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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
CCDC6 8030 coiled-coil domain containing 6  10PTC, TPC, H4 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
22399611   2012Cell line : HCT 116

Source : -

Sample Type : -

No. of Sample : -

Stage : -

real time RT-PCR,2D Gel electrophoresis ,Peptide mass fingerprint, western blotting.Mutation- CCDC6 contributes to cancer development, possibly through malignant pathways involving 14-3-3?.


Gene Details



NC_000010.10 (61548505..61666414, complement)

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Gene Type protein coding
Gene Family -
Description This gene encodes a coiled-coil domain-containing protein. The encoded protein is ubiquitously expressed and may function as a tumor suppressor. A chromosomal rearrangement resulting in the expression of a fusion gene containing a portion of this gene and the intracellular kinase-encoding domain of the ret proto-oncogene is the cause of thyroid papillary carcinoma.[provided by RefSeq, Sep 2010]  
Chromosome 10
Location 10q21.2
Start 61548505  
End 61666414  
Strand -  
Gene Sequence

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Length 117910  
OMIM ID 601985   
HGNC ID HGNC:18782   
Unigene ID Hs.591360   
Ensembl ID ENSG00000108091   
PharmGKB ID PA134904022   

mRNA Information


mRNA ID ?NM_005436.4
Exon join(1..535,53955..54104,74004..74132,91902..92005, 93862..94022,99579..99735,102137..102237,112060..112184, 113546..117910)  
mRNA Sequence

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Length 5842  



CDS Information


   
Location233..1657
CDS Sequence

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CCDS ID CCDS7257.1



Protein Information


      
Protein IDNP_005427.2
Protein Namecoiled-coil domain containing 6
Molecular Wt. (Da)0
Protein Sequence

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Length 474  
Uniprot IDO95373
Ensembl Protein ID ENSP00000369042  



Post-translational Modification Information (Source : HPRD)


Residue Type site
SPhosphorylation240
SPhosphorylation244
SPhosphorylation254;-
SPhosphorylation240;-
SPhosphorylation328;-
SPhosphorylation323;-
SPhosphorylation325;-
SPhosphorylation52;-
SPhosphorylation249
TPhosphorylation349
SPhosphorylation351
TPhosphorylation376
SPhosphorylation352
YPhosphorylation356
SPhosphorylation371
YPhosphorylation372
SPhosphorylation361
SPhosphorylation367
SPhosphorylation362
SPhosphorylation363
TPhosphorylation115
SPhosphorylation243
SPhosphorylation418
SPhosphorylation350
SPhosphorylation46
SPhosphorylation65
SPhosphorylation284
TPhosphorylation380
TPhosphorylation386
SPhosphorylation391
SPhosphorylation413
SPhosphorylation395
SPhosphorylation419
SPhosphorylation431
SPhosphorylation472
TPhosphorylation185

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

No matching records from HPRD source could be found.

Pathway Information


            
Pathway Name Pathway ID
Pathways in cancer hsa05200
Thyroid cancer hsa05216


Structure Information


No matching records could be found.

Domain Information




ID Location Description
PRK14644118-207  PRK14644
cl00259118-207  Sm_like superfamily
cd0018796-330  TOP4c
cl1908496-330  TOP4c superfamily
pfam0975552-341  DUF2046
COG119655-336  Smc
TIGR0216955-333  SMC_prok_A
COG119655-330  Smc
TIGR0216855-326  SMC_prok_B
COG119655-315  Smc
COG119655-318  Smc
TIGR0216855-318  SMC_prok_B
COG119655-336  Smc
PRK0391856-330  PRK03918
TIGR0216955-318  SMC_prok_A
TIGR0216856-326  SMC_prok_B
TIGR0216855-213  SMC_prok_B
TIGR0216955-335  SMC_prok_A
pfam13166102-280  AAA_13
TIGR0216855-291  SMC_prok_B
pfam0562255-311  HOOK
TIGR0216955-254  SMC_prok_A
COG041955-330  SbcC
TIGR0216956-326  SMC_prok_A
TIGR02168139-336  SMC_prok_B
COG041954-330  SbcC
pfam04111128-274  APG6
pfam0246368-336  SMC_N
TIGR02168110-328  SMC_prok_B
PRK1270494-233  PRK12704
COG041957-336  SbcC
PRK0040996-238  PRK00409
TIGR0216954-335  SMC_prok_A
pfam04111172-320  APG6
COG491362-343  COG4913
PRK12704118-237  PRK12704
TIGR0216955-237  SMC_prok_A
pfam0411156-205  APG6
pfam0052174-251  DNA_topoisoIV
TIGR02168163-335  SMC_prok_B
COG041955-330  SbcC
COG2433227-332  COG2433
PRK0391855-335  PRK03918
TIGR0452355-233  Mplasa_alph_rch
pfam0149650-237  V_ATPase_I
pfam0246368-332  SMC_N
COG041957-285  SbcC
smart0043449-246  TOP4c
TIGR0421155-151  SH3_and_anchor
pfam1212886-330  DUF3584
TIGR0421155-167  SH3_and_anchor
pfam08317141-277  Spc7
PRK0391855-330  PRK03918
TIGR0452357-330  Mplasa_alph_rch
TIGR0106998-231  mutS2
COG1579141-324  COG1579
COG4942144-330  EnvC
PRK0486361-318  mukB
COG243355-152  COG2433
COG1293155-315  YloA
PTZ0012193-326  PTZ00121
pfam06818144-324  Fez1
TIGR03346144-334  chaperone_ClpB
COG119655-176  Smc
PRK0391856-294  PRK03918
TIGR0061855-334  sbcc


Ontology Information


   
HPRD ID5896
Molecular ClassCell cycle control protein
Molecular FunctionMolecular function unknown (GO:0005554)
Biological ProcessBiological_process unknown (GO:0000004)  



SNP Information


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Drug Information


No matching records could be found.

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO