Search results:


General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
CANX 821 calnexin  5CNX, IP90, P90 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
18678097   2008Cell line : -

Source : -

Sample Type : -

No. of Sample : 17 patients with LARA, clinical stage II, III according to IUCC were enrolled into our pilot study

Stage : Clinical stage II, III

Low-density oligonucleotide microarraysUp-regulation-8 genes (RB1, RBBP4, HYOUI, JUNB, MDM4,�CANX, MMP2, TCF7L2) significantly upregulated in NR.


Gene Details



NC_000005.9 (179125019..179158642)

View Larger Image
   
Gene Type protein coding
Gene Family -
Description This gene encodes a member of the calnexin family of molecular chaperones. The encoded protein is a calcium-binding, endoplasmic reticulum (ER)-associated protein that interacts transiently with newly synthesized N-linked glycoproteins, facilitating protein folding and assembly. It may also play a central role in the quality control of protein folding by retaining incorrectly folded protein subunits within the ER for degradation. Alternatively spliced transcript variants encoding the same protein have been described. [provided by RefSeq, Jul 2008]  
Chromosome 5
Location 5q35
Start 179125019  
End 179158642  
Strand +  
Gene Sequence

   Download   Select all

Length 33624  
OMIM ID 114217   
HGNC ID HGNC:1473   
Unigene ID Hs.567968   
Ensembl ID ENSG00000127022   
PharmGKB ID PA26055   

mRNA Information


mRNA ID NM_001164444.1
Exon complement(join(<1..620,2228..2329))  
mRNA Sequence

   Download   Select all

Length 810  



CDS Information


   
Location57..785
CDS Sequence

   Download   Select all

CCDS ID CCDS4447.1



Protein Information


      
Protein IDNP_001157916.1
Protein Namecalnexin
Molecular Wt. (Da)27212
Protein Sequence

   Download   Select all

Length 242  
Uniprot IDQ9UIF7
Ensembl Protein ID ENSP00000346354  



Post-translational Modification Information (Source : HPRD)


Residue Type site
SPhosphorylation554
SPhosphorylation564
SPhosphorylation583
SPhosphorylation554
SPhosphorylation564
SPhosphorylation583
TPhosphorylation562
TPhosphorylation562
SPhosphorylation583;-
SPhosphorylation583;-
KAcetylation137
KAcetylation137
SPhosphorylation392
SPhosphorylation392

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

                                                                                                         
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
338APOB133NP_000375.2in vitro;in vivo14498830   
2492FSHR639NP_000136.2in vivo9528938   
3459IFNGR1127NP_000407.1in vivo8136357   
3973LHCGR1073NP_000224.2in vivo9528938   
4035LRP1138NP_002323.2in vivo14980518   
6521SLC4A1175NP_000333.1in vitro;in vivo10364201   
11170FAM107A9753NP_009108.1yeast 2-hybrid16169070   


Pathway Information


                              
Pathway Name Pathway ID
Antigen processing and presentation hsa04612
HTLV-I infection hsa05166
Phagosome hsa04145
Protein processing in endoplasmic reticulum hsa04141
Thyroid hormone synthesis hsa04918


Structure Information


No matching records could be found.

Domain Information




ID Location Description
pfam0026269-440  Calreticulin
cl0282869-440  Calreticulin superfamily
PHA03169268-386  PHA03169


Ontology Information


   
HPRD ID3247
Molecular ClassChaperone
Molecular FunctionTranscription factor activity (GO:0003700)
Biological ProcessRegulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism (GO:0019219)  



SNP Information


View SNP Geneview Report   

Drug Information


Uniprot ID DrugBank ID Name Type
P27824DB00025Antihemophilic Factor (Recombinant)BiotechDrug
P27824DB00031TenecteplaseBiotechDrug

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO