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General Information
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 22998821 | 2012 | Cell line : - Source : First Affiliated Hospital and the Third Affiliated Hospital of Harbin Medical University. Sample Type : - No. of Sample : 880 CRC and 848 controls Stage : TNM Stage I - IV | Catalase Activity Assay, Genotyping | Polymorhpism | - | Association of polymorphism CAT-21A>T with colorectal cancer. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | This gene encodes catalase, a key antioxidant enzyme in the bodies defense against oxidative stress. Catalase is a heme enzyme that is present in the peroxisome of nearly all aerobic cells. Catalase converts the reactive oxygen species hydrogen peroxide to water and oxygen and thereby mitigates the toxic effects of hydrogen peroxide. Oxidative stress is hypothesized to play a role in the development of many chronic or late-onset diseases such as diabetes, asthma, Alzheimer's disease, systemic lupus erythematosus, rheumatoid arthritis, and cancers. Polymorphisms in this gene have been associated with decreases in catalase activity but, to date, acatalasemia is the only disease known to be caused by this gene. [provided by RefSeq, Oct 2009] | Chromosome | 11 |
| Location | 11p13 |
| Start | 34438925 |
| End | 34472060 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 33136 |
| OMIM ID | 115500 |
| HGNC ID | HGNC:1516 |
| Unigene ID | Hs.502302 |
| Ensembl ID | ENSG00000121691 |
| PharmGKB ID | - |
mRNA Information
| mRNA ID | NM_001752.3 |
|---|---|
| Exon | join(1..155,10268..10439,12064..12174,13153..13283, 14166..14270,14877..15002,17087..17278,17741..17893, 22327..22465,25181..25311,29364..29471,32034..32117, 32444..33136) | mRNA Sequence | Download Select all |
| Length | 2300 |
CDS Information
| Location | join(90..155,10268..10439,12064..12174,13153..13283, 14166..14270,14877..15002,17087..17278,17741..17893, 22327..22465,25181..25311,29364..29471,32034..32117, 32444..32509) |
|---|---|
| CDS Sequence | Download Select all |
| CCDS ID | CCDS7891.1 |
Protein Information
| Protein ID | NP_001743.1 |
|---|---|
| Protein Name | Catalase |
| Molecular Wt. (Da) | 59625 |
| Protein Sequence | Download Select all |
| Length | 527 |
| Uniprot ID | P07355 |
| Ensembl Protein ID | ENSP00000346032 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| Y | Phosphorylation | 231 |
| Y | Phosphorylation | 386 |
| Y | Phosphorylation | 308;- |
| K | Acetylation | 476 |
| S | Phosphorylation | 515 |
Enzyme Information
| EC | 1.11.1.6 |
|---|---|
| Name | catalase equilase caperase optidase catalase-peroxidase CAT |
| Class | Oxidoreductases; Acting on a peroxide as acceptor; Peroxidases |
| Sysname | hydrogen-peroxide:hydrogen-peroxide oxidoreductase |
| Substrate | H2O2 |
| Product | O2 [CPD:C00007]; H2O |
| Reaction (IUBMB) |  |
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 81793 | TLR10 | 5884 | NP_112218.2 | yeast 2-hybrid | 16482509 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Amyotrophic lateral sclerosis (ALS) | hsa05014 |
| Carbon metabolism | hsa01200 |
| FoxO signaling pathway | hsa04068 |
| Glyoxylate and dicarboxylate metabolism | hsa00630 |
| Longevity regulating pathway - mammal | hsa04211 |
| Longevity regulating pathway - multiple species | hsa04213 |
| Peroxisome | hsa04146 |
| Tryptophan metabolism | hsa00380 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd08156 | 68-497 | catalase_clade_3 |
| cl09506 | 68-497 | catalase_like superfamily |
| smart01060 | 31-404 | Catalase |
| cd00328 | 68-497 | catalase |
| pfam00199 | 28-413 | Catalase |
| cd08157 | 53-495 | catalase_fungal |
| cd08154 | 27-497 | catalase_clade_1 |
| cd08155 | 65-493 | catalase_clade_2 |
| cd08150 | 70-366 | catalase_like |
| cd08153 | 72-366 | srpA_like |
| pfam06628 | 431-498 | Catalase-rel |
| cl09977 | 431-498 | Catalase-rel superfamily |
| cd08151 | 72-341 | AOS |
| cd08152 | 72-335 | y4iL_like |
| COG0753 | 26-490 | KatE |
| PLN02609 | 28-506 | PLN02609 |
| PRK11249 | 4-418 | katE |
Ontology Information
| HPRD ID | 1061 |
|---|---|
| Molecular Class | Enzyme: Oxidoreductase |
| Molecular Function | Calcium ion binding (GO:0005509) |
| Biological Process | Signal transduction (GO:0007165); Cell communication (GO:0007154) |
Drug Information
| Uniprot ID | DrugBank ID | Name | Type |
|---|---|---|---|
| P04040 | DB01213 | Fomepizole | SmallMoleculeDrug |