CoReCG

Evidence Information

Pubmed ID	Year	Sample Information	Techniques	Mechanism	Fold Change	Remark
15274335	2004	Cell line : - Source : Changhua Christian Hospital,Changhua, Taiwan Sample Type : CRC tumor and Normal tissue No. of Sample : 185 Stage : -	Methylation-specific PCR and sequencing	Methylation	-	Aberrant promoter methylation of the caveolin-1 gene may occur at the precancerous stage, regulated by gender-related factors and is associated with gene silencing of caveolin-1 in the development of colorectal cancer.
16820915	2006	Cell line : - Source : Tumor Bank Network established at the Centro Nacional de Investigaciones Oncol?gicas (CNIO). Sample Type : - No. of Sample : - Stage : -	Pyrosequencing and FRET assays.	Polymorhpism	-	The results suggest that CAV1 alleles might modify CRC heritability. In this study detected a correlation between rs3807990 and CRC aggregation, nuclear forms and familiar antecedents of CRC). In these groups, found an over-representation of the allele T in all familial forms. In addition, rs6867 (G>A) was also associated with the familiar manifestations of CRC.
15769846	2005	Cell line : - Source : Kyung Hee University Medical Center (Seoul, Korea) Sample Type : CRC tumor and Normal tissue No. of Sample : 100 Stage : -	ral time RT-PCR, SDS-PAGE and immunoblotting , Immunocytochemistry	Unknown	-	In human colorectal carcinoma cells, expression of caveolin-1 influences the expression of prouPA and its receptor, uPAR, and the localization of cathepsin B and its receptor, p11. Downregulation of caveolin-1 expression reduces both the degradation of ECM by these cells and their invasiveness. Caveolin-1 affects the expression and localization of cathepsin B and pro-uPA,and their receptors, thereby mediating cell-surface proteolytic events associated with invasion of colon cancer cells. HCT 116 and NIH 3T3 cells were used.
17848589	2007	Cell line : - Source : - Sample Type : - No. of Sample : - Stage : -	Antibody Microarrays,Protein Labeling and Microarray Assay,Tissue Microarray Design and Immunohistochemistry	Up-regulation	-	-
22706202	2012	Cell line : - Source : - Sample Type : CRC tumor and Normal tissue No. of Sample : 360 CRC and 550 controls Stage : -	real time RT- PCR, immunoblotting, and promoter methylation assays, Cell-cycle analysis	Up-regulation	-	CAV1 may render tumor cells growth advantages by enhancing aerobic glycolysis. Eelevated expression of CAV1 may protect cancer cells from metabolic stresses and thus contribute to tumor progression through the regulation of glucose metabolism.

Gene Details

Chromosome: 7; NC_000007.13 (116164839..116201239)
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Gene Type	protein coding
Gene Family	-
Description	The scaffolding protein encoded by this gene is the main component of the caveolae plasma membranes found in most cell types. The protein links integrin subunits to the tyrosine kinase FYN, an initiating step in coupling integrins to the Ras-ERK pathway and promoting cell cycle progression. The gene is a tumor suppressor gene candidate and a negative regulator of the Ras-p42/44 mitogen-activated kinase cascade. Caveolin 1 and caveolin 2 are located next to each other on chromosome 7 and express colocalizing proteins that form a stable hetero-oligomeric complex. Mutations in this gene have been associated with Berardinelli-Seip congenital lipodystrophy. Alternatively spliced transcripts encode alpha and beta isoforms of caveolin 1.[provided by RefSeq, Mar 2010]
Chromosome	7
Location	7q31.1
Start	116524785
End	116561185
Strand	+
Gene Sequence	>gi|568815591:116524785-116561185 Homo sapiens chromosome 7, GRCh38.p2 Primary Assembly GGGAGAAACGTTCTCACTCGCTCTCTGCTCGCTGCGGGCGCTCCCCGCCCTCTGCTGCCAGAACCTTGGG GATGTGCCTAGACCCGGCGCAGCACACGTCCGGGCCAACCGCGAGCAGAACAAACCTTTGGCGGGCGGCC AGGAGGCTCCCTCCCAGCCACCGCCCCCCTCCAGCGCCTTTTTTTCCCCCCATACAATACAAGATCTTCC TTCCTCAGTTCCCTTAAAGCACAGCCCAGGGAAACCTCCTCACAGTTTTCATCCAGCCACGGGCCAGCAT GTCTGGGGGCAAATACGTAGACTCGGAGGTAGGCATCCGTGGGGGGGCGCCGGCTCGGGCGTGCGGGGAG TGTCCGCTTCTGCTATCTGCCTCTCCAAATATCCCGACTGCTGCCCTGGCCCCAGCCCTCTCTCCACTTC GGAGCACTCCTCTGGCGTTGGCACCGCTGAGGAATGGGCCTGGGCGGGGAGGTGAAGAGAAGCCAGGAAT GTTTTATGTTTTCCTAATGGAGAGGGGGCCTAGGGAGCCCCTGAGCTAGGAGGACACGGAAAAGGGGATT GGGGTCCTGAGATTGGGTCTGTTGGGCCCAGGACGCGTTTTCTGGATGGGTCTAGGATGCTCCCTTGTCG CGGGACCCCCGCGGTCCGGCCCTGCCTGCTGGGGGTTCGAAGAGGTGGAGTGCAGGGTGGAGGTGTTATT TACCCGAGTCCTGGGGACAGTCCCCGGGACTCTCCGCCAGGCGCCCAGACCGGCAGGTCCCGCAGGCGGC GCGCGGTGTGTTTGCACTTTCCAAAGTTCTTGAACCATCTCAAGAACTCCTTCTGCATCTTGGCGTCTGG CAGGGGTGTTCCGAGAGAGGTAGACCTCCCCTCCCCAAACTGCCACCATCACTTCCAACGCCCTCCACGC GCTGGAGCTCTGCCCGGGTGTGGAAACCTCGTCTTCCAACACGTAGCTGCCCTTCAGCCACCCGCCCGCA GCCTGGGAGTGCCCTGAGGGTGGGTCGGGGGAGCTGCGCAGGTGAGACTGAGTTCTAGGACATTTAGGGG GTCTGGTGCCTGGCTCCGCCAAAAATGGGGACTTTCGGGATTGTGATCATCACGGCGGATTGAGCAGGGA GAGCCGTGGAGGGACAAGAGAGGGCCGAGGCAGGGTGGGGGGCGCGGGCAGGTGCGAGGGGGATGCGGCC AAGAAGCAGCGATAAAGGGAACATTCCACGGGTCGGGCGGCTGCTGTTGGATCTTAGATAAAGCTGGAAG GGATTACCGGGGCAGGGGTAATAGGGACCGGGGACGGGAACGCGAAACAGGTGAAGCGCTCAGGGCGAGA GCGACTCGGCTTAGGGAGTCCGGGAGAAGCCTGCGGCTGCCCCCTCGCCGCCGAGGTCCTGCGGGTCCTG CGGGTCCTGCGTGCTGAGCCGGGGCGTGCGCGGGCGGGGGCCTTCGGACCGCGCGGCGGGGCCTGCCCTG ACCCCTGGCGGCGGGCGGGGGAGGCAGGCGCGCCCTGCAGAGTACAGAGGGGTGTGGTGTCCTCTGCGAG ATCCTCTTAAAAAGCTGGCTACGCGCAGGCGGTTTCTGTGCACGGAGCCGTAGCTGTCGGAGCGGTTAGT TCGATTTCGAGCTCGAGGTTTCCCCCGCCGCCAGGCTGACTTCTCATCGCTTGTTTTTCTTTTTGCATTT TTCCTCCCACCGCCGTTGCCGCCCTCCCCGTCCTGGCCGTCCGCCCTCCGCCCTCTGCAGGGACATCTCT ACACCGTTCCCATCCGGGAACAGGGCAACATCTACAAGCCCAACAACAAGGCCATGGCAGACGAGCTGAG CGAGAAGCAAGTGTACGACGCGCACACCAAGGAGATCGACCTGGTCAACCGCGACCCTAAACACCTCAAC GATGACGTGGTCAAGGTAAGCCAAGGCGACCAACAGGGAAGGGCTGGGACAGCTCTCCTCTGGCAGTTAG CCCGTGCATCCTTCTTTAGCATTGCCGTGTACGCACACCCCACCCCGCCCCCTACACGCGCACACACACA CACACACAGAGTTTTGTGGGTTTGATGTGTGGGAGCTCCCGCAGTCGGCAGAAACGTTACATCTCCCTTC CCCCATCTCCCCCCAATAGTTAGTTCAGCTGAAATTCAGCTAAAGTGAGTTTTGTAGAAGTTCCTATAAC TACACTTTTATCCTAGCAAATGAGCCTATTGACCTCAGCAACAGACGGCCCATACTCCTTGGGACGGTGA GATGGTTCCTATCCATTCCCAGGTTGAAAGTCTAGTGACAGGTCCCCACTGCACGTGGCATTAAGACAGT CAGATAATTGTGTCAGGTCTTGTGCTGAGGATGAGTCAGAATACAAGATGGGCATGTTCCCCCAACTAAA ACGATGGGAAGTGATTTTCTTAAAAATACTACAGTGGATGGAAATGCCTAGGACTAAAGACAAAGAAAAT ACGTACTTATTCATATACATATGAAAGTTACTTTAACTAGACTAACAAGTCACTTGTGCACAACTAAGCA AATTTACAAAACCAAAAACAATGTATGCCTCTTGGTTTCTTCTATCTATGGACACCTGCACTTAGATGTG GAAAGCTGCTTCTTTAGTAGCTACCTGGGTCAGCCTGCCCTGAGCTAATGGCACATTCAGGTTGGAGTTC CTTTTCATACTTTCAGGATGTGCTTGGTGAGATTAAAAATAATTGGACTGGGTTATTGGCCAGACTTAGA TCTGACTCAGTGGTCAGTTTTAAATTATCATTGTTATTAGATTTTGACCCTTTTAGCCAATCTAGTGGGA GGAATTTATTGCCTAAACACATCTGGATTGGGATATCATGGGCTAGAGCCATCCTTGGCAAAGGGTTTTC TCTGAGAAATGGAGGGCTAAGGAAAAATCCTGGCTCAGGGACTGCAGTGTGAAGATCTACTCCTATACAA CCCCCAGCAATCAATGAGGCGGATGAGCAATTTCCACCCACCACGCCTGCTATCTATGGATGGGAGGAGC TATAGTTCACAAACCGTTTACATTCATGAATAATATATTTCAAAAGGGGAAACAGTTTAATCTGTAACTG GAAGGGAAAAAAAAACTGTCAGAATTGACTCCCTTGGCTTCCTGGAGTAGGAAAAAGGAAAATTGGAGCA TTTGCAGCTTTTTTTGACTAGCTGGATTATGGAATATTTAAAAGCAACAGCAACAAAAGTACCTTATAAA CTAGAAAATAGAATTGCTAAAAAACTATTTACTAAAAACATTACCTTAAAGGGAGAGGATATTTGTGTTT TCCCCCACCCCCACCCTTCTCATGTGGCTTTGAACAAGAAGGAGAGTTGCCAGGAAAAGAGGCAGATTTC AGAGAGGGCTGGCTTCACTGGATCCTCCCTGTTGTTCCACTGCACTGTGAGTGAGATTCCCTGGAGCAAG CGAATCTCCCGGGATGAGTCAGAGAGGCCAACAGTGTGGATGTGGGTCTCCACACATAGCATGACTAAGT TGAGAAAGAAAGGCCCCACTGGGAAAAGAGACTTCAACACAGATGGAAAAAAAACATAACAGGCTTGGAG GAAATAGCAGTTTACAAAACAGCATTTCAAAGAGCAAGTGTGGGGATCCTCAAATTAAAGAAATTAAAAG AAAAAGCTAGAGCAAGCTCCTGCTAGCCTAAAGAAACCAAACCCTGACTACTTGCTCATAGAACTGTGAG CAAAACAAGACAGTCAAACCAAAAAATCCACCTAGAAAAGAATTTGGCAGTCTCACTCAGATGCCTGGCC TAGAGGGGACTTCAGAGAATGCCCTACAGAGAGACACCAAGACTACAAATGCAAATTCTGCCCAAAGAGT GCCTGGCCGATGAACAGGGTCCTATCTACATCTTATGGAGACTCCTATTTTATAAATATGTATCCTCAAG TCCAAGCACAAACAAAATAACAGAAACAGGGATGATTCTCTCCCAGTTTCCATGACAGTAAATAATAAAT TTCCCTAAATTTTACTTTCAACAACATAGACTTTTTTTATTTTTATTTTTATTTATTTATTTATTTATTT TTTGAGACGGAGTCTCACTCTGTCACCCAGGCTGGAGTGCAGTGGCATGATCTGGGATCACTGCAACCTC CACCTCCCAGGTTCAAGCAATTCTTCTGTCTCAGCCTCCTGAGTAGCTGGGACTACAAGTGCACGCCACC ATGCCGGGTTAATATTTGTATTTTTAGTGGAGACGGGGTTTCACCATGTTGGCCAGGCTGGTCTTGAACT CCTGACCTCAAGTGATCCACTGGTCTTGGCCTCCCAAAGTGTTGGGATTACAGATGTGAGCCACTACACC TGGCCAACAACACAGACTTCTTAAAAAAATCATGACAATAATTTTGGGTGCTTCTTAAAAGCACCCAAAG CTTTACTGCTAATGCATGGTAGCTTAAAACTTCACATAATAAGAAAGAACCAGTGGCCAATGGAATCTAC TGTTAAAGGTACCCAATCAAGTAAGGAAAAGTTGGTCCTAAAAGCAAGCAGCCCTGTAAAAGCTGCTCTG TCCAATATGGTAATCACTAGCCATTTGTGTTTCCATTTAAATTTCAAGTAATTAATATCAAGTAAAATTT AAAATTCAGTTCCTTAGTCACACTAGCCACGTTGTGAGTGTGCAACAGGTAAAGCTAGTGGCACAGACAT AGAACATTTCCATCAGCACAGAAATCTCTATTGGACAGTGCCAGATTAGGGTGTTCTCTGCATTGTAAAA GCATCCCCTTGCCAAGTTAAAGAAAACAACAACAAAACTCTAGAGAAGAAATGAAACCCCAGTTTCATTT CTGGAGAGGAAAGAAAACTCATGTGTGGCATGAGTTTATATTCAAGAAGGTGCAGCATTATTACCTATTT TACTAGTAATAATGACACACATTATAGTATACAATCCAGTTCCAATAAAATTAATTTCTCATCTTACTAA AAGCTTGCTGCTCCACATTATGAGACAATTTACCCAAATATAGACATTTACCCAAAAATATTAAGTAGCT TGTGAATACTTTTTAAAATTTCCTTTAATTAAAGTGGTCACAAACTCAAACCCTTCATTCTCCCTCTGAG ATTTCTGTGTCATCTTTTGTTCACATTGTTATTCACATGTTTATTATGTACTTATTTTGATTTTCTAGAT AAATAAAATGGCTTCAAATCTATAATTCTGATAAAATTAGCCATCAATTAATTTATTTATTAAACCCATG CAATATGCTAGATTAGATGCTTTGCTATGTAATTCCTACAATAAATCCTAGCAATCACAAAGATTACAGT TAGTGAGACGACATGCACACAGGTAAAAAGTGTTTTTAAAAAATACATACATACAACCAAAACAGTAAGT CACTGCTACATGGAAACTGATTGGTCCTTTTTCCTTTTTTTTTTTTTGCCTTGACTGCCAGGAAGCAGTT TCAAATCTATAGCTGGATTTTAAGTTTCATTAATTCATGTTCCCACATATGGTTCTGTATTTTCACTTCC CCCTTTTAACTGACATACTGTCTTATGTGATCTCTACTGTAAGCCTTCTCATCATTTTGGAAACAGACCA AATATAATATATATGATAAGGAATCAAAAGTAAATACAGTAGTGTTGAATATTGCATAACAAAAAGGTTT TTAAATAGGGAATGGTATCAATATGAAGTGTTAGGGAGACCCAGCCATGAAAAGGATAGCAGGGTCAGAG AAGGAGGATGTATTGCAGCTGGTTTAATGGAGAATGGTATGAAGGAGGTGCAGTTTGAATTGGGTCATGG AGGACAGATGGATTGCAAATAGCTGGGGCAAAAGCACAGGAAGGCATTCTAAACGAGCCAGGCATGGAGA CAAGAATGTCTCCCACAAGGGAGTTGTAGTAGCTCAATCAGACTGGGATTTGAGATTTCATGTGGCAGAG TGGTAGGTGATAAAGGTGAAAAGACTGATCATAGTAAAATGCGGAGTCTGTAAATCCAGCACTCATGATA AGTTTGGACATCATGTCAACAGTGGACAGCCATAAATGACTGCAAGCATCGGTGTGGTATAATGAAGGTG ACGTTTTTGTAAAATGACTCTGGTGAAGGTACAGAAGGTAATGAAAAGTAGCCAGTCTAGTTGAGCAGAA AAGAGTTCAGATGTAATTGCATCATGGTCCAGATGTGAAATGAAGACAATGCGAAGTGGCATTGTGGATC GAAACATACATGCACAAAATGACAGAATTTTAGAATTTGAAGGGATCATCATGGTTACCAGGCTGGCCTC CAATTCCTCTTTTGTAATATTAATAGAAATTAAGGGCTAACAAGTTTAAAATGTTATCCATCTTTTTACA TAGTTACTGCCCAAAGTGAATATTTTGAAATGTATCATTAAAGAAGAATAGATAAGATTATGTGATTCAC CATGGACTATTGTCATGAGAGGAAAAATGTGTTTAGATGATTCTGTTAGCACTGAGACAAATCAGGATAT CTGAAAGGAGGTCTTTGTTGAAAAACAGAAATATGCATTCATAACTTGCTTTTCTAAAATTGGAATGTAA TGATTCTTAAATATGCACAGACACAAATTTTTCTTTAACAGTCAAGAAAATGCACGCAGGTGATAATCAG ATCAGTTTTGGTTATAGTACAAAGGTTTAATGCCTCCGTGATCCCTTTCAACTTGAAAGCATTCTAGAGC AATTGGTGATTAATATCAGTATAACAGTCATTTATAAAATTATTATTTATTTGATATACATCTAATCAAA GCATAAGATTTATTTTTATTATTATTATTATACTTTAAGTTTTAGGGTACATGTGCACAATGTGCAGGTT AGTTACATATGTATACATGTGCCATGCTGGTGCGCTGCACCCACTAACTCGTTGTCTAGCATTAGGTTTA AAAGATCAGATTGTCTCGGCACCATGTTAATATCTTTTTCTGTTGGCATTAGTATTAGTTTTGCTTGTGT ATTTGTTTAGGAGATAGCTTCACAAGTTGGTGATTGATATTCTACCATGTATGAAGTCATGCGTGGAATT CAGAATCCCCAGCTTGTAAAATTGCATTATGATCATCTTTAGTGGGAAATTGTTCTCAGAATACTGAGCA AAGGATGATACCAAAATGGCAGCTATTATTCATTCTTAAGCATATGAAATGCTTTCAGGTTCAACCCAAA ATTACATACATTTTAAATGCTTACTAAAAGAGTCTTTTCCCTCCTCCATCTATTAACTGCAATCAAAAAA CTTCGGTTTTAACTGAACATGATTTCATATTATTTATTAAAATTTAAGGCAAGGTGCACCAAGTACCCTT GAATTATGAAAAGCTTCATGATGTGGGATATTCTTTCAGTTAACGGCAGGGTTGGCTACACTTTTAAGGG GTTCAAAGTAGGAACAGCTGCAATAGTGAGCTGCATCTGGAAAGTCCAGTAATTTGAAAAACCACCTGTT TATGTATCCTGCCCACTCAAGTCCATAAAATAACAGACACTTTCATATTCCAAATGAAACTGCTTTTTAG TTTGCCCTACTTTTAAACATAACTCTTTGTGATGGAATGACCAGAAACAGCTGGTCTCTAAGAGGACAGG GCTATGTGCGCTCACCTGCGGGGTTGGACCTTCCATAATCCCCCTGGCTGTGGGGAAAGTTGAGGGCTGC TGTCTTTATACAAAGATGGTTTATTCCAAGATACACACACTCTTCTTCCACACCCTGGAGACCTTGCATA TTTAGTATCTTCTTTACCATAATCTGAGGCCCTAGAGAAAAAGATTTGCAAACTATACTTGTTTTAAAAC AACTTTCTAAAAAAGACACTCTCAGCCCCTAGAAATTATGCCTAACACATAGATGCTCAGAGGCAACCTG TTGTAGTGCAAGAGGATTGTGCCAAGATTAGAAAACAAATATTTGCAACTTTTGTAACTGTCTTCTCTAA AACTTGAATGTGGTGATTCTAAAGTAAAGACCGACACAAAATTCTTTTTCTTTAGCAGTCAGGAAAAGGC ATGCATGAAGTAATCAGATCAGGTGTGGTTTCAGCATAATGGCCTAATGCTTTCATGATCTCTTTCAACT GGAAAGCGTTCTAGTCCCACTGGACACCAAGGAGGAAGAAGGGACGGAAAATATTAGGCCCATAGGTTTA TCTTCCTCAGTAGTCCACGAGATTTGAGCTTATATGTAGGGAGCAAAATTGTTTGTCTAAAAGCAGTTAA TAAATGCCCCAAAAAGGCTGGGCGCAGTGACTCACTCCTGTAATCCCAGCACTTTGGGAGCTCAAGATTG GTGGATCATGAGGTTAGGAGAGCAAGATCATCCTGGCCAACACGGTGAAACCCCATCTCTATGAAAAATA CAAAAATTAGCTGGGTGTGGTAGCGCGTGTTTAATCCCAGCTACTGGGGAAGCTGAGGCAGGAGAATGGC TTGAACCCAGGAGGCCAAGATTGCAGTGAGCCAAGATTGCGCCACTGCACTCCAGCCTGGTGACACAGCG AGACTCCGTCTCAAAAAATAAAATAAATAAAATAAAATAAAATAAAATAAAATAAAATAAAATAAAATAA AATAAAATAAAATAAAAATAAAATGAACGCCCCAAAAATATTTTGGGCAAACTATTTTGTGTTTCTTTTC TTTATTTATTTATTTCTTTTGAGACAAAATCTTGCTCTGTTGCCCCGGCTGGAGTGCAATGGCACAATCT TGGCTCACTGTATCCTCAACCTCCTGGGCTCAAGCAACTCCTGAGTAACTGGGACCACAGGGATGTGCCA CAATTCCCGGCTAATTGTTTTAGCCAGGATATAAATGCTGCCTACATAGAGTTTGTAGCTATCTCCTTGA CTTTCTTTATGCAGATTCCTTCACAAACTTTTGATGGATTCCTTTACCAAATTCTACTGTCTGTTAAAAT CTTCTATCTTTATATCTTTAGTCCAAACAACACGTCATTTATAAACCTTAAAATTGTTTCTGGGCAAATA AACAAGGCAAAATAGGAATATATATTTTTAGGCAATTTACTTCTGTTTTGGTCTCATAAAAAATTGTAAT TAAATTGTAGAAAATATTTCAATTCCTCTTTAATATCCTCTCCTCACATACTGGCTCTCAACTTCTAATC CTCCTATTGAAACATTGATTGGGAGGCCAAGGCAGGCGGATCAACTGAGGTCAGGAGTTTGAGACCAGCC TGGCCAACATGGTGAAACCCTGTCTCTACTAAAAATACAAAAGATTAGCTGGGCATGGTGGCATGCACCT GTAGTCCCAGCTACTTTGGTGGCTGAGGCACGAGAATCGCTTTAACCCGGGAGGCAGAAGTTACAGTGTG CCAAGATCAAGCCACTGAACTCCAGCCTGGGCGACAGAGTGAGACTCCATCACAAAAAAATAAAAATAAA AATTGAAATTTGCAGCCTTTTTAAAACCCCATAGCCTCTTTATAAACCCAAAAGCACTATCAAATTTGGC GAGGTGTCAAAAGAATCAGAGGAATGTTTACAAATACAGATGCCTGGGCCCACCTCAGATATATATATAT ATATATATATATATATATATATTTTTTTTTTTTTTTTTTTTTTGAGACGATGTCTTGCTCTGTCACCCAG GCTGGAGTGCAGTGGCATGATCTCAGCTCACTGCAAGCTCCGTCTCCCGGGTTCACGCCATTCTCCTGCC TCAGCCTCCCAAGTAGCTGGGACTACAGGCGCCCGCCACCACGGCTGGCTAATTTTTTCTATTTTTTAGT AGAGACAGGGTGTCACCGTGTTAGCCAGGATGGTCTCAATCTCCTGACCTTGTGATCCGCTCGCCTCGGC CTCTCAAAGTGCTGGGATTACAGGCGTGAGCCACTGCACCCGGCCCAGATATATTAAATTAGAATATCTA GAGGTGGAGCCTGAGTATCTGTATTTTTCAGAGTTTCAAATGATCGTTCTTCAAATGATTACACTGTGAA GTCAGATTTAGAAATGACTGTACCCAAGGTTGGCTAAAAGATACACACCCTGGTTGATTCTACCTGAAGA GAGCAAATAAGATACACAGCAAAGTTGTAGATGTTTTCCCTGCCAGTAGAATACTTGCGGGTTAGGCCAT TTAAAACCCTGCCAGAGAGTTTTGAAACACTGTGGAGGGCTCCCAAATCAACTTGCTCAATGGTTCTCCA TCCCTTCAGGCTACTTGGGCTTAAAGCCAACTGCAAGCTTAGAGCCTCAGAGTGACCTAGGAATGGGGTG ACCATATATTCTAGGTTGTCTCATACAGACTAGCCAGCACTACTCAGCCGCAAGTAATAGCATCCAGGCA TGCTCAGAAGTGTCCCATTTGGAGGAAAAAAACAATATTGTCACAAATGAATTGGCAATGGCCTGTCTCT GATTCTTATACCTGGAATATACTGGAAGTCCCTACTCATGCTATTTTCTAGCAGAATAGGCAAAATTTCT ACATTCCAGGCATGTCAGGCCTTTCCCTGATTCCTTTCTCTAATGTCACTCGTCTGCTGTCTTTTATCAC AGCCATTAAACTGCACCCTAACTTAAAGAGGATCCCTTATGTTCCAATCTACTCATCCCTCAGATCTTTC TTTCTCTGAAACACAGGGTTAATGAGACTGACATCCTTCCATCACATATTTTCTCAGCTACTCAGTAAAA GATGTAAATGTTTAAAATAGTTTAAACTATTTTTCAGTTAGTCCAGGAAACATAAAATGGCATGCTTGCA CATAAACCATTGTTTAGGGTGGGGGAAGTGTTTTTAATTTTGCCTTAAAGGAAATCTGCATGATCCACAG GCTATGCAACTACCAAGGGAATTAGTTGGTAGAACAGAATTACACCTGCACAGAATACAAATTTCCTGCC TTTCATGGGAACTATGTTGATGTTTCAGATATGAAATACATCTTGTTTTCTTTATTGAACCTCGAGAAGA TGTCTCTTGTTGGTCATTATTTCATGGCAGGGGAAGTACATATTCCTAAAGACACAACCGAGTTTCCCTT TAACCATCATTAGTTGGGCTGGCCATTAAGAACCAGACGCTTTTATTTTCAAAGAGACTTAAGTTTTGAT GTTGTACATATGTGCCTAATATTCTATCTCATAGCAATTTAAAGGTGACGTTTTAAAAAGCTGCATTCAG TGTATAAACTTCTCCTGATCCCAGCAAGGATGTTGTGATGATTTTATTTAAAAAGGTAAGTTGTGTCTAG ATATGGCAGTGGGTCATCTCATGCATGGTGCAGATGTCAAACACAATTACATTTTCTTATTTGCAATGAC TAAAAAAAGAAGCTGAGCCCAAGCAGTGAGAAAGTAGGAGATTGGGAGGACAAGAAGCAAAGGAAAAAAG TAACATGAGCACCGTTCTCCCTGTCCTGCCACTTGCTCCATTATGGACTGGGCTGCGATATCTCATATCC CAGCTCCACAACTCCCAACAACCATTTATGTGCATGGTGCTTCCATGTGTGATGACCCAATCAGGCTCAG GTGTGGACTGAGTAGTTAAATTATAACCCTTGTCTCTGAAGAGTTTAGGGCTTAGTGGGGAAACAGACAT GTAAACAAACCTGAGTGAGGTCATGTAATCAAAGGACAGGCCACAGTCAACCACAAAGAAGAGAGTTCTC AGCAGTCTCCAAAGCCGAACATATGTTTACCAGGAACAGGGTCCCAGCAGAGGGAGCAACAGGAGCAACC AGAGCCTTGAGGGGTCGTGGCCTGTTCTGGGCACCAGCAGTGGATCAATGTGGCCAGAGCCAGGGATACT AGCAGAAGCCAGAGCAGCAGGGCCTTCCTTGTCCAGCAAAGGCATTTGTCTCTTTGTAGGCCACAGCGAC CCACAGAGGGCTTTTTAGGCCAGAAAAAAGCCATTAAGGCCGGGCGCGGTGGCTCACGCCTGTAATCCCA GCACTTTGGGAGGCCGAGGCGGGTGGATCACGAGGTCAGGAGATCGAGACCATCCTGGCTAACAAGGTGA AACCCCGTCTCTACTAAAAATACAAAAAATTAGCCGGGCGCGGTGGCGGGCGCCTGTAGTCCCAGCTACT CGGGAGGCTGAGGCAGGAGAATGGCGTGAACCCAGGAAGCGGAGCTTGCAGTGAGCCGAGATTGCGCCAT TGCAGTCCGCAGTCCGGCCTGGGCAACAGAGCGAGACTCCGTCTCAAAAAAAAAAAAAAAAAAAAAAAGC CATTAAAAAGGGAGTCATGTCTCTTGTTGGTCATTATTTCATGGCAGGGGAACTACATATTCTTAAAGAC ACAACCATTTCCTCTTAATCCTCATTAGCTGTGCTGGCAATTAAAAAACCAAAAGTTTTTACTTTCAAGA AGATTTAAATAACTTCTGAGGGTGTACATATGTGCTTAATATTCTGTCTCACAGTAATTTAAAAGTGAAG TTTTGAAAAGCTGCATCCTGCGCTTGTCAGAACCATGTCTGATGAGATATCCCCTTTAAAGGGCTCTCGG TGCAATGGGGCAAATCAAGGGGGTTTGTGCAAGTGGGAGTGAGACAGGAGATGGGGTGCTTCTTCCAGCA CTCCCTATAGGCTGACTGAGTGACAAAGATCATTTTACTGACACCTCCAATGGCCCTATGAGATGGGTAC TATTATTATTATCACCATCATATTCCTTTTGCAGATAAGGAAACTCAGGCTTAGCAGATTGCCAGAACAA CACAGGCAGGAAGTGGTAGAGTCAGGGTTTGAACCCAGGTAGTGAAACTCCAAAGCCCGGATTCTTAACC ACTGTCCTCCAGTGCCTCTCTGTAATAAGTCATGATCCCAGAAGCCATTGGTGTGGCCACAATATGGAAA GAGATGACAGTGTCCTCACACTGGGTGAGCAGCTTATGGTGATTCCAGACATGATCTCTGTTGGGAGTGA CAGGTCTGAGCTTCTAGGATCAGACCCTAGATCTTGGCAAGTGGTTTGAGGAAAGAGAAGGACCAATGTA AAACCCCAGGCTTCAAGGAATGTGGATGCTGGGCAGGGAGGATTAAGCCCCAAAGACCAGAAATGGGGTA CACAGGGCAGGTGTGGCCAGAGTAGAACTAGAGTAGAACTTCCAGTGACTAGAAATAGAACCAGACACGT TGCAGTGGTGGATAAGGTAGAATCGCTTAAGTCTTTAAAGTGCCCCTGATCACCCAAGTTGGCCAGAGAC CCTGGGGTGGGGCTGATTCTGTCTGGATATACGGGGAGGGGTAAGCATGAGGAAAGGAAGCAGGTCCTGA CAGGTACTTTGCACTAAACAGCTCCTTATAAGGTTCTCAATTTGCCTGCTCAATTTCTACAGACATTTGT GGGACCACACCAGTACATTGTAAAAGCAGGAAACAATTGAGAAAAACCTGAGTTTTATGTTGGTAGGAGA AATGCCTATGGAATATGGCAAATCGTTTCTCTGAGACTTCCTCCCTAGTAATTACATATTTGTTCTCAAA AACAAATGCCAGAAGGAAGAAGCAGATTTAATAGTGCATTTTACAAGGCACCATTAATCTCTAAGAAGAA CAATTAAAATGTCTCAGCAATCATGGTTCACTGTATATCTTTTCTATCTTCTTAGAAGTAATATATGGCT GGAAATGGGCATACCAAAATATGTCAAGGAAGTGGAATTGCGTTCATTAGATTTCACCACTAATTATTTT AGTTAGCTTCACAGATCTCTCTTCCTTGCTTGTTCTTGAGAGCGAGGCTTTTTAGTAGGAAGAGAAATTG TCTAAAACGATTAATAACCACAAATTCACCAAACTATTTTGGGTAAGTCCCTCTATTTCTCTAGGTCTAA AGCTAGGAATAAGAGTCATTCTCATATAATGTACTGTCCCAGAAAGGGCATTATATTAGTCTGTTTTCAC GCTGCTGATAAAGACATATCCGGGATTGGGTGATGTATTTAAAAAAAGAGGTTTAATGGACTCACAGTTC CACATGCCTGGGGAGGCTTCACAATCATGGAGGAAGGTGAAAGGCACATCTTACATGGTGGCAGACAAGA CAGAATTGAGAGCCAATCAAAAGGGGAAACCCCTTATAAAAGCATCAGATTTCGTGGGACTTATCACTAC CACAAGAACAGTATGGGGGAACCGCCACCATGATTCAATTATCTCCCACAAAATGGGAAAATTATGGGAA CTACAATTCAAGATGAGATTTGGGTGGGGACACAGCCAAACCATATCAGGCATTCAACCAATATTTGGGA AGCACCAGCCCTGCACCAGGCACGGAGCACGTCATGAGTCCTGCCGTACCACAGCCTGCCTGACAGACCT CAGTCATCCTCTGGAGCTTGCCTCTGACATCTGGACCTCCTCAGAATCAGCATCTCTTCTCCTTGCCCCC GCCATCCTTTGTTTTTATCTCTGCTGTGGCATTCATCAAAGCCTTCCAACTATCCTGCGTCACTGTCCTT CAGTGTCCTCTCTCCTCTCCCTTCCTTCTCACCCCACTTTGTGCCTGTATCCTTCAAGCAGAGCAATGGC ACCCTCACTTCTGTGGCTGCCCAGTGCCCCATGCAGAGTCAGACATCAGAAAATAGATGCTGAATTCAGT TGACACTCTGAAATTCTTTTTAAAGTAAGTTAATGTGTGCTTTGAATGAAAAGACACTGGGATTACATTA TTGAGTGTCTTTCTTCCTTTGCCACTTTTGTCCCTATTGGCCATATTTGAAAATCTTGTTGGAAAAAAAA ATTCAAGAACTTAATAAATAAATTCAAAAACATTTAGTCTATTTACTTAGGTGAAGAGAAAACTCATTCT AATATGTGTGTATATTTAAAATATTTGTTATTTAGACTTTTTTTTTAAGTCTCCAGGTTGAGGAGGACAC AAATATATCCTCCTAAACCTTCCAGTAAGCAAGCTGTGGCATCCAGATGATCTCCTGGGTCATGGGGGAT AAGGCTAATCTCCTAGGTGTCTGGCAGACAGGACAGGCAAATTCCCAGAATGCCAAAATATACCATCTGC TGCTGTTTGGCATTGCCCTTAAGTCCAGAGTGTGGAGGCTGGGGGTGGGTCTCTGGCTACAGGAGAAGTC CCCTGGCAAGGGAGGGGTGAAAGGAGTGCCTGTTGAACCCCCCATCTATCCCCGCACTATGGCAAGATTG AGAGGAATGACTAGATCAGGGAATGGCCCGAAAGAAAAATCCAAAACCTCCCAACCCTGGACAAGGCCAC AGCTTTGAGAAACCGAAGCCTCTGCTTCCTTCTCTTTGGCTTTACTGCTTCTAGATGCAAATACACAGAG CTCTGAGATTTTGTGTGCTGGGAGGTGATAACTGTTAACCCTCTATTCCAATAGCACAGAAATTTCTCTT TGCCTCAGAAGTGGTTTCTCATAGATCTCAGATCTCTTTTCAGGAAAAAGAAAAACAACAACAATAACAA CACATTAATGACTCTGAAAGAGTCAGACACCATTAATTCCATTATTGGTGTCTGTGCCAAGTGAAATGAA CGTCAGCTCTTTTCCCAGATATGTTTCCTTCTTTTGCCTCCTATAATAAGAGATGATTTTACTGTAATAA TATAAGACTCATCAATTTGACTCCAAATAGCTTTCCTATCAACAGGCTAAGTGTAAAATACCAGGATCAT TATTCAGTTGAGAATAGATAGAACTAGGAAGTAGCCATCAAAAAAGAATGATGAGGTGCATTGTGGATTT GGGGTGTAACTTGGTATCTAACATACAGCCAGAATCACAGTCATAGCACACTTAATATTTTATCAGAAAC TTGCGTGAACAAGTTAAGAGGACTCTCAACTTAAAAATGACACCAATTGCAATGATCTTGTTAACATTTG TGATGAAAATAATAGCAAAGTGACTTAGACAAATTACAATAGCCCATAAAAATAAGATAAAGTTTAACAC AAAGTAAGATGATGTTAAAAGACTTGAAATAAAACAGATATGTTAAGTAGGCAACACATAGGTAAGCATA TAAAAACAAGAAGATACCAGGATAGAGCTGTCATTTTTGTGGGAGCCTGTGATGTGGAAAACCAAGATGC CTGGTGAGTATAATGGATATGGAAACCCCCCTTGTAATAATTCCACAGTTCCAAGGGGCCAAGGTCTCCA GGTTGAGTCACTATTGTAAACACACCCATAGATGAATCCACATGCCATACCTCCTTGAGTAAGTGGGGAC TCAAACTAGGTCTGTCAATTGTTCCAGAAAATTAAGCATCTAAATAATTTAATGATAATTTAAAAGAAGC ACAATGAAATATTTCAAGGAATGTCACATACAAGATTCTGTACCTCTTCTGCTTTGGTTAGACTCATTCA GAATAGGTTCCTGCTTTGATCTTAAGAGGGAGGTAGAGATTCTGGAGAAGCCCTAGGGAAGAGCAAAAGG AAAGGAATAAGGAGCCAAGAGGAAACCCAGGGTAAGGCTGAGGAGGGACTGTTTCGTGTAGGTGATTTAT TGGAAGGGTTGGAAGGAAACATGGAATGACAATTACCTTTGGTTATTGTCAGGTTAGTATGAGACTTACA AGAAAAGCACTGCTCAGACGCAATTACCATTCAAGATAAGAAATAATAGGAAAGGCTAGCACACTTAGCT TTTTATTTAAAAAAGTGTTAGGTAGGCTGAGCACGGTGGCTCACTCCTGTAATCCCAGCACTTTGGGAGG CCAAGGTGGATAGATGACTTGAGCCCAGAAGCTTGAGACCAGCCTGGACAACATGGTGAAACCTCATGTC TACAAAAAAATACAAAAATTAGCCAGGCATGATGGCATGCACCTGTAGTCTCAGCTACTTGGGGGGCCAA GAGGTGGGAAGATTGCTTGAGCCCAGGAAGTCGAGGCTGCAGTGAGCCATGATTGTGCCACTGCATGACA GCCTGGGCAACCGAGTGAGAGCCTGCCTCAAAAAAAAAAAAAAAAAAAGTGTTAGGTGACATGAGAGAAG ATCTTCCAAGTAATAAGAGTGGCTAATCCCAGGAATGTGTCACCAGAGGTTATTTTGTAATAGTCGTGTG TTAAATTCCTTATTTGTCTATATAACTTCTCAAATCCTTCTGCCTCTACAGTTATAGTTTAACTGGCGCA TAACAGCCTTCACACACAGCCTCATAATTAAACATAGACATACATATGAACACTTTCCCCTATGCCAGCA GGATACTTGGTTTGTTTAGGGGCAAAGAGGAATTGATGTGGCGTTGTTTCAATCAGTGGTTGAAAATGCA AGTGGTAAACATTGAAAAATAGAACACTGCAAAAGGCATGCATTGTATATACCAAAAGGTCAGCATGAAG CATTATCTGTATGGCAAGCCTGCCCATCCACTCCCTCCTACACGTTGCATATTCACACAGTTTTGCAGCT TGTATAAACCCCTATTGTGATAGAAACTCATGAAAGAGTGTGGTCTCTGCGAAAGCTGGCTGTTCTGTGA ATTTAGACCAGTGGTTCTTCACCCTGGCTGCAAATCATCTGGGGAACATTTAAAAACACTGTTTTAAACA CCCCAACCCTAGAAATTCTGATTTAATTGGTCTGTGGTGGGGCCCAGAACTCTGTATTCTTTTTTTAAGG CTCTCAGGTGCTGCTAATGTATAGCTAAAATTGGGTCTGGTTTAGACTCTCAGAATTTCTTAATAATTAA ACACTTTATCATGACAAGACTTTCAGGACCTTAAAGGCCACAGTGGGGTAGTTATCATTTCACTAGGTCC TCATCTGGGGAGGTCCTTGGCATTTTTACTGGAATATATTTGTCACTCAAATTTCTATTACAAAAAATTC TTTCTTGCACACTGCTTTAGCAACTACATGAGATATACTTTGTACATAGCACAAATCTCATATCACTTAT GTAATCCAGCTCTGTGGTTCCTTCCTTTCCTTTGCCTGTTTATTTTTAATTCTTCCCAAGAGGAAGCTTA GCCAGTTAGAACACCAGAGTATCATCCCCCTCCCCCTTTTCCCACCTGAGTTCATGGCTTAGACATACTA GGAATGAAGCTGACAACATGCACTAGTTTTTTTCGAAATTATGCAGCAAAATTCCCAAAGTGCGAGTGGC CACAGAGATCTTCACAGGGCCCAGGGACAGGCAGACATCATTCTTTCTCCAGTTCCTGGCACAGAAAAGA GACCTTAGGTTACTGAGAAGATACCAGTCCCTCCTCAGAGCAGACAAGGAAACTGAGCCTCAGAATGAAA GACTGAATTTCAGTCCTTTCTTGAACATGGACCTCCAGGGTTATATTGGGCCTTGGAAAAGGCACTTACA CTCTGGACTGTAGTTTCTTCATCTATAAAATCAAGAGGCAGAAACAGACAATCTCTAAGTTGCCTTTATT TATAAAATTCCGAGATTCTAGTTGACCAGTATTCATACAAGAGTTGAAGCCTGTAAGAGTGCAGAAAGCC CACACAAAGAGACAGTGGAAGACCTCTCATCAGTAGTATTTTTATTACCCTCTTCCTAGGTTTTACCAGT CAACATCCTCACTGTTAATATACAGACCGTGGTATTTAATTAAATCATCTTTGAAATACTGAGCTATCAA CAGATGGCATGCTGAATGCAAAAGGACCACAAATAAATATTTGGTACTGAAGAAGATCAAGAGTTGGAGT TCATTTCCCATTCTGATCTGGGCTCAGAACTCTGTGGTCTTCCCTCTAATCATCCTTGCCACCAAATTGG CTGTATCTGTTCTAAGATGGATCAGAAAATCAGTTCCAAAGTTGGCTACAAACTTTCAGGTTTGGGTTTT GTTTTGTTTTTTTGTTTTGTTTTGTTTTGTTTTTGCAACCAGCCAATTCATCTTAGTTCACATGACAGAG AAGTGCATAATTACTTGCAACTTTAGTTAGAGCAGTGGCCTTAAGAAGGTCTAGCTAAATAAAAAGTGCT CAGACTTTCTGAGTGCTGACAGTTGTCAAATTCACCTAGTTCACATGGCCCCATTTCTATCGTTTGTTTT GTTTTGTTTTTGTTTTTTAACAGCCCATCTGTGAGCAATAGGATCAGATGACTAAGAGCTACAGGGCAGA AACACTGTTACTTAGAGTCAAATTTTCCCATTACCTAGCTGTAAAGAGTTTGTTTCTCTCTGACTCATAT AAAGTTTACCATTTAGGCCCCTGCATGATTTTAATTCCATCACTTAACACCCCAGCCATATGATTCTGAA GGTAAACATGAAGGCGTTTGAATTCCAGACCACCTAAACATTCTTAAGGAAATCATCATCTCCACGGGCA GAGCTATGCCAAAATCTGTAGGTTTTAACTCAAATTTCATGATAAGCAAAAATTGAATTAATTTGTCTTC CATTTTGTTCACCTTTTTGCCAAAATTATGCCTGGATTAGAATAAATAAATTCAATCAATGAATGCAATC ACTAATTCTTACGCCAGATAATAACACATTCAGAATTCTCCTTTCCCTGGGAGATTTTATCAGGTTAGTG TTCTTGTAAACAGGAGAAAGAGAAAAATATAACTTAGTAAATAGCAGTATTCACTAATTCATTCATTTAT TCAACAAATATTAATTTACTACCTACTACATTCCAGGGAGCTTAGAGTCTAGTATCAGAAATAATAACCA CACACACACATACACACACACTACATTAAATAAGGATGTGATAGGCTAGATGAAATAAATAAATAAATAA AAGGTCCAGGTGAGAAAAGAAGGTGGGGGCTAGAAAGAAGTCATTGAAGAAAAAACATTTAGGTTAAAAC ATTATGAATAACTTAGAGTGAGCCAAGTGCAGAGTGCTGAAGGAGTGCTCCAGGCAAAATCAACAGCAAA TGGGGAGTCCTTGATGTAGAAAAGGGTTTGAGGAATTGTCCTGGGAGAAATACTCAAGATTCCAGTCTGA ATTCTAGAGGTTAGTGATTTAGAGAGGCAAGTACGAAAATGACTTCCTCTCTTACCTTAAAAGTAAGTGC ACCATAGAAGGAAATCACCCTTCCTTGGTAATAATTCCTGAGTGAGCCTGAGAAGCCAGAGGCCATCTCT ATTTTATAGGCACTGTCCCCTTTTCAGTTACCCATGGCTAGCTCATTGACCTTGTCCTGGTCGTTTCCTC ATTTCACTTACTCCATCCTCAAAACGTAGACGCTTCATAAATATTGTATAAATGAATGAACTCACAAAGT CACAGTACAGCAAGGCAAAAGTGCCTGCAATAAACAAGCATTCTAGGCTAGAAATATTTCTCAACTTCAA ATTGTGTCTTATTACATTGTATTCCGATTTTCTAGAGTGGTAGTTCTCAGTCAAGGGAAAGTTTTTCTTC CCTTCCAGGGGATATTTGGCATTGTCTGGAGATAGTTTTAGTTGTCACGATTTGGGGGATGCTTCTGGCT CAACTTGGGTAGAGAAGCGGGGATGCTTATAATCATCCTACAGTGCACAGGACAGTACCCCCACCCACAC TCCAGTAATGAAGAATCATTAGACCTAAAATGTTAATGGTGTCCAGGTAGAAAAACCCTGTTGTAGAGGT TGGGGACTGCGTCTTGACAGCCACATTATACAGTGTATCAAACAATTCTGTATAATGGGCTGTAATTATC CTTGCCTAGATTTTGCAAGAACCCTAGTGTGTATCTTTTTCCTCACTTGCCAAGCAATGTTCAAACCTGC AGAGATTTATTTCATTCATTTTCTGTGTGTTTAGTAAACAGACTAGAAGCACTGGAGGAAAAAATATTCC AGCAATGAGGTAAGACGAAAGCTATTAGTAACCCTAGTTTAACTTAGCTGAATAGTAGGAAACAACCTCT ACCGTGAGGAAGTGTATTGTAGAAACTGAAAAGACGCTAATGATGTTTAAAAAGCTGTAGTTCAAACAAA TGTGCATGCAGACCAATGGGTAGACTGAAAATGATGAAGACATTTCCGTTTCTTGTGTCTTTGATAGAAA AGAAAGAGCTTTTATTTTCTTTAGTGTGGCAATCATTCAGATTTGTCCCATGACATGCCCAGAAGGTTGA AGAATAACAAACTCCCAAGTGTAAACACAGAATTTAGCGAAGAATCCAGGCCTCTGGATGAATCCCTGTA ATTGCATGTTTGGATAAAATAAGATTTTCATACATTAAACAAGGTAGGATTTTTCTATCTGGGACGGAAC TTTCAACACTTGGAGGGGTTGTAGTTATTTCTCCTCAAAGATGGCAAACATGAGTGCCCCGAGTTATCCC TCCTCTCTGTTCAAGTTCGCTAACTAATCACCCAGTATCCATGCTATCGCTGGCCCTTCTGTGGCCTATT TTTATACTGTTCACTGTTCAGTGTCACTTGTTTGGTAACACTCAACATCAACATGTGCTACCAAATTGAC ACCAGAGGACAAAAAAGAATCAAGATATGTACAGCCTGCTTTGTACTGAGCCAGCTGCCACTAGATGTTT TTTGTGATAATGAACACGTGAGGCCATGTGGACGCGAGAGATGGCTCCGGGTTCCCTCAGACGGCTCACA GCCAGCTGGTCTGCAGTGCGGTTTTAGATTCCGATGTGGGAACCCCATAAAAAAGAATATGCAGGCCAGG CGTGGTGGCTCATGCCTGTAATCCCAGCAATTTGGGAGCCTGAGGCGGGTGGATCACCTGAGGTCAGGAG TTCGAGACCAGCCTCGCCAACATGGTGAAATCCTGCCTCTACTAAAAATAAAAAAAAAAAAAATTAGTCA GGTGTGGTGGCGGATGCCTGTAATCCCAGCTACTTGGGAGGCTGAGGCAGGAGAATCGCTTGAACCTGGG AGGCAGAGGTTGCAGTGAGCAAAGATCGCACCATTGCACTTCAGACTGGGCAACAAGAATGAGACTCTGT CACAAAAAAAAAAAAAAAAAGTCTGCAGGCTGCATAAAGAGGTATGAAAATGTTCCAGAAATCCCAAATC CTATCCCTGAGGTTCATTTTGGTGAGGGAATGTGTGTGCATTTTCTAGGGCTTCCCTAAAAAAGTATCAC AAGCTGGATGGCCTAAAGCTACAGAAATTTCTTGGGGACAAATTTCATGATTCTGGAAGCTAGAGGTCCA AAATCAAGGTGTCAGCAAGGCTATGCTTTTTCTGAAGCCTATAGGGAAGGCCTTCCTTGTCTCTCCTAGT TTCTGGTGGTTTGCTGGCAATGTTTGGCATTCTGTGGATTGCAGCTACATAACTCCACTCTGCCTCCATC ATTAATGGCCTTCTGCCTGAGTGTTTTCATATGACCATCTTCATATAAGGACACCAGTCATATTTGATGA GGGTTCCACCCTACTCCAGTATGACCTCATCTTCACTAACTACATCTGCAATGACCCTATATCCAAATAA AGTCACATTCTGAGTGTCTGGGGATTAGAACTTCAACAGAGCTTGTTGAAGGGGGCACAATTCAATGCAT AACAGGATGGAAACTAGAAACGGGTATGTTTTTATCAGTGTAGAAAGATTTAGCTTAATTTTTCAAAGTG TAATAAAAACCCCAGGAAAACTCATACTCCCTCCTAAGAAGAGCAAAAGATGGAGAAACCCGATGGTTAC CTTCAAACAAAAGGAAAGGAGGAATAAGATGAAAAGGAATTAATCCAAAGCAAAGAGAGTGGCTTATATG GAATGTTGGTGCAACTTTCTCTGACACATCTGTGCACTCATCAGCTGGGGCATCATCTCCCTGGGGTACA TTTGGTCACTGTGTGCCTCATGGTAATAAACTCCAGAAGCCTCATTGACTTGCTAGAGATGAGCTCATCC TTCTTGCTTGCTTAATGGCAAAATACAAAATAAGCAGTCACTGACATGGAACGATTTCAGGAATGCCAAA AGGTTCTCCTTTTCCAAAATATCTCTTCCATCTTCCCAATACTGTTACTGACATCACTAACACCTCTCCA CTTCCGGTTGAGACACCTGGGCCAGAGCTCCTGATGTGGCAGGCAGTGCCCTAAACGTTTTGCATAAATT AACTGATGCCCAGAGCAACAACCCTAAGATATAGGTACTATCATACCGCATCTTACAGATAAGAAACTTA GGCACAAAGAGGTTTAGTAGTTTAGATGAGATAACCCTGATGAGCAGAGATTCGAACCCAGCCTCCATGC TATTAACCAGGACATCATATTGCCTTTCATACATGCTCTTCAAAGGCAACACAGTAATCGATTATCACAC TCACTCACATCTGATTGTCACATTTTTCAGATCTGCTCTCCTAGCAGAGAATGAAGCCTAAGGTATCCTT GTTTCTCAAAGTGTCCTCCCCAGACCAGCTGCATCAAAATGAGGGGATGAGGTGCAAATGCCTGGACCCT GCCCTTGGAGCACTGATTCATAATCTCAAGTCCCAAGAATCTGCATTTTAACAAGCATCCCCAGAAATTT CTTAAGTATACTAATGTATGGGAACCACTGACACTAAAGAAATGGAATAAGGGGAACGTACAATGTTACA GTAAACCAGGAAAAGCCAGAAAGACATGACAACACAGTGAGGACTCTGGTAGCCAATGGTCAGTCAAATG CCCAGGGGCCCTGGCCAGAAGAGAGTTAGGTTGCTGAGGAGTAAGAGTGATGCTGAATGTGGAGGCTTGA GAGCAGAAGGAAGCCAGCCAGCTATATCCTCTTGCTTGGATCACACACCCTTTCCTTGGTGGAAATGGTT ATTTGCAGAGTTAGAGAAGGCATGTTTTACAGTTTGGATGGCAGGTATGGATGTAGACAATAAAGAGCAA CCAGAGTCCATGGGTTCAGAAATCCCCATGTGTTTCTGTTTGAATGAGACGCTTGCATAAACAGCACAAG GAGTTTGGGGTGGGGTTAAAGAGAATGGTGTGGTATAGGGAGAGCTGAATGAGGAACTGAGAGAGCAAAA TCCTGTGTTTGGTTCAATCACTGATTACAACCTCCCTGAGGCTCGGTCTCCTAATCTGTAAAATGGGGGG AAATAATACCTGCCTTGCAGGTCCTCACACACAGGGCATGATGTGAATCCACTGAGGCATATAGCACTGT GTAACATGAGTTATTGCTATTCCAAGGCCCGTAAAAGGCTCTTGCCTTGGAATATATCTGCCACACCAAT GCCTGCAGTCCATTAATGACACATAAAGGACACTGGAGATAACGATGTCCCTTGTTCTATGCATCCCTCC CACCCATGCCAGAAAAGAAAACACAGTCACCTGAAGTCATTCTAAAGAGTATGCCTGCCTCTTTTCCTGC ACAGACACATATACACAGACACGCACATACACAGACCATGCACATACACACACATGGGAAAACATGAGGA AAAGTGGAGACAAGAGGCACCAAAGGACAAAGTCACTTTTGTCGCCTGTCCCTTCCCCAGCAGGGCTGGG CCTGGGCTGCTTCTCCTGCCTCCTCCCTGAAGCCCCCTCCTCATCATATTCCAGTGCGTGTCCACCACTT TGGGGCCAGGTCTACACAACTGCAGTGATTCAGGTCACGGGAGAAAACCCAAACAAGCACAAAACATGCT TCAACCTATATTTTCTAAATTGTTTTTCTTTAAAGGTGAAGACTTCTGAGCTTGAATTATCCCCTTGTCA GTGGGCTTTCCATGCTGTCCAAGTGACCTAAGTGATAATCAACCTCCATTTCATTTTGAGAATGGTTGTG GTATTTTAGAGCTATGGTGAATAAGAAAATCATTTAAAATAAAATGATTTTTATTTATTTATTGTTTTTA TTTATTTTATCTTAAATGAATTTTAAATCATTTAAAATAAAATAATGGGATAAAAGAGGATGCTAAAAAT AATAAATATATATGTATCAAAGTGTGCTTGTAATACCAGGCAAAGAATTAATAAGAGATAATATTATGGT TGGTGAAATGTTATGTATGGCTACATCCTTTCAATGAGCATTTATAGTTCCTTTAAAATATGCCTACTGA AGAAATATTTACATGCTAATTAACATGTGCATAGTACCACTAGGTATTATAGAGGATACCAGATGTTTGT AGTAGACACAGACCTTGCCCTAAGTCCTGGTCTTGATGTAGTCACTTTTTAGTCACTACAGGTGACTACA TTTAGTCACTACAAGTGACCTTCCTTCAATGGGGAAATAAAGGACTTTACAAAAGACGTAGAAGACAATT CTTAATATAAAAGTGATTTAGATCTTCACAAGTTTGTGAAGAGAAGCAGATGAGTGAAATAGAACACTAT CAATGTAAAATATTATTCTGAGGCCTCTGTAATGACTGGGAAGCAACAAGAGGGAGGTCATTTCAGAGAG AGAGGCTCTAGGTTCCAAGCTGGATGCTCAGGTCAGTGACTGCAGGTCCCCTCCACACCCATCACCCCAC ACCCTAACCCTCTTCAGTTGCTCACAAAGGTAGATAAATACCCACATTTTTGCCCTCTTCCATCTTGAAA CCCTGGAAACCCTTGCTTCCGCCAGGGGAGGTTACTTAGTATCTGTCACCCCAAGGGAACCAACGTCGAA GCCCAAGAATAAGAGTCAATACTCCTACCAGAGGTTTACATTTTTCCCAGGGGTCTAGGTGGATATTCCT GGGAACCCCCGTCAACACAGGCATCTACAGTACAATCCAGGCCTCCTGTTTTCAGCAGGGGCTGCAAGAG CACTGCAGCCTTTTCCCCAGAGGTGTCAGTTTGGCCCAGTAAAGATTGCCCCTGAGAAAACACATGGGCA ATTAGAGCAAAGTTCCTATGTTCTGGTAACATTTAATTGTGCTATTTCTCAACCTCCTCTGCACCCACAC ACTCACACACAACATTTATTCCACTGACTTCAAAGGAAGCTCAACGTGTTAAAAATATGTGTGGGAACAA AGAAGGGAGTTTGAAATTGGTCTAAACTCTGTATAACTGGGTTTGACACGTACATTAGGATTTTACAAGT ATGTATTTAATCTTTTTTTAAAAAAAGCGTTTACATAGGGTTCAGAATAATGACAATAAATCAACATTTC TATTGTCCATTTGTGTGTTTTCATAGTAAATAATGCTCATTTATCCTTAACCAGTAATACATACTTATGG GCTTAAATTAGCAAAAGCCTCTCAAAAAGTAGCTCCACTCATTTATCCACCAGTGTCCAGATGCCATCCA GCACATGAGGAGCTCCCAGAAAGGAGCAGGGAACAAACTAGGGCTGTCAGGAGTGGAGGAGAAAGAATGG CATATGCAAAAAGGAGCTGTAATTAAATCCAAGGGAACATGGCACACTCTAGTCTTTTGCACGAGACAAA GGGCAATCCTGGTAAAAATACAGATCCCCAGGCCCCACCCCAAAGAGTCTGATCTGATTCTGAAATGGGG CCGGAGAATCTGCATTTTAACAAGCACCTTCACCAGGTGATCCTTTTGCTGAGAACCCCTGAGAAATGAG AACCCTGTGCTAGTGCTGAATGGAGCATTATATTCCAGAGTTGAAGTTTGGTGATCAGTTTTCCAGATGG AGCTGGTCCTTGGTGCATACCTGGGTATAAATCCAAGCCAATTCAGGTATATGAGCTGATATTTCAACCG AAACACTATCTATAGCCTAAATTTTTTCTAATATTCTGTTTGGTATGAATTCTAGAAAGTTGTAAATGCT ATATTTCCTTCTCATCTATTTCTGGACTTTGTCCCAAGACCAAATCCCAGGGCATCTGATAGACATTCAT TGCATACATTTTTCTGTAAACATGAAAACTGAATTGTCTAATAGAAAAGGGCAAGGAAGTAGAAAATAAG AAATCATCATCAGAAGTGGTTTGTTTTGGAATTATATTGTCCAGCTGCATAACAAATCACCCCCAAAATT GAGTCGCTTAGAACAACAAACATTGATCCTCCACAGTTTCTGTGTGTTAGGAATCAAAGTGATTTAATTT AATGGTTCTGCTCAGGGTCTCTCGGGGGCTGCAATCCAGGTCTCAGGCTGGGATCCTTTCAAGGCTGAGC TGGGGAAAGATCCATGTCTAAGCTCACTCACATGGCCGATGGCGGGATTCAGTTCCTCTTAGGCTGTCAG ACTGAGGGCCTCCGTGTCTCAGTGGTTTTAGCCAGAGCCCTCTCTCAGTTCCTTTCCACATGGGCCTCTC CACAGGGCAACTCACAACATGGCAGCTGGTTTCCAGTAGAGCAAGCGAGTGAGAGAACAAGAAAGGCAAG CAAGGTGAATGTCCCAGTCTTTTGTAACCTCATCTCAGAAGTGTTAACCCATCACTTTTGCCATGTTTTA TTATTTAGAAGCAAATCACTAAGTCCAGCCCACAATTAGAGGGATGGCATTACACAAGGGAATGAACACC AGCAGACAGGGTCATTGAAAGCCATCTTAGATGCTGTCTATCGCATCTAAGTGTGATTTTTCCAGATGAA AAGAATATATTAATTTGTTTCAGTCTTAGTCGATGTGCCATCCCATTTGTGCTTTGCTAAAACTTGTATC AATGTAAAGCAAACATTTTCTGATACAATTTAGGTAGTGTATTGTGGTAATAGAGACCAGTAGTGTTGAA AAGATATGTTGAGGTCAGAAATTAAGCTCATGTTTCTAAAAGAGGAGATATGTACAACTACTATGCAAGC CAACAGGAAAGAGTGTTTTAAGAATGCTTTCTGCTACAGGTAACTAAAAACCTAAACAGCTGTGGCTTTA AAATAAAGGTATATCTAAGTCACATAAGCAAAAGTCTAGGGGTGGGCAGCTGCTGGCATTGCTTCAGTAG CTTGATAATGGCAAAAGCAGCATCTCTTCTATTTCCTTGGCCTTCTAATCATGCATGTCACCTCACAATC ACAACATAGGCAACACCTCATATTCTAAGCAAGATGAAAAGGGCAAAGAGTCATGCCATATGCCTCTGTC TCTTTTCATAAGGAAGACAAAGCTTCCCTGGAAGTCCCCTCTAGCAGATTTCACTTAGATCTCATTGGCC AGAACTGAGTCACATGCCTGCCTTAAACCAATCACTCACCAAGAAGACTAACATTATCATGGCAAGTCTA AACCAACTGTGACTCATCTCTGAAATCAAAGGATTATTACCATTACCCGAATCCATCAGGATCCTGTTGG CAGAGAAGTGGGACTGTAAATTTTGAGCAGGCAACAAACAAGTCTTCTGTAAACTTCTTATGTGTTGTTT TTTATGTGTTCTATATATCCAGTAGAATCACAATTTCCAATAACAGTCTAAAAAGATATTTTCCAATAGA AACAGAATGTGTAAGATCATTACTTATGAAATCCCAAATGTACTTAAGGTTTCCTTCTTGAAAATTCCTT ATTCAAAATAAAATGTCCAGATTTTGAAACCCAGAAAAGATTCTATATTTTAAAAATCCTGTGCACATGT AAACTGTTTTTCAAATATTGCCTTCAGATACATTGAACAGAATGAAATCTTCTGAGATTTACTACATCAG CCAAGTATTATCAAAACAAACAGGACAGATTGCTTTTCTTGACGTCTGCTGCTTGATTTGTGTTAACTCA TGTTTCTGAAATTGTAGTATCATAAGCCAATGCTGCACAAAGGTATTTCATGTCATTTATAAAAATCTAG TAATGTAAACTGTTAACTCCTTATAAAGCATCTGTTGACACACAAAAATATCACTGAAGTGCATTTATGC CTTTCTTCTTTAGGTCTGCATAATACTTCCCTCCAGAAGGCCAAGTTGTTCCATAAATTACAGAACAGAA AGTTGGTTGTGGGAGGAATAGCTCAACCTCATCTGAGGCATCCCACTCTAAGAAACTAATGGCACCTACA CCTCTTGGGCATTGAGTTTTTAAGCCCATTTTTAATTCTTGTTCTGCTCATATTCTAAGTGAGCACATAA AGTGCTGCTCCAAGCAAGACCAGCCCTTGTAGAAGGGCAAGTGCAGTCAGTCCCCTAGGAAACGGGACTG GGGAGTGATCGTTTCAATGAGAGATAAATCAAACTGATGCTAAACATGAACAATGAGCCCATTAGAGATT GTGAGAAAGAGGCATCATCATCCACTCAACAATAGGCCTGTGGGACCTCTTGATAGCCTGAGGATGTTTA ATTTCAGGTGCAGGTATCCAGAATGTAGCAGCTAGACTGATCAAGGATGTGTGATGACAGCAAGCAGTAG TGGAAGAGCCCAGGAGAGTTCCTAAGCCTGAATTGCAATCCTGTGCTGCCATAAAATGGGAAGATATACT TGGTCCAGTCATCTGACAGCTTTGGTCATCAATTTCTCTATCTCATATGTGACTCTATTGCTTTAAGAAT CCCTTTAGCTTTAAATATCTATGAATCTGCTGAAGCAGCTGTGCTTTGATTGATGTGGATCTCTGAACTC CCTTAAATACAAAGACCAATTATTTAGCCGAGCTTTGTTGGATTCAGTGCATTCTGAATACATGTCAAAA TATACTTGGATTTGTAAAAAATATTCCTTCCTGTTTTTTTCACCATAGATAGATGTACAAAAATGTCCGT GTTCACACCGTGGAAAGGACATTTCTCATAAACTCACACAGAGATACCTTTCAAGTCAATGCCTTAGAAA GCAATGAGAGATTTAAAGGAGACCTAGAGATATGAATGGAGTAGGCAGAGAAGGTATGTGAGGAGAATGA TGTAACTTCCTAGGGAAAAAGTATGAAGCACAAGGCTGGACATAGACCTGGGAATCAGGAAATTAGAGTT CTAATTGCAGCTTTTCCATTGATTCACTTGGGATCTTGAGAATATCTGTCTCATTTTAATCATTCTGGGC CACAGTTTCCATATCTGTCAATTAGAGTAAGAGTCCCTGGCTGGGTGCCCAGGATTGTGAGAACATACCA TTCAGAGCCATAAAAATGCAATCAGTACCAATAATGTACTAGTACCAGTACCTAGGATGCAAAACATCCT AGATACTAGGTGTCCTAACTTAAAGTGGAAACATTAACAAGAGTAATTCTTTGAATCATCAAACTGGGAA TATTTTAGGAAGCATATCTATCTGGGTGAAAACTAAGCAAATAAGACAATTGTAAAGGCTTGTGATCTCA GGAATACAAAGGCAAAAATGCGCAGACTTGAAATATGACAAGTTCTAGTTTTGTCACTTAGCATCTCTGT GACCTTGGATAATTTCTTAACCCCCGGCAGTATTCTCATCTGTAAAATGGGAATAATGACATGCACTTCA GTGGTTTGTGGTGAAGATTATTACAAATAGAAATTAGCTCTTTTGAGCCACTGGTGGGGTTTAAATTCCC AGCCCTTATGTGCTTTGCAGCTGTTAGTTCCTCTTATTACAATTGTCTATTTAAAAACCTAGTCACAGCC CGGTGCAGTAGCTCACGTCTGTAATCCCAACACTTTGGGAGGCCAAGGCAGGAGAACTGCTTGAGCTCAG GCGTTCAACATCAGCCTAGGCAACATAGTGAGACCCTCTCATCTCTACAAAAAGCAAAAAATTAGCCAGT GATGCATGGCTGTAGTCCCAGCTATTCTGAGGGCTGAAGTTGGAGGATTGCTTGAGCCCAGGAGGTCAAG GCTGCAGTGGGCAGTGATCATGCCGCTGCACTCTAGCCTGGATGACAGAGCAAGAACCTGTCTCCAAAAA AAGAAAGGAAGGAAGGAAGGAAGGAAGGAAGGAGGAAAGAAAAGAAAGAAAGAAAGAAAGAAAGAAAGAA AGAAAGAGAGAGAGAGAGAGAGAGAGAGAGAAAGAAAGAAAGAAAGAAAGAAAGAAAGAAAGAAAGAAAG AAAGAAAGAAAGAAAGAAAGAGAAAGAAAGAAAGAAGGGAGGGAGGGAGGGAGAGGAGAGAAAGAAAAAG GAAGGAAGGAAGGAAGAGAGAGAGAGAGAGAGAAAGACCTAGTCACCAAAAGCAAGAGATTTTTTAAATG CTACTATTTTTTGGGCATTTACTAATCATATTGCTATGCTCTGCACCCAAGCTAAGTAATTTAAATAAAT TATCTCATGTACTCCTCTAAAACTAATTACTGCTGTGTAAATGGAGGTAGAAAGAAACTAAGCTTTATTT CTGCCTCTATTGTTTCTTTAACCTGCCTTGCTTCCTTTTTCAGTTGCACCTAATTGGCTGTACTTTTAGT TTTCTTTAAAACTGCCTTAAATTTCAAAGACTAAAGCAGCAATAACTAACTGAATATATTTATATAACAT GTTATTTTTGTCATGTTGCTTTCCACCCCTGGAGACCTGCTCTAAATTCACTTGGACGTTTGAGGATAAA TCATGCTCACTAGCAGTTTCTGAAAATGCAGTTTCACTGAAAATGCAGGCATCCAGAAATTTAGTAAGCA ACTTAAAAGAAAGTGTAAGAATCTCCTATGTATTCATTGAAAAATAATTTGAATTTATGCTTAGAAAAAT AGAATTATTATTAAGAAATCTTACACACTCATGTTTTTAAATATCTTCACTAAGGACCAATTGTGTATAT GGTGTAACACTGTCCTCAAAGAACATGCCGGGAGAATTGTTGCAGTTACCAGAGGGTTAAATTTGGCAAA CTCTTTTTTATTAACGTGCCTTTTAATTATGAAATAGCATACTCACCTTAGATAAAATTTGAAAACCATT TTTGTAAAGTGGTACAATATTGAAGAAAGTTGATAACTTTCAGACCAGATTTAAGCCTCAAATCTACCTC TCTTTTACCTGGACAACTCATTAGCATTTCTGAACCTCACATTTTTTCTATAAAGTGAGAATACTATATT ATAGAGTTGTTGTCAGTTAAATGAGAACAGTGTCTGATCACAACTAGTCAACAAATGTTCACAACTCTTC CCCTCCTAGGAAAAGAATCTCAAGGCAGACCTGCTTCGGGTCTGCTCTGTAAAGAGGTAGGAATCCTCTG CTCCCGGTAAATTGCTTCCTAACCTTCTTTGGTAATAGACTATTTTTTAATAAAGGTGATGGATCATTTC CCATTATACACTCAAAATGTGTGTCCATTTCAGGGCAGTCATGGATGACCATTGCCCATCTTTTGACCCC AGATTAAGAACACCTGCTGTAGTATTTTAATTCTGCCTTCAAATCCTCTTACAAAACAAAGACATCTTTA AAAAATAAAATTCTTTAGGTGTCTTGCAGTTGAATGCAGGAAAACCAGAGCCCCTTATTTTTGATAGTTT TGGGAAGAATGCAGTGTCAGAACACAAACCCATAATAGACAAATAATTTGCACAGAAACTTCATAAAAGT ATTGACCTGATTTGCCATGTATTTGCCACCTTTTAAAACACACAACTAAATGTTTACCCTGTGTCTAGAT CCAAATGGGTGAAGAAAAATGAGTGACAATACATCTACTTAAGCTCACTTACATAATTGTGGCCATGCCG TTTTTTTCACATTACATTATTAGAACATTGGACAATAAGTCAAGAAACAGAATGTTCTACAAAATAAACT TTAAAAATTGGTAAGCATCATGTGCTTTTTCCAGAAGACATTTTATTTTGTTGAATCAAAGGTGGCTCTT TGGCACTGAGTAGCTCCGTGGAGTCATGGCAGTCCTCATTCCCTAATCCTGAGCCTGCCTGAGTCGCTGC TGTCAGTCATCCACTTGTTGGGATTTCAAACTGCATTAAATCCCCTCCTATAGCTGTCACTGCCAAGCAG TTGCACTGGCTCTGTCCTACCTTTCTGTTGGTAATTCTGTTTTTAATCCTGTGCTTCAGTGTAGTTTATA TAAATCTTTACAGAGGGATAAAACTTCCTGTAATTAATTGTTTGGGTGAACATGTACCTGGGAGAGCTAT TGGGAAAGGGGCCAAATTTGCATTCCAGCTCCTTTCATCCCCACCCTTGAGCTAACCAAGTCCTGTGGAT TCTTCCCTTAGCATCTCTGGAACCTTCTTTTCTTTTCTTTTTTTTATGACCACCTTTCCAGTCCTGGCCC TTCAAACTTGAGTGACAGCAACAGTCTCCCTGCCTTGAGTCTCTTTCCTCCTTCTCCCAGTGTGCATACG GTTGTCAAACTCATCTTGATAAACTACTGCATCGATTGTGGCTACACTCCCCTGCTCCCACATCTTCCAT AGACCCCACTGTCTGTAAAATAATATTCAGTCTGGCCTCAACCTGTCTTTCCAGCCTCGGTGACACAGGT CTATTCTGCCTGAGACACTTACTATGACACCCTTGCTTGTTCCTGGGGCTTTGACACATTTCCAACGTCC CATTGTTCTTCCTCTCCAAATCAGCCAATTGCCCAAGCCCTGCTCAAATCTCCCACCTCATGAAGCCTTC TTGATGCCTCCCAGCACACCATGATCTAATTTCCTGAAGTAATTATGCTAATTGGGCATTTGAAGAATTG TTAACCGATTATCAACTAACTGCCCCTTAACATTGCATGTGTAGTTGTCTTCAAAGGCAGTTAAATTATG TCATGTTCCTTACATTGTACTGAGTGCCTCGTATCCTTATCCATGTTTGGGGGTTTTACTTTAAGTCAAG AAATTTAATCACATCCATTTGGTTTTCTCTAGAGCTGTAGTTCTCAACCTTTTGTGTGGTAGAGAAACAC CTAGAGAACATGTTTAAAAATATCCTGGGTTCCACCCTTGAGAGATAATAAGGTCCAAGGGGAACCCAAA TATCTGTGTTTCAGGTCAGCTTATTGGCTCATCCTATTATACCAACTCCTCAGAAGGCCAAGGTGGGTGG ATTCCTTGATCTCAGGCGTTCAAGACCAGCCTGGGCAATATCGTGAGACTCCATCTCTTAAAAAAAAAAA AAAAAAGGATTAGCCAAGTGTGGTGGCATGAACCTGTGGTCCCAGCTACTTAAGAGGCTGAGGCAGACAG ATTGCTTGAGCCTGGGAAGTCGAAGCTGCAGTGAGCCATGATCATGCCACTGCACTCCAGCCTGGGTGAC AGAGCAAGACCCTGTCTCAAAAAAATAAAAATGAAAAAAATCTGTGTTCCCAAGTTCCAAGTGATGCTGA TGCTGCTGGTTGCCTTTAAGCATCTCACAAAGAACGAACTCATAAATGCTAATACAGTATATGTCTATGG ATACTGAATAGTGGGTTTTTTTTCTCTTTTCTTCTATTCTGTGCTCATGTTGTGTCACTTCTTCCTTTTA GATTGACTTTGAAGATGTGATTGCAGAACCAGAAGGGACACACAGTTTTGACGGCATTTGGAAGGCCAGC TTCACCACCTTCACTGTGACGAAATACTGGTTTTACCGCTTGCTGTCTGCCCTCTTTGGCATCCCGATGG CACTCATCTGGGGCATTTACTTCGCCATTCTCTCTTTCCTGCACATCTGGGCAGTTGTACCATGCATTAA GAGCTTCCTGATTGAGATTCAGTGCATCAGCCGTGTCTATTCCATCTACGTCCACACCGTCTGTGACCCA CTCTTTGAAGCTGTTGGGAAAATATTCAGCAATGTCCGCATCAACTTGCAGAAAGAAATATAAATGACAT TTCAAGGATAGAAGTATACCTGATTTTTTTTCCTTTTAATTTTCCTGGTGCCAATTTCAAGTTCCAAGTT GCTAATACAGCAACAATTTATGAATTGAATTATCTTGGTTGAAAATAAAAAGATCACTTTCTCAGTTTTC ATAAGTATTATGTCTCTTCTGAGCTATTTCATCTATTTTTGGCAGTCTGAATTTTTAAAACCCATTTAAA TTTTTTTCCTTACCTTTTTATTTGCATGTGGATCAACCATCGCTTTATTGGCTGAGATATGAACATATTG TTGAAAGGTAATTTGAGAGAAATATGAAGAACTGAGGAGGAAAAAAAAAAAAAAGAAAAGAACCAACAAC CTCAACTGCCTACTCCAAAATGTTGGTCATTTTATGTTAAGGGAAGAATTCCAGGGTATGGCCATGGAGT GTACAAGTATGTGGGCAGATTTTCAGCAAACTCTTTTCCCACTGTTTAAGGAGTTAGTGGATTACTGCCA TTCACTTCATAATCCAGTAGGATCCAGTGATCCTTACAAGTTAGAAAACATAATCTTCTGCCTTCTCATG ATCCAACTAATGCCTTACTCTTCTTGAAATTTTAACCTATGATATTTTCTGTGCCTGAATATTTGTTATG TAGATAACAAGACCTCAGTGCCTTCCTGTTTTTCACATTTTCCTTTTCAAATAGGGTCTAACTCAGCAAC TCGCTTTAGGTCAGCAGCCTCCCTGAAGACCAAAATTAGAATATCCATGACCTAGTTTTCCATGCGTGTT TCTGACTCTGAGCTACAGAGTCTGGTGAAGCTCACTTCTGGGCTTCATCTGGCAACATCTTTATCCGTAG TGGGTATGGTTGACACTAGCCCAATGAAATGAATTAAAGTGGACCAATAGGGCTGAGCTCTCTGTGGGCT GGCAGTCCTGGAAGCCAGCTTTCCCTGCCTCTCATCAACTGAATGAGGTCAGCATGTCTATTCAGCTTCG TTTATTTTCAAGAATAATCACGCTTTCCTGAATCCAAACTAATCCATCACCGGGGTGGTTTAGTGGCTCA ACATTGTGTTCCCATTTCAGCTGATCAGTGGGCCTCCAAGGAGGGGCTGTAAAATGGAGGCCATTGTGTG AGCCTATCAGAGTTGCTGCAAACCTGACCCCTGCTCAGTAAAGCACTTGCAACCGTCTGTTATGCTGTGA CACATGGCCCCTCCCCCTGCCAGGAGCTTTGGACCTAATCCAAGCATCCCTTTGCCCAGAAAGAAGATGG GGGAGGAGGCAGTAATAAAAAGATTGAAGTATTTTGCTGGAATAAGTTCAAATTCTTCTGAACTCAAACT GAGGAATTTCACCTGTAAACCTGAGTCGTACAGAAAGCTGCCTGGTATATCCAAAAGCTTTTTATTCCTC CTGCTCATATTGTGATTCTGCCTTTGGGGACTTTTCTTAAACCTTCAGTTATGATTTTTTTTTCATACAC TTATTGGAACTCTGCTTGATTTTTGCCTCTTCCAGTCTTCCTGACACTTTAATTACCAACCTGTTACCTA CTTTGACTTTTTGCATTTAAAACAGACACTGGCATGGATATAGTTTTACTTTTAAACTGTGTACATAACT GAAAATGTGCTATACTGCATACTTTTTAAATGTAAAGATATTTTTATCTTTATATGAAGAAAATCACTTA GGAAATGGCTTTGTGATTCAATCTGTAAACTGTGTATTCCAAGACATGTCTGTTCTACATAGATGCTTAG TCCCTCATGCAAATCAATTACTGGTCCAAAAGATTGCTGAAATTTTATATGCTTACTGATATATTTTACA ATTTTTTATCATGCATGTCCTGTAAAGGTTACAAGCCTGCACAATAAAAATGTTTAACGGTTAAACAGTC A    Download   Select all
Length	36401
OMIM ID	601047
HGNC ID	HGNC:1527
Unigene ID	Hs.74034
Ensembl ID	ENSG00000105974
PharmGKB ID	-

mRNA Information

mRNA ID	NM_001753.4
Exon	join(1..308,1741..1905,34162..36401)
mRNA Sequence	>857 GGGAGAAACGTTCTCACTCGCTCTCTGCTCGCTGCGGGCGCTCCCCGCCCTCTGCTGCCAGAAC CTTGGGGATGTGCCTAGACCCGGCGCAGCACACGTCCGGGCCAACCGCGAGCAGAACAAACCTT TGGCGGGCGGCCAGGAGGCTCCCTCCCAGCCACCGCCCCCCTCCAGCGCCTTTTTTTCCCCCCA TACAATACAAGATCTTCCTTCCTCAGTTCCCTTAAAGCACAGCCCAGGGAAACCTCCTCACAGT TTTCATCCAGCCACGGGCCAGCATGTCTGGGGGCAAATACGTAGACTCGGAGGGACATCTCTAC ACCGTTCCCATCCGGGAACAGGGCAACATCTACAAGCCCAACAACAAGGCCATGGCAGACGAGC TGAGCGAGAAGCAAGTGTACGACGCGCACACCAAGGAGATCGACCTGGTCAACCGCGACCCTAA ACACCTCAACGATGACGTGGTCAAGATTGACTTTGAAGATGTGATTGCAGAACCAGAAGGGACA CACAGTTTTGACGGCATTTGGAAGGCCAGCTTCACCACCTTCACTGTGACGAAATACTGGTTTT ACCGCTTGCTGTCTGCCCTCTTTGGCATCCCGATGGCACTCATCTGGGGCATTTACTTCGCCAT TCTCTCTTTCCTGCACATCTGGGCAGTTGTACCATGCATTAAGAGCTTCCTGATTGAGATTCAG TGCATCAGCCGTGTCTATTCCATCTACGTCCACACCGTCTGTGACCCACTCTTTGAAGCTGTTG GGAAAATATTCAGCAATGTCCGCATCAACTTGCAGAAAGAAATATAAATGACATTTCAAGGATA GAAGTATACCTGATTTTTTTTCCTTTTAATTTTCCTGGTGCCAATTTCAAGTTCCAAGTTGCTA ATACAGCAACAATTTATGAATTGAATTATCTTGGTTGAAAATAAAAAGATCACTTTCTCAGTTT TCATAAGTATTATGTCTCTTCTGAGCTATTTCATCTATTTTTGGCAGTCTGAATTTTTAAAACC CATTTAAATTTTTTTCCTTACCTTTTTATTTGCATGTGGATCAACCATCGCTTTATTGGCTGAG ATATGAACATATTGTTGAAAGGTAATTTGAGAGAAATATGAAGAACTGAGGAGGAAAAAAAAAA AAAAGAAAAGAACCAACAACCTCAACTGCCTACTCCAAAATGTTGGTCATTTTATGTTAAGGGA AGAATTCCAGGGTATGGCCATGGAGTGTACAAGTATGTGGGCAGATTTTCAGCAAACTCTTTTC CCACTGTTTAAGGAGTTAGTGGATTACTGCCATTCACTTCATAATCCAGTAGGATCCAGTGATC CTTACAAGTTAGAAAACATAATCTTCTGCCTTCTCATGATCCAACTAATGCCTTACTCTTCTTG AAATTTTAACCTATGATATTTTCTGTGCCTGAATATTTGTTATGTAGATAACAAGACCTCAGTG CCTTCCTGTTTTTCACATTTTCCTTTTCAAATAGGGTCTAACTCAGCAACTCGCTTTAGGTCAG CAGCCTCCCTGAAGACCAAAATTAGAATATCCATGACCTAGTTTTCCATGCGTGTTTCTGACTC TGAGCTACAGAGTCTGGTGAAGCTCACTTCTGGGCTTCATCTGGCAACATCTTTATCCGTAGTG GGTATGGTTGACACTAGCCCAATGAAATGAATTAAAGTGGACCAATAGGGCTGAGCTCTCTGTG GGCTGGCAGTCCTGGAAGCCAGCTTTCCCTGCCTCTCATCAACTGAATGAGGTCAGCATGTCTA TTCAGCTTCGTTTATTTTCAAGAATAATCACGCTTTCCTGAATCCAAACTAATCCATCACCGGG GTGGTTTAGTGGCTCAACATTGTGTTCCCATTTCAGCTGATCAGTGGGCCTCCAAGGAGGGGCT GTAAAATGGAGGCCATTGTGTGAGCCTATCAGAGTTGCTGCAAACCTGACCCCTGCTCAGTAAA GCACTTGCAACCGTCTGTTATGCTGTGACACATGGCCCCTCCCCCTGCCAGGAGCTTTGGACCT AATCCAAGCATCCCTTTGCCCAGAAAGAAGATGGGGGAGGAGGCAGTAATAAAAAGATTGAAGT ATTTTGCTGGAATAAGTTCAAATTCTTCTGAACTCAAACTGAGGAATTTCACCTGTAAACCTGA GTCGTACAGAAAGCTGCCTGGTATATCCAAAAGCTTTTTATTCCTCCTGCTCATATTGTGATTC TGCCTTTGGGGACTTTTCTTAAACCTTCAGTTATGATTTTTTTTTCATACACTTATTGGAACTC TGCTTGATTTTTGCCTCTTCCAGTCTTCCTGACACTTTAATTACCAACCTGTTACCTACTTTGA CTTTTTGCATTTAAAACAGACACTGGCATGGATATAGTTTTACTTTTAAACTGTGTACATAACT GAAAATGTGCTATACTGCATACTTTTTAAATGTAAAGATATTTTTATCTTTATATGAAGAAAAT CACTTAGGAAATGGCTTTGTGATTCAATCTGTAAACTGTGTATTCCAAGACATGTCTGTTCTAC ATAGATGCTTAGTCCCTCATGCAAATCAATTACTGGTCCAAAAGATTGCTGAAATTTTATATGC TTACTGATATATTTTACAATTTTTTATCATGCATGTCCTGTAAAGGTTACAAGCCTGCACAATA AAAATGTTTAACGGTTAAACAGTCAAAAAAAAAAA    Download   Select all
Length	2723

CDS Information

   

Location	join(279..308,1741..1905,34162..34503)
CDS Sequence	>gi|290542357:279-815 Homo sapiens caveolin 1, caveolae protein, 22kDa (CAV1), transcript variant 1, mRNA ATGTCTGGGGGCAAATACGTAGACTCGGAGGGACATCTCTACACCGTTCCCATCCGGGAACAGGGCAACA TCTACAAGCCCAACAACAAGGCCATGGCAGACGAGCTGAGCGAGAAGCAAGTGTACGACGCGCACACCAA GGAGATCGACCTGGTCAACCGCGACCCTAAACACCTCAACGATGACGTGGTCAAGATTGACTTTGAAGAT GTGATTGCAGAACCAGAAGGGACACACAGTTTTGACGGCATTTGGAAGGCCAGCTTCACCACCTTCACTG TGACGAAATACTGGTTTTACCGCTTGCTGTCTGCCCTCTTTGGCATCCCGATGGCACTCATCTGGGGCAT TTACTTCGCCATTCTCTCTTTCCTGCACATCTGGGCAGTTGTACCATGCATTAAGAGCTTCCTGATTGAG ATTCAGTGCATCAGCCGTGTCTATTCCATCTACGTCCACACCGTCTGTGACCCACTCTTTGAAGCTGTTG GGAAAATATTCAGCAATGTCCGCATCAACTTGCAGAAAGAAATATAA    Download   Select all
CCDS ID	CCDS5767.1

Protein Information

      

Protein ID	NP_001166366.1
Protein Name	Caveolin 1, caveolae protein, 22kDa
Molecular Wt. (Da)	16892
Protein Sequence	>857 MADELSEKQVYDAHTKEIDLVNRDPKHLNDDVVKIDFEDVIAEPEGTHSFDGIWKASFTTFTVT KYWFYRLLSALFGIPMALIWGIYFAILSFLHIWAVVPCIKSFLIEIQCISRVYSIYVHTVCDPL FEAVGKIFSNVRINLQKEI    Download   Select all
Length	147
Uniprot ID	P12429
Ensembl Protein ID	ENSP00000264908

Post-translational Modification Information (Source : HPRD)

Residue	Type	site
C	Palmitoylation	156
S	Phosphorylation	168
S	Phosphorylation	80
Y	Phosphorylation	14
S	Phosphorylation	88
S	Phosphorylation	88
Y	Phosphorylation	6
S	Phosphorylation	37;-
K	Acetylation	5
Y	Phosphorylation	25
Y	Phosphorylation	42

Enzyme Information

No matching records could be found.

PPi Information

(Click to view network : Source STRING)      View   

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    

Interactant Gene ID (Source: HPRD)	Gene Symbol	HPRD ID	Ref Seq ID	Technique	References
156	ADRBK1	182	NP_001610.2	in vitro	10085129
351	APP	100	NP_000475.1	in vitro	9553108
367	AR	2437	NP_000035.2	in vitro;in vivo	11278309
387	RHOA	1323	NP_001655.1	in vitro	9647788
660	BMX	2111	NP_975010.1	in vitro	11751885
683	BST1	2665	NP_004325.2	in vivo	11866528
695	BTK	2248	NP_000052.1	in vitro	11751885
1445	CSK	496	NP_004374.1	yeast 2-hybrid	11805080
1759	DNM1	3851	NP_004399.2	in vivo	11956154
1901	S1PR1	3578	NP_001391.2	in vivo	10921915
2064	ERBB2	1281	NP_004439.2	in vitro;in vivo	9685399
2099	ESR1	589	NP_000116.2	in vitro	11563984
2316	FLNA	2060	NP_001104026.1	in vitro	10637311
2319	FLOT2	580	NP_004466.2	in vivo	10212252
2697	GJA1	414	NP_000156.1	in vitro	11980479
2700	GJA3	415	NP_068773.2	in vitro;in vivo	11980479
2706	GJB2	413	NP_003995.2	in vitro;in vivo	11980479
2771	GNAI2	764	NP_002061.1	in vitro	8621645
2869	GRK5	2926	NP_005299.1	in vitro	10085129
2886	GRB7	3311	NP_005301.2	in vitro;in vivo	11075810
3265	HRAS	1813	NP_005334.1	in vitro	8621645
3611	ILK	3842	NP_004508.1	in vitro;in vivo	15722199
3643	INSR	975	NP_000199.2	in vitro	10598578
3791	KDR	1867	NP_002244.1	in vitro	12529448
4804	NGFR	1197	NP_002498.1	in vitro	9867838
4843	NOS2	1225	NP_000616.3	in vitro	11114180
4846	NOS3	1224	NP_000594.2	in vitro	8910295
4914	NTRK1	1869	NP_002520.2	in vitro	9867838
5156	PDGFRA	1429	NP_006197.1	in vitro	10066366
5337	PLD1	3855	NP_002653.1	in vivo	1   242   984   010   090   760
5595	MAPK3	3479	NP_002737.2	in vivo	12388423
5621	PRNP	1453	NP_000302.1	in vivo	10988071
5743	PTGS2	2599	NP_000954.1	in vitro;in vivo	11432874
5770	PTPN1	1477	NP_002818.1	in vivo	12176037
5777	PTPN6	1475	NP_536859.1	in vivo	12176037
5781	PTPN11	1470	NP_002825.3	in vivo	12176037
5792	PTPRF	1552	NP_002831.2	in vivo	12176037
5957	RCVRN	1558	NP_002894.1	in vivo	12507501
6011	GRK1	1585	NP_002920.1	in vitro	10085129
6342	SCP2	1700	NP_002970.2	in vitro	15182174
6654	SOS1	1681	NP_005624.2	in vivo	15976327
7046	TGFBR1	1822	NP_004603.1	in vitro;in vivo	11102446
7133	TNFRSF1B	1862	NP_001057.1	in vivo	11112773
7189	TRAF6	3833	NP_665802.1	in vitro	14665433

Pathway Information

                              

Pathway Name	Pathway ID
Bacterial invasion of epithelial cells	hsa05100
Endocytosis	hsa04144
Focal adhesion	hsa04510
Proteoglycans in cancer	hsa05205
Viral myocarditis	hsa05416

Structure Information

No matching records could be found.

Domain Information

ID	Location	Description
pfam01146	34-177	Caveolin
cl07832	34-177	Caveolin superfamily

Ontology Information

   

HPRD ID	111
Molecular Class	Structural protein
Molecular Function	Calcium ion binding (GO:0005509)
Biological Process	Cell communication (GO:0007154); Signal transduction (GO:0007165)

SNP Information

View SNP Geneview Report