CoReCG

Evidence Information

Pubmed ID	Year	Sample Information	Techniques	Mechanism	Fold Change	Remark
24465592	2014	Cell line : - Source : Spain, Italy, USA, England, Czech Republic and the Netherlands collaborating to the international consortium COGENT (COlorectal cancer GENeTics). Sample Type : Population basedCase-control study No. of Sample : 6,733 CRC and 7,576 controls Stage : -	Multi-centric case-control study	Polymorhpism	-	Robust clarification of the effect of rs3834129 on the risk of developing CRC in Caucasians.
24842234	2014	Cell line : - Source : PubMed, EMBASE, Cochrane library Sample Type : - No. of Sample : - Stage : -	Meta-analysis	Polymorhpism	-	CASP8 is a candidate gene for CRC susceptibility. The CASP8 -652 6N ins/del polymorphism may play a protective role in CRC development especially among Asians.

Gene Details

NC_000002.11 (202098166..202152434)
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Gene Type	protein coding
Gene Family	Caspases
Description	This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain, a large protease subunit, and a small protease subunit. Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. This protein is involved in the programmed cell death induced by Fas and various apoptotic stimuli. The N-terminal FADD-like death effector domain of this protein suggests that it may interact with Fas-interacting protein FADD. This protein was detected in the insoluble fraction of the affected brain region from Huntington disease patients but not in those from normal controls, which implicated the role in neurodegenerative diseases. Many alternatively spliced transcript variants encoding different isoforms have been described, although not all variants have had their full-length sequences determined. [provided by RefSeq, Jul 2008]
Chromosome	2
Location	2q33-q34
Start	202098166
End	202152434
Strand	+
Gene Sequence	>gi|568815596:201233443-201287711 Homo sapiens chromosome 2, GRCh38.p2 Primary Assembly GTGCTCTGAGTTTTTGGTTTCTGTTTCACCTTGTGTCTGAGCTGGTCTGAAGGCTGGTTGTTCAGACTGA GCTTCCTGCCTGCCTGTACCCCGCCAACAGCTTCAGAAGAAGGTGACTGGTGGCTGCCTGAGGAATACCA GTGGGCAAGAGAATTAGCATTTCTGGAGCATCTGCTGTCTGTGAGATTAAGCACTATGTATATTGCTTTA TTCACTCCCCACAGCAACCTTACCAAGCAGTTCTTTTCCACGTGAAAAGATGGAGGCTGGGTGGAGCAAA AGGAGGTATTTAGAGTCCTCAGCAAGTGAGAGGCAGAGCTGGGATTTGAATCCAGATCTGCCTGATACTG AAGTCTAGGCTGGTTCCACCTCTCCGGACTGCTTTCCAGGGAGTAGAAGACAGATATTTTACCTTAGCTG GCTGCTTCTAGAAGTCTGACCCTGCTGGCTCAAAACGACTTTAGTTCCTTGCCCAGAGGCTGCGGGCTGC GGGTCAAGACATCAGTAGAAGGAGGGCCCAGCCAGAGAGGCTGACATGGGCTTCTACTCACCGTCATCTC TCCTTCCTTCCAGGAGCAGCCCCTGGGTGCGTCCACTTTCTGGGCACGTGAGGTTGGGCCTTGGCCGCCT GAGCCCTTGAGTTGGTCACTTGAACCTTGGGAATATTGAGGTAAGCCTGGGATTTCCAGAGGAGGTTTGG GGGAAAGAGAAGTGGTGAACGCTATTACTGTTCCCTATCTAGACACCAGTGGGCCGAGTGGAGCAGATGC CAGTTGGGACCTTCCCGCCCTCTCTTTGGTTATTAATCCATTATTGTTCCCTGTACACTGGTATGAGTGG ATGGGGGAAGTATTTAGCCAAGTTTTTGAGACCTGTACTCGGAGCTAAAATGCATTGTCTTCCTATAGTG CGGGACCCCACAACTGTGGAGGAGCCGCAGGGGATACTGGGTAGTACGCAGACATTATGCACTAAATGAC AATGGCTCACATAGTGAAAAGTTATTCTTTTTTATTTTTTTTTTTGAGAGGGAGTCTTGCTCTGTCGCCT AGCCTGGAGTGCAGTGGCGCGATCTCAGCTCACTGATATCTCCGCCTCCCGGGTTCAGGTGATTCTCGTG TCTCAGCCTCCTGAGTAGCTGGGATTACAGGCACCTGCTTCCATGCCTGGCTAATTTTTTTTTTTGTATT TTTAGTAGAGATGGGGGGGTCTCACCATGTTGGCCAGGCTGGTCTCAAACTTCTGGCCCCAAGTGATCTA CCCACCTTGGCCTCCCAAAGTGCTGGGATTACAGGCCTGAGCCACTGCACCCGGCTGATTTCACATTTTT AGATAATATGACCACATTATAAAAATTTATGTATTTTTATATAATGTGACCACTAGATGAAAGCAATATA CTTAGGCTTTTATTTCTTGGTTAAGTTCCTACTTATTATGAATTTACTCTGCATGCCAGGAATTCTAAGA ATTTGCATGTATTAACTCATTTGATTCTCGTAATAACCTTCACATGCAGGAGTCACTATTACAGTGACTG TATGAATGAGGAAAGAAAGGCACTAACAGAATTGATTTTATGTTACTTAGGTCAAGATTTTATGTTATTT AGGTCAAGGTTAATTGTGTTGTTCAAATCTTGTATAACTCTACTGCTTGTCTGTCTTTCTTACCCATTAT CGAGAAGGGAACATAAAAATCTTACACTATGACTGTAGATTGTCAATTTCTCATTTTAAATTAGGATCAT TTTTCCTTTATGTCTGCCTTATGTGATATTAGTATAATGATATCAGTTGGTACATCTTTTTCCATCCTTA TACTTTCAGTGTTTCGGTGTTCTTATACTTGAAATGTGTCTGCCGTAAGTGGTGTATTGTTCAAGTTTTT CTTTTATTATAGAAAAATGTATTCTGGAAGGTACTTTTCTTAAAATTACAGTATTTAGTCCATTTTCATT TAATGTAATTGTCAATATAATTGGGCTAAAATCTACTATATTTCCAGTTGTTTTTTATTCGTGGCATCAA TTCACTTTTCTCTACTTTCTTGATTTCTTTTAGACGAATTAAGTAATTTTAGAAAGTTCACCTTACTCCT TTATTAGCTTGTTAATTATGCATGCTTTTAGTATTCTCTTAGTAATTGCACTTGAGTTGTACTACCTAAT AGTACAGCCACATGTTGTTTAAAACAGCTTTACTGAGATATGATTGATATACAACAAATGGCATATAAAG TATATAATTTGATAAGTTTTGACATATGTATGACATATATGACAGTCATATAGACACACTCATATATATA TTCATGTGCCATTTCAGTCAATGACCGACCACATATATGATGGTGGTCTCATAAGATTATAATACGGTAT TTTTACTGTACCATTTCTATGTTTAGATATATTTAGATATGCAAATACTTACCATTGTGTTACAATTGCC TACAATATTCAATACAGTAACATGCTTTGTAGGTCTGCATCTTAGGAGTAATAGTCTAGACCATATAGCC TAGGTGTGTAGTAGGCTATACCATCTAGGTTTTGCATAAGTACATTCTATGATGTTGGCATAATGACGAA ATCACTGACGATGCTTTTCTTGGAACTTATGCCTGTCATTAAGTGACGTATGACTGTATATATTTGAGTG GAACTATCACTGCAGTCAGGATAGTGAACATATATATTACCTCCAAAATATTTCGTATGCCCTCTTGAAT CCTGTCCTCCTGCCCCTCCCCACCCCTGCTCCTTTTAGGCATTTAGTTCTGTAAATTTTCTCCTAGCCTT GCTTTAGCGGCATCCCATGCATTTTGATATTTTGTTTTGATTTTAATTTAATTCAATACTACATAATTTC CTTTTGATTTCTTTTTTGACCCATGGATTATTTAGAGTTGTGTTATTTCATTTCCAAATATTTGGGGATT TTCCAGACATGTTTCTGTTGTCCAGGCCAATAACAAATTCCTGACGCCATGAAGTCAAAGATCTAACTCC CCAGGGGGAGAGTTATGCCCAAGAACCATCGGTATTTTGTGTTAGTGGTCATTGCCAGAGTGAATTCCAC AGTGTTTGTGATAAACCCTAATAATTCCACCAGAGGGCAGCAAGCCAACATGAAAATTCTATTAAAAAGT CTTTTTTTAGAGACAAGAGTTTGGCTCTGCCGCCCAGGCTGGAGTGCAGTGGTGTGACCTCGGCTTACCG AACCCTGGCCCCACCGCAGACTCAACCTCCCAGGCTCAAGTGATTCTCCCACTTCAGCTCCCCATCTGCG AGTAGCTGGAATATAGGTGCGCACCACCGCACCTAGTTAATTTTTGCATTTTTTGTAGAGATGGAGTTTC ATCATGTTTCCCAGGCTTGTCTTGAACTCCTGGGCTCAAGCTATCCATCTGCCTCGGCTGCCCAAAGTGC CGAGATGACAGGCGTGGGCCACTGTGCCTGGCCAGACAGAAGTTTTCAAGTAAAGAATAAATTTAGCTGA AGAGCAGTGTCAAATTATTTCTATCCCCACCCTCCTGAATTAAATCTTCGTAGTCTCTGATTCTCTTTGT CATATTCTTAACCATTTGGATTCTTTTCAGTGCGTCTGTGTTTGTTCCTTTTCCCCAGTATGACCCCTTT CTATTTTTTTTTTTTTTTTTTTTTTTGAGACAGAGTCTTGCTGTGTCGCCCAGGCTGGAGTGCAGTGGCA CGTTCTTGGCTCACTGCAACCTCCGCCTCCCAGGTTCAAAAGATTCTCCCACCTCAGCCTCCTGAGTAGC TGGGATTACAGATGCCTGCCACCTTGCCCAGATAATTTTTGTATTTTTAGTAGAGATGGGGTTTCAACAT GTTAGCCAGGCTGGTCTCAAACTTTTGACCTCAAGTGATCTGCCCGCCTCGGCTTCCCAAAGTGCTGGGA TTACAGGCGTGAGCCACCTTGTCCAGACCCTTTTCTCTATCTTTATGAAAACATCTCTCCAGTAGATCTT CAGAGTAAAAAAAAAAAAAAAAAAAGGAAAAAAGAAAAGAAAAAAGAAAAAGAAAAGAAAACATCCAGCA AGGTCTCGGAGGAAAAATAGAAAATTAGAAGACTGGAGTGAGTCATGTTGATTTTCTGGTGTAAAATTTG TATCGAAACCTTACATAAATACTGAAGAATTCACAAGTTGTAAATATACAGCTTGGTGACTGATTTTGAT ATCCAGACAGTTTTTTTCCCACTTGCACACACTCCCCGCAAGAATGCATGCTGGTTTGTAAAGTCATTAA TTTACTGGTGCATCAGTGGATGGCTCTGTGTCTTCTGGCTTTATCTTGGCCCAGAAAGACAGGAATTAAC GTTGAGCCTAGTAGTCTTTGGCCTTTGTGCCAAAGCAGTCTGTGGGCCAGCCTTGTGTAGTGATCAAGCA GTATGTTTAGATGTCAGGCATGACACGGGTTAAAAAGCCAGCTAGGGGAAAAATGGGAAGTGGCATTTTG CGATCTCATCAAACAATCTTGATATAAACTTAGAGAACAACCTCTTGGCAAATGGAGAGCAGCTGTAGGT TTCTGACTGAATGTGCAAGAAGAACGTGAATGAAAGAGATATACTAGGTGGGAGCAGTCAGGGTAGACTT CCTGGAGGAAGTGGACAGTGTTGTGTGGATTCACACTTTGGAGATATCAAAGAGGAAGAGTATTCCAAGT GGGGGTAACAAATAACAAGGGAGGCAAAAAAGAAAAGTATGAGGGAACAACAGGATGTTGTCAGGAAACT AAGGCTGAGCTGAAATCCAGGTGACCCAGAGAAGCCTTGAGAAGGCTTGTGGCATCTTGTGGAGCAAGTG GGGAACTTGCTCTGTTTGAGAGAATATGCCTGGAATATATGGGATATCATTTAAATTTTCTAAAGGTTAT CTACAAGATAATTTCAGAGAATATTCGCTCCCACCTCAGCGTAGGAAACAATGAAACCCTGAAACATTTA TTTATTTATTTTCCTTGCTTTTCTTTTTTCTTTCTTTTTTTTTTCTTGAGATGGAGTCTTACTCTGTCAC TCAGGCTGGAGTGCAGTGGCGTAATCTTGGCTCACTGCAACCTCCGCCTCCTGGGTTCAAGCAATTCTCC TGCCTCAGCCTCCCGAGTAGCTGGGACAATAGGCATGTGCCGCTATGCCTGGCTAATTTTTTGTATTTTT AGTAGAGACGGGGTTTCATCATGTTGGCCAGACTGGTCTTGAACTCCTGGCCTCAAGTAATCTGCCCGCT TTGGGCTTCAAAAGTGCTAGGATTACAGGTGTGAGCCACTGCACCCAGTCTTTTCCTTACTTTTTATTTT ATTTATTTATTTATTTATTTTTTAATTGATCATTCTTGGGTGTTTCTCACAGAGGAGGATTTGGCAGGGT CACAGGACAATAGTGGAGGGAAGGTCAGCAGATAAACAAGTGAACAAAGGTCTCTGGTTTTCCTAGGCAG AGGACCCTGCGGCCTTCCGCAGTGTTTGTGTCCCTGGGTACTTGAGATTAGGGAGTGGTGATGACTCTTA AGGAGCATGCTGCCTTCAAGCATCTGTTTAACAAAGCACATCTTGCACCGCCCTTAATCCATTCAACCCT GAGTGGATACAGCACATGTTTCAGAGAGCACAGGGTTGGGGGTAAGGTCACAGATCTACAGGATCCCAAG GCAGAAGAATTTTTCTTAGTATAGAACAAAATGAAAAGTCTCCCATGTCTACCTCTCTCTACACAGACAC GGCAACCATCCAATTTCTCAATCTTTTCCCCACCTTTCCCCCCTTTCTGTTCCACAAAACCGCCATTGTC ATCATGGCCCGTTCTCAATGAGCTGCTGGGTACACCTCCCAGACGGGGTGGTGGCCGGGCAGAGGGGCTC CTCACCTCCCAGTAGGGGCGGCCGGGCAGAGGCGCCCCTCATCTCCCAGACGGGGCGGCTGGCCGGGCGG GGGGCTGACCCCCCACCTCCCTCCCGGACGGGGCGGCTTCCTTACTTTTTAAAAATACGTTTGTCTTCAA CTATTGGATATCTTCATCTAATTTCTAGTGTTTTTTTTGGTTGTTGTTGGCTTATTTGATTTTTACTTTT TGGTTAATAACAAACCTTTTAAGGAGTTACATAGACTCTTATCAGTTTACTTTTCTAATTTGTTTTCTCC TGAATTCTCAGTTACCTTGGATTGATTGTGCTTTGGGTTCATCTTGCTTTTTCTTAGTGGCTACTTTCAG TTTCCTTCCTCTTCAGTTTGGCAATTTTTTCCCTTTTCAAGCAAGGAGCTCCTCCCTGTTGAGGCGTCAC GGGTGGCGGGCAATCCTTACCCGGATCCTCCCACAGCTTGCTCTCTGGAAGCTCACACTGCACCGTAATT ATGAAACTTTTGATATTGTCCCTGATGGCTTCTGATGCAAGCTGGGACAGCATTTGTCTGTTGATAAGTG AAACCAAGTTCCTGAGATCTGGCTCTCTTTTGCCCTTCTATCCAATACCAGCAAGGCCCTAGTTTCAGAG CATTTTGGGGACTTATGATCCCTTCTAGTTACCTCTGCATCTGTGCCCCTTTTCCCCTCAAATTAGTTCA TAGAGATTTTTGAAGCACCCATGTTACTCAAATAGGCCCATTTTTAGCATGTGGGAGGTAAGGCCTAGAT GTGAATCCCTCATAAGCCAGGCAGATCAAACTGTGTGTATGCATGCAGATTTGGCCCAGGAACACTCTTC TCCTTCAGGGCCCATTGTCTACAAGGACAGAAAAGAATTCTTAAGGCCATTCACTATCTCACATTTTCTG TTATTTTTCTGTCTTTTCCTTTTCCCCCTACCCACAGAGAAACATTAGAATCATTGCCCTTTAGAAGAGC AGAACTATGATGCCTCCTGTCAGGGATGGAACGAGGCATTCCATGCAGATGACAACCCAAAGAGAGCAAG AGTGGCTCTATTTATATCAGACAAAATCGACTTTAAGTCAAAAACTGTCACAAGAGACATTAAAGTATAT TATATAATGAAAAAAGCATCAATCCACCATGAAGATATAACAATTATAAATATATGCACTCAATATCAGA GCACCTAAATATATGAAACAAACAATGACAGAACTGAAGGGAGAAATAGCCAGCCATACAAAAATAGTAG GAGACTTCAACACTGTACTTTAAATAATGGATAGAACATTCAGACAGAAGATTAATAAGGAAACAGGGGA CTTAAACAACATTATAGACCAAATGGACCGAACAGAAATACACAGAACGTTCCACCCTACAGCAGTAGAA CACACATTATCCTCAAATGCACATGGAACTTTCTCCAAGGTAGATCACAAGTTGGGTCACAAAACAAGTC TTTGCAAATTTAAGAGACTGAAATCATACCATGTATCTTTTCTGACCATGATGGAATGAAACTAAAAATC AATGGCAGAAGGAAAAATAGAAAGTTCACAAATATGTGGAAATTAAACAACACACTCTTGAACAACAATT AGGCCATAAAAATAAAAAAAGAAATTAGGAAATATCTTGAGATAAATGAAAAGAAAAGCACAACATACCC AAACTTACAGGATAAAAGCAGTACTAAGCAAAGAAGTACTAAGAGGTACTTTATTGCAATACACATCTGC AGTGAAAAAGAAGAAAGATCTCAAGTAAATAGTCTAACTTCGTGCCTCAAGGAGAGGAGAAGAAGATGAA GAAGAAGAGGAACTAAGCCTAAAATTAGTGAAGGAAATAACAAAGATTAGAGTAGGAACCAAGAAAATAC AGAATAGAAAAGCAATAGAAAAAAAATCAACAAATTTTTTGAAAAGAATAACAAAAGAATTGGTTTTTTG AAAAGATAAACAAAATCAACAAATCCCTAGTTAGGCTAAGTAAGAAAGAGAGAAGACTCAAATAAACAAT ATCAGAAATAAAAGAGGAGACATTACAACTGATGCCACAGAAATAAAAACATGAGGCTATAATGAACAAT TCTATTCCAACAAACTGGATAATCTAGAAGAAATGAATAAATTCACAAAACCTTCCAATCTACGATGACT GAATCATGAAGAAATACAAAGTCTGAACAGACTTATAACTAATGTGGAGGTTTAGTCAATAATCAAAAAT GTTCCCCAAACGAAGAAGTCCAGGACCAGATGGCTTCACAGGTGAATTCTTCCAAACATCTCAAGAAGAA TTAATGCCAGTTCTTCTTAAACTATTTTTAAAAATTGAAGAAGAGGGCACACTTCCAAATTTATTTTATG TGGCCAACATTATCCCGATACCAAAGCCAAACAAAGACACCACAAGAAATGAAAACTGCAGGTCAATATC TCTGATGAATATACATATAAAAACTCATAACAAAATACTAGCAAATCAAATTCAACAGTACATTTAAATG ATCGTACATCCTGACTGAGTGGCATTTATCCCTAGGATACAAGTATGGATCAACATACAAAAATAAATCA GTGCGAAATGGCCTATTAACAGGGCAAAGATATAAAGATAACATGATCATCTCAATAGATGCAGAGAAAG CATTTGACAAAATTCAATACCCTTTCGTGATTAAACAATTTTTCAACAAACTGGAAATAGAGTCTCAACA TCATCAAGACCATATATAAGAAAATTTTCACTGTTGAGTATTATATTAGATGTGAGCTTTTCATATATGG GATTCATAATATGTTTCAAATATATTACAAAGCTATAGTAATTGAAACAGCATGGGAATAGCATAAAGAC AAACACATAGGCCATCAGAAGAGAAGAGAGAGCTCAGAAATAAATCCATGCATATACAGTGCCTTAGTCC ATTCAGCCTGCTAAAACAAAATACCATAGACTGGTGGCTTATAAAACACAGAAATTTATTTTTCACAGTT CTGGAGGCTAGGAAATTCAAGATCAAGTAGCTAGCAGATTTGCTATCTAGTGAGGGCCTGCTTCTTGGTT CATAAATGGCCATCTTCTCCATGTGTCCTCATGGAATTAGGGTGATGGAGCGCTCTGGGATTTCTTTTAT AAGGCACTAGTCCCATTCATAAGTGCTCTACCTTCATGACCTAATCACCTCCCAAAGGTCCCATCTCCAA ATACCAACACATAGGGGATTAGGTTTCAACATATGAATTTTAGGGGAAACAAACATCAGTCTATTGCATA TACTACCTAAAGCAATCTACAAATTTGGTGTGATCTCTATTAACATCCCAATGGATTTTTTTTTTACAGA AAAAAACCTCTGAAGTATAAAAAGGACCACAAATAGCTAAATCAGTTTTGAGGAAGAACAAAGCTAGAAG CACCATACTTCCTGATTTCTAAATATATTATACTCCCATGGTCATAGCAGCACTATTTACAGTAGCCAAG ATGTGCAAACAACCTAAATATCTAGGATGGGGAAAGAAAATGTGGTAGTCACATAAAATGGAATATTATT TGCCTTATAAAGGAGGGAAATTCTATAATATAAGACAACATGGATGAATCTTGAAGACATTATGCTAAGT GAAATAAGCCAGTCACCAAAAGACAAATACTGTATGATTCTACTTACATGTGGTATCTAAAGTAGTCAAA TTTATAGAATCAAAGAGTGGAATGGTGGTTGCCAGGGGCTGGGGAGGGGGGAAATGAGTTGCCTGTCAAC AAGCATAAAGTTTTAGTTAAGCAAGATGAGTAAGTTCTAGAGATCTGCTGTACAACATTGTACCTATAGT CAACAATACTGTATTGTACACTTAAACATTTGCTAAGAGGGTAGATCTCACTTAAATGTTCTTACTACAA TAAAATATAATTGATAAAGCAATAGAAAAGGATTCCTATACATAGGATTCCTATACATAAAAAGGTCAAT ACCTAATTTCCATTTAATTAAAAGCAATGAATAGTCAATTTACACACAAGACAATTTCTGTTATTGAGGC AGCTATAGGATATAGAAGAGATTTCCCAACTCACTTTGCAAGGTGCACATAGCCTTGAATCCACAAGCAT AATGTAAATAATTTACTTTTAAGAAACTCAGACAGAAAAATCCTATAATCATCTCAAAAGATCCTGACAT TTCTTTTTGATAATTTAATGCCCCTTTCTGATTTTTGTCAAATACTAGGAAGCTAATAGGTAAGGAAAAG TCCCTAACTTGATAAAAATACCTACCAGATGCCCAAATCAAAAATCATATGAATTAGGAAGTTCTGGAGT GCTTCTCATTAAACTCAGGAACGTGTAATATCGTTATTAATGTATTGTTCCACCCTGTTTTGGAGGGCCT GGCCAATTTAACAAGTTAGGTGATTTGATAAGTTAGTTTAATACGCATAACAGCATGGCTGTCCCGAGGC ATACAGGAGGCGATGGGCTGAGTCCTGACTGCAGCTCCCCCAAGGACCTGCCACGCATGGATTATACACA AAGTCTGTTCAAGTCTGTTGAGGGAGTGAAGGGTCGGGGGGCAGCAATCCCCTGTTTGGCCTGCCAGGTA AAGCCTTTGTAATTGCTAATGGCTGGGCCTGACAGATTACACATAGGATTTTGGCCTGGAGCCCAAATAA TTCCTAAACTCCATCCTTTGATTTTTCAGAGCCCAAGCGAGAAACATAGGCTACCCCATCATGGACCTGA ATGGGTTGGATTTTGAGGGTCTCTGTTAGGAGCCAGGTTATTAGTCTGCAGTTACAATAAATAGACCATG GTCAGGATCAAGATCACTTCCAGCATCGTGTACAGATTAATATGCCTGGGGTAGCTTAGGTACCAGAAAA ATCCATGTTTACAGAAATGTTTGTTTGCAGCATTCAGTGGCACAGGAACAAAATATTTATTTGTGGGGAT ACATCCAGCATTTTGTCAAATTCACTGGGGAACTGCCTGGGACAGGCATATCAATGAATTTAGTGACTTG GAAGTCACACAGTCTATTCTGTAGGAGAGAGAGAAGGAAGGTTAGATTCCCACTTCTCCCTCCTCTGTAC CCTGGCTCATGGGTTCATAGGCGCTCACGTTGGGGGAATTTTCCCCAACCACTGTGACATGGGTAAGGGT AGCATCTTCCGACTATCCTCCAGGGAGGTGGGCTGTAATCTGGCCTGGATCCTCTGATGACTAAAAAAAA AAGTTTCTCTTCTGTACATTGATATCCATCCCTTGAAAATAACCAGGCAAAGCAACAAAGCCACTTTATG GAAAACATTGAATTAGAAGCCTCAAGTTGATAGTGATTATTTTTTGCAGGCAAAAAAATCCATGCTCAGC ACCAAAGGGATAACTGATGAAGAGGGTTACTGTCTCTCATGCTTTGTTTTTTAATAGCTAATCTAATCTC TCACCTATCTGAGTCTTTAGAAAGGAATTGAAGGGGGTGGGGGGCCCTTGTAGGGTTCCCCAGAGAGACT GAGGCTGTGCAATAAAAGGAAGCAGGTAGACAGTCTGATCAAATATGCAGCGCAAATGATGACTGCCCCT TTGAGGAATGCCACACTGGGACCCCAGACTGTTCCCCTGAGATGCATAGTCCAGGCCGAGGTTCTTTTAT TCCCTCCTGTCAGTCACTTAACCCTGTCCTTCAATTGTCTACTAAAACACTCAATCATCCCTGCTGCTTG GAGGCGATAGAGAGCATAGGGCGTCCATCATATATGCCCCATGCTTGGGCCCATTGATGTGTGGCTTGGG CCACAAATCTGGGGCCATTATCAGATGCATTCTATGCCTGGGAATCAACCATCTAAGATCTGAAATTGTG TCACCGATTGATTGACCTGACCTCACAAGGAGGTTTTTTATTTGTTTTTGTTTTTTTTTTTGAGACAGAG TCTCACTCTGTCACCCAGGTTGGAGTGCAGTGGCTCAATCTCACTGCTACTTCCATCTCCCAGGTTCAAG TGATTCTTATGCCTCAGCCTCCCGAGTAGCTGGAATTACAGACACGCACCACCATGCCTGGCTAATTTTT GTATTTTTAGTACAGACAGGGTTTCACCATGTTGGCTAGCCTGGTCTCGAACTCCTAACTTCAAGTGATC CGCCCACCTCGGCCTCCCAAAGTGTTGGGATTACAGGCGTGAGCCACTGTCCCCAGCCACTGGACTTGAT AACCATCCGGAGTATCATGAACAAAGCTAGAAATCTGAGTCTGGTTGCAACCTCATCATCTGCTGCTTCC ACTTCCTTATCATAGACCCAGGGGACCACCAGTGTAGCCTGCCACGGCTCCAGGTTTGGAGTGAGGCGTA GGTTCCAGGCAGCTCCTGTTGACCCTGCTGCTGCAGGCCAGGTCAGCTGTCCTTGCCCAGGTGTGAATCA TGGGCATGTATCTCCCTGCTGGGCTTCCGCTTTGCTGCCCTTTCCTGGCCCTTTGGCCAGAGAGAGCAGG CTTTTCTTTCTGTTGCTTTTCCTTGTTTGTTCTTTTTTTTTTTTTTTTTTTTGAGACGGAGTTTCGCTCT TGTTGCCCAGACTGGAGTGCAATGGTGCAATCTCGGCTCACCGCAACCTCTACCTCCCAGGTTCAAGCAA TTCTCCTGCCTCAGCCTCCCAAGTAGCTGGGATTACAGGCATGTGCCACCATGCCCGGCTAATTTTGTAT TTTTAGTAGAGACGGGGTTTCTCCATGTTGAGGCTGGTCTCGAACTCCCAACCTCAGGTGATCTGCCTGC CTTGGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACTGGGCCCAGCCATTTGTTCTTTCTAATTTA GGCCTGTTGGTGGTTCTGGATTGCAGGCCTCTTTCGTTTTCAGTCTGGCATGTGTGGGAATAAAAAGACA GCCCAGGGCACAAAACAGGGTGTTGTTCCTGCCTCTGGGTCCCCCGCCAGTCTGCCTCTACTTTCCACCT CTCAGGGTTGTGTGATTGTCTGTTGATTTATTCCCAGGGTATTTAGGTGTCCTTAGAGGGGAGAAGCAGG GAAAAGTGAATCTATGCCATCGTGTCTCGGAACTGGAAGTCCACCCCCATCCCCACACACACTAGAATTG CAGAAGAAAAATAAGATGAGAACTTGAGTGAAAAAAACATATTATTATGCAATCATCAAATGTTTGGACA GAAAGTGTTCTTAGACAACCTCTAGTCTAATTTCTCACATTTGGAAATCTGGAAGTTGGACTAAGACCTG AATCGACCACCCTCACCCCCAGTTCAGCTGACTGACTCCCCAGCCTGTATTCTCACCATTCCACACCAGG ATCTGTCCTGAGGCTTTGAAAAAATGTGAACTGCATGTCCTGCTCAGATCCCAACCCTCCCACACCACTT TGCTAAGAGTCTGTTCTGTCTGCAAAAATCCCAAAAGTTGTGTCAACTGGAACGCAAAATGTTCTTCATT TGACTTTCATTGTTTTTTGGAATTTTGGGGGGCCAGGGAGGAGCAAGAAAGGAGCTGCAATTGCCCTTGG GTAAGATTTGCTTAGAATTTTAGGAAGAAGTTGTCTGGGCACAGTGGCTTACTCCTGTAATCCCAGCACT TTGGGAGGCCGAGGTGGGTGGATCACGAGATCAGGAGTTCAAGACCAGCCTGGCCAAGATGGTGAAACCC TGTCTCTACTAAAAATACAAAAACTAGCTGGGTGCAGTGGCAGGCGCCTGTATTCTGCTAGGGAGCTGAG GCAGGAGAATTGCTTGAGCTGGCGGGGTGGAGGTTGCAGTGAACCAAGATCACACCACTGCACTCCAGGC TGGGCGGCAGAGTGAGACTGTCTGTCTCAAAAAAAAAAAAAAAAAAAAAAAAAGAAGAATTTTAGGAAGA AATCTATCTGATTCTAGAATTATCTAGGCTGTTGAGGATGTGTGTCTGGTGGCCACTGGGACATCAGGGT GAGACTTTTCTTTTAACTGCATGTATGTGAATTAGGTTGCTTCTGGAGCCTACTGAGAGCTCACTGGGTC CCCATAGCATCCATGCTGAAGGCGCCTTCCTTCTGTCTGTGACCTTGACCCTCAGCTCCACATTTCCCCA GGGGCTGCAGGATTTCTCAGAATCCTCATTAGCACAACCTATTTTTTTTTTTTTTTTTCCTGAAACAGAG CCTCACTCTGTTGCCCAATGCAGTGGTGTGATCTCGGCTCACTGCAACCTCTGCCTCCCAGGTTCAAGTG ATTCTCATGCCTCAGCCTCCCAAGTAGCTGGGACTACAAGCGTGTGCCACCATTCCTGGCTAATTCTTGT ATTTTTTTTTGAGATGGAGTCTCGCTCTGTTGCCCAGGCTGGAGTGCAGTGGTGCGATCTCGGCTCACTG CAACCTCCACCTCCCGGGTTCAAGGGATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGGACTACAGGTGCC CGCCACCACACCTGGCTAATTTTTTGTATTTTTAGTGGAGACAGCGTTTCACTGTTTTAGCCAGGATAGT CTCGATCTCCTGACCTCGTGATCCGCCCGCCTTGGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCAC TGCGCCCGGCCAACTTTTGTATTTTTAGTAGAGATGGGGGTCTCACTATGTTTGTCAGGCTGGTCTTGGA CTCCTGGCCTCAAGTGATCCACCTGCCTCAGCCTCCCAAATTGGTAGGATTACAGGTGTGAGTCACTGTG CCTGGACAGCACCACCTATTAGTGAATGACAGCCTTGACTTTTGAGGCTAAAACTTTCCACTTCTTTAGT ATAGTAATTAAATCTCTCGCTTTTTCTACTATTTCGGTAATTAAGCAGGTAAAGAAAAATATCCAGAACA ATATAATAGGGAGTAGGGCAAGAAAATCCTGAGGAACCACGACCTGTGGGTGGATCGAGTGCAGGGGTCC TTGAGTGTAGCTGGTTGCAGGAAGGCCCCAGCAGAAGGGGGCTTTGATGAGCATCCACCTTGTGTACCGA GTGAATGTCCGTCCAGATGAGGTGCGGATGCAGCTGACAATGGAGGCGACTGTAATGGACTATCCCAAGT AGCAACATCATCAATTTAGGTTTTCAGCCTGAGTGAGACTTTCAGTTAATACTCAACTGAAAACAAGATG CAAATTTTCCTTCAGAAATTTGTTGAAAGTGTTTTCACTTTGGTACTATTGATCTATTAAAGGGCTGAGA TGCAGAGGAGACACCATTGTGTAATTTCTAGTGGCCGCTCTTTTTGTCCGTTATCTGTTCACTGTTCTAT CCATGCTGTTCTGCCACACCCCTTTTTCACTTACCAACACATGTTGGAGATTGCTCTCTATCATAGCATT TCCTCTCCTATTCTCTAGCCTGCCTCTTCACTCTCTTAATGGTATCATTTTTCTGAAAAGAAGCTCTTAA TTCTAAAATGGTCCTGTTGGTGGTTTTTTCCCCTTATGGTCAGCACTTTTTGTGTCCTTTTTGAGTTTTT GTCTACTCCAATATCATAAAGACATTCTCTTAGGATTTCTCATAAAGTTTTACTGCTTCCTTCTTTTTTG AGAGAGTCTTACTCTGTTGCCCAGGCTGGAGTGCAGTGCTGCGATCTTGGCTCACTACAACCTCTGCCTC CTGGGTTCAAGCAATTCTCATGACTCAGCCTCCTGAGTAGCTGGGACTACAGGTGCCCCCCACCATGCCC AGCCAATTTTTGTATTTTTAGTAGAGGTGGGGGTCTTGCCATGTTGGTCAGGCTAGTCTTCAACTCCTGA CCTCAGGTGATCCACCTGCCTTGGCCTCCCAAAGTGCTGGGATTATAGGTGTGAGCCACCACGCCCTGGT CAATTGCTTCCTTTTTATATTTAGATTGACTATCCATCTGGATTTGAATTTTGTGTGGGTAGGAAATCAA GGCTCATTTTATTTTTATATGGCTATCTTGTTGATCTGTCGTTATTTACTATAAAGACGATCCTTTTTTC ACTTCACCTCATTGTCACCTTTACCCATGTATCAAGTGAGAATAGAGTGTGAGACTTTAAAAAATTAATG GATTATTTTTTAAGAACAGTTTCAGGTTTAGAGAAAAAACAGAGCAGATTAGCTGGGCATGGTGGTATGC ACCTGTAGTCCCAGCTTATTCATATGCTTATTTGCCATCTGCGTATCTTTTTGTGAGGTGTCTGTTCAGA CCTCTTGCCCACTTTTCAATCGGGTTGTTTTCTTATTGTTGAGTCTTAACAGATTAGCTTAATCAGATTG GCTTCGGGAGGCTAAGGCGAGAGGATCGCTTGAGCGCGGGAGGCGGAGGTTGCAGTGAGTTGAGATCACA CCACTGCACTCTAGCCTAGGTGACAGAGAGAGACCCTGTCTCAGAAAGAAAAAAAAAGAAAGAGCAGAAA GTAGAGAGTTCCCATATACCCTCTGCCTCCTACACTTCTCCCCTCCCCACACTTTCCCGTTATTAACATC TTGCATTAGTGTGGTACATTTGTTACAAGTGATGAACCAATATTGATATTGTAGGGGAGGGCAAATCTGT TTTCCTTCTACCCTTCTAAGTTCATGGCTGAGAACCCTATAACAGAAGACAGATTAATAAGAGAAAAGTG CATAAACATATTTAAGTTTTATGTGACATGGAAGCCTTTATAAGGAAATGAAGACTCCAAGAAGCAGTTA CAGTTTGATGTAGGTTTGATAAAGGGTGGACAGTTGTGGAGGATATGATAGAGCAAAGAGTTTGAAGTAA GTGTAGTCCGCTGGCAGAAGCTTATCAAGGCCCGTTTGTTTAGTTAGATTCCTCTCTGTGTCCCTTTGTC TTCACAGATACCACCAGGTATAGGGAGGGCATCTCTCACCTGAGGGTCTTATGACCTGGCTTCAGGAGAA GGTCAGAAAACCCTTCCTGCACATGCTGCTTTTGCAAATTCCTTCACCTTAAAATATTCAATATGTCATT GTGTTAGTCTGTTCTTGCATTGCTCTAAAGAGATACCTGAGGTTGGGCAATCTATAAAGAAAAGAGTTTT AATTGGCTCATGGTTCCACAGACTGTATAGGAAGCATGATGCTGGCATCTGCTTGGCTTCTGGGGAGGCC TCAGGAAACTTACAATTATGGTGGAAGACAAAGGGGGAGCGAGACATCTCATGTGGCTAGAGCAGGGGAA GCAAGAGAGCGGGGAGGTGCCACATATTTTTAAACAACCAGAATATCATGAGAATTCTATCATGCAAACA GCACTGTGGGGATGGTGCTAAACTATTAGAAACCACCCCCAAGATCCAATCACCTCCCACCAGGCTCCGC CTCCAACATTAGGAATTACAACTGGACATGAGTTTGGGTGAGGACACAAATCCAAACCATGTCAGTCGTG GTGCCATATTTTGTGGTAGCACGTCCTGAATCCCATCAATAAATTATTCTGAACTAAAGTTCCATAGTTT CCATTAGGGTTCACTTTTGGTGTACATCCTACCGGTTTTGCCAAATGAATAATGCCATGTAGAACCGTTA CAATATTGTACAGAATAATTTCACTCCCCTAAAAATCCCCTGTGCTGAACCTATTCACACTTCCTCCCCT GAGTCCCTGGCAACCACTGTCTCTATAGTTTTAATCAGAATGTCACATAGTTGGAATCATACAGTATGTA GCCTCTCCAGATTGCCTTCTTTCACATAGTAACATTCAATTAAGGCTCTTCCATGCCTTTGCGTGGTTTG ATAGCTCATTTCTTTTTATTGCTGAATAATAATCTATGGTATGGATGTGCCACAGTTTATCCATTCATTT ATTGAGGGACATCTTGGTTGCTTCCAACTTTTGGCAGTTATGAATTATGAATAAAGCTGGTATAAACATT CATGTGCAGGTTTTTGCATGGACATAAATGTTCAATTTGGGTAAATATCTAGAAACGTGATTGCTGGATC TTGCGGTAAGCATATGCTTTGGCCAGGCGCGGTGGCTCATGACTGTGATCCCAGCACTTTGGGAGGCTGA GGTGGGATCACCTGAGATCAGCAGTTTAAGACCAGTCTGGCTAACACAGTGAAACCTCATCTCTACTAAA AAAAATACAAAAATTAGCTGGGCGTGGTGGCGTGTGCCTGTAATCCCAGCTACTCAGGAAGCTGAGGCAG GAGAATCGCTTGAACCTGGGAGGTGGAGGTTGCATTGAGCCAAGATGGCGCCACTGCACTCCAGCCTGGG CAATAGAGTGAGACTCTGTGTCAAAAAAAAAAAAAAAGAAAAAAAAATGGCCAGGCGCAGTGGCTCACAC CTGTAATCTCAGCACTTTGGGAGGCGGAGGCAGGTGTATTATTTGAAGTCAGGAGTTTAACACCAGCCCG ACCAACATGGTGAAACCCTGTCTCTACTAAAAATACAAAAATTAGCTGGGCGTGGTGGTCATGCCGGTAA TCCCAGCAACTTGGGAGGCTGAGGCAGGAGAATCGCTTGAACCCAGAGGCAGAGGCTGTAGTGAGCCAAG ATCACACTTGCCGTTGCACTCCAGCCTGGGAGACAGAGTGAGACTCCGTCTAAAAAAAAAAAAAGCTTCA TGACAAACTTCCAGACTTTCTTCCAAAGTGTCCGTATGAGTTTTCATTCCCACGAGTAATGAATGAGAGT TCCTGTTACTTCACATCCTTGCCAATGTTTGGTGGTGTCAGTGTTTCGGATTTTAGCAATTTTGGCAAAT ATGTAGTGGTATCTCACTGTTGTTTTAATTTGCAATTCCCTAATGACATATGATGTTGAACATCTTTTCA TATGCTTATTTGCCATCTGTATATGTTTTTGGTGAGGTATCTGTTCAGATCTCTTGCCCACTTTTCAATT GGGTTGTTTGTTTTGTTATTGTTGAGTGTCAAGAGTTCTTTGTATATTTTTGGATAACAGCATGGTTTTT GTTTTTGTTTTTGTTTTTTTTTGAGACAGAGTCTCGCTCTGTCACCAGGCTGTAGTACAGTGGCATGAAC TTGGCTCACTGCAACCTCTACCTCCCAAGTTCAAGCAATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGGA CTACAGGTGTGTGCCACCATGCCCAGCTAATTTTTGTATTTTTAGTAGAGACGGGCTTTCACCATGTTGG CCAGGATGGTCTGGATCACTTGACCTCGTGATCCACCAGTATGGTTGAGTTTTAAGAGTTCTTTGTACGC TTTTGGGTAACGGTCTTTTGTTTTGCAAACATTTTCTCCCAATCTGTGGTTTGTCTCTTCACTCTTAACT GTATCTTTTGAAGGGGGATCTCAAAGAACATCTGGTCCCCCACAACAACATGTCATGTCAGGTGAGAGAT GACTCATTTTCTCAGAAACTAGGATTTTGTGTCATATGTTGTAAACCACGAAAAGTTAATTTTATAACCC ACCTTCTAGATCTACTGAGAATACGTGGTGTTATCACTAACAGTTTTGAGGAAAGAAATAATTGCCTAAT TCATTTTGTAGTGAATGTGTTTTGTTACTACCACAGATACTCTTAAAATCCACTTATTATGGAGGGGGAA AAAAAAGGAATTTTCTTTACAGAAAGTGAGGAGTGAAACCTAATGGAGAAAATATCTGTTTCAGGGAATA ACCCTCCCAACATCTGATTTTTTTTTGTTTTAGACAGGGGCTCGCTCCGTCCCCCAGGCTGGAGTGCAGT GATGCAATCATAGCTCACTGCAGCCTTGAACTCCTGGGTTTAAGCAATCCTCCTGCCTCAGCCTCCTGAG TAGCTGGGACCACAGGTGTGCACCACCACTGCACCACCACACCCGACTAATTTTTTTGATTTTTGGTAAA GACAGTATGTTGCCCAGGCTGATCTTAAACTCCTGAGCTCAAGTGATCCTCCCACTTCAGCCTCTCAAAG TGCTAGGATTATAAATGTGAGCCACTGCACCTAGCCTGATCTTTTTTTTTTTTTTTTTTTTTTTTTTTTT TAAGAAACAGTCACTAGTGCTGTATGTAGGTTACAGTAGCTATGTAGGCCCTTCAGAGTCACTTCACTTT TCTGAGCTTTCGTTTCTTCAACGTCTTCCTGTCTGTAAGACACATGCTCTTCTACCCCTGAGACCAAAAA ATGTTACCAGTGAGGATCTAATGATATAAAATAGGGAAAATGCTTTAAAACTGCACAGTGCTTAACAAAT GCACTGTTATTATATCATTAAAAGTGACTCCTGGGTGGTGGGAATGGTTGCATAACGACGTGAATGTACT TGATGTCACTTAAAACTGGTTACAATGGTAAATTTTATGGTATATATATTTTACCACAATTAATACATTT TAAAAGATGGTTCTTGACAATTATTCTTAGCGTCTGAGGTGCCCCATTTCTTGGGTATGGGCATATAGTG CCTCAAGAATATTGGGGATCCTCACCTCTTCTATGCCCAAACCTTTAAGAAAATTCTGGGCCAGGCGCAG CGGCTCACAGCTGTAATCCACCACTTTGGGAAGCCGAGGTGGGTCGATCACCTAAGGTCGGGAGTTCGAG ACCAGCCTGACCAACATGGAGAAAACCCGTCTCTACTAAAAATACAAAATTAGCTGGGTGTGGTGGCACA CACCTGTAATCCCAGCTACTCGGGAGGCTGAGGCAGGAGAATCGCTTGAACCCAGGAGGCGGAGGTTGCG GTGAGCCGAGATTGCACCATTGCACTCCAGCCTGGGCAACAAGAGCAAAACTCCATCTCAAAAAAAAAAA AAAAATTCTGGAAAAGCTAGGTCAGTGACATGAATATTGGAATCAGAGTCTAACAAACTCAATTTCTTCC TTTCTAAATCCGTGGTACGGATTCATGTCTGCAGTAGTTTTTCTGAGAAAGCAGAAGGGGTAGGTATTGG CAATCAACAAGCTGCAGAGTATGCAGATTGAGGTCAGTAACTGTAAATGCCCCATGACTGTCTGATCATT TTAATACCAAAAGAAAAACTTAAAATCCCAGTTGCTAAAATCTTTGTCTTAGACAACTCTTTGAGCCTCT CCCTACAAGGCCCAGAAAGGAATGAGATAGATGTGAATGGAATCTGTTTTCCCTTCCCTTGCCACGCTCT GGAGGAGGAGTCTAGGGCAGTAGCCAAGGCCAGCTGCCAGTCAAGGAAAGGGGAGCGGCCCCGTTGAATC CACAAACCACACCATCCTGGCCCATGGGTTATATACAAACTCCCACATTGGCAACAAACAAAGGGCATGC ACATTCAGGGGATTTTGCTTTCACTGTGAGTGTTTATCTTTGAAGGGTGTCACATCAAGATGAATGGGAA GGGTGTGTTGCAGTTGAGCTGAGGTTTGGTCTTTCTTGGCTTTTTTAGGGACACTTACAGGTCCAAATCT GCTTTCAGCCGGCTGGTGGACATGGTAGGAGACACAGTAGTCTCAGGACCAGGCCTCCAGGTGGGAGCTG AGATTCTAGAGGGTGGAAACCACTTGGAGATTGAGTCAAAGCAGACCTGTCCTCATTCTGTGCTGGGCAG GAGCCAGCTCTCCATGTCCCTGCAGCTCCAGCAACACCTCCGGATCTTTCAGCTTCCCTGGGACTAAGGA CCATGCACATTATTAATTCTGATATAAACAGTCACACAGGCACATGTCTCAAGATGAGGGTGAGAAGTTG GTTACAGCAAATGAAGTAATAATGATCTTTGTGCTTCACAATAGGAATTCAACCAACCTGAGGTTTATAA TTCACTTATTAACACTTTTTATTTTTGTTGAGACGGAGTGTCCCTCTGTCACTCACGCTGGAGTGCAATG GTGTCATCTCGGCTCACTGCAACCTCCGCCTCCTGGGCTCAAGTGAGTCTCGTGCCTTGAGTGGCTGAGA CTACAGGCACATGCCACCATGCCCAACTAATTTTTTTGTATTTTTAGTAGAGATGGGGTTTTGCCATGTT GGCTAGGCTGGTCTCAAACTCCTGGCTTCAAGTGATCCGCCTACCTCAATCTCTTCAAGCGCTGGGATTA CAGGGGTAAGCCACTGTGCCTGGCCATAATTCATTTATCAGTCATATATATATACACACACACTGGGAGA ATCTAGGGTCAGTGCCTTACAAATGGCACAAGTTGAAGCCCTGAGACTCCCACTCCTACCCTGCTCCCCC CATTCTCAGTACTGCTCCTCAGATGCCTCCAGCAGATCATCCATTTCTGCTAGGCTGGGCCTGGGTACAT GCAGGGAGATGTGTACAGGGGCTAAGAGCAGAAACTTTTGAGTGAGACACTCCTGAGTTCATGCACTGGC CCTGCCATTTGTCAGCTAATTGATGTTGCATTTAATTGCATCATCTGTATGTAAGCCTAATAATTTATAG CCATCTTAGAGATGTTGTGAGCTTAAATAACATAGTAGTGAATATTTATTTATTTGTTTATTTATTTATT TAGACAGGGCCTCGCTCTGTCACCTAGGCTGGAGTGCAGTGGTGTGATCATAGCTCACTGCAGCCTTGAC CTCCCACACTCCAGTTATCCTCTCACCTCAGCCTCCTGAGTAGCTTGAGACAACAGATGCATGCCACCAT AACTGACTAATTTTTTAAAATTTTCTGCAGAGACAGTGTCTCCCTATGTTGCCCAGGCTGGCCTCGATCT CTTGGGCTCAAGCGATCATCCTGCCTTGGTCTTCCAAAGTGCTGGGATTACTGGTGTGAGCCACTGCACC CACAGCCTATTTATTGAGAAATGTGGAAGGCCCAGGCACTATTCTAAGTGCTCCAGCTGTTTTATCTCCC ACAGTTTTGCTCAGATAGGAGTTCCAAAGCTGGAGCTGGAAGACTCATATTTTTAGAAATGTTACAGTTA ATTCTGAGGTGGGTCAGATTGAGATTCATGGCTATGCATTAATGTTTAGGTGGTGACTAACCACTCAGGG TTTTAGAGACAAACAGACCTTATTCTGTCACTCACTGACTGAGCGTGGCCAAGTCTTTCAGCCTCTCTAA GCCTCAGTGTCCTCATCCATAAAATGGGACCAATCGTAGCATCCACTTCTGAGAACTGTTCAGAAGTGGA AATGAGCTAGTTTAGGTGGCTGTGTCTGGCATACGCCAATGGTTTGATAAGTATTAGCTTGTGCCTTTAT TAGGCCAACTCCTTTTTGTTAGGTGACTGAGAAACCAAGGACCTTCTGCCCTTTATGCACCAGTCACTAT TAGTTTAAATTTGTTGCTCTTCCATCCACATGATTCATTCCAAATTTGAAGTGTTGGAGAAAGGGAGTTA GTATGTCATAGAAAAATCTCTGTTTTTGGCTCAGCAGGACTGAGTTTGACTCCATGTAACTGTCTGAGTC TTAGTTTCCTCATCCATAACATGGGAGAACAATACCCTGAATTAGAGAATTCTGCTGCCAGAATTAGAGA TAGTTCATGTCAAGGTGCAACATATAGGTAATGTGTTATTGCTGGTGTTCTGGTTATAAAATGTACAAGA TGTGAAAGCAAAAGGGCAGAAAACCCTTTTTAAAAATTCATGGCTGGGCGCGCTGCCTCATGCCTGTAAT CCCAGCACTCTGCCAGGCCGAGGCGGGTGGATCACCTGAGGTCGTGAGTTTGAGACCAGCCTGACCAACA TGGAGAAACCCTGTCTCTACTAAAAATACAAAATTAGCCGGGCATGGTGGCGCATGCCTGTAATCCCAGC TACCCAGGAGGCTGAGGCAGGAGAATCGCTTGAACCCGGGAGGCGGAGGTTGCTGTGAGCCGAGATGGCA CCATTGCACTCCAGCCTGGGCAACAAGAGCGAAACTCCGTCCCCCGAACAAAAAATTCAAATGGGAAAGA GAGGCAGATGGCAGAGAACAGGGGAGGGGCTGGGCACCGTGGCTCATGCCTGTAATCCCAGCACTTTGGG AGGCCAAGGCGGGTGGATTTCTTGAGGTCAGGAGTTCAAGACCAGTCTGACCAACATGGTGAATCCCCAT CTCTATTAAAAATACAAAAATTAGCCGGGGGTGGTGGTGGGTGCCTGTAGTCCCAGCTACTCGGGAGGCT GAGGCAGGAGAATCACCTGAACTCAGGAGGTGGAGGTTGCAGTGAGTCAAGATCGCACCACTGTACTGTT GCCTGGGCAACGCACCGAGACTCCGTCTCAAAAAAAAAAAAAAAATGAGAGAACAGGGGAGGGTCTAGGG CTCAGAGCTTTGGAGAACAGACCTCAGTAGCACCAACACTCCAGGATCAATGCTACAAAGACACGGGTTA CAACTAAACTGGAGAACATGGCCAAGGATGGGAACTCAGCCTGAGCAGGGCTGAGCCGAGCAGGGCTAAG CCAAGTAGGGCTGAGCCAGAACACTTCCTCCTTTTTTCTGAACAATCTACCTACATTTCAGCTACAGGGC TGGCTTTACCCAGTCCGGCGGGAGGGAGGAGAGGGCTGGTCTGTGACTTCAGTGCTGAGGTTTGATCAAG GCAAAGGGAAACTTCCTATTCCCAGACCCTTTGCAAGAAAGAATGGCATATTACTTGCCACCGACAGGGG TTATTATTACTAAATGGAGTCAGTATAAATGCTTTCCAATAAAGCATGTCCAGCGCTCGGGCTTTAGTTT GCACGTCCATGAATTGTCTGCCACATCCCTCTTCTGAATGGTTGGAAATTGGGCATCTGTTCCTTTAAAC AGGAAACATTTCTTGTTCGAGTGAGTCATCTCTGTTCTGCTTTAGGAGTAAAGTTTACCCTGCAGTTCCT TCTGTGGTGAAGTTTTCTCTTTCTCTCGGAGACCAGATTCTGCCTTTCTGCTGGAGGGAAGTGTTTTCAC AGGTTCTCCTCCTTTTATCTTTTGTGTTTTTTTTCAAGCCCTGCTGAATTTGCTAGTCAACTCAACAGGA AGTGAGGCCATGGAGGGAGGCAGAAGAGCCAGGGTGGTTATTGAAAGTAAAAGAAACTTCTTCCTGGGAG CCTTTCCCACCCCCTTCCCTGCTGAGCACGTGGAGTTAGGCAGGTTAGGGGACTCGGAGACTGCGATGGT GCCAGGAAAGGGTGGAGCGGGTGAGTGCCTGTTGCCAAGGTGGCCTCTTCAACAGGAAACCACAATATTT TTGTTTCTTGACTTGCTCTAGAAACAGGGCTGTGGGGGTGGGGAAGCAACTTGGATCTGCCCTTCTGAGG ACACCTCTGGGTGCTGCCTGGCCCAGGTCTCCTGTGTGGTTTCTCTCTGAGCCGTTGCCTCTGACTTTGC TACTTTTTCACTCTGAGCAGTCTCCAGTTCCTCTGCTACCTTTTTGTCCTCCAAGCTTCCCTGCCGCCTC GAATGCAGATACACGGTCTCCCTCCTGTGGACCCGTTTGGAGAGTCCAGAAGACTTTATCAATCCACTTT TTTTTCTTTTTCATTTGGCCCTGGGGCCGACGGTTAAGTACTTTATTCTGTCATTCTGTCGAATCACGAT GCCCTGAGGTGCACAGCCCCTTCCCCCTCTTCCGTGTCTGAAGGGTTTCCTTTTATCTCTCCACCCCCAC CCTTGCCCTCCTGCCCTCTCTCTTGTTCCCCAAAGACAGTTCTCTAATGTTTTGATGTGGATTCGTGAAT TTATCTGTATCTTTGCAAAATGTATTTTTCTTTTGTATGTGTACACTGTTTTTTAACTATGCGATCTCAG GCAAGTAATTCCTCTGTGCCTCTGTTATCTCATCATTAAATGATTAATAATGCCTCCAGAGGTGACTGTG AGGCTTGAAGGAGATAATACGCATACATCACTTACTACACGAGTTAGCAATTATTATTGCATATTAATAC TATTGGTATTTTATTTTGCTCATTCTGTTTCTATTTCTTTTTTATTTATTTATTTTTTGAGACAAAGTCT TGCTCTGTCACCCAGGCTGCAGTGCAGTGGTGCAATCACGGCTCACTGCAGCCTCAACATCCTGGGATCA AGCAATTTTCCCATCTCAGCCTTCAGATTAGCTGGGACCACAGGCGCGTGCTACCACACCTGGCTAATTA AAAAATTTTTCTTCATAGAGATGGTGTCTCATTTTGTTGCCCAGGCTGGTCTCAAACTCCTATGCTCAAG GGATCCTCCCACCTTGGCCTCTCAAAGTGCTAGGATTACATGCATGAGCCACGGTGGCCATCCAGGCATT GATATTATGAGGCCATCTTGACCTAGCCCTCTCTGGTGAAGAGTCCTTTTCAGATACTTCGTTCAGTCTT CTCAGCTATGAGTCCCTACCCTCTGAAAGCTTATATTCTATTTGGGGAAAGACAAAAGGCAGTTTCAAAG AAGAGAGGTGTTTGATTTTCTTTTCCTACTTTTAATATCAGAAAACATTTCATCTAACTCTCAGTATGAA GGCAATATTTTGTTTACTGGTATATCCCTAGAGCCCAACATGGTGAGGGCCCCAGGATTTGCTTCTTTGA TAAGATGGTAAACCCAGCTTTCAGCTAACTTCATGGTTTCCTCAGCTACACTCATATACAAGGATCACCT TTGGTAAGATGGACTTACCATCTTACCAAAGAGTTTTTGCATTTTAGAGTTTTTTCTTTTTAGATTTTTT TCATTTTAGAATTTTTTTATTTCAGAGTTTTTTCTTTTTAGAGGTTTTTCATTTTAGAGTTTTTTCTTTT TAGAGTTTTTTTTTTTTTTTAATTTTAGAGTATTTTAGGCTGCTGAGGGTGGAATCTGGTGACCTTGGGG CCACAGAGATGCTCCTTGGCTAAACCAGGGGCTTTAGCTCTGAAAGTTCACAGCCACCCTGAGAACCAAG ATGAGAGGGCTCTGCAGTGTCCAATCTCAAGACCTCTCTGAGGTGCTCCATCAAGATTCATTGAATGAAA AAATTAAAGTCTTAATGATGAACCCAGAAAAATCTTTAAATCCTAAATATGAAATGAAAGTGTTCTTAGT TACAATCCAGTCCAACGTCCTTGTTTTGGAATGTGGAAATGAGGCCCCAAAGGTAAAATGGCCCATCCAA AGTCACAGCCAGGGGCCAGTGCTCAGGTGGCCAGGTGCCCTGCGTGCGGTCTCCTGGACCACCAGGCCTT TTTCCTGCAGCTTTAGAAGCTTTAGAAGGCACTCTGCTCACTCAGGGGCAAGTGGTAAGCGCTCTTTCCC CTCTAGTGTTTGTGACTCAGGAGTTTCGAAACAGGAAGTAGAGCTGGCTGGCTGTGCCCTTCCGTCCTTC ATTAGACGTTTGCTCTTGTCTTAGATGCTCAGATGGTAGTGGATAGGCCTGTGACGAAGGTGCTACCATC GTGAGAGTAAGGTAAGGATTTGCCTCTTTGTTAAGGTCAGAGGGGCCTTTTGGGAGGAAGGCCTTTGATT CTGGAGTTTTCTAGGCTGCTGAGAGTGAGATCGGGTGGCCCTGGGGCCATGGAGGTGATCCTCGTATGTG AGTGTGGATGGGGAAACCATGAAGTTAGTGTAAGAGGTAGCAGTCCCTCTGAGAGCCTTGCCGAGGGCCG TGCAGTTTCCAGATCTGAAGGCCATTCTAGCTTAGACTGATGAAGTCCTAGGAGCTTCTGAAATGCTGCA AGTTTAACTACTTGTATAAAGGCCTCATCCTGATCCCAGTCAAACTTGTGAAATAATAGAAGCCAAAATT TAAATCTCTACTGACTTTGCTGCTACAGCTATCCTCCCACCAACACACATACCCACCAACATACACACTT GCCAACATAAACGCACACACACATACACACAAACACACCCATGTGGTCCTACTAATTCAATTATTTATTT TTTAAAGAAATTAAAAAAGACTGGGCGTGGTGGCTCTCGCCTGTCATCCCAGCACTTTGGGAGGTCGAGG CGGTGGTTCACCTGAGGTCGGGAGTTTGAGACCAGCTTGACCAACATGAAGAAACCCCGTCTCTACTAAA AATACAAAATTAGCCGGGCATGATGGCGCATGCCTGTAATCCCAGCTACTCGGGAGGCTGAGGCAGGAGA ATCGCTTGAACCTGGGAGGTGGAAGTTGTGGTGAGCCGAGATCGTGCCACTGCACTCCAGCCTGGGCAAC AAGAGCGAAACTCCGTCTCAAAAAAAAAAAAAAAAAAAAATTAAAAAGATACAGAACAGTTCAAAAAACA ATATAATGGGAAGACTAGATAGACACAATCAGAGACCTGCACTTGTGGGGTTAAGAATTTACAGGTGAAG TTGCAAGTTTCATTCTGTTTGAAAATGATGGGATTATATGTTTTGCTGAGGTTTGGACACCTTTGCTGGG TTGTTTGAATGCCGTGGCTGCAGCGCCCTGTTATGGACATCATGTGCGTGCAGAATGGATGTCTGTCAGG TTCCGGGGCAGCCCGCAGTCTGAGGCAGCCAGCCTGGATTGGAGGGAGTGGCAATACTACCTGCCGGTTA GGGGTTTGGGCCTGAGAGCGAGTGGCTTTCAGGTTCTCTCAAGCTTCGGATGAGATGCAGGTTTCTGCTT CCGATGGCAAATGCATGTTTTGCTTTTTAGTTATCACTGCAAGAGCTAGGATGCTGCTAGAATATTACTG GAATGATTGTGATGAGATGGAATGTATTTACAGTTTAATTGTGACATGTAATACAGTGGTAGAATGGGAC TCTGGAATGAGATGCTGGGGCCTAGATTCTAGCACTTCCTTTGTGAGGCTCTAACCCCCTCTCCTATAGT GGATTTGTTAAGAACTTCTGTTTTTGTGGCTTTGTTATTATAAAATTTTTTGAAATGTTGTTCTCTAAAA AAGTTATGATTTTATGTTTTTCTTCATGAGATTCTTTCACTGCCTTCCAGCTGCAAGTAGAATGACGTCT AAATCTTTGTGATCTGTCACTGAAGCCCTTGAGTGAGACACTTAAATCTGGCTGTGGCTCTCTCTCTTAC TAGCTTATTTCCAAGCCGTGATTTTTCACAACAGAAAAATGGGGACAGTAATAGTAGTTTCTTCAGAGGC TTTTAGTGAAATGAGGTTAAAAAATATTTTTATGTTTATATGGATATATAGATTACAAACATTTATATAT CATTTATTTATATGATTATTATAAACACATATTTATATTTAAATACTTTGGGGCATAAATATATAAAATA ATAAATATACTTATGTAATACAAATAGACTTATATACATTTACTATTTAGCAGAGATTATATAAAATATA TGTATTACATGGCAACATATTCAAATTTACATATGTTATATATACATGTGGAAAAAAAATTGGGAAAAGG CCACAAAATGTGACCAAAGAATTACTTCCAAATGGCAAGTTTTTAAGTAATTTTTATTTTCTTTTTATAC TTCTCTGTACTTTCTCTATGAAACAAGTGTTACTTTTACTGTTTTTAGGAACCAAAAATACAAGTACATT GTTTAAAAAATACTAGCTTAACAAAGTTTCTAGCCCATAAGCTAGTGCAGAAAATCTAGGTCCCATAAAA CAAGAACTGCCACACGATGTCTCTCCCCTTACAGTGCTGGATGGCCCGTTGTTAATGGTGTCATAAATCC TTTGCAAGTGACTGTTTTCTAGGTACTATGACTAGAGGGATGTGTAACTTAAGCAAAAAACAAAAAACAG AAAAGGCTGACTATCATCTGACAGTGTATCCTGGAACACCTAGGCCAGAGAAGAAGCCACGTTAGCATTT TCCCTTCTAAATGTCAGTTATGATTTGATGGGGAAACCACTTAAAAAGCATTGTCACGTTGTTGAAAAGG TAATGAAATGAGTGAGATGAGATGGCTATGGAGGACGGAGCTATGCGCCAATCTTATTATATCCAAATTC ATGTCATCTCAGCCTTGGATTGTATTGATTTTTATTATATACTGTCAGAAAATGCTATTGAATGTGTAAC AAGAGCCTCAAAAAGGTTTATTCATTTTGACACCATAATACTACTTTTAGGAAATTATTCTAAGAAAATA ATTAGAGGTATTCTTAAAGATTTGCGTTTTAAAGTCATCCTAAATGTAATCAGGAACTGGCTATGTAAAT TATAGCCCATCTCTAAGATTAAGTGCCTTACAGATATTAAAACCCATGCTGTAGAAGAAAAACTAAAGAC AGGAAAGTACTTACAATACAAGATGTACTTACCAGTGGAAAAATCCACTTATACTACAGAAATATGATGT GTTCAAATATAAGGAAAAATGTGTATGCATAAAATATTTGGTAGGAAAGAGTAAAATATTACTGGGCATT TATATTTGGATGGTGGAATTATACATAATTTTAATTTTCCTTTTTATCTTTTCTGTATTGTCTAAAATGA ATACACTAAGCATTGTTATCCTCAGAAAAAAATAATTGAGGGATGGGGGAAAGGAAGTCCTGCTTTCATT TGATTCTTTGGTTGGTTTTATTCTGTAAGATGAGACTTTAACAGAGGTTAGAATGCATTAAAAATTGTAA AGACAGTTGACCTAATGGCACTAAACAGGGTTAGATCTAGTTTAGATCTTTTCCAGCATGTGAATAAGAA TGGATCTTTAAATAAAGATTTTAACTAGGTATATGTTTTAGAATAAGTCATACATGTACATGGTAAAAAT TCAAACAGTACAAACTGTGCAGCAAGGTATGGGAAATAAAGCAGCTCTCACTGTCACCTCCACCCATCAG CCTTCTCACACTGCACGCCCACATCTGTGTGTAATTCTGCTTTTCTTTAACATTACTGAAGGAACTTCCT GTGCATTTTTTGTCAGAGCTCTTCTGTGAATACACAAAATATGTACTGATCAATACATTATGTAGATCAC GCAGGCTCAACCACATTGATCTTCCTATTCTTTCTAGTAGCCAAATAGAGTTCCCTGGAATATGATTAAT AGCTTGCCTAAATCTTCTAATGCTGATAAACAGTTGTTTCTGCTCTTTCGTTATTTCAAGGAATGCTACC ATGAATAGCCTTATATATGGTTTTGAGTATACTTGTTTAAGTGAATGTAGGAAAAACTCTTGGAAGTTAA ATTGTGGGCCAGTTTATGTGAATTTTATATTTTGACAGAGATGGCTAAATTACCCACCTGTTTTTTTGTT TTGTTTTGGTTTTGGTTTTGCTTTTTTTTTTTAAGAGTTGGGGTCTTGCTACCTGGGGTCTTGCCACCTG GGGTCTTGCCCAGGGTAGACCTGAACTCCTGGGCCACGTTGGTTTATTTTACTGCATTCCCAGGGCCTAG AGCAACGATTGACACGTGCTAGCAGTATCTATTGGAAATTCTGGCCAACTTGCAATAGACCTGATTATTT CTACACTGAACATGTCTAAGATAGCTATTACTATTCATTCAGGAAAGCCCAGACAATTATCATGCCAGCA GCCTGAGACAGTAGCCAGTAATAGCCTGGTGTGGTAGTTTGCTCCTGTAGTCTCAGCTACTCAGCAGGCT GAGGTGGGAGGATGGCTCTAGCCTGGGAGGTGGAGGTTGCAATGAGCCAAGATTGCGCCCTGCACTCCAG CCTGGGTGACAGAGTGAGACCCTGTCTCAAAAATAAAAATAAGAATAAAAAATAAACCAGCAAAAGTTTC TGCCCTCACAGAGCTTCCATTCTAGTGAGAGGGTAGTTTGTCATCAGGAGGGTGACGCCGGTAGGGCTGG GGGCCAGCTCCCTGCAGGGAACAAACATGATCGCAGTGGGGTGGGAGTAGGGGATGAGTCCCCAGAGCCT CTGTGGTTTCCATTTCCACACAAAAAAACCACTGCTGCTGTAATCAGGAGGGGGAAAAGATTTTTAAAAA TTTTCTTTCAGGGAATGGAAGGAAAGGATATTTTTGAAAGTAAGACTTTGAAAACTAAAAGTTTTGGGTC ACTTAAAAACTCAAAATCTTTAGGTCACTTTAAAAATATTTAATCTTGGAGCTGGAGGCCATTATTCTAG GTAATTAGCTGGGTGTGGTGGTGTGTCCCTGTAATCCCAACTACTAGGAGGCCGAGGCAGGAGGATTGCT TGAACCTGGGAGGCGGAGGTTGCAGTGAGCCGAGATCGCGACACTGCACTCCAGCTTGGGTGACAGAGCA AGACTGGGTCTCAAAAGAAAAAAAAAAAACGAAAACTAAATACCGTATGTTCTCACTTAAAAGTGGGAGC TAAGCTATGAGGATGCAAAGACATACAGAGGGATATAATGGACTTTGGGGATTGATGGTGGGGTTGAATG GGAGGTTGGTCCTAATAGGTCCTAGTACGTCCCCTACTTCTAAGTCTTCCAGTCTGTCCTTTGCACTTTG AATGTTAATTCCAAGTTGGATAATGTCATTCTCATTTTTACAGTCCTTTCTTAGCTCCTCATCACCTCCA GGACAAAGCCTAAACCCCTCGCCCCATGGTAATGCGGCCCCTTTGTGACATGGTACCTGGCTAGAGCTTC ATCCCTTTGTCCCATCACTCTCCATCCCAGACACTTTGTAGTTACTTTATTGAGCTCCTTGTGCCTGCCT GAATGGACTTGAAAGTTCTTACCTCCATCTTTTACATTAATTGTTTCCTGTAAGAATTGTGCTTTCTCGC ATTCTCCCCAAAATCCCTTCCCCATAGGAAGCCCTTCTCCCAGGCTAAGTTAAGGTTTCTTCCTCTACAT CCCTACCACACTCTGGTCACAACCCTCTAACCATTGGCTTGTTTTTTTTGTTTTTTGTGTTTTTTTTTTT TTTGTGAGACGGAGTCTTGCCCTGTCACCCAGGCTGGAGTGCAGTGGTGCAATCTCCGCTCACTGCAACC TCCACCTCCTGGGTTCAAGCGATTCTCCTGCCCCAGCCTCCTGAGTAGCTGGGATTACAGGCACGTGCCT CCACACCTGGCTAATTTTTGCACTTTTAGTAGAGACGGGGTTTCACCATGTTAGTCAGGCTGGTCTCAAA CTCCTGACCTCGTGATCCGCCTGCCTTGGCCTCCCAAAGTGTTGGGATTAGAGGCGTGAGCCACCGCGCC CAGCCCATTGGCTTGTTTGTATGTCTACCTTCCTAAACAGTAAGAGGGAACTTGTCTGGTGTTCTTTTTT TCTCTCCTGTGCTGACAGCACAATGACCAGTACCTAGTAGTTGCAGTAGCCTTTGATGAACAAGCCAGCA AATGGTACTTTTCTTCCTTATCTGAACATACCATTTATTTTGACTTAGATTATATTCTCCTGCCTTTTAA AAAGATGGACTTCAGCAGAAATCTTTATGATATTGGGGAACAACTGGACAGTGAAGATCTGGCCTCCCTC AAGTTCCTGAGCCTGGACTACATTCCGCAAAGGAAGCAAGAACCCATCAAGGATGCCTTGATGTTATTCC AGAGACTCCAGGAAAAGAGAATGTTGGAGGAAAGCAATCTGTCCTTCCTGAAGGAGCTGCTCTTCCGAAT TAATAGACTGGATTTGCTGATTACCTACCTAAACACTAGAAAGGAGGAGATGGAAAGGGAACTTCAGACA CCAGGCAGGGCTCAAATTTCTGCCTACAGGTGGGTGGAAACTCCCATTGTGGGACTGGGAGGTGTGGGTT GAATGGACAGCCTCTGAGCTGATTGGGGCTTTTTTTTGTGGTACCCTGCCTAGTGCCTGGGAACCCAGCA GTGCCACAATTCTAAGCTTCTACAGAAAGACAGTAGTGCCTTGGGTGGTCCTGCTAAAGGCTGTAAAACT TAGCTTCTCCCCACCCTAGAGAGAGTGGGTAAACAAAGGCGTGAGAGAGAAACCACATTCAGTATCACTT GGGAGGCTTTGGGAAGATGTCCCACCGGAGCCAGATTAAGAAATTTAGGGGCCTTATATATAATTCTATA GAAATGCTAAGACCATAAAATAAAAATTTATTTTTCAAAGTGAAACATTACTTAGAGGTATGCTGAAGTT ATAATAGAGTTTTTCTAAGTGTTCTCATTTTTTTCCTCTCTTATCTTGATGCCTCTCGATATCCAGATTG TGTGCTTACTTTGCCCATCCATTGAGTAAAGCATCATGGCTTCCCACCCTGAAATCCCCCTCCCACCTGC TTGCGGATGGCTATGAAAATTTTCAATGAGATTTAAGGGTTTTCTGCCACACTTAAAGACTCGAATGACT AAGTTCTTTACGGAGCTGTAAGCCGCTGGCCTGGCACATACAGCTAGGCAGTCTCCACCGAGGCTGCCCA GTTCCTGTGAGCCCGGCTGTATGACAGTTCTAAGCTTCTATAGGAAGACAGTGGCACGTTGGGTCATCCT GCCAAAGGCTGTAAAACTCAGCTTCTCCCCACCCTAGGGAGAGTGGGTAACCAAAGGTGTGAGAGAGAAA CCCCATTCAGTTACAACTTCATGATGCTGTGACAAGACTTTAAAAACAGAAACACATTGTCACTTTCTCT CTTTCAACATCTCCTATTATCGGACACTACTTAAAGCAATTTTAGCTTTGCTTTCAGGAAACTTCTACTG AAGTCTTCGTTCTGGGCCCATTTCATTGTCTCTGTTTGCTTGTTGATAACTATGGCATGTGAGATGGAAA GGGTTCACAACCAGGGCTGACAGCTGCTGTCCTCTGATGGCTCAGCCCATGAATGCTCTGGTCTTTCTAT TCTCAGAGACTATTTTTTGTTTTGAGGCTTGACTATTTTTTGTTTTGTTTTGTTTTGTTTTTGAGACGGA GTCTCGCTTCATCACCCAGGCTAGAGTGCAGTGGCATGATCTCGGCTCACTGCAACATCTACCTCCAGGG TTCAAGTGATTCTTCTGCCTCAGCCTCCTGAGTAGCTGGGATTACAGGTGTGTGCCACCATGCCCAGCTA ATTTTGTATTTTTAGTAGGACGGAGTTCCACCATGTTGGCCAGGCTGGTCTCGAACTCCTGACCTTAAGT TATCCACCAGCCTTGACCTCTCAAAGTGCTGGGATTATAGGTGTGAGCCACCATGCCCAGCCAAGGCTTG ACCATTTTGATTTTAAGTGAAAAAAGAGATATTCTGGGCCGGGTGAGGTGGCTCACGCCTGTAATCCCAG CACTTTGGGATGCTGAGGAGAGCTGATCACCTGAGGTCAGGAGTTCAAGACTAGCCTGGCCAACATGGTG AAACCTCATCTCTACTAAAAATACAAAAATTAGCTGGGTGTGGCGGCTCACGCCTGTAATCCCAGCTACT TGGGAGGCTGAGGCAGGAGAATTGCTTGAACCCAGGAGGTGGAGGTTGCAGTAAGCTGAGATTATGCCAT TGCACTCCAGCCTGGGCAACAAGAGTGAAACTCTGTCTCAAAAAAAAAAAGAAAGAGATATTCTGGGTAT ATAAGTTTCCTAGGGCTGCTGTAACAAAGTAACACAAACTAGCAGGTTTAAAACAGTTTTTAAAATGTGT TTTCACAGTTCTGGAGGCCTGAGTCAGAAGTCAAGATGCCAACAGTGTTGGTTCCCTTTTAAGAGGCTCC GAGGAATAATCTTTTTCATGCCTTTCCCTGCTTCGGGTGGGTGGAGGAATCCTCAGTGCTCCTTGTCTTG TAGATGAGGCACAGCAGTCTCTGCCTATGTTCCCTTCTCTGTGTCTAAATCTCCCTCTTATGAGACAGTC ACTGGATTAGGAATTAGGGCCCACCTAATCCAGTATGGCCTCATCTTTGTGTGTGTGTGTGTGTGTGTGT GTGTGTGTGTGTGTGTGTGTGTGTGAGACAGTGTCTCACTACATCGCCCAAGCTGGAGTGCAGTGGCATG ATCTCGGCTCAGTGCAACCTCCACCTCCTGGGTTCAAGCAATCCTCCCACCTCAGCCTCCCAAGTAGCTG GGACTACAGGCACCCGCCACCATGTCTGGCTAATTTTTGTATTTTTTTGTAGAGATGGAGTTTCAAAATG TTGCCCAGGCTAGTCTTGAACTCCTGGGCTCATGCAATCTGCCCACCTCAGCCTCCCAAGTTCTGGGATT ACGGGCATGAGCCACTGCGCCTGGCCAGCATGACCTCATCTTAATGAGATTTTATCTGCAAACGTCCTGG GTCCACATAAGGTCGCATTCTCATATTCCAGATAGACATGAATTTTGGGGAAGAGGGGAGAACACTATTC AACCAGTACACTAGATAGCTTTGGTTTACTAGCATTGTGAAGTCTTTATAAGGCACTTATTCATTAAGGC GCCAGTTAGTCCTAAAAACCCACAGCCCCAGAACAAGGAAAGCCGAGGGGGGTCTCATCTTGTGCCCACC ATCTTGGTCCTTTGAAGGTTCCACTTCTGCCGCATGAGCTGGGCTGAAGCAAACAGCCAGTGCCAGACAC AGTCTGTACCTTTCTGGCGGAGGGTCGATCATCTATTAATAAGGCAGGATCTCTCTTAAAATCTTTAATG TATTGGCTTAGAGATAAAAGGGTCCGGGCAATCCTGACTTACTGCTTGTTCATTATCATTGAATACTAGC CAGAAGCTAATAAATATGCTAGGGTGACCACTTACCATTATAAGAAAACACTAGACATTTTATTTTCCAG TTATAATTGCTACCTATAAAATAAAGATCTTATAAACTATTCAGGTTCATTACTAAATGGTGATGGTACA AGAAAGCCTATAGGCTTCAATAATGAGGAAAGCAAAAGGGTAAATACCTTGTAATAAAGGTGAAAGAGTC AGAGTAGCTTTGGATTAGATCCAATTTTGGCCAAACTGAAAGCTTTAGATAAACACTTCTAGGGTAGAGA GTCCATGAGAAGGGGGATAAGGCAGATGGTAATACTGAGTAATTTCTGTTTCTACGCCATTTTTATTTTC AGAATTTTACTTTTCTAATTAAATTTTAAAGTCAACGTGTTTTTGTATTAAAATTATTTTCCTTTACACC ATAGTATTGAAAGGTTTGCTGACTTCTAAAACATTCCTTTGTTCACCTATTCGACAAGCATATTCCAAGA GCCTAAATGTGCCAATCACATAAATGTGATAGGCATAGATTAGGAAATAGTAACACCTATCACTCATTGA GCACTTAGTGTGTTGCCAAAGACTGATTTAAGTACTTCACATAAACTTATTTGTGTAACCCTCGAAACCT TCCTATGATGTGGTTACGGATAATTATCTTCAGTCTATGGACGAGGAAAAAATGTGTAACATGTCTAAAG TTAACACTGCTCAAAGATAGTGGAACCAAGGCTCCAACACCAATAGCCTGGGTCCGCTGAGCTCAATCAT TGCACCTCACAACCCTCTGGGTTTATGAAAATAAAAAGGGTACGGACCTGGCCACTAGGGGACTTGAACA GTTTCTAAACAGACAATTATTTTCTGTTTTTATTTTTAGTGTGGTGGCATGATCACAGCTCACTGCAGCC TCAACCTTCTGGGCTCAAGTGATCCTCTCACCTCAGCTTCTGGAGTAGCTGGGACCACAGGTGCATGCCA CCACACCCGGCTAATTTTTAAATGTTTTTGGTAGAGATGGGGTCTTGCTATGTTGCCCAGGCTGGTCTCA AACCCCTGGGCTCAAGTGATCCTCCTTCTGCCTTGGCCTCCTAATGCGCTGGAATTAGAGGCATGAACCA CTGCACCAGGCCAACAGACAATTATGTGTGTTATCGTTTTGGGGTTACTAAGTCATAGTGGAGTGAATGC AGCTTTGAGGATGCTCAGGCAATGCTTGAGCTGATTGTTCATGGATGGGCCTCTGCAGATAGACAAGGGG ATGGGGTGTAGCGGCACCACAGAAAGGGGTGAGGGCAGGGCAGCTGGGTGTGTTTGGCTTCAGGTCCTTT CGTGTTTGCGGTCTGGTCTGTGATAGGGATGTATTCGGAGACTTTGTATTCCAGAACCGAATGCTTGGCC GTCTTACTGAAGATAATGACTGGGAGAATACTGACCAGTTTTGATTAGGGAAGTCATGAGCCAATGTGCA TTTTGAAAAGCATAATTTCCAAAAGGCAAAGCATTTTGCTATTGCAACAAAATCTCCATTTTACAGAAAA AAAAAAAGGAAAACAAGATTTACTCAACTGAAATAAACTGAAAGAAAAGTTGATAGAACTTTAAATTGTT AAGGGTGGGAAAGTCGGGGAGGAGCCAGTAGACTTCTGTGTCACCACACCAGCCTCTTTCCAAGGGCTCA ACTCATAAACCATGCCATTAACTGGCTTTATGTTGAAGGGAGGCCTTTGGAATCAAGCCCACTGTGACTC CATATATCAAATGGGAAATTATTTGGGAAAAGATTTCTAAAGTGTCTCCATTTCCCACCACAGGGTCATG CTCTATCAGATTTCAGAAGAAGTGAGCAGATCAGAATTGAGGTCTTTTAAGTTTCTTTTGCAAGAGGAAA TCTCCAAATGCAAACTGGATGATGACATGGTAAGACCTGGTATCTTACTGAGATTTAGTCCTGAGACTTG GTTAGCCAGGGGGCATTTCTGAGACCAAAGAGAGGGGTATTTTGGTAAAAGCAACCTGGATTCTCACTTT TTAACTAGAAGAAGAAAGTTGTCAGCACGAGTGTTACAGATGTGATTCCTTTAGACCGAAGTGCTGCTCA TGTTAATTATTGGGAGCAAGGCAGAGTCAGAGGCCGGGAGAAGGAGGCTGTGCAGATGCAGCCCAGACCC GGCAGAGCTGGGAAAGACTGCGGTGGGTCTGAGATATTTCCTCCACTTCTGCAGTCCCCGAAACAACCTG GGACCTGAAACTCTGTGTGTATATTGTGTCTGTGTGTTGTGTGTGTATTTCCGTGTCTGTGTGTGCCTTT CTCTGTGTATAGTGTGTGTCTGTATTTGTGTGTGATATGTGTATCTCTGTGTGTCTCTGTATAAGTGGTG TGTGTGTCTGTGTATCTCTGTGTGTGTGTTCTCTGTGTGGTATGTGTGTCTGTGTGTTGTGTAGTGTGTA TTGTATTTATGCCCCTGTGTGTGTATCACTGAGTATACTCTGTGTGTGTTGTATCTGTGTGTGTATGTGC ATGTGGTGTCTGTGTGTGTGTGTCTGTGTGTCTGTATGTACTCAGGTCTGGAGAGGCAATGCTGGGGGTG AGGCTGTTCCCCAGGGTGTCACCATGATGACCGGGCTGCTGTCTCAGGTTGTTTCACAGTCCCCAAGTAA TGCATTCGCAGGAGATTTGAGCACAGGGCCTGGGGACTGGGTGACATCTGACATGGCTTCTCCTTTATCC TCTCACTTCTGTCTTTCTGGGCCAGAAAACATGGAATCGCTTCCCTAGTAGCCTGCTGGCTGTGAGAGAC CAGCAGAAACTGTCAGAAACTTGGGAAGCAAGGGCAGGTCCTTGGTTGGAGAAATTGGAAATTAAAAAAA AAAATCTAATCTAAAAACCAGTAGGGCTCAATCCAGATTCCCAACTTTATTTCTCCTCCTCTTAGAACCT GCTGGATATTTTCATAGAGATGGAGAAGAGGGTCATCCTGGGAGAAGGAAAGTTGGACATCCTGAAAAGA GTCTGTGCCCAAATCAACAAGAGCCTGCTGAAGATAATCAACGACTATGAAGAATTCAGCAAAGGTAGAA ACAACCTGACAGCCGGGAATCGGCAAAACCTACTCTAAAATTGAAACTGACAAATCGCTCCATATCACAG TTGTTTCTAATCAAATATTGTTTGGGGTTTCCCCTTTTAATTCAGAGAGAAGCAGCAGCCTTGAAGGAAG TCCTGATGAATTTTCAAATGGTAATGCTTGGAGATACATTTTCAAGATTTAGTTAATTTACTATCTGGTA CCTGCATGTGTCCTCCCCACAGCCTTCTACCACATGCACATCTTAACGTGCCTGCTCTACTTTTTCTTTT TTTTTTTTTTTTTGTGAGACAGTTTTACTTTGTTTCCCAGGCTGGAGAGCAGTGGCACCATCTCGGCTCA CTGCAATCTCCGCCTCCCAGGTTCAAGCAATTCTCCTGCCTCAGCCTCCTGAGAAGCTGGGATTACAGGT GCGTGCACCACCACGCCTAGCTAATTTTGTATTTTTATTAGAGATGGGGTTTTACTATATTGGCCTGGCT AGTCTCAAACTCCTGACCTCAGGTGGTCTGCCTGCCTTGGCCTCCCAAAGTGCTGGGATTACAGGCATGA GCCACTGCGCCCGGCCGCACCTGCTCTCCTAAGACCTGTAGCCCAAGCTGGCAAGTTTGAAATAGGTGCA GAGTTAGTCAGTAGTAAGTAATTTAACATCATTTTTTCTATGTGGCTTTTTTTTTCTCCTTGACGTGCTG CTCATGTTATGCACTGAGTAGCTGGATTTAAATTATGTTTCATAATTTTCTTGGTTAAGTCACTTTCTCT TTCAACACCTTCTACACTAAGTCACTCCTTTCAACTTCCTTTCACTTTTTCTACCTGATAAGCGAGGCTG AACCAAGAGAGAGAGCTCTCAACGATCTCCTTCAAAATTTTGATTAATCAAATAGTCTTTTTTTTTTTTT GAGACAGTGTCTCACTTTGTCCCCCAGGCTAGAATGCAGTGATGCAATCTTGGCTCACAACAGCCTCGAC CTCCTGGACTCAGATGATCCTCTTGCCTCAACCCCCTGAGTAGCTGGGACCACAGGCACAAGCCACCATG CCCGGCTAATTTTTGTATGTCTTGTAGAGATGGGGTTTCGCTATGTTGCCCAGGCTGATCTTGAACTCCT GAGCTCAAGCCATCCACCTACCTGGGCCTCCCAAAGTGCTGGGACTATAGGCAATTAATAAAGTATTCTT TCTGATTAGAAAAATTATATACACTAATTGAAGATTATTTTAAATTCAGAGAAATTTTTACAAGTCCAAG AACACCATCACTCCATTCATATTATGAATATTTTTATTGTATTTTTACGTTGGCTCTTTGTGGTGTGTGT GTGTAAAATACATTTTGGATCACTCAAATGTATTTTAAAGATTAATGTCTATGCAGGCTGTCCTTCCCTT TCCCCTCTGCCTGCTGAGCCTAAGGCCTTAAGAATACTTTAAGGAGTAAAGTACTAAATCATTAATTCAT CCTGAGCTAGTGGCTTTATTAATGAGTATCTCACAAATACCACAAAAATTCAACCTGGCCATGTGGAGCA ATATAAAATTATGGCATTTCTTGGTATGTTTTTCTCTTTGGCGAGGAGACAACTTGATCTTGTGTTTCCA GAAGCATGTTAATTGCCCTGCTTGCAGAATCTCTCTGGCTTGAAAGGAGATTATATTCATGGCAGTCTGT GAATTTTCATTTTATTTCATTTATTTATTTGAGACAGAGTCTCACTCTGTTGCCCAGGCTGGAGTGCAGT AGTGCGATCTCAGCTCACTGCAACCACTACCTCCCAAGTTCAAGTGATTCTCCTGCCTCAGCCTCCTGAG TAGCTGGGACTACAGGTGGCTACCACCACGCCCGGCTAATTTTTTTGTACTTTTAGTAGAGACAGGGTTT CACCATGTTGGCCAGGCTGGTCTTGAACTCCTGACCTCAAGTGATCTGCCCATCTTGGCCTCCCAAAGTG CTGGGATTACCGGCGTGAGCCCCTGTTCCCAGCTTGAATTTTCATCTTAAAAAAGACCTTATGTTGTCCT ATGTGCTACATATTTCATTACCAGTGTACCTTTCCTGCCATGTCTCATTCTAGATGTGTCTCTTCGTTGT TTGCAGGGGAGGAGTTGTGTGGGGTAATGACAATCTCGGACTCTCCAAGAGAACAGGATAGTGAATCACA GGTAGACGGAAACCTCCAAATCCTTTTTTTTACATTACAGATTCTAGTTATTTAATTTGTTAGCTTTTTT TTTTTTTTGCTGCCAGATAAACTGACAAGGGGCAGAAACTTACTGAAAATTTTGAGAACTGTAGAAAAAA TTCACACAAAAAAAGTTAAAAATGTGACTTAATTTTTAAAATGTGACTCCTTCAGTTTTCTATACATTTG AATTTTATTTTAAGACCCGAGATGAAGATACTGGAATAGTTGGAGGGTGGAGGGGGTAATAAGCCTCCTA CCAAATCTTCTAGCAGCCGTGCCAGCCTGGATGGGGGAGTGGTTTGGAGAAAGAGTCTAGCAGGAATGGA AAAAGCCAAGCCTTTTCCTTTAGCTTAATGTTTCAAAAATGCTTCTCCTTGGTGATGAGGTGTAAGCAGC AAACTCTCACAATCTAGCCATCTCTGTGTTTTTGTCTCAGTGAACCAGCAGAAACATGTAATTTTTAGGC ATAATAACTTCTCTTTATGTAATCAACAATCCACCAAATACATCCTGACTTATTAGACGATCTGCTCCTC CTCATGGTAGGAAGAAGAGGAAATCCTGAATATCTGAAGTAGGCTTGAGAGAGATTATTCACTAGTGTGG GCTCCTGAGAAAATTACCAGACCTCTTTCATCTGAAAGTCAAGGATTAACCCAAGTAATGTGGTACTTTC TAAACAGTATAGCATGCTACAAGCATTGTCCCCACTGAAGAGCTAAAAACACTGTCTTAATATCTTAGTA AATCTTAGTATCTTTTTCCTTTTTTAATGTTTTATTGAGACAGGGGTCTTGCTACGTTGCCAAGCCAGGT CTCGAACTCCTGGCCTCAAGCAATCCTCCTGCCTTGGCCTCCCAAAGTCTGGGATTATAGGTACTAGCCA CCGTGCCTGGCCAAATCTTAGTGTCTTAGTATCTCAGTAAATACACTTAATATGCTTAATAAATACTTAG AACACAACTGTAAATAATAAAAACTTAACATACTTGGTACAAACTTAATCAAATATTTAATATCTTAGAG TTAACATATTAAGATAACAGGTTATTTGCCCAAAGTCATAAGGTGAAGTAGAGGCAGGAATTGGGCTTCC TAGCCTGGAGTCCTTTTCTCCACCTCAAGGGGCTACGCAGACCTCCAACTAAATGCTGAGTTTCTCGGTA CTGAAACAGCCCTAGGAGAATGAATAGGACACAGCGCCATCCCTGGCCAGTACTATCAGGTACTACAGTT TGGATACCATAACCTACAGTGTAGCCAGGACCTCCCTGACCAGCCCATCTCTTCCCAGCAGCCACCGTGG TCCTGAGAGCTGGGTTAAGCCATCACCTTTAAAATCCTGGGACCACACTGTGCAATGCATGAATGGGAGA CCCTCAGCTGTTAGCCACGAAGCACAGATGAGTTCAGTAGACAGCCAAGAGAATCACAAGTCATGGCGTG GGGGCAGCCAAAGACATTCATTCATTCAGTGACTCTTGATTGAGCTCTCACAAGTTAATACACCGTAGTC CCTGGCACAGATGTTATGAACCTCAAGGAGTCTTCTGTATAGTATGGGAAGCAGAAATGAGAACAAACAA TAATACAATGTGATGACAACAATATTAATATATGTGCAAAGTGCTCAGGAGGCCCAGGTATTGGGACACT GACTTTACAACGATGGGGCAGAAGTCTGAGAGGTCCTGTGTGAAGGAAATAGGTAGAAACTAGTTCTTCG AGGAAACGACCCCGAGTTGGGGTGGTGCAATGGAAAGCAAGTCCTCTTACTAGGGAGTTGTTTGTTTACA TCTCTAGTGTTTGACCCACAGAGTCAGCTCCTGGGTTGGGTTTTTGTTTTCCAGACTTTGGACAAAGTTT ACCAAATGAAAAGCAAACCTCGGGGATACTGTCTGATCATCAACAATCACAATTTTGCAAAAGCACGGGA GAAAGTGCCCAAACTTCACAGCATTAGGGACAGGAATGGAACACACTTGGATGCAGGTACAGTAGAACCC AAAAGAGAAAAGTAAAATATTTCTTATGCCTATTTTTTTTTAAATCAAAAGGGAGAGAACAAAAGCTATA CCAAAAGGGCCATGTTTCAAGAAAATGGATTTAAACATATTTCCCTGTGGAGGTAAAGAACATTCTTATA CATTTATCAGTTTCCTGCTTTTTTTAAAAATTAATTTTTTAAATAAAAGTAATGTATGTATAAATATAAA ATATCAAATCTTACTAAAAGACATAATGAAAAGCAGTAATAAGCTTTGTTTTGAATTCAGCTAAATGCAT AGCGCTTCTGTGGAATGTATTAGGCGATGAAATTGCTGTGGTATCAAAGTTCTTATAGAGGCTGCATTTT TACAGGTTGGGCTGTTAAGTGCAGCAGAAATTGTGGGTTCTTAACAGAAATAGCATTTTCAAGTATTAAA TATTAAACTGGTTAGCAATTCTTTTGCTCAGCCAAATTAAGCTAAGATCAAGAACTTACAAGTTAAATGA AAAAACAATTTGTAGTATGTGAATATAAAAAGTGACTACAACAACAAAAAATAAAAATCATCCATCACCA TTGAGAGATTAATAATTTTGATTTGATCAAAGAACTTTTGGAAATAGTGTTTATCAGGCATAACATCAAT TATTGATTTGTTTTGCAAATGGAGGTAAGTTTAGAAAATTAATGTAGACTGATTATAATCATCAGGAGTC TGTAATGGCCCCTATTAACATTTTTTTTTTTTTTTTGAGACAAAGTCTCACTCTGTTGCCCAGGCTGGAG TGCAGTGGTGTGATCTCAGCTCACTGCAGCCTCCACCTCCCTGGTTCAAGTGATTCTCCTGCCTCAGCCT CCCAAGTAGCTGGGACTACAGGCACACACCACCACACATGGCTAATTTTTGTATTTTTAGTAGAGATGGG GTTTTGCCATATTGGCCAGGCTGGTCTTGAACTCCTGACCTCAAGTGATCCGCCTGCCTCGGCCTCCCAA AGTGCTGGAATTACAGGTGTCAGCCACCTGTACCTGGTCCCTGCTAACATTTGATTTGTTTATTTAAGCA AATCTAAGCCTTTAAAAAGGCACAGAGATTAAGTCCATTGATTACATCATTCGTCACTATGCGCTTGGTA TTGAAAAAAATATTTTGGACCCTTGATTTGTATTCTTTTAAAATTAAAACATTTCTATTAAAATAACATT TGCTTCTATTTCTGGCAGCTCATTTTCTTATAACTGGCCCATGATTGACTAGTCTCTGGTAGGCATTCGA GTCTGTGTGTCCTGCTTTTTCTGTTCCTGTTCTTATGTTTTATGCTGAATGAGTAAAAGTAGGAGACCCA GCTGCAGAAGTCATTTCTCCTGAGAGACTCCCTTCTGTCCTGCTTCAGTGCCTTCAGACTTGCTTTACAG TCATTTTTTTAATCAACATTCCACATTTCCAAAGGATCAGAATTTTTTTCACAGAACCAACACACTGTAT TAGTCTTGCCAAAGTGCTTCCAAATCAACAAGGGCCTATTGCATTTCAGTTATTTTTTTCTATTCCTAAT GCTAGACTGTATTTTTTCTTTTTTTTTTTTTTGAGGCAGAGTCTCACTCTGTTGCCCAGGCTGCAGTGCA ATAACATGATCTTGGCTCACCGCAACCTCTGCCTCCCAGGTTCAAGTGATTCTCCTGCCTCAGCCTCCCA AGTAGCTGGGATTACAGGCATGTGCCACCATACCCAGTTAATTGTATTTAGTAGAGATGGGGTTTCACCA TGTTGGTCAGGCTGTTCTTGAACTCCTGACCTCAGGTGATCCACTCGCCTCGGCCTACCAAAGTGCTGGG ATTACAGGTGTGAGCCACTGCACCTGGCTGAGACTGCCTTTTGACTGATGACTTATGTTTAGCTCTGATG TGCTGACAGGGACAAAATGCTGGAGAAGGAATAAAAAAGGAATAATCCAACAAGGATCAAGAGAACAGGA AAGGAGACAATAGCTAATGAAAGGTTTCCAACAATTTGGGGGAGTTGAAAAAAAAGAGTCGAGGTAATTG ACTTAACAGAGAAAGCTACAACCTCACTGATTACAGAGGGGAACACGGAAAGGAGGCAAGCCTATTTACC CCCACAGAATCCTGGAAAAATTCAGCAATTGGAAGTACAAAGTGTAGGTGAGGCAATGAGCAGAAAACAG GAAGATTCTTTGAAAGCCTATATAAGCCTATACAATCCTCTGATTCATACCTTCCTCTCATAGAGCCAGC AACTATTCTTATTCTACCATCATAAGGAACAGGAAGTTTGTTTTCTCATAAAATTGAACCAGAGAGGCTC TACACTTCGGTGTGCCAGGCCCAGCAAAGGAAGCAATGAAGCATTTTACTGAACACAGAGAGACTGAAGA AAACCTGCTGGTGGCATGGAGTCAGATCTCTAAACCAACTTGGTTCCAAGACACTGGCAGCAGATACAGA CTTACCTCTGGAGAAGCTGAAAGCTCTAGCTAAAATACATACAGATAATGACATCTGGAGGTTTCCTAAT GAAATGATCAGGTCCCCAACCAATCATCTTGCTATGAAATCCCTCAGAGAACAAGCCACATCCACAAACA CAGAGCTTTCAGTCGACTTTTTAATGGACTAATTAGTCAATTTATGAATGGACAACCAAAGGTCAGCAGG CATTTGAAGAAAGGCTCTAATACGAAAGAGAGGTAGCTTGGTACGGTGGCGTGAAAATCCAGCACTTTGG GAGGCCGAGGCAGGCGAATCGCCTGAGGTCAGGAGTTCAAGCCCAGCCTGACCAACATGGTGAAACCCCA TCTCTACTAAAAATACAAAAATTAGCCAGGCATGGTGGCAGGTGCCTGTAACCCCAGCTACTACAGAGGC TGAGGCAGAAGAATCACTTGAACCTGGGAGGTGGAAGTTGCAGTGAGCTGAGATCGTACCACTGCACTCC AGCCTGGGTGACAGAGCAAGACTCCATCTCAAATAAATAAATAAATTACTAGATAAATGAGAGGCAATGC AAACAACAAGAAAAACATGAAACAGAATATGAATGAAAAAAAGATAATGTTGAGAAAAAAGCAACCTTTT TTAATGCTTAATATTGGTATTTAGTATTCTTAGAGAGTTAGTTAAAGGTCCATGAAAGAACAAGATGTTA TGAAAAAGGGACAGAACAAGCAAGTCTCCTTGAAAATTAAAAATTTGAGCACCAAAATGAAAAATTCAAT AAAGTAGAAGATAAAGTCTAAGGAAGTAGGATAAAAAGACAAAAATAGAAAATAGGAGTGAAAGATAAGA AAATTTGAAGCTAAATCAAGGATGTCCAATTTTTGACAATAAGAGTTCCAGAAAGAAAGGACAGAGAAAG GGGAAATGGAACTTTCCAAGAACGAAATGACGCAATCTCCAGATTGAAAGGGTATAATGGATTAAGATTC ACTTCCAAACATATCATACCCTAGAAGCTTCTGGAAAGAGAAAAAAGTAAGCCAAATATGTAAAGTATCA GAAATGGAAAGTCTTCTCTCTAGCAACACTGAAAGCTAAAAGACTGTGAAGAAAGGCCTTCAGAATTCTG AGGAAAAATGCTTTTGGAAATAGAACTCTATAAACTAAAGACTCATACAGGGGCTCAAAAAATGTACTTC TCATGGTTATGCTCCAGCAAAGGAAACTGATAAGAAAGAGGAAGTCATAGATGGAGGAAACAGGGAACCT ACTATGGAAGAGACAGAGAGATGTCCCAGGAGAAGAGAAATTCATCTGGCCTATGGAACAGCCAGTTGGT ATTACAGCAGAAGGATGCAGTGCTCTGGATGGAAAGTTTTCCAGGAAGAAATAAAAATGAGTCAGACAAG TAGCCTGAAAATGTTGAAAGATTTTGGCCAGATCCATTGAGCACTTGGAGAAAAAACAGTGTTAAGCATA TAGGAAACAAAGCAGATGAAAAAATAATACAATTACAAGTTCCAGGAAAGGCAAAAAGGTTAATAAGAAA GGAAACATAATGAAAGAACATTATGTTTACATAGTCTTAATAATAGAAATATTACTATGGGCCGGAGGTG GTGGCTCATGCCTACAATCCCAGCACTTTGGGAGGCCAAGGTGGGTGGGTCACTTGAGGCTGGGAGTTTG TGACCAACCTGGCTAACATGGCGAAACCCTGTCTCTACTAAAAATACAAAAATTAGCTGGGTGTGGTGGT GCGTGCCTGTAGTCCCACCTGCTTGGGAGGCTGAGGCAGGAGAATTGCTTGAACTTGGGGGGCAGAAGTT GCAGTGAGCTGAGATTGTGACACTGCACTGTAGCCTGGGTGACAGAGTGAGACCTTTTCTAAAAAAAATT AAAAAAATAAAAATATTACTATGGATTCAACCAAAACTTGTAAATAATTGAGTAAGAGCCCAAATGCTTA TTCTCCATAATAAGAACTCAATGCGAAAGTCTAAAATTTATAAATGAGTAATTAGCAGTGTACCCAAATT CATTACAAAATGGAGCTCAATGTGGAAAAAAGTGGTTAAAAACTGAAAGTGGTTGCCTTCATGGAATGTG ACTAGGTAATGGGGAGGGATAGAGAGGGGATAACCTTTTGTATAAGGTCTTCTAGTTCTATCTTATTAAT TCATATCTTTTATTTTGCTATACATAAATAATTTTGAGAAGGTTTAGGATAAAATAAGTTGGATCTTTTA TTCAAAAATTGTTTTGTTTTTTTCTGATTATGTAAATAATATAATCATTTTTAAAATTGGTTCAGTAGTA AGCCTAAATGATAGCTTACCCATCTTGTAAACTAGTTTACTAGAGAAAACAGACCAACAATAACACTCTC TCCTTTCTCATTTGCTTCAGGGTTTGAGAATGTTTTTAGCTGGTGGCAATAAATATTAGAAGCCTGCAGA ATCCAGCTACGAATATAGAGGGTTTTGCTCTTGAATTTCTGGTTCAAATTCTTTTTTTTTTTTTTTTTTT TTTATTGATCATTCTTGGGTGTTTCTCGCAGAGGGGGATTTGGCAGGGTCACAGGACAATAGTGGAGGGA AGGTCAGCAGATAAACAAGTGAACAAAGGTCTCTGGTTTTCCTAGGCAGAGGACCCTGCGGCCTTCCGCA GTGTTTGTGTCCCTGGGTACTTAAGATTAGGGAGTGGTGATGACTCTTAACGAGCATGCTGCCTTCAAGC ATCTGTTTAACAAAGCACATCTTGCACCGCCCTTAATCCATTTAACCCTGAGTGGACACAGCACATGTTT CAGAGAGCACAGGGTTGGGGATAAGGTCACAGATCAACAGGATCCCAAGGCAGAAGAATTTTTCTTAGTA CAGAACAAAATGAAAAGTCTCCCATGTCTACTTCTATCCACACAGACCCGGCAACCATCCGATTTCTCAA TTTTTTCCCCACCCTTCCCGCCTTTCTATTCCACAAAACCGCCATTGTCATCATGGCCCATCCCCAATGA GCCGCTGGGCACACCTCCCAGACGGGGTCGTGGCCGGGCAGAGGGGCTCCTCACTTCCCAGTAGGGGCGG CCCGGCAGAAGCGCCCCTCACCTCCCAGATGGGGCGGCTGGCCGGGCGGGGGGCTGACCCCCCCACCGCC CTCCCGGACGGGGCGGCTGGCCAGGCAGAGGGGCTCCTCACTTCCCAGTAGGGGCGGCCGGGCAGAGGCG CCCCTCACCTCCTGGATAGGGCGGCTGGCCGGGCGGGGGGCTGTTCCCCCCACCTCCCTCCCGGATGGGG CGGCTGGCCGGGCAGAGGGGTCCTCACTTCCCAGTAGGGGCGGCCCGGCAGAGGCGCCCCTCACCTCCCG GACGGGGCAGCCGGCCGGAAGGGGGGCTGACCCCCCCACCTCCCTCCCGGACGGGGCGGCTGGCCGGGCA GAGGGGCTCCTCACTTCCCAGTAGGGGCGGCCGGGCAGAGGCGCCCCTCACCTCCCGGACGGGGCGGCTG GCCAGGCAGGGGGCTGATCCCCCCACCTCCCTCCCGGACGGGGCGGCTGGCCGGGCGGGGGGCTGACCCC CCCCACCTCCCTCCCGGACGGGGCGGCTGGCCGGGCAGGGGGCTGACCCCCCCTCCCCCCTCCCGGACGG GGCGGCTGGCCGGGCGGGGGGCTGACCCCCCCACCTCCCTCCTGGGCGGGGCGGCTGGCCGGGCAGAGGG GCTCCTCACTTCCCAGTAGGGGCGGCCGGGCAGAGGCGCCCCTCACCTCCTGGACGGGGCGGCTGGCCAG GCGGGGGGCTGACCCCCCACCTCCCTCCCGGACTGGGCGGCTGGCCGGGCGGGGGGTTGAACCCCCACCT CCCTCCTGGACGGGGCGACTGGCCGGGCAGAGGGGCTCCTCACTTCCCAGTAGGGGCGGCCGGGCAGAGG CGCCCCTCACCTCCCGGACGGGGCGGCTGGCCAGGCGGGGGGCTGACCCCCCACCTCCCTCCCGGACTGG GCGGCTGGCCGGGCGGGGGGTTGACCCCCCCACCTCCCTCCTGGACGGGGCGACTGGCCGGGCAGAGGGG CTCCTCACTTCCCAGTAGGGGCGGCCGGGCAGAGGAGCCCCTCACCTCCCGGACGGGGCGGCTGGCCGGG CGGGGGGCTGACCCCCCCACCTCCCTCCCGGACGGGGCGGCTGGCCGGGCAGAGGGGTCCTCACTTCCCA GTAGGGGCGGCCGGGCAGAGGCGCCCCTCACCTCCCGGACGGGGCGGATGGCCGACCACCCCCCCCCGCC TCCCTCCCGGACGGGGCGGCTGGCCGGGCAGAGGGGCTCCTCACTTCCCAGTAGGGGCGGCCGGGCAGAG GAGCCCCTCACCTCCCGGACGGGGCGGCTGGCCGGGCGGGGGGCTGACCCCCCCCACCTCCCTCCCGGAC GGGGTGGCTGCCGGGCGGAGACGCTCCTCACTTCCCAGACGGGGTGGTTGCCAGACGGAGGGGCTCCTCA CTTCTCAGACGGGGCGGTTGCCAGGCAGAGGGTTTCCTCACTTCTCAGACGGAGCGGCCGGGCAGAGACA CTCCTCACCTCCCAGACAGGGTTGCGGCCCAGCAGAGGCGCTCCTCACATCCCAGACAGGGCGGTGGGGC AGAGGTGCTCCCCACATCTCAGACGATGGGCGGCCGGGCAGAGACGCTCCTCACTTCCTAGATGGGATGG CGGCGGGGAAGAGGCGCTTCTCGCTTCCTAGATGGGATGGCGGCCGGGCAGAGACGCTCCTCACTTTCCA CACTGGGCAGCCAGGCAGAGGGGCTCCTCATATCCCAGACGATGGGTGGCCAAGCAGAGACGCTCCTCAC TTCCCAGACGGCGTGGCGGCCGGGCAGAGGCTGCAATCTCGGCTCTTTGGGAGGCCAAGGCAGGCGGCTG GGAGGTGGTTGTAGCAAGCCGAGATCACGCCACTGCACTCCAGCCTGGGCACCATTGAGCACTGAGTGAA CGAGACTCCATCTGCAATCCCGGCACCTCGGGAGGCCGAGGCTGGCGGATCACTCGCGGTTAGGAGCTGG AGACCAGCCCGGCCAACACAGCGAAACCCCATCTCCACCAAAAAAAAAACGAAAACCAGTCAGGCGTGGC GGCGCGCGCCTGCAATCGCAGGCACTCGGCAGGCTGAGGCAGGAGAATCAGGCAGGGAGGTTGCAGTGAG CCGAGATGGCAGCAGTACCGTCCAGCTTTGGCTCGGCATGAGAGGGAGAGGGAGACGGGGAGAGGGAGAG GGAGAGGGAGACGGGGAGAGGGAGAGGGAGAGGGGTCAAATTCTTATCTATCAATGTTATGCCCACTGTG CTCTCCAGCTGTGGTCTGTGAATTACTGTGGTATAACGTGACTGTTCAAATTTCACTTTTCAGGGGCTTT GACCACGACCTTTGAAGAGCTTCATTTTGAGATCAAGCCCCACGATGACTGCACAGTAGAGCAAATCTAT GAGATTTTGAAAATCTACCAACTCATGGACCACAGTAACATGGACTGCTTCATCTGCTGTATCCTCTCCC ATGGAGACAAGGGCATCATCTATGGCACTGATGGACAGGAGGCCCCCATCTATGAGCTGACATCTCAGTT CACTGGTTTGAAGTGCCCTTCCCTTGCTGGAAAACCCAAAGTGTTTTTTATTCAGGCTTGTCAGGGGGAT AACTACCAGAAAGGTATACCTGTTGAGACTGATTCAGAGGAGCAACCCTATTTAGAAATGGATTTATCAT CACCTCAAACGAGATATATCCCGGATGAGGCTGACTTTCTGCTGGGGATGGCCACTGTGAATAACTGTGT TTCCTACCGAAACCCTGCAGAGGGAACCTGGTACATCCAGTCACTTTGCCAGAGCCTGAGAGAGCGATGT CCTCGGTAAGTTTTGCCTACTCAGCCCTCCTCACTGTTACACTACCTTCCCCCCCTACTCCATCACACTA CTATCTACTCATATTCAGAGCCTATTAGAAAGTGCTATGTGATTTAGATCACATTAACAGGTCAGAGAAC TGTCCAAGGGGAGTGGTTTCCGTTCAACTCTAAATGTCTAGCTGTAGATCACATAGCTGCATTTCCCAGG TCAGTTACAAAGTGGGAGAGTGGCAAGTGTTAACATCCTTAGTTTATAGATGGAAAAGCTGAGATGCTTT ATTCCTTTATTCAGCACCTCAAAGGACAATCAGGGTATCACAGAGCAGGAAAGGATAGGAAAGTCATATA CTCCAGCTCTCTGTCTTTAGGCCAAAACATGACTGAGCCAATTCAACTAGTTTTGGAAATCTTCCAAGAA GGCAGTAACCCAATTCAATGTTTAAACATCCTCCAACTCTGTCAAAAGTTCTATAATAGCAAACCATCCT CAAAACCTCTTGGTGCATTATGGGAGATAAATAGCAGGTTCCTTCTAGCCCTGTATTTCATGTTTTGAGT ATATGAAGAGTGAGAATTTCCCGTAACTTAGATCATGAATCTAACTTAGATTTCGTAACTTAGATCATGA ATCCTGCAAGGTTTCCGCGGCTAGCTACCAAGGTAGAAGAAGAGGTTGCCTAACAAAAATGCTAAGAGAT CCTGGTGAGAAGAAGGTGGGAGTAGCTGCAGGAGACGTTATACTTTCACTTGCCTTAAGTTTAATTGCAT CAAAGATGAATCCGCAGATGCGATGTCAATTCGAGGCAGAGAGTATTGGGGGGCATTGAAGCAATGGGGA GCCAAGTAACGTGGAGAAGAGTGAGAGACACACAGGTCAGGAGAGAAAGAAACCAACTCTAATACTGACA CCGAGGTTTCTGATGGTCAAAAGAGTTCCTGAATAAACCAAAAGTAAGTTATTAAGCTCTGAGACAACCC ATTTACCAGGAAAGCTGGGGTAGGTCTTGGTTTCGCACCTTATTGTTTCAAATGACTGATATTTTGAGAG AAAGAACTACAGAACTATCTCTGAGCACAGCAGAGGAGACAGTTCATCAGTTGCTTTCCCCCACAGACAG TCACAATATTATGTGATGTATTTCAGAGGCGATGATATTCTCACCATCCTGACTGAAGTGAACTATGAAG TAAGCAACAAGGATGACAAGAAAAACATGGGGAAACAGATGCCTCAGCCTACTTTCACACTAAGAAAAAA ACTTGTCTTCCCTTCTGATTGATGGTGCTATTTTGTTTGTTTTGTTTTGTTTTGTTTTTTTGAGACAGAA TCTCGCTCTGTCGCCCAGGCTGGAGTGCAGTGGCGTGATCTCGGCTCACCGCAAGCTCCGCCTCCCGGGT TCAGGCCATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGGACTACAGGGGCCCGCCACCACACCTGGCTAA TTTTTTAAAAATATTTTTAGTAGAGACAGGGTTTCACTGTGTTAGCCAGGGTGGTCTTGATCTCCTGACC TCGTGATCCACCCACCTCGGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACCGCGCCTGGCCGATG GTACTATTTAGATATAACACTATGTTTATTTACTAATTTTCTAGATTTTCTACTTTATTAATTGTTTTGC ACTTTTTTATAAGAGCTAAAGTTAAATAGGATATTAACAACAATAACACTGTCTCCTTTCTCTTATGCTT AAGGCTTTGGGAATGTTTTTAGCTGGTGGCAATAAATACCAGACACGTACAAAATCCAGCTATGAATATA GAGGGCTTATGATTCAGATTGTTATCTATCAACTATAAGCCCACTGTTAATATTCTATTAACTTTAATTC TCTTTCAAAGCTAAATTCCACACTACCACATTAAAAAAATTAGAAAGTAGCCACGTATGGTGGCTCATGT CTATAATCCCAGCACTTTGGGAGGTTGAGGTGGGAGGATTGCTTGAACCCAAGAGGTCAAGGCTGCAGTG AGCCATGTTCACACCGCTGCACTCAAGCTTGGGTGACAGAACAAGACCCCGTCTCAAAAAAAATTTTTTT TTTAATAAAACAAAATTTGTTTGAAATCTTTTAAAAATTCAAATGATTTTTACAAGTTTTAAATAAGCTC TCCCCAAACTTGCTTTATGCCTTCTTATTGCTTTTATGATATATATATGCTTGGCTAACTATATTTGCTT TTTGCTAACAATGCTCTGGGGTCTTTTTATGCATTTGCATTTGCTCTTTCATCTCTGCTTGGATTATTTT AAATCATTAGGAATTAAGTTATCTTTAAAATTTAAGTATCTTTTTTCAAAAACATTTTTTAATAGAATAA AATATAATTTGATCTTATT    Download   Select all
Length	54269
OMIM ID	601763
HGNC ID	HGNC:1509
Unigene ID	Hs.599762
Ensembl ID	ENSG00000064012
PharmGKB ID	PA26092

mRNA Information

mRNA ID	NM_001228.4
Exon	join(1..180,574..670,33019..33349,36068..36163, 38074..38179,39196..39334,41447..41511,43385..43526, 51374..51875,53017..54269)
mRNA Sequence	>gi|122056470|ref|NM_001228.4| Homo sapiens caspase 8 (CASP8), transcript variant A, mRNA GTGCTCTGAGTTTTTGGTTTCTGTTTCACCTTGTGTCTGAGCTGGTCTGAAGGCTGGTTGTTCAGACTGA GCTTCCTGCCTGCCTGTACCCCGCCAACAGCTTCAGAAGAAGGTGACTGGTGGCTGCCTGAGGAATACCA GTGGGCAAGAGAATTAGCATTTCTGGAGCATCTGCTGTCTGAGCAGCCCCTGGGTGCGTCCACTTTCTGG GCACGTGAGGTTGGGCCTTGGCCGCCTGAGCCCTTGAGTTGGTCACTTGAACCTTGGGAATATTGAGATT ATATTCTCCTGCCTTTTAAAAAGATGGACTTCAGCAGAAATCTTTATGATATTGGGGAACAACTGGACAG TGAAGATCTGGCCTCCCTCAAGTTCCTGAGCCTGGACTACATTCCGCAAAGGAAGCAAGAACCCATCAAG GATGCCTTGATGTTATTCCAGAGACTCCAGGAAAAGAGAATGTTGGAGGAAAGCAATCTGTCCTTCCTGA AGGAGCTGCTCTTCCGAATTAATAGACTGGATTTGCTGATTACCTACCTAAACACTAGAAAGGAGGAGAT GGAAAGGGAACTTCAGACACCAGGCAGGGCTCAAATTTCTGCCTACAGGTTCCACTTCTGCCGCATGAGC TGGGCTGAAGCAAACAGCCAGTGCCAGACACAGTCTGTACCTTTCTGGCGGAGGGTCGATCATCTATTAA TAAGGGTCATGCTCTATCAGATTTCAGAAGAAGTGAGCAGATCAGAATTGAGGTCTTTTAAGTTTCTTTT GCAAGAGGAAATCTCCAAATGCAAACTGGATGATGACATGAACCTGCTGGATATTTTCATAGAGATGGAG AAGAGGGTCATCCTGGGAGAAGGAAAGTTGGACATCCTGAAAAGAGTCTGTGCCCAAATCAACAAGAGCC TGCTGAAGATAATCAACGACTATGAAGAATTCAGCAAAGGGGAGGAGTTGTGTGGGGTAATGACAATCTC GGACTCTCCAAGAGAACAGGATAGTGAATCACAGACTTTGGACAAAGTTTACCAAATGAAAAGCAAACCT CGGGGATACTGTCTGATCATCAACAATCACAATTTTGCAAAAGCACGGGAGAAAGTGCCCAAACTTCACA GCATTAGGGACAGGAATGGAACACACTTGGATGCAGGGGCTTTGACCACGACCTTTGAAGAGCTTCATTT TGAGATCAAGCCCCACGATGACTGCACAGTAGAGCAAATCTATGAGATTTTGAAAATCTACCAACTCATG GACCACAGTAACATGGACTGCTTCATCTGCTGTATCCTCTCCCATGGAGACAAGGGCATCATCTATGGCA CTGATGGACAGGAGGCCCCCATCTATGAGCTGACATCTCAGTTCACTGGTTTGAAGTGCCCTTCCCTTGC TGGAAAACCCAAAGTGTTTTTTATTCAGGCTTGTCAGGGGGATAACTACCAGAAAGGTATACCTGTTGAG ACTGATTCAGAGGAGCAACCCTATTTAGAAATGGATTTATCATCACCTCAAACGAGATATATCCCGGATG AGGCTGACTTTCTGCTGGGGATGGCCACTGTGAATAACTGTGTTTCCTACCGAAACCCTGCAGAGGGAAC CTGGTACATCCAGTCACTTTGCCAGAGCCTGAGAGAGCGATGTCCTCGAGGCGATGATATTCTCACCATC CTGACTGAAGTGAACTATGAAGTAAGCAACAAGGATGACAAGAAAAACATGGGGAAACAGATGCCTCAGC CTACTTTCACACTAAGAAAAAAACTTGTCTTCCCTTCTGATTGATGGTGCTATTTTGTTTGTTTTGTTTT GTTTTGTTTTTTTGAGACAGAATCTCGCTCTGTCGCCCAGGCTGGAGTGCAGTGGCGTGATCTCGGCTCA CCGCAAGCTCCGCCTCCCGGGTTCAGGCCATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGGACTACAGGG GCCCGCCACCACACCTGGCTAATTTTTTAAAAATATTTTTAGTAGAGACAGGGTTTCACTGTGTTAGCCA GGGTGGTCTTGATCTCCTGACCTCGTGATCCACCCACCTCGGCCTCCCAAAGTGCTGGGATTACAGGCGT GAGCCACCGCGCCTGGCCGATGGTACTATTTAGATATAACACTATGTTTATTTACTAATTTTCTAGATTT TCTACTTTATTAATTGTTTTGCACTTTTTTATAAGAGCTAAAGTTAAATAGGATATTAACAACAATAACA CTGTCTCCTTTCTCTTATGCTTAAGGCTTTGGGAATGTTTTTAGCTGGTGGCAATAAATACCAGACACGT ACAAAATCCAGCTATGAATATAGAGGGCTTATGATTCAGATTGTTATCTATCAACTATAAGCCCACTGTT AATATTCTATTAACTTTAATTCTCTTTCAAAGCTAAATTCCACACTACCACATTAAAAAAATTAGAAAGT AGCCACGTATGGTGGCTCATGTCTATAATCCCAGCACTTTGGGAGGTTGAGGTGGGAGGATTGCTTGAAC CCAAGAGGTCAAGGCTGCAGTGAGCCATGTTCACACCGCTGCACTCAAGCTTGGGTGACAGAACAAGACC CCGTCTCAAAAAAAATTTTTTTTTTAATAAAACAAAATTTGTTTGAAATCTTTTAAAAATTCAAATGATT TTTACAAGTTTTAAATAAGCTCTCCCCAAACTTGCTTTATGCCTTCTTATTGCTTTTATGATATATATAT GCTTGGCTAACTATATTTGCTTTTTGCTAACAATGCTCTGGGGTCTTTTTATGCATTTGCATTTGCTCTT TCATCTCTGCTTGGATTATTTTAAATCATTAGGAATTAAGTTATCTTTAAAATTTAAGTATCTTTTTTCA AAAACATTTTTTAATAGAATAAAATATAATTTGATCTTATTAAA    Download   Select all
Length	2914

CDS Information

   

Location	304..1794
CDS Sequence	>lcl|NM_001228.4_cds_NP_001219.2_1 [gene=CASP8] [protein=caspase-8 isoform A precursor] [protein_id=NP_001219.2] [location=304..1794] ATGGACTTCAGCAGAAATCTTTATGATATTGGGGAACAACTGGACAGTGAAGATCTGGCCTCCCTCAAGT TCCTGAGCCTGGACTACATTCCGCAAAGGAAGCAAGAACCCATCAAGGATGCCTTGATGTTATTCCAGAG ACTCCAGGAAAAGAGAATGTTGGAGGAAAGCAATCTGTCCTTCCTGAAGGAGCTGCTCTTCCGAATTAAT AGACTGGATTTGCTGATTACCTACCTAAACACTAGAAAGGAGGAGATGGAAAGGGAACTTCAGACACCAG GCAGGGCTCAAATTTCTGCCTACAGGTTCCACTTCTGCCGCATGAGCTGGGCTGAAGCAAACAGCCAGTG CCAGACACAGTCTGTACCTTTCTGGCGGAGGGTCGATCATCTATTAATAAGGGTCATGCTCTATCAGATT TCAGAAGAAGTGAGCAGATCAGAATTGAGGTCTTTTAAGTTTCTTTTGCAAGAGGAAATCTCCAAATGCA AACTGGATGATGACATGAACCTGCTGGATATTTTCATAGAGATGGAGAAGAGGGTCATCCTGGGAGAAGG AAAGTTGGACATCCTGAAAAGAGTCTGTGCCCAAATCAACAAGAGCCTGCTGAAGATAATCAACGACTAT GAAGAATTCAGCAAAGGGGAGGAGTTGTGTGGGGTAATGACAATCTCGGACTCTCCAAGAGAACAGGATA GTGAATCACAGACTTTGGACAAAGTTTACCAAATGAAAAGCAAACCTCGGGGATACTGTCTGATCATCAA CAATCACAATTTTGCAAAAGCACGGGAGAAAGTGCCCAAACTTCACAGCATTAGGGACAGGAATGGAACA CACTTGGATGCAGGGGCTTTGACCACGACCTTTGAAGAGCTTCATTTTGAGATCAAGCCCCACGATGACT GCACAGTAGAGCAAATCTATGAGATTTTGAAAATCTACCAACTCATGGACCACAGTAACATGGACTGCTT CATCTGCTGTATCCTCTCCCATGGAGACAAGGGCATCATCTATGGCACTGATGGACAGGAGGCCCCCATC TATGAGCTGACATCTCAGTTCACTGGTTTGAAGTGCCCTTCCCTTGCTGGAAAACCCAAAGTGTTTTTTA TTCAGGCTTGTCAGGGGGATAACTACCAGAAAGGTATACCTGTTGAGACTGATTCAGAGGAGCAACCCTA TTTAGAAATGGATTTATCATCACCTCAAACGAGATATATCCCGGATGAGGCTGACTTTCTGCTGGGGATG GCCACTGTGAATAACTGTGTTTCCTACCGAAACCCTGCAGAGGGAACCTGGTACATCCAGTCACTTTGCC AGAGCCTGAGAGAGCGATGTCCTCGAGGCGATGATATTCTCACCATCCTGACTGAAGTGAACTATGAAGT AAGCAACAAGGATGACAAGAAAAACATGGGGAAACAGATGCCTCAGCCTACTTTCACACTAAGAAAAAAA CTTGTCTTCCCTTCTGATTGA    Download   Select all
CCDS ID	CCDS2342.1

Protein Information

      

Protein ID	NP_001219.2
Protein Name	caspase 8, apoptosis-related cysteine peptidase
Molecular Wt. (Da)	57570
Protein Sequence	>lcl|NM_001228.4_prot_NP_001219.2_1 [gene=CASP8] [protein=caspase-8 isoform A precursor] [protein_id=NP_001219.2] [location=304..1794] MDFSRNLYDIGEQLDSEDLASLKFLSLDYIPQRKQEPIKDALMLFQRLQEKRMLEESNLSFLKELLFRIN RLDLLITYLNTRKEEMERELQTPGRAQISAYRFHFCRMSWAEANSQCQTQSVPFWRRVDHLLIRVMLYQI SEEVSRSELRSFKFLLQEEISKCKLDDDMNLLDIFIEMEKRVILGEGKLDILKRVCAQINKSLLKIINDY EEFSKGEELCGVMTISDSPREQDSESQTLDKVYQMKSKPRGYCLIINNHNFAKAREKVPKLHSIRDRNGT HLDAGALTTTFEELHFEIKPHDDCTVEQIYEILKIYQLMDHSNMDCFICCILSHGDKGIIYGTDGQEAPI YELTSQFTGLKCPSLAGKPKVFFIQACQGDNYQKGIPVETDSEEQPYLEMDLSSPQTRYIPDEADFLLGM ATVNNCVSYRNPAEGTWYIQSLCQSLRERCPRGDDILTILTEVNYEVSNKDDKKNMGKQMPQPTFTLRKK LVFPSD    Download   Select all
Length	496
Uniprot ID	Q99836
Ensembl Protein ID	ENSP00000390565

Post-translational Modification Information (Source : HPRD)

Residue	Type	site
D	Proteolytic Cleavage	227
D	Proteolytic Cleavage	233
D	Proteolytic Cleavage	391
D	Proteolytic Cleavage	401
D	Proteolytic Cleavage	210
D	Proteolytic Cleavage	216
D	Proteolytic Cleavage	374
D	Proteolytic Cleavage	384
D	Proteolytic Cleavage	195
D	Proteolytic Cleavage	201
D	Proteolytic Cleavage	359
D	Proteolytic Cleavage	369
D	Proteolytic Cleavage	129
S	Phosphorylation	236;-
S	Phosphorylation	219;-
S	Phosphorylation	204;-
S	Phosphorylation	219;-
S	Phosphorylation	204;-
S	Phosphorylation	278;-
S	Phosphorylation	234
S	Phosphorylation	247
S	Phosphorylation	217
S	Phosphorylation	230
S	Phosphorylation	202
S	Phosphorylation	215
S	Phosphorylation	217
S	Phosphorylation	230
S	Phosphorylation	202
S	Phosphorylation	215
S	Phosphorylation	276
S	Phosphorylation	289

Enzyme Information

No matching records could be found.

PPi Information

(Click to view network : Source STRING)      View   

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     

Interactant Gene ID (Source: HPRD)	Gene Symbol	HPRD ID	Ref Seq ID	Technique	References
351	APP	100	NP_000475.1	in vitro	10911620
355	FAS	609	NP_000034.1	in vivo	1   110   186   717   159   900
367	AR	2437	NP_000035.2	in vivo	17170703
596	BCL2	1045	NP_000624.2	in vivo	11406564
598	BCL2L1	2497	NP_612815.1	in vitro	11733517
637	BID	3590	NP_932070.1	in vitro;in vivo	97   274   911   108   574   300   000   000   000   000   000   000   000
836	CASP3	2799	NP_004337.2	in vitro;in vivo	11437602
839	CASP6	3321	NP_001217.2	in vitro;in vivo	12232792
984	CDK11B	8909	NP_001778.1	in vitro	9632733
985	CDC2L2	308	NP_277073.1	in vivo	9632733
999	CDH1	1885	BAA88957.1	in vivo	12189238
1027	CDKN1B	2867	NP_004055.1	in vitro	11420686
1107	CHD3	9071	NP_001005271.2	yeast 2-hybrid	16169070
1147	CHUK	2811	NP_001269.3	in vivo	11002417
1499	CTNNB1	286	NP_001895.1	in vivo	12189238
2890	GRIA1	695	NP_000818.2	in vivo	11751897
3092	HIP1	3461	NP_005329.3	in vivo	11788820
4137	MAPT	1142	NP_001116538.1	in vitro;in vivo	12888622
5071	PARK2	3967	NP_004553.2	in vitro	12692130
5130	PCYT1A	438	NP_005008.2	in vitro;in vivo	12052891
5339	PLEC1	3180	NP_958782.1	in vivo	10891503
5590	PRKCZ	1504	NP_002735.3	in vitro	11016947
5594	MAPK1	1496	NP_002736.3	in vivo	17290218
5595	MAPK3	3479	NP_002737.2	in vivo	17290218
5610	EIF2AK2	1468	NP_002750.1	in vitro;in vivo	11555640
5663	PSEN1	87	NP_000012.1	in vitro;in vivo	10069390
5664	PSEN2	2860	NP_000438.2	in vivo	9   990   034   921   969   510   000   000
5925	RB1	1574	NP_000312.2	in vitro	15735701
7024	TFCP2	1790	NP_005644.2	yeast 2-hybrid	16169070
7185	TRAF1	3418	NP_005649.1	in vitro;in vivo	1   109   806   011   181   070
7186	TRAF2	3538	NP_066961.2	in vitro;in vivo	1   622   762   911   340   070
7341	SUMO1	3554	NP_003343.1	in vivo;yeast 2-hybrid	15782135
7431	VIM	1899	NP_003371.2	in vivo	1   142   390   410   469   170
8428	STK24	10385	NP_003567.2	in vitro;in vivo	12107159
8554	PIAS1	16029	NP_057250.1	yeast 2-hybrid	15782135
8615	USO1	9135	NP_003706.1	in vitro;in vivo	12438416
8737	RIPK1	4583	NP_003795.2	in vitro;in vivo	110   024   171   052   139   000   000   000
8837	CFLAR	4671	NP_003870.4	in vitro;in vivo	928   949   192   088   471   000   000   000   000   000   000   000   000   000   000
10038	PARP2	9660	Q9UGN5	in vitro;in vivo	12065591
10134	BCAP31	2319	NP_001132929.1	in vivo	933   433   812   668   660
10210	TOPORS	11642	NP_005793.2	in vivo;yeast 2-hybrid	17290218
10928	RALBP1	9013	NP_006779.1	in vitro;in vivo	16227629
60401	EDA2R	2230	AAN73210.1	in vitro	15280356

Pathway Information

                                                                                                            

Pathway Name	Pathway ID
Alzheimer's disease	hsa05010
Apoptosis	hsa04210
Chagas disease (American trypanosomiasis)	hsa05142
Hepatitis B	hsa05161
Herpes simplex infection	hsa05168
Huntington's disease	hsa05016
Legionellosis	hsa05134
NOD-like receptor signaling pathway	hsa04621
Non-alcoholic fatty liver disease (NAFLD)	hsa04932
p53 signaling pathway	hsa04115
Pathways in cancer	hsa05200
RIG-I-like receptor signaling pathway	hsa04622
TNF signaling pathway	hsa04668
Toll-like receptor signaling pathway	hsa04620
Toxoplasmosis	hsa05145
Tuberculosis	hsa05152
Viral carcinogenesis	hsa05203
Viral myocarditis	hsa05416

Structure Information

No matching records could be found.

Domain Information

ID	Location	Description
cd00032	225-477	CASc
cl00042	225-477	CASc superfamily
cd08333	Mar-84	DED_Caspase_8_r1
cl14633	Mar-84	DD superfamily
smart00115	226-477	CASc
pfam00656	234-476	Peptidase_C14
cd08813	98-180	DED_Caspase_8_r2
cl14633	98-180	DD superfamily
cd08775	99-178	DED_Caspase-like_r2
cd08334	98-180	DED_Caspase_8_10_r2
pfam01335	Mar-86	DED
smart00031	Jan-80	DED
cd08792	Mar-75	DED_Caspase_8_10_r1
pfam01335	101-182	DED
smart00031	99-178	DED
cd00045	Jul-77	DED
cd08336	Jan-78	DED_FADD
cd08776	Jul-79	DED_Caspase-like_r1
cd08814	98-180	DED_Caspase_10_r2
cd08334	Feb-66	DED_Caspase_8_10_r2
cd08341	Jan-75	DED_Caspase_10_r1
cd00045	101-169	DED
cd08338	Feb-84	DED_PEA15
cd08333	101-169	DED_Caspase_8_r1
cd08340	99-160	DED_c-FLIP_r2
cd08337	Jul-87	DED_c-FLIP_r1
cd08336	100-179	DED_FADD
cd08790	Oct-75	DED_DEDD
cd08340	Sep-74	DED_c-FLIP_r2
cd08814	Mar-65	DED_Caspase_10_r2
cd08813	Jul-71	DED_Caspase_8_r2
cd08792	101-176	DED_Caspase_8_10_r1
cd08339	Oct-83	DED_DEDD-like

Ontology Information

   

HPRD ID	1177
Molecular Class	Cysteine protease
Molecular Function	Structural molecule activity (GO:0005198)
Biological Process	Cell growth and/or maintenance (GO:0008151)

SNP Information

View SNP Geneview Report