Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| CADM1 | 23705 | cell adhesion molecule 1  | 11 | NECL2, ST17, BL2, SYNCAM, IGSF4A, Necl-2, SYNCAM1, RA175  |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 20340131    | 2011 | Cell line : - Source : - Sample Type : - No. of Sample : - Stage : - | real time RT-PCR, western blotting and immunohistochemistry,bisulfite genomic sequencing and the methylation specific PCR | Hypermethylation and down-regulation | - | Epigenetic inactivation of CADM1/TSLC1 gene is a frequent alteration in development of colorectal cancer and can be a potential biomarker for molecular staging of patients with colorectal cancer. Downregulation of CADM1/TSLC1 expression was observed in 7 of 8 (88%) colorectal cancer cell lines and in 39 of 54 (72%) primary colorectal carcinomas. Hypermethylation of CADM1/TSLC1 promoter region occurred in 6 of 8 (75%) colorectal cancer cell lines and 32 of 54 (59%) primary colorectal carcinomas, and was correlated with advanced colorectal carcinoma. Sample size: 54 primary colorectal carcinomas and their corresponding non-cancerous tissues. |
Gene Details

| Gene Type | protein coding |
|---|---|
| Gene Family | Immunoglobulin superfamily / V-set domain containing, "Immunoglobulin superfamily / C2-set domain containing", "Immunoglobulin superfamily / Immunoglobulin-like domain containing" |
| Description | -   | Chromosome | 11 |
| Location | 11q23.2 |
| Start | 115173625   |
| End | 115504523   |
| Strand | -   |
| Gene Sequence |    Download   Select all |
| Length | 330899   |
| OMIM ID | 605686    |
| HGNC ID | HGNC:5951    |
| Unigene ID | Hs.370510    |
| Ensembl ID | ENSG00000182985    |
| PharmGKB ID | -    |
mRNA Information
| mRNA ID | NM_001098517.1 |
|---|---|
| Exon | join(1..253,264104..264250,265872..266024,273034..273171, 275253..275411,286533..286632,289744..289916, 325749..325880,327932..330899)   | mRNA Sequence |    Download   Select all |
| Length | 4240   |
CDS Information
| Location | join(130..253,264104..264250,265872..266024, 273034..273171,275253..275411,286533..286632, 289744..289916,325749..325880,327932..328050) |
|---|---|
| CDS Sequence |    Download   Select all |
| CCDS ID | CCDS53711.1 |    
Protein Information
| Protein ID | NP_001287972.1 |
|---|---|
| Protein Name | cell adhesion molecule 1 |
| Molecular Wt. (Da) | 47347 |
| Protein Sequence |    Download   Select all |
| Length | 471   |
| Uniprot ID | P01042 |    
| Ensembl Protein ID | ENSP00000265023   |    
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| N | Glycosylation | 113 |
| N | Glycosylation | 113 |
| N | Glycosylation | 101 |
| N | Glycosylation | 101 |
| N | Glycosylation | 304 |
| N | Glycosylation | 304 |
| N | Glycosylation | 301 |
| N | Glycosylation | 302 |
| N | Glycosylation | 301 |
| N | Glycosylation | 302 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING)      View   
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 4356 |    MPP3 |    3069 |    NP_001923.2 |    in vitro;in vivo;yeast 2-hybrid |    13679854    |
| 6386 |    SDCBP |    3741 |    NP_005616.2 |    in vitro |    12202822    |
| 8573 |    CASK |    2164 |    NP_003679.2 |    in vitro |    12202822    |
| 23136 |    EPB41L3 |    5622 |    NP_036439.2 |    in vitro;in vivo |    12234973    |
| 55729 |    ATF7IP |    9811 |    NP_060649.3 |    yeast 2-hybrid |    15231748    |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Cell adhesion molecules (CAMs) |    hsa04514 |    
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd05881 | 46-140  | Ig1_Necl-2 |
| cl11960 | 46-140  | Ig superfamily |
| cd05883 | 161-242  | Ig2_Necl-2 |
| cl11960 | 161-242  | Ig superfamily |
| cd05717 | 46-140  | Ig1_Necl-1-3_like |
| cd05761 | 161-239  | Ig2_Necl-1-4_like |
| cd05882 | 49-140  | Ig1_Necl-1 |
| cd07701 | 49-140  | Ig1_Necl-3 |
| cd05885 | 161-239  | Ig2_Necl-4 |
| cd05884 | 162-239  | Ig2_Necl-3 |
| cd07705 | 164-229  | Ig2_Necl-1 |
| pfam08205 | 157-226  | C2-set_2 |
| cd04968 | 250-331  | Ig3_Contactin_like |
| cl11960 | 250-331  | Ig superfamily |
| cd05851 | 245-330  | Ig3_Contactin-1 |
| pfam13927 | 242-317  | Ig_3 |
| cd05745 | 259-320  | Ig3_Peroxidasin |
| pfam13895 | 258-327  | Ig_2 |
| cd05740 | 259-330  | Ig_CEACAM_D4 |
| cd05725 | 264-330  | Ig3_Robo |
| cd05719 | 158-226  | Ig2_PVR_like |
| cd00096 | 263-324  | Ig |
| cd05731 | 263-330  | Ig3_L1-CAM_like |
| cd05724 | 260-326  | Ig2_Robo |
| cd04967 | 265-324  | Ig1_Contactin |
| cd07703 | 166-224  | Ig2_Nectin-2_like |
| cd05749 | 260-324  | Ig2_Tyro3_like |
| pfam00047 | 260-315  | ig |
| cd04969 | 267-330  | Ig5_Contactin_like |
| cd07693 | 251-324  | Ig1_Robo |
| cd04978 | 260-330  | Ig4_L1-NrCAM_like |
| cd05754 | 258-317  | Ig3_Perlecan_like |
| cd05743 | 260-320  | Ig_Perlecan_D2_like |
| cd05728 | 260-330  | Ig4_Contactin-2-like |
| cd07704 | 141-239  | Ig2_Nectin-3-4_like |
| cd05849 | 247-324  | Ig1_Contactin-1 |
| cd05730 | 260-331  | Ig3_NCAM-1_like |
| cd05732 | 245-327  | Ig5_NCAM-1_like |
| cd00099 | 52-140  | IgV |
| cd05736 | 265-332  | Ig2_Follistatin_like |
| cd05746 | 263-328  | Ig4_Peroxidasin |
| cd05856 | 260-330  | Ig2_FGFRL1-like |
| cd00096 | 162-234  | Ig |
| cd05733 | 265-324  | Ig6_L1-CAM_like |
| cd05723 | 267-330  | Ig4_Neogenin |
| cd05755 | 144-223  | Ig2_ICAM-1_like |
| pfam13895 | 52-142  | Ig_2 |
| cd05876 | 263-330  | Ig3_L1-CAM |
| cd00098 | 176-232  | IgC |
| cd07706 | 51-136  | IgV_TCR_delta |
| cd05867 | 260-330  | Ig4_L1-CAM_like |
| cd05764 | 260-330  | Ig_2 |
| pfam07686 | 259-317  | V-set |
| pfam07686 | 49-142  | V-set |
| cd05722 | 252-317  | Ig1_Neogenin |
| cd05848 | 265-320  | Ig1_Contactin-5 |
| cd05869 | 261-321  | Ig5_NCAM-1 |
| cd05772 | 156-232  | IgC_SIRP |
| cd05887 | 96-141  | Ig1_Nectin-3_like |
| cd05759 | 166-239  | Ig2_KIRREL3-like |
| cd05771 | 109-226  | IgC_Tapasin_R |
| cd05718 | 88-143  | Ig1_PVR_like |
| pfam13927 | 147-224  | Ig_3 |
| cd00096 | 60-137  | Ig |
| cd07698 | 261-312  | IgC_MHC_I_alpha3 |
| smart00410 | 252-330  | IG_like |
| smart00410 | 50-140  | IG_like |
| smart00408 | 158-226  | IGc2 |
| smart00409 | 252-330  | IG |
| smart00408 | 259-320  | IGc2 |
| pfam07679 | 248-322  | I-set |
| smart00409 | 50-140  | IG |
| pfam07679 | 50-125  | I-set |
| smart00410 | 155-223  | IG_like |
| smart00409 | 155-223  | IG |
| smart00408 | 56-125  | IGc2 |
Ontology Information
| HPRD ID | 4114 |    
|---|---|
| Molecular Class | Adhesion molecule |
| Molecular Function | Transporter activity (GO:0005215) |
| Biological Process | Transport (GO:0006810)   |
Drug Information
No matching records could be found.
External Links
| ArrayExpress | GO |    
|---|---|
| ICGC | GO |    
| Cancer3D | GO |    
| COSMIC | GO |    
| NCG | GO |    
| TSGene | GO |    
| Tumor Gene Family of Databases | GO |    
| CCDB | GO |    
| G2SBC | GO |    
| Osteosarcoma Database | GO |    
| RCDB | GO |    
