculeDrug

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO