CoReCG

Evidence Information

Pubmed ID	Year	Sample Information	Techniques	Mechanism	Fold Change	Remark
25197379	2014	Cell line : - Source : West China Hospital, West China Second University Hospital, Sichuan University Sample Type : CRC tumor No. of Sample : 367 tumor (gastric cancer 97 , ovarian cancer 65, cervical cancer 104 , colorectal cancer 101) Stage : -	Immunohistochemistry	Down-regulation	-	-
25738796	2015	Cell line : HCT116 Source : - Sample Type : - No. of Sample : - Stage : -	real time RT-PCR, western blotting	Down-regulation	-	Downregulation of NIT2 inhibits colon cancer cell proliferation and induces cell cycle arrest through the caspase-3 and PARP pathways.
26122204	2015	Cell line : - Source : - Sample Type : Male Sprague-Dawley rats No. of Sample : - Stage : -	real-time PCR	Down-regulation	-	-

Gene Details

NC_000004.11 (185548850..185570629, complement)
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Gene Type	protein coding
Gene Family	Caspases
Description	This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 6, 7 and 9, and the protein itself is processed by caspases 8, 9 and 10. It is the predominant caspase involved in the cleavage of amyloid-beta 4A precursor protein, which is associated with neuronal death in Alzheimer's disease. Alternative splicing of this gene results in two transcript variants that encode the same protein. [provided by RefSeq, Jul 2008]
Chromosome	4
Location	4q34
Start	185548850
End	185570629
Strand	-
Gene Sequence	>gi|568815594:c184649475-184627696 Homo sapiens chromosome 4, GRCh38.p2 Primary Assembly ACATCTCCCGGCGGCGGGCCGCGGAAGCAGTGCAGACGCGGCTCCTAGCGGATGGGTGCTATTGTGAGGC GGTTGTAGAAGGTATGAGGAGGCTGTGCGGTGACTGCCGCCCTCGCTCCGGGCCGTCAGCCCTGCCCCCG CTCCCTGCGTTCTCCCAGGCCCTGCGCCCGCCCGGGTACCTGCCCGGTCTGGAAGGCGGAGTGTTTGTTT TGCCACCTCGCCCGGGCGGGGGCGAGCAGTGAAGCCCGCGGAGCGAGAGACTTGGCCCGGAGGCGGGAGC CTGGGCCGGGGCCGGGGAAGCCAGGCAGCGGGTTAAGGCTTTTGATTTAGGGAGAGGGACCTGGGGGTAA CCTAAGGAAAGGCCTCAGGTCATCGGAGGGGAGACCTGGCCCGGGGGCGGGAGGCTGGGCTGGGACCGGG GAGGCCGGGCAGCGCGAGGCCGGGCCGGGGAGGCCAGGCAGCGGGAGGCCTGGCCAGGGGAACCGAGCCC GGGGCCGGGAGGTCGGGCACGGGGCACCGAGCTCCGAGGGCGGGAGACCTGGCGGCCGGCCGAGTGCCGG AAGGCCGGGTCAGGCGGCGGAAGGCAGCGGCAAGCTGGGAAACGGACGGCGCTACCGCCGGCGGAGGAGT GGCCCCGGGAAGCGGTGCTGCGAGGGCTGGGGCGGCCGGGTGCTGACTGTGAGATACTCGCCCTGGGGGC TGATCCTTCCAATTTTGGACGAGGCTTCCGTCTCTGCTGCCTTCCATGCCTGGGGCCTGGATTATCCCGG GTTGACAATGTGGTTTAGCTCTTCCAGAGAGATAGTTGCAGGGTTTAAACTCCAATTCCTTTTCGGCCCT GCAGAGTTTCGTGAGTGCTCGCAGCTCATACCTGTGGCTGTGTATCCGTGGCCACAGCTGGTTGGCGTCG CCTTGAAATCCCAGGCCGTGAGGAGTTAGCGAGCCCTGCTCACACTCGGCGCTCTGGTTTTCGGTGGGTG TGCCCTGCACCTGCCTCTTCCCCCATTCTCAGTAAGTGGCACCCAAGCAGGAAACCGGAAAACATCGTTC GCAGCCCCCTCTCGCCCACCCACTTCTTTTCCTGCTTAGTCGCCAAGCCTTGTCGACCTTGTAAATGTCT GCCAGATCTGTCCGCGTCTCTCTATCTCTGATTTCAGCCGTCTGACCACAGCAGCCTCTTCCCTGGTCTC TCCACTTCCAGACCCGCCTGCTCCTTTGCAGTCCACTTTTTACAGCACAGGCAGAGGGATCTTTATGAAA TGAAAGTCTAGAAAGCTCGTCCTTTGCCCTTAGGTTAAACCCAGCACTTAATATGGCTAACAAACCCCTG CGTGTGTTGGGTCCTGAGTGCCCCCACCCCTCCTTATCTTTAGCACCGGTTCGATTTCTGCACGGCAATG CTGACCTTCATACCTAGTGTCTGCCTGCAACACCTCTGCACTCCCTTTCTCCCGCCATCACATTTGATTA GAAGAGCTGCTACTTAAATTTCTGTTTTCATTAAACAGTTTAAGGTTAAATCTTCCTATGCTGTGTTCTT TCTGCAGCCAGCATTCCCTAAGAGAGATGTGTCATATCCTTTGCAGTTGCTTGTTTACTATCTTCCCTGC TAGATTTGCAAGCAAACTCCAGGAGGGACGGACTTGGTTTATCTTGGTATCCTTAGTGTCTTGCCCCAAA TGCGGGGCCTGGCATAACACAGTGAATGCCCATCCATTGTATTTTTACTTTTATGCCCTATCTAGAAAAA GTAGACCTGGTTTAGGATTATTCAGCAAATAATAATTAGAAAAGAAATGGTAGAGGTGACATACGGAGTC ACTGAAACGATGTAAACCTGCAAGATAGCTGAAAGAGGGCCAGGCAAGGTGGTTAGACCAGACTGTATCA AAATGGGCTCAGCCACTGTGAATGTGCGTGCTGTGGTTACATAATCTCTAAAAATGAAATATAAAGCTTA AATCATCTCTATCACAGCCCGATGCTTGGACTTTGGTTTTGCTTTGCCTTTTTGCAAAAGAAGGTTTTTG AAAGTGAAAATTATTTTAGTGAATGGATGAACAGTTTATTGGAGTATGGCAATAAAACCTGTTCAAAGTA AGAGACATTAGACATTGTACCTAGTTAAATCAGATTTGCTTTTGCTATCCTGAATAAAGGCCTTGCCTCT TGCCATTTGAAGAGACTGGCATCTGATATAGGCAATTATAATGCTTCTTTACTGTTTTGTTTTCAAACCT CGTTTAACACAATCTCCTACTGCTTCATCCCCCTACAAAGCAGTCTTTATTTTGATGAATGATATATTAC ATTGCTTCTGGTGCCTACTATTAGATCTTTAAGCTCTGCCCCAAAGATAAGAAGCACTGGTGTTTGGGCC TAAACAAAGATGGGAGAATTCTTAGATTTATATAATATTCTTTCTCTGCATGTTTTGTTCTTACCTTCAC ATGTTGCCTGTAGAGCTTCTTTGCATTACAATAATGAAATCAAGCTACCTGATATGTATTGGACACGGTC TGGCATCTGCCTTGTTGAGCCACTTTTGAATACCAGTGAGCATCGGTATAAGCCCTGAATAGAGATAGGG TTTGTCTCTTCCACTGCTTGATACACTCAGGGTCTAGTATAGTACTCTGCACACAGTTGGTGTTCAGTAA ATTGTTATGGTGCAAATATCAAATGAATAAATGCTACTGAATCTGAGTTTTGGCAGTTTCAGTCTTCCTG ACAGCAGGATTTCTTCAAGCGGTTTTAAACTTGAATCTGATTCTGCAAAGTAGTCATCCTTGGTGGGAGT GCTGAGGCTTTAAAGTCATCTGTAATTTTTATAAAAAGGCATCCGAGATCCTCCATTTTACACTTATATC ATACAAATCATTTAGATCTGTGAAGGCTTTCCCATTTTCTCCTTTTGTCCTTCCAAAAACACCATCTTAG GACTTCACCTGGCACAGGGAAGACAGATCGTTTGCACATACTAAGTGCCCTTCTTTCTAACTTGTGTCAT AAACTCAGAGGCTTTGAATAGTGGAGAGTGCTCTGTACTGTCTTCCTGGTCACGTGGCCCTTGCCAGAGG AAAGGAAAGGATGGTTTGTTTGTATAGTACAATGGAACTTATTTCAATGTATTCTGTATTTGATTTTACA TTCCTGTTCTCATATTTTTACCTTAATTACATAACAAATATTAAAAGATTGACTTCACCAGGCCCAGTTA CAATCGCCAGTTTGATAATTCTTATACGTACTCAAATGAATTCAGAGACCAGATGGGAAAAGATTTTGAT AAAACCTCTGGTACATCACAACTGAAGTCTTTTCTTGTCCAAACTATTGTGAAACAGATGTTCTTTCTGT TTCATTTGCTAAATCTGGAAACGTGACTGCTTTTGAGACTTTGTCCTCTCTGACAGGTAATAAATATAAT CCTGATATTTTTCAAGTTGTTTGACAGAAGTGTAATCTCCCCAGAAGTCCTGCTGGACAGGCTTCACTTT TCCTTTGGAGGAACACAGAGATACAGGGAATATGTTTTAATGACATATACCTAACGCTGAACATGAAACC AGTTATTTTACTTTTATTATTATTATTTTTAGAAACAGCCTTGCTGTGTCACCCAAGCTCAAGTGCAGTG GTGCGATCATAGCTCACTGCAGCCTCCAATTCCTATGCTCAAGTAATCCTCTTGCCTCAGCCTCCTGAGT AGCTGGGACTACAGGTGTGTGCCACCATGCCAGGCTACTTGTTTTTACTTTGTTATAGAGATGGGGTCTC TCTGTGTTGCCCAGACTGGTCTTGAACACATGATCTCAACCATTCCTCCCACCTTGGCCTCCCAAAGTGC TGGGATTACAGGCGCGAGCCACTGTGTCTGGCCTATTTCACTTTAGAAGTAAATTGAATGCCACATGCGA AGTTTGTTAAATTTTTTTAAAAAAGGAAAGAAAACACAAAAGTAAACTACCTAGTCGCATCAGAAATGCC ATAGTCATTTTTGCCATTTTTTCATTCATTAGAATTCAGTGCATTATGTTATTTTGTTATCTCTGCAGTA ACTTTCTATCATGTTATTTATTTTCTTTGTCTTATTTAAAGCTTCTGAGATTATGGATTTTTGTTTCCTT CCCTGAAGTTAAGTGTTATCATTCCTATATAGTACTAAGCTGTCTACAGAATAGTGGGAGTCTGCCCTCT TGAGTTGGGAAGATCCTAGTTTGAATCTTGGCTGTGCGACTTTAAAGTTCATTAACTTCTCTTAGCCTCA GTCACCTGAACTCTGCAGTGGGGATCCTTATGCCTCAGAGTGTCATTGGGAGGACTCACGAAAATACGCT TGTACTTTGAGTTCAGTACCTAGCCTGTATGAGCCAGCATTAAGAGGGACAGTCATCACGCAGCGCTTTG CACACAGCTCTCACGCCACATCCTTTGGCTACTGTTTTGGTAAATCTTTACTAGTAAATGTTTCTTAAAA GCATTTACATTCATGGACATGATTCAGAAACTAACAGTTGTTTTTTAGGTCTCACTTTGAGATTTAAAAA CCCTTAGGGCAGAGACCAGATTTTATTTCTTACCTCAGAGTTTCCCTGTAGGACAGGAACCAGCAACAGC CTAATGAGCTGATTAAGAATTTTAGAGATTTAAAATTTAAATTAGGATTGCCAGTTTTAGAGACTGGCAC ATAAATGTTTTCATTTAAGGCAGTGACTGTTTCCTTTAGGATATGATTTTTTATCTTTCTAAGATGAGAT CACCATCCTCAGAATAATTTGTACCCCGCTGGGCACTAGCTAATGGAGGTGATGTCATGCTAAGCAGCAC TTCAGTGAGTTTTGCGGGAACCAAAGCTCTGCTCCCAGGAGTGTGGATTTGGTGCTTTCATGTGGAAAAA GCGGATGATGACAAGTAGAGAGCAAATGTGCGCATGTCTGATGCTGTAAGGATTTCCTTTACCATCATAT AAATTTTTAAAGTATATCAAAATAAACTGATAACTGAGAAAATATATGTTGTTCAGATACTAATAATGAA GTTAATGAAGTCCACTATAGTATTTGTCCCTGAGAAATCTTTATCAAATATTTTAAATCCTATTGTAAAA TAATGTATTTTTTCTTTCAGTTTTAGAGACTGGCAATCCTAATTTAACATCTCCTTTTGAATTCCCCACC ACAGGCACACTTTCACACATTCACTCTTTAATAACAGGTTGTTTCAAATTGTTAATACTTTATAGCTTAA TATAGAAATTTCACTTTAGAAATTAATTTTTATTTCTCTGCCTTAATGCTATAGATGTTGTAGTCTGCTT TACTTCAGTATTGTAATGAGTAGTTGGCTAACCACCATGTAAATAGGGAGAACATTCTAGTTTTTTACTT GTGTAGGAAAACACAGCTTGAAATGTCTAAGTATCTATTTTAGAGTGAAGTAAATTTATACTGACAATAT TTTTTTGTGTTTGAAGACCTGACTGTTACAGCGTTGGTGGCAAGTGTTAAGGGATCCAGGAACTAGACAA GTGATTCTGAGACCTGAGTTCCAGGTTTCTAAGTAATATCAGTTGGTCTACTGAGAACTTTGCCATAAAC ATATGTGTTCAGAAATTTCCTTTCTTAGCAGCAGCATCCTGAATTGAACAGAATTACACACACATCAGCC CAGTAAGAAACAATTCATGTTAAGTCCATTGCTATGCCAGGATAAATCTTTTAAATCACAATTATTTTTC CTATTTATATTTTGTCAAATAAGAATGTTCTAAAAACCAAAATTTCTGTTTTCTTTTTTTTTTTTTTTTT TTTTTGAGACGGAGTCTCACTCTGTCGCCCAGGCTGGAGTGCAGTGGCGCGATCTCGGCTCACGGCAAGC TCCACCTCCCGGGTTCACGCCATTCTCCTGCCTCAGCCTCCTGAGTAGCTGGGACTACAGGCACCCACCA CCACGCCTGGCTAATTTTTTATATTTTTAGTAGAGACGGGGTTTCACCGTGTTAGCCAGGATGGTCTTGA TCTCCCGAACTTGTGATCCGCCCGCCTCGGCCTCCCAAAGTGCTGGGATTACAGGCAAAATTTCTGTTTT CATTTAAGGCAGTGACTATTTCCCTTAGGATGTGATTTTTTTATCCTTCTAAGATGAGATCACCATCCTC AGAATAATTTGTACCCTGCTGGGCACTAGCTAATGGAGGTGATGTCATGCTAAGCAGCACTTCAGTGAGT TTTGCGGGAACCAAAGCTCTGCTCCCAGGAGTGTGGATTTGGTGCTTTCATGTGGAAAAAGCGGATGATG ACAAGTAGAGAGCAAATGTGCGCATGTCTGATGCTGTAAGGATTTCATCTACCATCATATAAATTTTTAG AAGTATATCAAAATAAACTGATAACTGAGGCAATGTATGTTGTTCAGATACTAATAATGAAGTTAATGAA GTCCACTATAGTATTTGTATAGTATTTGTATATTACAGTACTCTGAAAAGCTGGTCACTATTTAAAGTTT CCATTACCAGTCACAAGGAGAGAATAATTTTATCCCACAATTTTATTGCTGGCAAAAGACACAAGTTTAT TAAAAGTCAGTATTTCAGTGTAAGAGTTACTAGACTGTTTGCAGAAGTGTTCAAAAGAGATCTTTAGGTC CTTGGTTGTCTGTGGAAGCTGATCAGCATTTAGGGGTTCCTGAGCACAGACTGTGAACCCTGCATTTGGC ACATGCATTCAGAGAGCCAATTTGAGGCAGACTGGGGGCTAGAAAGGATACTGCCAGGAGCTCCAGGTTC AGCTTCCGAAGTTATTAAGTCTTATTTCCCAGTTTTTAAATTAGACTTCATTTTTTAGAGCAGTTTTAGG TTCAAACCAAAATTGAGAAGAACGTACAGAGACATCCTGTATCCCACCTGCCCCCCAACACGTGCGTAGT CTCCCCCATTATCAACATCCTGCACCAGAGTAGTACATTCTTACAAAGGAACCTACACTGACACGTCATC ATCACCCAAACGCCATCGTTCACAATCAAGTTCACTCTTGGTGCTGTTTATCCTATGGTTTTGGACAAAT TTACAAGGACTTGTATCCACCATTATATTGTCACACTGAGTAGTTTCACTGCCTTAAAAAGTCTCCGTGC GGGCCGGGCACGGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCCAAGGCGGGCAGATCACGAGGT TAGGAGTTCGAGACCAGCCTGGCCAACATGGTGAAACCCCGTCTCTACTAAAAATACAAAAATTAGCCTG GCATGGTGGCATGCGCCTGTAATCCCAGCTACTCAGGAGGCTGAGGCAGGAGAATCGCTTGAAACCTAAA GGCGGAGGTTGCAGTGAGCCGAGACCACGCCACTGCACTCCAGCCTGAGCAAGGAGCGAAATTCCATCTC AAAACAAAAAAAAAAAAAAAAAAAAATTCTCTGTGCTGTCTCCCTCCCTCCTAGCCACTGGCAACCACTG ATCTTTTTACTGTCTCCATAGTTTTGCCTTTTCCAGATTGTCAGATAGTTGGAATCATGCGGTATATATG GCCTTTTCAAACTGGCTTCTTTCACTTAGTAATAATGCATTTAAAGTGTTCATGGCTTGCTAGCTCATTT CTTTTTAGTGCTCAGTAATATTCTGTTCTCTGGATATACCACGGTTTATTTATTCATTCACCGACTGAAG GACATCTTAGTTGCTTCTAGTTTTGACAGTTATGAATAAAACTGCTATAAACATCTGTGTGCAGGCTTTT GTGTGAACATAAGTTTTCAACTCCTTTGGGTAAATACCAAAGAGTGCGTATTTACCATATGGCTGGATCA TATGGTAAGAGTATGTTTAGTTTTGTAGGAAACTGCCAAACTGTCTTTCGAGTTGGCTGTACCATTTTGC ATTTCCACGAGCAGTGATTGAGAATCCCTGTTGCTCCACATCCTCACCAGCATTTGGTGTTGATGGTGTT CTGGTTTTGGCCATTCTGCTAGGTATGTAATGATACCTCATTGTTGCTTTAATTAGCATTTCCCATTATT TGCAGTCTGTGTATCTTTGATGAGGCCCACTGGATTTTCACTTTAGATTTTCTATAGATTGGCCATAAAG TCTTGAAACAAAGATATTTTCTCATGGATTATAATGCAATATCAGTAAACTATTATGTGTTCACCTACGT TTCCAGACTTGTTAGCTACCCTGTACTGTTCTCTCAGTTAATCAAGTTAACCACAATTTGTTTCTCAACC ACAGGTGGCTAATGATTTTGTATGTGGTCTGTCCGCTTTGAATTGATGTGCATGGGGCAAGTTGGTCTCT ATGATATTCATGGTTCAAGGAAGTTCGAGATTTCCTGGTACCTAATACATGTTTATTGTACATATGAAAG AAAAAAGGGCAGATAGAGGGGAACATGGTACTGAGCATGATAGAGGCAAGGAAGGGTGGCTACTTTGATA GGAGAATACCCCTATTTTTGTCACTCTTGAAACAGGGCCAAGAGTTGAAATTGGCTAGAACAATCCTGAC CTTTGTTGATATTATTTTATAGAATAATATTTGTTACTGTTTTCTCACTTTTAAAAAATGCAGATGTTAT AGAAAAATTAGAAGATATAGAGGAATGTTAAGGAGTAAATAAGGTGTCAGTAATGCCATCACCCAGACAG CCACTGTTAATAAATATGTTAATATGTGAAGACATACTAATATGTAATATGTACTGAGTGACTAATGGCA GGTCACTTAGTAGCTGTCTCGATTATCAGATCAACTGTCATGGTATGGCAGTGTTTATGTTCAGGTACCC GTATTAGTTATTGTTGTTAATCCCTTTCTGCGCCCAAGTTATAAACTAAACTTTTTCATAGGTATGTACG TATAGGAAAAAATATGCTGCATATAGGCTCAGTACTGTATTTGGTTTCAAGCATCTACTGGGGGACTTGG GAGGTACCCCCTGCCCCTGCCCCACAGGTATACTACTGTATAATTATTCTTCTATCTAAAGTAAGATCTA ATGGAAGATAGGAACTTTGTCTTGTCTTCCACTCTGTCCTATTTCCCAGGATGATACCTGGCACAAAGTA TTTGTTTACTGACAAACTAAAAGATGATTTATCCCAATTATACTCACATCTTCCCTTGATTTTCCAGAAA GCCTACAGGAAGTAAGATGGTAGAAAAGCAAAGTCTTCGTAGAAATGCAGAGCATAGACTGGCTCTTGGA GAAGGTCAAACATCACCCTCTCCTGTGGTTAAATTGAGATGGTGGCACTGGCTGTCTTCTATATTATTGC TGCACCTTTCCTCACCAGGGGTGCACACAAAACTGGGAGAGAGGGGAGGAAGGAGCTTAGCTTTGTCTTA ATAGAAGGGAAGAAATGATGTTTTCCAAGAGACCTTGAAATTGGGGACCTTGGTAAAGGTTTCAGTTTGG GAAGATAAAAAAGTCCTGGGATGGATTCCAACAGTGTAACTGTACTCAATGCCACTGAGCTGTACGCTTA AGAGTGGTAAATTTTATGTCTATTTCACCACAGTTTTAAAGATTAAAATTTTTAAAAGTGGGGGAAGTTA CCTAGGACTTTCTAGAAGGACTTTTGAGGGTGAGCAAGTTCTGTTATAGGCTTGTGTATTATTTTGGTAT TTCTGATTTTATCATAGGAGTGAGGTTAAAGTTGTATTTTGACTGGAATTTTTGACATTGTCAGGGTTTC TAGAGTGTGGAGAAGGTCACTCAGTATTTTTTGTTTTTGTTTTTTGTTTTGCCTTTGTTCTTGTTTTCCT CTATTTAGGGAGGTGGATTGCCATGGGAAGTACCTTTGCTTCGAAAAGCCAGAAAATGCCTGGTAGAACT CCAGAAAAGTAGTAAGGAGCTGGCTTCTTCAGAGGCAGCATAGCAGAGTGGGAAGAGGGCCCTGTCACTT AGATTGTGACTGTCGACAAAGTCACTTAACCACCAGAAGTTGGGTTTTCTGACGTTTAGAATTTTGAAAA GATTAAAACTGAGTGCCTTGCAAAGTACCTGGTATATATTAAGTGCTCAATAAGTGATAGTTGCTTTGAT TCTAAGAACTGGTTCACCTTGTGAGATATAATTGTGTAATGGAAGAATGAAAGCAGAAACTTTAGTTTCT ACTTTTACATTTCCTGGGCCATTTTACTACCCTAAATGAGAAGCTGGGCTTCCAAAACCCACTTTAAAAG TAAAGACTAGGCCGGGTGCGGTGGCTCTTGCCTGTAATCCCAGCACTTTAGGAGGCCTAGGTGGGCAGAT CACTTGAACTCAGGAGTTTGAGACCAGCCTGGGCAATACAGCGAGACCGTATGTCTACAAAAAATACAAA AATTAGCCAGACATGGTGGTGCATGCCTGTAATCCCAGCTACTCGGGAGGCTGAGGCGGGAGAATTTGAG TCCAGGAGATCGAAGCTGCAGTGAGCCGTGATTGCGCCGCTGCCCTCCAGCCTGGGTGACAGAGTGAGAC CCTGCCTCAAAAGAAAAAAAAAAAAAGAATAAAGATTAATGGAGATTTGGAACATCTTGATACTGTATCT TGGGAATCTAAGCATTGTAGAATTGTGTTATGTGAGTTATACCATTGTGGTGGGAAGTTTTTGATTTTTG TTTTAACTGTGTTGAGTTGCAGTTCTTAGAAATGACCCGAGGTGTTGTCTTACAAAAGAAATAAACTGTA ATCTGTATCTTGATCTGATGAGGGTATGTAAATATAAAAAATCGAGCTGTATACTTTCTATATGCTTTAT GTAGTTCACTATATATAATTCATAGCTCAATTAAAAAGAGAGAGAGAGGCTAAATTGTATGTACCATTGC AAAGAAATCATTATCCCCAGAACTGACTCACATACACCTTTAACAGTAGAGGGAGAACTGAGGTATTAAT TTGGAAAAATAATCACTGGGATAATTAATATAATGCAGTGGTTTTATGACTGATTTTTTATTAACTTCTA TTTTCTTTGTATTCTAGTTAATAAAGGTATCCATGGAGAACACTGAAAACTCAGTGGATTCAAAATCCAT TAAAAATTTGGAACCGTGAGTATTTAAATTGAATTCTTTATAATCAGAGAAAGATGGGGATGTGTAATAA GCAAACCTCGAGCAGTGGGGCAAGAGGAAAGAGAGTGGTCTCTCTCTCAGGCCAGAGAGACCAAGTGACT TCCTACCTCAGACAGCTGTGTGGCTTTGCATAAACTGACTTTTCTTCTCTGAACCTCGTCTTTAACATGG GGCTAAAACTTTCACAGAACTGAAGGGAAGATGAAAGGAAAGGCCTAGTAGGGTGTGTGACCCATAGTTG GAAACCTAGTCCTGGAACCAAAAGGACACCACAGGAGAGGCAGGACTCCCAAGCGCCGGTGCTTTCTACC CTCCCGAATCGCTCTATAGGATTAGAGGGTTTAGGTTTGGGAGGAGTTTCTTGACCTCTTGTTTATGAGT TTTTACGACTAAAATGCAATGCCAGTTTTCAGTCCGGGGACAAACTGCCTAGTTATGGATGAATTTTACC CTTTTTTTCCCCGTGTCTTTTTGGAATATTCTGCTTATTAATGCTTCCAATAACTAGCAGATGGAAAAAG GAAAAAGATAAAACTCAAATTCACTTTTTAATTCTTGTCTGTTATTATTTATTTGGGATCTCTCGTAATA CTTTAAATTCTGAAAGTTTATTTCTGAAACCCAGTATTGTTATTCTCGGCTGCCCTGAATATTACAAACT AATTTTATTACTAAACAATATGATTACAGAAATACTATTAACAAGTTACCACTAAAGATTTCACAATTTT GTTTAGCAAAGGGATTTTTCTAGAAAGTAAACTTTTAAAATGCAGTCCCATTTTAGAGAGTTGTTGCTGT CATTTAAATCATTTTAGCCAGTGCAGTGGCTTGCTCCTGTAATCCCAGCTACGTGGGAGCTGTGGCAGGA GGATCACTTGAGGTGGAGAGTTTGAAACCAGCCTGGGCAACATAACGAGACCCTGTCTCTACAAAAAAAC AAAAAACAATTAGTCCACCATAGTGTGTGTGCTTGTAGTCAGTCCTAGCTACACGCCAGAGGTTACAGTG AAGTAAGACCCCATCTCTTCAAAAAAATCCTTTGAAAGTGATTTACACATTTTCCTACTATTTTTTTTTT CTTTCTTTTTTGAGACAGGCTGGAGTGCAGTGATCTGATTATGGCTCACTGCACTCCTGGGCTCCAGTAA TCCTCCTGAGTAGCTAGGACTACAGACATGTGCCACCATGCCTGGTTATTTTTGTTTTTTATTTTTGTAG AGATGGGGGTCTTGCTGTGTTGCCCAGGCTGGTCTCCAATGCCTGGCCTCAAGGGATCCTCCTGCCTCGG CCTCCCAAAGTGCTGGGAGTACAGGTGTGAACCACCCTGCCTGGCCCTACCTTTTCATGTCATGCAGAAC ACCACTTCAATAACAAGTTGCACGGAAGCCCCAGACAGGTTTAGGGTTGTTTCGATCCTTTGGTAAGTTG CCCTCACAGTCCCGGCTTTCACAGCCTCTGCCTTTTATTAGGAGTATCCCCTCGTGGACTAGCTATCATA TGCTTGTAAAGTACCTACCTCCTTAGGAGGCACCCAGAGCACGTGGGGAAGGGGTGTCGGGAGCTGGGAG TCATAAGTCCCATGATCCATCATCTGTAGGACTCAAAGGTCAAGTCACGCTTTCAGGATTTAACTTCAGT CTGTAAATGTGAGGCTGTTCACCTCTGGTTAAAAATCATAACTGTTTTCTCACGTTGACTCCTTTAATTT ACTACATTTAATCTTTTTCCAACAGTATTTTTGGAATTGTGTATAATGTGAGATGCTCTTAAGGTTAAGT GCATGAGTATATGGACTGTAGGTGTTAGTGTTTGGTAGTTCCTAGACCTGTTTTTGCCTGACTCTTGGTC TAGATCAGGGATCAAGCTTAAGGCCTGTTTTTATCAACTTTCGTTGGAATATAGGCACATCCATTCGCTT ACATATTGTCCTAAGCCCGTTTCACCAGTATAATTGAGCAGCTATGGCTGGGCACAGTGGCTCACAACTG TAATCCCAGCACTTTTGGAGGCCAAGGCAGGAGGATCACTTGAGGCCAGGAGTTCAAGACTAGCCTGGGC AACATAGCGAGATCCTGTCTCTAAAAAAGAAAATACAGAAATTAGCTGGGCATGGTGGGGCATGCCTGTC TGTAGTCCTAGCTACTCAGAAGGCTGAGGAAGGAGTATCACTGGAGCCCAAGAGTTCAAAGTTGCAGTGA GCTATGATGGCACCACTGCACTCCAGCTTGGGTGACAGAGCCAGACCATGTCTCAAAAAAAAAAAAAAAA GAATAGAATTGAGTAGCTGTAACAGAAACCAGATGGCCCACAAGCCTAAAACACTTAATATTTAGCCCAT TAAAAAAAAAGTTTACTGACCCCAATCTAGATAGCAGAGGTTTTTTTAGATAAGTGACTTCCAGACAGAT ATTTTCAATTATTTACAATAATGCTTTTATATATTAATAAATTACTAATTTGTTTAGCTCATGGGGTTTA AGGAATAATTTATGAATTGTGATAAATATTGTGCTTTGAGTTATATTTGCATTTTGTTGATTTCCCATCA TTTCAGGGTAATTTTTAAGATTTTTACTCTTACCTCAAAGGATAAAATATTTCACAAAGTTAATAAGTAA TTTTTAAATTATAAAGGTATTTGATGAAATTTTGAAGAATTTAGAGGAAAATGTAAAACATGGAAGTTAA AAGCCTGAACTCTGAAGTCCAACAGATGCTTTCCTTCCTTCTTGGCTGTGACACAATATTTGCATAACCT TTAGCACATTACTTAGCCTCACGTCAGGTCATTTTCTCATCTGTATAACTGTTGATGTGAAATTGAAATG AAGACAGCCTGGTTTATAACATTCAACAAGTGTTAACTGTTACTGTGAGTTATAAAAATTGCACTAATAT AAACAGAAGGCGTGGTCATTTCTACCTTTGTAAAGCTATTATTTGATTTCTAAACAGAAAGATCATACAT GGAAGCGAATCAATGGACTCTGGAATATCCCTGGACAACAGTTATAAAATGGATTATCCTGAGATGGGTT TATGTATAATAATTAATAATAAGAATTTTCATAAAAGCACTGGTATGTGTCTTACATAATTTTTAATCCT TTTCAAATGTTTGTGCCATTTACATTTGATATAATATTAAAAGCAGTATTATTGAGGTATTAGACAGTAA ACCGTGACACAGACTAGCTGTGAAGTAGAGATTGGGCAGGACCTACAGGTCCTCTGATACACTGTGAACG CGTCACTCTTCTGCCCAACTTCATAGCCTCCTCTTGCTGGCCTCCTATCTGTATGCTTGGTTGCCTCTGC CCTGACTTCTCTGTAGCCCTTGCTTCTTTTTCTTCTTTCTGCTTCCTCTTTGATCCCAATGGAAGGTTCT CAAAAAAACAGTTAAGTGGTAGTATTTATTTTTTCCCCAGAAACTGCAAGAGATATCACAAGCATTGCCT TATTTAATTTATGACAACCTGGAAAGTAACGATGAGATTCTGAAAGGTTAAAGACCTCGCGCAGTCACAC AGTATGGCGGCAGAGCTAGGTCTGTGTGGCTCCAAAGCCCAAGCTCTGAATCCATCTTCTGTTCTGCTTC ACTTCCTTGTATCCTCATGTGCTCTGTTGCCTGTCTTCCCTTACCCTACGAAGCTCCCCATCTTAGAGAG ACCTTTCTTTTACTCTGTTCCTTTTGATTCCTTTGATATTTTGTCTCCTTCCCTTCTTCCTTAAATTTTG AATACATGTAGTTTAAGCTTGTACTCTTCATTTGTTTCCATTCCTTCTTGAGTCTTTTTCCATTTTCTGT CTCTACTACTAAAACTGCTTGCTTTAAATTTACCATGGCCTTGCCACCAGATCCCCCTCTCGATTTCTGT ACTATGTACAACTTGAATGTAGTACTACATTTGAGAATGTTTTTTTAGAAATATAGATAATAAAATCCTT CACAGTGCCAAAAAAGCTAATTAATATTTGGTGTATTGTTATTTTTTCTTGGCAGTTCTTTTTAAAGCTT GATTTTATTCATAACGTATAAGCAATGTTGTCTTCTGCTTGTTTCACTTAAAGGAATAGCATTTTTCATA TTGCTGCATAATTTTCATATCTGTTATAATGATTATATAATACTGCATCCCCAAAACTACCATTCACTTA ATTTGAATAATTTACTGTATGAATGAACATTATGGCTGTTTCCCTTTTAAATTGATGCTATGATAATTCT TTGAATTGGCCTATTAATCATATTAGAGTTAATTTTTAATTAGAGAAGCTGTAGTAGATCTAAGGTGGGC CAGTACCTATCAGAGTGGTGGTGGAAATGGAAGGAAGCCAGATTACACTGGGAAGATAGCAGGGTTTGTG TCAGATTAATTATAAGGAGTGAGAAGAGAATAGTTGAAAATGGAGCTCTAAATGGCATCAGTTTTATTGC TTTTGGCTATAAGTTGAGATGCCACCTTCAACCATTAACTTAAAAACACAACACCTTGTTTACTTTTGCT TTACGCATATTTGAAAATTTACTTCTAGATATTCTGCCTCACATTTCTAGTTAGGATACCTCCTTCCTAT AGAATTTTGCACTGTTGGCTCTATTGTTTCAAAAACCAAAAACAAGCATATTATTCCACTACCACCAGCA CCTCCCCCCACATATTTAGACCAGCAGTCTGGGTTTTGCCCAGTGAGCTCCTTTCCTACTTTGCAATGTA AAGGTCAGGTTCTCATGAGATCTCTGGCAGGCTGGTGTTGGGCCAGGCGCCATGGCTCACACATGTAATC CCAACACTTTGGGAGGCCAAGGCAGGAGGATCCTTGAGCACCAAAGTTCAAGATCAGTCTGGGCAACACA GGGAAATCCCATCTCTACAAAACAGAAAAAAGGTAGCAGGGTGTGGTGGTGCGCACCTGTAGTCCCAGCT ACTCGGGAGGCTGAGGTGGGAAGATAGCTTGAATCTGGGAGGTTGAGGCTGCAGTGAGCTGTGGTTGCTG TACTCTAGCCTGGGCCACAGAGCAAGATCCTGTCTAAAAAATAAAAATAAATAAAAATTAAAAGGCAGCC AACACATCAGCACCAGAAGCCAGTGACCTTGTCACACAGCTGAGATAATCAACAACATTTTGGAGATACA TGTAGACTTTCTGTATTTAATCTTCATACCCATCAAATTTACTCAATTCTGAGGGATGTTTCCCACCAAG ATTTAGCATTTTGAAATCTGAGTGCATCATGCAGTCAATCTGTACGTTAATGTGGAAGGTTCTCTAAAGG AGTGGTAGAAAGCCCAGGAGCCCTGGATACAGGCCCAGCATAGCTTTGTCACTTTGGACTGGTTTGTTAA CTCTGCTACATGTCCCACATCTGCACAAGTGAAACTAGTAATAATATGACTCTCATGGTGATTGGAAGGA TTAGAGATTAGCCATAGCAGAATACCTGATGAACAGTAATAATGTTTGGGGGTTTTCCTTGAAGGCACTA TAAATGTTGTAATGCTATCTTAAAATTGTTGGGAAGTTAGAGTCAGAGAAACGCATTTCCTCTGAGTGTG ACAGATGTGTGTATGTATTATAGGATCGTATTGTTTTCTAGTCTTATTTTTTTAAACTGATGATTTTCCC ATGGCAACATTTTATCTGTGAAAATGACAACATAGTATATCCCATTATATAAGTTAGTATAGCTTGTCTA ACCAAACCCTTATTGTTAGACATTTGTGTTTTTCACTACCTAAACCGCTGTGAAAGACATCATTTTGGCT ATAACACTGATGAGCTTATATTATGAAGTATCTTATAAGCTACAAAATTGAAGAAATTTTGTTCACCATG TTCAAAATAGTTAGAATTCTCTTACCATTTAAAAGGAAGAATTTATTGTGGACTTCTGAATTGCTGAGTA GTTAATTTCATTTCAAAGTAGTTATTCTTTGTTTTCCATACAATTAAAAGTAATTCTTTCTGTTCCAAGG AATGACATCTCGGTCTGGTACAGATGTCGATGCAGCAAACCTCAGGGAAACATTCAGAAACTTGAAATAT GAAGTCAGGAATAAAAATGATCTTACACGTGAAGAAATTGTGGAATTGATGCGTGATGGTAAGAAGAAAC AATTAGAATGAACTTCATTGTACAATTAATTTTATACTATGGTCTAGCAATAATTATATGTATAATAAAA TATGAGAATTGTGGAATTATACTGTACATAACCCTAATCTTACATACTTTAGTAAGAAGTTTAAAAAAAG TTATTTATGCCAACTTCCTAAAATGGTTTGAGATGTGTTGCCGTGCCCCAGGTTAGGTTAAGATGACCTC TTAGTTTTAGTCTCAGTTTCTTCATCATGTTCCCATACAGTATATCTGAAGTTGTTGAATAAAGTCATGG ATTTTTTTTCCTTTTATTTGCAAATGTCTTTACAGTTTCTAAAGAAGATCACAGCAAAAGGAGCAGTTTT GTTTGTGTGCTTCTGAGCCATGGTGAAGAAGGAATAATTTTTGGAACAAATGGACCTGTTGACCTGAAAA AAATAACAAACTTTTTCAGAGGGGATCGTTGTAGAAGTCTAACTGGAAAACCCAAACTTTTCATTATTCA GGTAATGTCTAACTGAGTGATTTGGTTATTGACGATTAAGCAGGGGTTACTATTCTCAACTGTAAATTAT CCAAAGGATAATTTTTTTCCTGAAGCTAATGAACTATTGTTACTTTTCATTTATTTACCACTTAAAAGAT ATAGAGTAAATTTTAATTTTATACTTATATCAAAAAGACTCAGCATAATTAACATCCTTTTTTTTTTTTT TTTTTTTTTTTTTAGACAGAGTCTTGCTCTGTCGCCCAGGCTGGAGTACAGTGGCGCGATCTCCGCTCAC TGCAAGCTCTGCCTCCTGGGTTCACGCCATTCTCCTGCCTCAGCCTCCTGAGTAGCTGGGACTACAGGCG CCTGCCACCAGGCCCAGCTAATTTTTAAATTTTTTTTTAATAGAGACAGGGTTTCACCATGTTAGCCAGG ATGGTCTCGATCTCCTGACCTCAAGTCATCCGCCCGCCTTGGCCTCCCAAATTGCTGGGATTAAAGGCGT GAGCCACCGCGCCCGGCCAATTAACATCCATTTTTACATAGCATTTCAATTTTTTAGAACTAAGTTATGT GTTCACACACAAATTTTTATAAATAAATATTTATTTTCTAACACCCAGGCCTGCCGTGGTACAGAACTGG ACTGTGGCATTGAGACAGACAGTGGTGTTGATGATGACATGGCGTGTCATAAAATACCAGTGGAGGCCGA CTTCTTGTATGCATACTCCACAGCACCTGGTGAGAACGTTACACATAATGAATGTTACATGTGGATTTTA AATGAATTAACTGTGACTGATCATAGAATTATACAATGAAAAGTGTGTTTCAGAGACTGTCAAGATTTTG ATATCCCTAAAGATATCAAAACTTGTCTATATTTTAGGGAACCTTCATCAAAGAGAAGTCTCAAAAAGTT GTCTTTAGCCAAAAGTTTGGCTAGAAAATATGCATATATAGCCAGGCACAGTGACTCACGCCTGTAATCC TAGCGCTTTGGGAGGCCGAGGCAGGTGGATCACTTGAGGTCAGGAGTTCAAAACCAGCCTGGCCAACCTC ATCTCTACTAAAAATACAGAAAAATTAGCTGGGCATGGTGGCACACGCCTGTAATCCCAGCTACTGGGGA GGCTGAGGCAGGAGAATCGCTTGAACCTGGGAAGCAAAGGTTGCAGTGAGCCAAGATCGCACCACTGCAC TTCAGCCTGGGCGACAGAGTGAGACTCCGTCTCAAAGGAAAAAAAGAAAAGAAAATATGCATATGTAGAG TAGACTAGCACGATGTCATTCATTGGACTTTATCAGGTAGATCTCCGCTACTAATATCAGGTAGAATATT ACGTGGCAACAGAGGCCAAGTCAGAGCTTCCCCTGCATCTTAGAGAAGAAGAGAGGTACGTTTCTCAGGA GTTATTTGAAAGGTAGTAAATAAAAAAGATAAACATGACTAGTATACAAGAGGATAGATGTGGAGTGGGA GAAAAGAAGGTAAAAAACGATACATGAATGTGCCGTTAACCTCCACGTTTTTACTGTTCTGCTGCACACG TCATCATCTAAATAAACATTTGTGGATTATACCACCATTTACTCACACAGCTAAGGGTGTCGGAGAGTTT GGAAACTTTAGGTAAATGTATTCTTAAGCAGTGTTGCATTTTAAAATATGCTCAATATGGTTTATCTTAT CCTCTAGGCATCTTTCCAAGCAAAGTACCTCTAAGTTAAAAGCAATGGGTCTAATAGTTAACCTAGAAAA AAAAGTATGATAAATATACTATTTTCCCTTTTTGGACCAATACTTGGTAGTGTGTTTATTATACTTTATT CAGATGCTCTGTAGACAAGTAGGACACTCAAAGCAATTTGTTTCTTGGCTAAGTCAGTATTAAAATAAGG TGAAATCTGATTGGAACACTGTGCTACTTACAATGATCCTTTTTATACATCTTTACTTTTGCATCTTACC TTCTGCGTGTTTGCTCTTCTTGCCTATTGAAAGGGGAGTCCAGAAAGTAAAACTTTCAATAATTCAGTGT TCGTGAAGCTGGTCCCCGGCCAGCTTTGCTGAAAGCAGGGGGTGTACGCATAGCACACATTCGTCCTTCA GCATCATTTCTTCTGAAACCAAAGGTGTCTTTTTTTTTTTATTTGTATGACTAATAAGACTTATGTAAGT TTATGCTTATTTTTGCCTTTATGACTACATAATAATTTATAGAATCAACTAAAATCAGCTATCCATGGTA TTTTGCTTGTATTTTGCCTTTTAGGTTATTATTCTTGGCGAAATTCAAAGGATGGCTCCTGGTTCATCCA GTCGCTTTGTGCCATGCTGAAACAGTATGCCGACAAGCTTGAATTTATGCACATTCTTACCCGGGTTAAC CGAAAGGTGGCAACAGAATTTGAGTCCTTTTCCTTTGACGCTACTTTTCATGCAAAGAAACAGATTCCAT GTATTGTTTCCATGCTCACAAAAGAACTCTATTTTTATCACTAAAGAAATGGTTGGTTGGTGGTTTTTTT TAGTTTGTATGCCAAGTGAGAAGATGGTATATTTGGTACTGTATTTCCCTCTCATTTTGACCTACTCTCA TGCTGCAGAGGGTACTTTAAGACATACTCCTTCCATCAAATAGAACCACTATGAAGCTACCTCAAACTTC CAGTCAGGTAGTTGCAATTGAATTAAATTAGGAATAAATAAAAATGGATACTGGTGCAGTCATTATGAGA GGCAATGATTGTTAATTTACAGCTTTCATGATTAGCAAGTTACAGTGATGCTGTGCTATGAATTTTCAAG TAATTGTGAAAAAGTTAAACATTGAAGTAATGAATTTTTATGATATTCCCCCCACTTAAGACTGTGTATT CTAGTTTTGTCAAACTGTAGAAATGATGATGTGGAAGAACTTAGGCATCTGTGGGCATGGTCAAAGGCTC AAACCTTTATTTTAGAATTGATATACACGGATGACTTAACTGCATTTTTAGACCATTTATCTGGGATTAT GGTTTTGTGATGTTTGTCCTGAACACTTTTGTTGTAAAAAAATAATAATAATGTTTAATATTGAGAAAGA AACTAATATTTTATGTGAGAGAAAGTGTGAGCAAACTAACTTGACTTTTAAGGCTAAAACTTAACATTCA TAGAGGGGTGGAGTTTTAACTGTAAGGTGCTACAATGCCCCTGGATCTACCAGCATAAATATCTTCTGAT TTGTCCCTATGCATATCAGTTGAGCTTCATATACCAGCAATATATCTGAAGAGCTATTATATAAAAACCC CAAACTGTTGATTATTAGCCAGGTAATGTGAATAAATTCTATAGGAACATATGAAAATACAACTTAAATA ATAAACAGTGGAATATAAGGAAAGCAATAAATGAATGGGCTGAGCTGCCTGTAACTTGAGAGTAGATGGT TTGAGCCTGAGCAGAGACATGACTCAGCCTGTTCCATGAAGGCAGAGCCATGGACCACGCAGGAAGGGCC TACAGCCCATTTCTCCATACGCACTGGTATGTGTGGATGATGCTGCCAGGGCGCCATCGCCAAGTAAGAA AGTGAAGCAAATCAGAAACTTGTGAAGTGGAAATGTTCTAAAGGTGGTGAGGCAATAAAAATCATAGTAC TCTTTGTAGCAAAATTCTTAAGTATGTTATTTTCTGTTGAAGTTTACAATCAAAGGAAAATAGTAATGTT TTATACTGTTTACTGAAAGAAAAAGACCTATGAGCACATAGGACTCTAGACGGCATCCAGCCGGAGGCCA GAGCTGAGCCCTCAGCCCGGGAGGCAGGCTCCAGGCCTCAGCAGGTGCGGAGCCGTCACTGCACCAAGTC TCACTGGCTGTCAGTATGACATTTCACGGGAGATTTCTTGTTGCTCAAAAAATGAGCTCGCATTTGTCAA TGACAGTTTCTTTTTTCTTACTAGACCTGTAACTTTTGTAAATACACATAGCATGTAATGGTATCTTAAA GTGTGTTTCTATGTGACAATTTTGTACAAATTTGTTATTTTCCATTTTTATTTCAAAATATACATTCAAA CTTAAAATTA    Download   Select all
Length	21780
OMIM ID	600636
HGNC ID	HGNC:1504
Unigene ID	Hs.141125
Ensembl ID	ENSG00000164305
PharmGKB ID	PA26087

mRNA Information

mRNA ID	NM_032991.2
Exon	join(1..81,11008..11075,14058..14182,17080..17208, 17536..17711,18319..18439,19975..21780)
mRNA Sequence	Download   Select all
Length	2522

CDS Information

   

Location	97..930
CDS Sequence	Download   Select all
CCDS ID	CCDS3836.1

Protein Information

      

Protein ID	NP_116786.1
Protein Name	caspase 3, apoptosis-related cysteine peptidase
Molecular Wt. (Da)	31477
Protein Sequence	>lcl|NM_032991.2_prot_NP_116786.1_1 [gene=CASP3] [protein=caspase-3 preproprotein] [protein_id=NP_116786.1] [location=97..930] MENTENSVDSKSIKNLEPKIIHGSESMDSGISLDNSYKMDYPEMGLCIIINNKNFHKSTGMTSRSGTDVD AANLRETFRNLKYEVRNKNDLTREEIVELMRDVSKEDHSKRSSFVCVLLSHGEEGIIFGTNGPVDLKKIT NFFRGDRCRSLTGKPKLFIIQACRGTELDCGIETDSGVDDDMACHKIPVEADFLYAYSTAPGYYSWRNSK DGSWFIQSLCAMLKQYADKLEFMHILTRVNRKVATEFESFSFDATFHAKKQIPCIVSMLTKELYFYH    Download   Select all
Length	277
Uniprot ID	P01106
Ensembl Protein ID	ENSP00000367207

Post-translational Modification Information (Source : HPRD)

Residue	Type	site
C	S-Nitrosylation	163
S	Phosphorylation	26
C	S-Nitrosylation	163
S	Phosphorylation	26
D	Proteolytic Cleavage	9
D	Proteolytic Cleavage	9
D	Proteolytic Cleavage	175
D	Proteolytic Cleavage	175
D	Proteolytic Cleavage	175
D	Proteolytic Cleavage	9
D	Proteolytic Cleavage	175
D	Proteolytic Cleavage	9
D	Proteolytic Cleavage	175
D	Proteolytic Cleavage	175
D	Proteolytic Cleavage	175
D	Proteolytic Cleavage	175
K	Acetylation	82
K	Acetylation	82
T	Phosphorylation	270
T	Phosphorylation	270

Enzyme Information

No matching records could be found.

PPi Information

(Click to view network : Source STRING)      View   

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    

Interactant Gene ID (Source: HPRD)	Gene Symbol	HPRD ID	Ref Seq ID	Technique	References
118	ADD1	36	NP_054908.2	in vitro	10823823
207	AKT1	1261	NP_005154.2	in vitro;in vivo	12124386
331	XIAP	2094	NP_001158.2	in vitro;in vivo	923   044   211   927   604   000   000   000   000   000
351	APP	100	NP_000475.1	in vitro;in vivo	894   323   215   178   331
397	ARHGDIB	4162	NP_001166.3	in vitro	8626669
596	BCL2	1045	NP_000624.2	in vitro;in vivo	119   483   979   395   403
637	BID	3590	NP_932070.1	in vitro	10364179
641	BLM	5211	NP_000048.1	in vitro	11470874
660	BMX	2111	NP_975010.1	in vitro;in vivo	11278797
672	BRCA1	218	NP_009231.2	in vitro;in vivo	12149654
790	CAD	6437	NP_004332.2	in vitro	11854437
831	CAST	233	NP_001741.4	in vivo	9705209
984	CDK11B	8909	NP_001778.1	in vitro	9632733
985	CDC2L2	308	NP_277073.1	in vivo	96   327   339   115   219
998	CDC42	309	NP_001782.1	in vitro;in vivo	11278572
999	CDH1	1885	BAA88957.1	in vitro;in vivo	11076937
1026	CDKN1A	298	NP_510867.1	in vivo	9   660   939   100   221   180   000   000
1499	CTNNB1	286	NP_001895.1	in vivo	9348292
1630	DCC	391	NP_005206.2	in vitro;in vivo;yeast 2-hybrid	11248093
1676	DFFA	3531	NP_004392.1	in vitro	117   520   609   108   473
1822	ATN1	6311	NP_001931.2	in vitro	9361003
1830	DSG3	1355	NP_001935.2	in vitro;in vivo	11500511
1965	EIF2S1	4881	NP_004085.1	in vitro	1   073   407   310   432   300
1975	EIF4B	4892	NP_001408.2	in vitro;in vivo	1   127   415   210   672   010
1982	EIF4G2	9084	NP_001409.1	in vitro;in vivo	11175261
2534	FYN	655	NP_002028.1	in vitro;in vivo	10435619
2802	GOLGA3	3990	NP_005886.2	in vitro;in vivo	10791974
2934	GSN	674	NP_000168.1	in vitro;in vivo	93   232   099   671   712
3064	HTT	883	NP_002102.4	in vitro	10770929
3146	HMGB1	1228	NP_002119.1	in vitro	11748221
3192	HNRNPU	4185	NP_114032.2	in vitro;in vivo	10671544
3329	HSPD1	318	NP_002147.2	in vivo	1   020   515   910   205   150
3336	HSPE1	2535	NP_002148.1	in vitro	10205158
3603	IL16	4329	AAQ86961.1	in vitro	104   796   809   422   780
3606	IL18	2976	NP_001553.1	in vitro	9334240
4001	LMNB1	1036	NP_005564.1	in vivo	11901153
4067	LYN	1301	NP_002341.1	in vitro;in vivo	11526478
4137	MAPT	1142	NP_001116538.1	in vitro;in vivo	1   288   862   211   162   250
4170	MCL1	8870	NP_068779.1	in vitro	15637055
4193	MDM2	1272	NP_002383.2	in vitro	9278461
4194	MDM4	4082	NP_002384.2	in vitro;in vivo	11840332
4205	MEF2A	2807	NP_005578.2	in vitro;in vivo	11904443
4292	MLH1	390	NP_000240.1	in vitro	15087450
4634	MYL3	1183	NP_000249.1	in vitro;in vivo	12186978
4734	NEDD4	3786	NP_940682.2	in vitro;in vivo	9593687
4780	NFE2L2	2732	NP_006155.2	in vitro;in vivo;yeast 2-hybrid	10510468
5062	PAK2	5428	NP_002568.2	in vitro;in vivo	978   686   916   204   230
5321	PLA2G4A	8986	NP_077734.1	in vitro	9875225
5530	PPP3CA	234	NP_000935.1	in vitro	11478781
5585	PKN1	3019	NP_998725.1	in vitro;in vivo	9751706
5586	PKN2	3972	NP_006247.1	in vitro;in vivo	9368003
5588	PRKCQ	2710	NP_006248.1	in vitro	9252332
5590	PRKCZ	1504	NP_002735.3	in vitro;in vivo	11016947
5591	PRKDC	2941	NP_008835.5	in vivo	8804412
5610	EIF2AK2	1468	NP_002750.1	in vitro;in vivo	11555640
5663	PSEN1	87	NP_000012.1	in vitro;in vivo	10069390
5664	PSEN2	2860	NP_000438.2	in vivo	9   990   034   921   969   510   000   000
5725	PTBP1	2823	NP_002810.1	in vitro;in vivo	12004072
5757	PTMA	1778	NP_001092755.1	in vitro	106   755   289   334   214
5829	PXN	3937	BAA18998.1	in vitro	11825902
5879	RAC1	3627	NP_061485.1	in vitro	11278572
5888	RAD51	1557	NP_597994.3	in vitro;in vivo	1   008   256   610   998   050
5921	RASA1	745	NP_002881.1	in vitro	10200531
5925	RB1	1574	NP_000312.2	in vitro	11420704
5981	RFC1	24	NP_002904.3	in vitro;in vivo	92   359   619   351   817
6093	ROCK1	3414	NP_005397.1	in vitro;in vivo	11283607
6667	SP1	1796	NP_612482.2	in vitro	10103059
6721	SREBF2	2726	NP_004590.2	in vitro	8605870
6722	SRF	2788	NP_003122.1	in vitro	11387340
6788	STK3	5433	NP_006272.2	in vitro;in vivo	11278283
7020	TFAP2A	128	NP_003211.1	in vitro;in vivo	11438643
7052	TGM2	1825	NP_004604.2	in vitro	10556977
7150	TOP1	535	NP_003277.1	in vitro;in vivo	9933635
7185	TRAF1	3418	NP_005649.1	in vitro;in vivo	11098060
7187	TRAF3	3539	NP_663777.1	in vitro	11261798
7409	VAV1	1284	NP_005419.2	in vitro	10713703
7431	VIM	1899	NP_003371.2	in vitro;in vivo	104   691   731   142   390   000   000   000
7531	YWHAE	5457	NP_006752.1	in vitro;yeast 2-hybrid	12657644
8394	PIP5K1A	4470	AAC50911.1	in vitro;in vivo	11042212
8428	STK24	10385	NP_003567.2	in vivo	12107159
8669	EIF3J	4883	NP_003749.2	in vitro	10672017
9135	RABEP1	4684	NP_004694.2	in vitro	10608812
9564	BCAR1	4248	NP_055382.2	in vitro;in vivo	10712510
10134	BCAP31	2319	NP_001132929.1	in vitro;in vivo	9334338
10197	PSME3	5500	NP_789839.1	in vitro;yeast 2-hybrid	11859414
10277	UBE4B	11659	AAD02233.1	in vitro	11802788
11168	PSIP1	4688	NP_150091.2	in vitro	12181742
11184	MAP4K1	3583	NP_009112.1	in vitro	10602493
22985	ACIN1	5191	NP_055792.1	in vitro;in vivo	10490026
23162	MAPK8IP3	12014	NP_055948.2	in vitro	10629060
30818	KCNIP3	5232	NP_038462.1	in vitro;in vivo	11278424
56850	GRIPAP1	2325	NP_064522.3	in vitro;in vivo	12207967

Pathway Information

                                                                                                                                                            

Pathway Name	Pathway ID
AGE-RAGE signaling pathway in diabetic complications	hsa04933
Alzheimer's disease	hsa05010
Amoebiasis	hsa05146
Amyotrophic lateral sclerosis (ALS)	hsa05014
Apoptosis	hsa04210
Colorectal cancer	hsa05210
Epithelial cell signaling in Helicobacter pylori infection	hsa05120
Hepatitis B	hsa05161
Herpes simplex infection	hsa05168
Huntington's disease	hsa05016
Legionellosis	hsa05134
MAPK signaling pathway	hsa04010
MicroRNAs in cancer	hsa05206
Natural killer cell mediated cytotoxicity	hsa04650
Non-alcoholic fatty liver disease (NAFLD)	hsa04932
p53 signaling pathway	hsa04115
Parkinson's disease	hsa05012
Pathways in cancer	hsa05200
Pertussis	hsa05133
Proteoglycans in cancer	hsa05205
Serotonergic synapse	hsa04726
TNF signaling pathway	hsa04668
Toxoplasmosis	hsa05145
Tuberculosis	hsa05152
Viral carcinogenesis	hsa05203
Viral myocarditis	hsa05416

Structure Information

No matching records could be found.

Domain Information

ID	Location	Description
cd00032	37-275	CASc
cl00042	37-275	CASc superfamily
smart00115	37-277	CASc
pfam00656	45-275	Peptidase_C14

Ontology Information

   

HPRD ID	3703
Molecular Class	Cysteine protease
Molecular Function	Receptor signaling complex scaffold activity (GO:0030159)
Biological Process	Cell communication (GO:0007154); Signal transduction (GO:0007165)

SNP Information

View SNP Geneview Report