Search results:


General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
CADM1 23705 cell adhesion molecule 1  11NECL2, ST17, BL2, SYNCAM, IGSF4A, Necl-2, SYNCAM1, RA175 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
20340131   2011Cell line : -

Source : -

Sample Type : -

No. of Sample : -

Stage : -

real time RT-PCR, western blotting and immunohistochemistry,bisulfite genomic sequencing and the methylation specific PCRHypermethylation and down-regulation-Epigenetic inactivation of CADM1/TSLC1 gene is a frequent alteration in development of colorectal cancer and can be a potential biomarker for molecular staging of patients with colorectal cancer.

Downregulation of CADM1/TSLC1 expression was observed in 7 of 8 (88%) colorectal cancer cell lines and in 39 of 54 (72%) primary colorectal carcinomas. Hypermethylation of CADM1/TSLC1 promoter region occurred in 6 of 8 (75%) colorectal cancer cell lines and 32 of 54 (59%) primary colorectal carcinomas, and was correlated with advanced colorectal carcinoma.

Sample size: 54 primary colorectal carcinomas and their corresponding non-cancerous tissues.


Gene Details



Chromosome 11 - NC_000011.10 (115173625..115504523, complement)

View Larger Image
   
Gene Type protein coding
Gene Family Immunoglobulin superfamily / V-set domain containing, "Immunoglobulin superfamily / C2-set domain containing", "Immunoglobulin superfamily / Immunoglobulin-like domain containing"
Description -  
Chromosome 11
Location 11q23.2
Start 115173625  
End 115504523  
Strand -  
Gene Sequence

   Download   Select all

Length 330899  
OMIM ID 605686   
HGNC ID HGNC:5951   
Unigene ID Hs.370510   
Ensembl ID ENSG00000182985   
PharmGKB ID -   

mRNA Information


mRNA ID NM_001098517.1
Exon join(1..253,264104..264250,265872..266024,273034..273171, 275253..275411,286533..286632,289744..289916, 325749..325880,327932..330899)  
mRNA Sequence

   Download   Select all

Length 4240  



CDS Information


   
Location join(130..253,264104..264250,265872..266024, 273034..273171,275253..275411,286533..286632, 289744..289916,325749..325880,327932..328050)
CDS Sequence

   Download   Select all

CCDS ID CCDS53711.1



Protein Information


      
Protein IDNP_001287972.1
Protein Namecell adhesion molecule 1
Molecular Wt. (Da)47347
Protein Sequence

   Download   Select all

Length 471  
Uniprot IDP01042
Ensembl Protein ID ENSP00000265023  



Post-translational Modification Information (Source : HPRD)


Residue Type site
NGlycosylation113
NGlycosylation113
NGlycosylation101
NGlycosylation101
NGlycosylation304
NGlycosylation304
NGlycosylation301
NGlycosylation302
NGlycosylation301
NGlycosylation302

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

                                                                           
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
4356MPP33069NP_001923.2in vitro;in vivo;yeast 2-hybrid13679854   
6386SDCBP3741NP_005616.2in vitro12202822   
8573CASK2164NP_003679.2in vitro12202822   
23136EPB41L35622NP_036439.2in vitro;in vivo12234973   
55729ATF7IP9811NP_060649.3yeast 2-hybrid15231748   


Pathway Information


      
Pathway Name Pathway ID
Cell adhesion molecules (CAMs) hsa04514


Structure Information


No matching records could be found.

Domain Information




ID Location Description
cd0588146-140  Ig1_Necl-2
cl1196046-140  Ig superfamily
cd05883161-242  Ig2_Necl-2
cl11960161-242  Ig superfamily
cd0571746-140  Ig1_Necl-1-3_like
cd05761161-239  Ig2_Necl-1-4_like
cd0588249-140  Ig1_Necl-1
cd0770149-140  Ig1_Necl-3
cd05885161-239  Ig2_Necl-4
cd05884162-239  Ig2_Necl-3
cd07705164-229  Ig2_Necl-1
pfam08205157-226  C2-set_2
cd04968250-331  Ig3_Contactin_like
cl11960250-331  Ig superfamily
cd05851245-330  Ig3_Contactin-1
pfam13927242-317  Ig_3
cd05745259-320  Ig3_Peroxidasin
pfam13895258-327  Ig_2
cd05740259-330  Ig_CEACAM_D4
cd05725264-330  Ig3_Robo
cd05719158-226  Ig2_PVR_like
cd00096263-324  Ig
cd05731263-330  Ig3_L1-CAM_like
cd05724260-326  Ig2_Robo
cd04967265-324  Ig1_Contactin
cd07703166-224  Ig2_Nectin-2_like
cd05749260-324  Ig2_Tyro3_like
pfam00047260-315  ig
cd04969267-330  Ig5_Contactin_like
cd07693251-324  Ig1_Robo
cd04978260-330  Ig4_L1-NrCAM_like
cd05754258-317  Ig3_Perlecan_like
cd05743260-320  Ig_Perlecan_D2_like
cd05728260-330  Ig4_Contactin-2-like
cd07704141-239  Ig2_Nectin-3-4_like
cd05849247-324  Ig1_Contactin-1
cd05730260-331  Ig3_NCAM-1_like
cd05732245-327  Ig5_NCAM-1_like
cd0009952-140  IgV
cd05736265-332  Ig2_Follistatin_like
cd05746263-328  Ig4_Peroxidasin
cd05856260-330  Ig2_FGFRL1-like
cd00096162-234  Ig
cd05733265-324  Ig6_L1-CAM_like
cd05723267-330  Ig4_Neogenin
cd05755144-223  Ig2_ICAM-1_like
pfam1389552-142  Ig_2
cd05876263-330  Ig3_L1-CAM
cd00098176-232  IgC
cd0770651-136  IgV_TCR_delta
cd05867260-330  Ig4_L1-CAM_like
cd05764260-330  Ig_2
pfam07686259-317  V-set
pfam0768649-142  V-set
cd05722252-317  Ig1_Neogenin
cd05848265-320  Ig1_Contactin-5
cd05869261-321  Ig5_NCAM-1
cd05772156-232  IgC_SIRP
cd0588796-141  Ig1_Nectin-3_like
cd05759166-239  Ig2_KIRREL3-like
cd05771109-226  IgC_Tapasin_R
cd0571888-143  Ig1_PVR_like
pfam13927147-224  Ig_3
cd0009660-137  Ig
cd07698261-312  IgC_MHC_I_alpha3
smart00410252-330  IG_like
smart0041050-140  IG_like
smart00408158-226  IGc2
smart00409252-330  IG
smart00408259-320  IGc2
pfam07679248-322  I-set
smart0040950-140  IG
pfam0767950-125  I-set
smart00410155-223  IG_like
smart00409155-223  IG
smart0040856-125  IGc2


Ontology Information


   
HPRD ID4114
Molecular ClassAdhesion molecule
Molecular FunctionTransporter activity (GO:0005215)
Biological ProcessTransport (GO:0006810)  



SNP Information


View SNP Geneview Report   

Drug Information


No matching records could be found.

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO