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General Information
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 18678097    | 2008 | Cell line : - Source : - Sample Type : - No. of Sample : 17 patients with LARA, clinical stage II, III according to IUCC were enrolled into our pilot study Stage : Clinical stage II, III | Low-density oligonucleotide microarrays | Up-regulation | - | 8 genes (RB1, RBBP4, HYOUI, JUNB, MDM4,�CANX, MMP2, TCF7L2) significantly upregulated in NR. |
Gene Details

| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | This gene encodes a member of the calnexin family of molecular chaperones. The encoded protein is a calcium-binding, endoplasmic reticulum (ER)-associated protein that interacts transiently with newly synthesized N-linked glycoproteins, facilitating protein folding and assembly. It may also play a central role in the quality control of protein folding by retaining incorrectly folded protein subunits within the ER for degradation. Alternatively spliced transcript variants encoding the same protein have been described. [provided by RefSeq, Jul 2008]   | Chromosome | 5 |
| Location | 5q35 |
| Start | 179125019   |
| End | 179158642   |
| Strand | +   |
| Gene Sequence |    Download   Select all |
| Length | 33624   |
| OMIM ID | 114217    |
| HGNC ID | HGNC:1473    |
| Unigene ID | Hs.567968    |
| Ensembl ID | ENSG00000127022    |
| PharmGKB ID | PA26055    |
mRNA Information
| mRNA ID | NM_001164444.1 |
|---|---|
| Exon | complement(join(<1..620,2228..2329))   | mRNA Sequence |    Download   Select all |
| Length | 810   |
CDS Information
| Location | 57..785 |
|---|---|
| CDS Sequence |    Download   Select all |
| CCDS ID | CCDS4447.1 |    
Protein Information
| Protein ID | NP_001157916.1 |
|---|---|
| Protein Name | calnexin |
| Molecular Wt. (Da) | 27212 |
| Protein Sequence |    Download   Select all |
| Length | 242   |
| Uniprot ID | Q9UIF7 |    
| Ensembl Protein ID | ENSP00000346354   |    
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| S | Phosphorylation | 554 |
| S | Phosphorylation | 564 |
| S | Phosphorylation | 583 |
| S | Phosphorylation | 554 |
| S | Phosphorylation | 564 |
| S | Phosphorylation | 583 |
| T | Phosphorylation | 562 |
| T | Phosphorylation | 562 |
| S | Phosphorylation | 583;- |
| S | Phosphorylation | 583;- |
| K | Acetylation | 137 |
| K | Acetylation | 137 |
| S | Phosphorylation | 392 |
| S | Phosphorylation | 392 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING)      View   
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 338 |    APOB |    133 |    NP_000375.2 |    in vitro;in vivo |    14498830    |
| 2492 |    FSHR |    639 |    NP_000136.2 |    in vivo |    9528938    |
| 3459 |    IFNGR1 |    127 |    NP_000407.1 |    in vivo |    8136357    |
| 3973 |    LHCGR |    1073 |    NP_000224.2 |    in vivo |    9528938    |
| 4035 |    LRP1 |    138 |    NP_002323.2 |    in vivo |    14980518    |
| 6521 |    SLC4A1 |    175 |    NP_000333.1 |    in vitro;in vivo |    10364201    |
| 11170 |    FAM107A |    9753 |    NP_009108.1 |    yeast 2-hybrid |    16169070    |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Antigen processing and presentation |    hsa04612 |    
| HTLV-I infection |    hsa05166 |    
| Phagosome |    hsa04145 |    
| Protein processing in endoplasmic reticulum |    hsa04141 |    
| Thyroid hormone synthesis |    hsa04918 |    
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| pfam00262 | 69-440  | Calreticulin |
| cl02828 | 69-440  | Calreticulin superfamily |
| PHA03169 | 268-386  | PHA03169 |
Ontology Information
| HPRD ID | 3247 |    
|---|---|
| Molecular Class | Chaperone |
| Molecular Function | Transcription factor activity (GO:0003700) |
| Biological Process | Regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism (GO:0019219)   |
Drug Information
| Uniprot ID | DrugBank ID | Name | Type |
|---|---|---|---|
| P27824 | DB00025 | Antihemophilic Factor (Recombinant) | BiotechDrug |
| P27824 | DB00031 | Tenecteplase | BiotechDrug |
External Links
| ArrayExpress | GO |    
|---|---|
| ICGC | GO |    
| Cancer3D | GO |    
| COSMIC | GO |    
| NCG | GO |    
| TSGene | GO |    
| Tumor Gene Family of Databases | GO |    
| CCDB | GO |    
| G2SBC | GO |    
| Osteosarcoma Database | GO |    
| RCDB | GO |    
