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General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| CASP4 | 837 | caspase 4, apoptosis-related cysteine peptidase | 11 | ICE(rel)II, ICH-2, TX |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 25943872 | 2015 | Cell line : - Source : - Sample Type : CRC tumor and normal tissue No. of Sample : 103 Stage : - | Irish UC patient population,Biopsy explant cultures,qPCR,Immunohistochemistry | Up-regulation | - | This study has identified epithelial-expressed caspases-4 and -5 as biomarkers with diagnostic and therapeutic potential in CRC. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Caspases |
| Description | This gene encodes a protein that is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain and a large and small protease subunit. Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. This caspase is able to cleave and activate its own precursor protein, as well as caspase 1 precursor. When overexpressed, this gene induces cell apoptosis. Alternative splicing results in transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008] | Chromosome | 11 |
| Location | 11q22.2-q2 |
| Start | 104813594 |
| End | 104839325 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 25732 |
| OMIM ID | 602664 |
| HGNC ID | HGNC:1505 |
| Unigene ID | Hs.138378 |
| Ensembl ID | ENSG00000196954 |
| PharmGKB ID | PA26088 |
mRNA Information
| mRNA ID | XM_011543019.1 |
|---|---|
| Exon | join(3..80,13598..13852,16536..16703,17501..17674, 18822..19056,19923..20066,21407..21516,23748..23851, 25626..25733) | mRNA Sequence | Download Select all |
| Length | 1376 |
Protein Information
| Protein ID | XP_011541321.1 |
|---|---|
| Protein Name | caspase 4, apoptosis-related cysteine peptidase |
| Molecular Wt. (Da) | 32542 |
| Protein Sequence | Download Select all |
| Length | 286 |
| Uniprot ID | P12524 |
| Ensembl Protein ID | ENSP00000361902 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| S | Phosphorylation | 83 |
| S | Phosphorylation | 83 |
| S | Phosphorylation | 27 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 317 | APAF1 | 3755 | NP_863651.1 | in vivo | 9539746 |
| 351 | APP | 100 | NP_000475.1 | in vitro | 15123740 |
| 836 | CASP3 | 2799 | NP_004337.2 | in vitro;in vivo | 92 337 639 694 885 |
| 843 | CASP10 | 3458 | NP_116759.2 | in vitro | 8962078 |
| 1832 | DSP | 513 | NP_004406.2 | in vitro | 15500642 |
| 3553 | IL1B | 985 | NP_000567.1 | in vitro | 19 190 017 797 510 |
| 3606 | IL18 | 2976 | NP_001553.1 | in vivo | 15326478 |
| 5272 | SERPINB9 | 3480 | NP_004146.1 | in vivo | 10477277 |
| 5321 | PLA2G4A | 8986 | NP_077734.1 | in vivo | 9875225 |
| 5663 | PSEN1 | 87 | NP_000012.1 | in vitro | 10069390 |
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd00032 | 125-374 | CASc |
| cl00042 | 125-374 | CASc superfamily |
| cd08325 | May-81 | CARD_CASP1-like |
| cl14633 | May-81 | DD superfamily |
| smart00115 | 126-375 | CASc |
| pfam00656 | 136-373 | Peptidase_C14 |
| smart00114 | Jan-89 | CARD |
| pfam00619 | May-89 | CARD |
Ontology Information
| HPRD ID | 5382 |
|---|---|
| Molecular Class | Cysteine protease |
| Molecular Function | Molecular function unknown (GO:0005554) |
| Biological Process | Cell communication (GO:0007154); Signal transduction (GO:0007165) |
Drug Information
No matching records could be found.