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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
CARD6 84674 caspase recruitment domain family, member 6  5CINCIN1 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
20025480   2010Cell line : -

Source : -

Sample Type : CRC tumor and normal tissue

No. of Sample : 58 ESCC, 100 GC and 103 CRC patients' tissues.

Stage : -

Immunohistochemistry using a tissue microarrayUp-regulation-CARD6 might be related to activation of NF-kappaB pathway in the cancers and might play a role in the development of most types of gastrointestinal cancers.


Gene Details



NC_000005.9 (40841410..40855456)

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Gene Type protein coding
Gene Family -
Description This gene encodes a protein that contains a caspase recruitment domain (CARD), an antiparallel six-helical bundle that mediates homotypic protein-protein interactions. The encoded protein is a microtubule-associated protein that has been shown to interact with receptor-interacting protein kinases and positively modulate signal transduction pathways converging on activation of the inducible transcription factor NF-kB. [provided by RefSeq, Jul 2008]  
Chromosome 5
Location 5p13.1
Start 40841410  
End 40855456  
Strand +  
Gene Sequence

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Length 14047  
OMIM ID 609986   
HGNC ID HGNC:16394   
Unigene ID Hs.200242   
Ensembl ID ENSG00000132357   
PharmGKB ID PA26076   

mRNA Information


mRNA ID ?NM_032587.3
Exon  
mRNA Sequence

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Length  



CDS Information


   
Location
CDS Sequence

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CCDS ID CCDS3935.1



Protein Information


      
Protein IDNP_115976.2
Protein Namecaspase recruitment domain family, member 6
Molecular Wt. (Da)0
Protein Sequence

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Length 1037  
Uniprot IDQ96P20
Ensembl Protein ID ENSP00000337383  



Post-translational Modification Information (Source : HPRD)


Residue Type site
SPhosphorylation468;-

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

                              
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
8767RIPK24585NP_003812.1in vitro12775719   
10392NOD15815NP_006083.1in vitro12775719   


Pathway Information


      
Pathway Name Pathway ID
NOD-like receptor signaling pathway hsa04621


Structure Information


No matching records could be found.

Domain Information




ID Location Description
cd01671Nov-79  CARD
cl14633Nov-79  DD superfamily
pfam00619Sep-92  CARD
smart00114Apr-82  CARD
cd0832915-79  CARD_BIRC2_BIRC3
cd08324Sep-79  CARD_NOD1_CARD4
cd0878627-73  CARD_RIP2_CARD3
pfam04929939-1034  Herpes_DNAp_acc
cl15563939-1034  Herpes_DNAp_acc superfamily
cd08787Nov-86  CARD_NOD2_1_CARD15
pfam15310953-1020  VAD1-2
cl21155953-1020  VAD1-2 superfamily
pfam15240871-1019  Pro-rich
pfam07223895-1031  DUF1421
pfam07223846-1025  DUF1421
pfam09606900-1019  Med15
pfam15402877-1033  Spc7_N
pfam15240939-1035  Pro-rich
PRK10263894-1032  PRK10263
pfam05539821-1027  Pneumo_att_G
PRK13335943-1025  PRK13335
PHA03247805-1035  PHA03247
PRK10927963-1033  PRK10927
PHA03247844-1036  PHA03247
PRK13042944-1028  PRK13042
PRK12757956-1024  PRK12757
pfam02389949-1023  Cornifin
pfam07223826-1029  DUF1421
PHA03378847-1034  PHA03378
pfam09770890-1023  PAT1
pfam15449943-1021  Retinal
PHA03378895-1022  PHA03378
PRK03427943-1024  PRK03427
PRK10263903-1024  PRK10263
pfam03154890-1034  Atrophin-1
PHA03378901-1037  PHA03378
pfam09606812-1024  Med15
pfam15279947-1017  SOBP
pfam15301925-1017  SLAIN
pfam09770815-1037  PAT1
COG3147894-1024  DedD
pfam03154887-1034  Atrophin-1
smart00818891-1010  Amelogenin
pfam13388957-1025  DUF4106
pfam15268910-1026  Dapper
PLN02258930-1006  PLN02258
PHA03369884-1035  PHA03369
pfam09726827-1016  Macoilin
pfam15512957-1033  CAF-1_p60_C
pfam02389957-1012  Cornifin
pfam15240966-1037  Pro-rich
PRK10819957-1024  PRK10819
pfam15268885-1027  Dapper
pfam03154894-1025  Atrophin-1
pfam03154900-1025  Atrophin-1


Ontology Information


   
HPRD ID13094
Molecular ClassAdapter molecule
Molecular FunctionMolecular function unknown (GO:0005554)
Biological ProcessBiological_process unknown (GO:0000004)  



SNP Information


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Drug Information


No matching records could be found.

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO