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General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| CAMP | 820 | cathelicidin antimicrobial peptide | 3 | CAP18, FALL39, FALL-39, LL37 |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 24282571 | 2013 | Cell line : HT 29, LOVO, Caco 2,DLD 1 Source : ATCC Sample Type : - No. of Sample : - Stage : - | Western blotting, real-time PCR ,RNA interference | Up-regulation | - | PDE3B expression and intracellular cAMP levels are correlated with the proliferation of colon cancer cells. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Endogenous ligands |
| Description | This gene encodes a member of an antimicrobial peptide family, characterized by a highly conserved N-terminal signal peptide containing a cathelin domain and a structurally variable cationic antimicrobial peptide, which is produced by extracellular proteolysis from the C-terminus. In addition to its antibacterial, antifungal, and antiviral activities, the encoded protein functions in cell chemotaxis, immune mediator induction, and inflammatory response regulation. [provided by RefSeq, Sep 2014] | Chromosome | 3 |
| Location | 3p21.3 |
| Start | 48264837 |
| End | 48266981 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 2145 |
| OMIM ID | 600474 |
| HGNC ID | HGNC:1472 |
| Unigene ID | Hs.51120 |
| Ensembl ID | ENSG00000164047 |
| PharmGKB ID | PA26054 |
mRNA Information
| mRNA ID | NM_004345.4 |
|---|---|
| Exon | join(1..366,1008..1115,1257..1328,1947..2145) | mRNA Sequence | Download Select all |
| Length | 758 |
Protein Information
| Protein ID | NP_004336.3 |
|---|---|
| Protein Name | cathelicidin antimicrobial peptide |
| Molecular Wt. (Da) | 0 |
| Protein Sequence | Download Select all |
| Length | 173 |
| Uniprot ID | Q6W4X9 |
| Ensembl Protein ID | ENSP00000406861 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| A | Proteolytic Cleavage | 133 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 1511 | CTSG | 289 | NP_001902.1 | in vitro;in vivo | 11389039 |
| 2358 | FPR2 | 647 | NP_001453.1 | in vivo | 11015447 |
| 5657 | PRTN3 | 1512 | NP_002768.3 | in vitro;in vivo | 11389039 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Salivary secretion | hsa04970 |
| Tuberculosis | hsa05152 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| pfam00666 | 32-98 | Cathelicidins |
| cl22991 | 32-98 | Cathelicidins superfamily |
| pfam12153 | 136-163 | CAP18_C |
| cl13572 | 136-163 | CAP18_C superfamily |
Ontology Information
| HPRD ID | 1810 |
|---|---|
| Molecular Class | Secreted polypeptide |
| Molecular Function | Transcription factor activity (GO:0003700) |
| Biological Process | Regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism (GO:0019219) |
Drug Information
No matching records could be found.