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General Information
- Evidence
- Gene
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- Protein
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- Enzyme
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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 18214032 | 2007 | Cell line : SW480, SW620, WiDr, HT29,
SW1116, Lovo, Colo205, Caco-2, SK-CO-1, LS180, Met-5A. Source : ATCC, University Hospital of Bern, Switzerland (Institute of Medical Oncology, Prof. M. Fey). Sample Type : Genomic DNA No. of Sample : 19 Stage : - | PCR amplification of genomic DNA and RFLP | Polymorhpism | - | The SNP513 in human CALB2 may thus be a predictive marker for colon tumors. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | EF-hand domain containing |
| Description | This gene encodes an intracellular calcium-binding protein belonging to the troponin C superfamily. Members of this protein family have six EF-hand domains which bind calcium. This protein plays a role in diverse cellular functions, including message targeting and intracellular calcium buffering. It also functions as a modulator of neuronal excitability, and is a diagnostic marker for some human diseases, including Hirschsprung disease and some cancers. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2010] | Chromosome | 16 |
| Location | 16q22.2 |
| Start | 71392616 |
| End | 71424341 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 31726 |
| OMIM ID | 114051 |
| HGNC ID | HGNC:1435 |
| Unigene ID | Hs.106857 |
| Ensembl ID | ENSG00000172137 |
| PharmGKB ID | PA26027 |
mRNA Information
| mRNA ID | NM_001740.4 |
|---|---|
| Exon | join(1..174,13441..13517,16033..16122,18955..19035, 24007..24063,24655..24732,25258..25313,25627..25666, 26071..26124,26865..26936,31037..31726) | mRNA Sequence | Download Select all |
| Length | 1485 |
Protein Information
| Protein ID | NP_001731.2 |
|---|---|
| Protein Name | calbindin 2 |
| Molecular Wt. (Da) | 31409 |
| Protein Sequence | Download Select all |
| Length | 271 |
| Uniprot ID | Q02817 |
| Ensembl Protein ID |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
No matching records from HPRD source could be found.
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd00051 | 111-180 | EFh |
| cl08302 | 111-180 | EFh superfamily |
| cd00051 | 20-92 | EFh |
| cl08302 | 20-92 | EFh superfamily |
| cd00051 | 159-225 | EFh |
| cl08302 | 159-225 | EFh superfamily |
| smart00054 | 111-139 | EFh |
| cl23347 | 111-139 | EFh superfamily |
| cd00051 | 199-234 | EFh |
| pfam13405 | 111-139 | EF-hand_6 |
| cl23634 | 111-139 | EF-hand_6 superfamily |
| cd00051 | 67-137 | EFh |
| pfam13405 | 199-227 | EF-hand_6 |
| cl23634 | 199-227 | EF-hand_6 superfamily |
| smart00054 | 199-227 | EFh |
| cl23347 | 199-227 | EFh superfamily |
| pfam00036 | 111-139 | EF-hand_1 |
| cl23489 | 111-139 | EF-hand_1 superfamily |
| pfam13405 | 20-48 | EF-hand_6 |
| cl23634 | 20-48 | EF-hand_6 superfamily |
| smart00054 | 20-48 | EFh |
| cl23347 | 20-48 | EFh superfamily |
| pfam00036 | 199-227 | EF-hand_1 |
| cl23489 | 199-227 | EF-hand_1 superfamily |
| PTZ00184 | 13-180 | PTZ00184 |
| pfam13499 | 161-220 | EF-hand_7 |
| COG5126 | 66-226 | FRQ1 |
| pfam13499 | 117-180 | EF-hand_7 |
| COG5126 | 20-185 | FRQ1 |
| pfam13499 | 26-92 | EF-hand_7 |
| COG5126 | 110-234 | FRQ1 |
| PTZ00183 | 111-229 | PTZ00183 |
| PTZ00183 | 15-180 | PTZ00183 |
| PLN02964 | 153-230 | PLN02964 |
| pfam13499 | 73-136 | EF-hand_7 |
Ontology Information
| HPRD ID | 11829 |
|---|---|
| Molecular Class | Calcium binding protein |
| Molecular Function | Molecular function unknown (GO:0005554) |
| Biological Process | Cell communication (GO:0007154); Signal transduction (GO:0007165) |
Drug Information
No matching records could be found.