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General Information
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 19652364 | 2009 | Cell line : - Source : - Sample Type : Mouse model No. of Sample : - Stage : - | Histopathology and immunohistochemistry,In situ hybridization,real time RT-PCR | Up-regulation | - | CCK2R may be a potential target in the treatment or prevention of colorectal cancer. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | GPCR / Class A : Cholecystokinin receptors |
| Description | This gene encodes a G-protein coupled receptor for gastrin and cholecystokinin (CCK), regulatory peptides of the brain and gastrointestinal tract. This protein is a type B gastrin receptor, which has a high affinity for both sulfated and nonsulfated CCK analogs and is found principally in the central nervous system and the gastrointestinal tract. Alternative splicing results in multiple transcript variants. A misspliced transcript variant including an intron has been observed in cells from colorectal and pancreatic tumors. [provided by RefSeq, Dec 2015] | Chromosome | 11 |
| Location | 11p15.4 |
| Start | 6280841 |
| End | 6293363 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 12523 |
| OMIM ID | 118445 |
| HGNC ID | HGNC:1571 |
| Unigene ID | Hs.203 |
| Ensembl ID | ENSG00000110148 |
| PharmGKB ID | PA26143 |
mRNA Information
| mRNA ID | XM_005253210.1 |
|---|---|
| Exon | join(1..469,10059..10310,10478..10727,11036..12517 | mRNA Sequence | Download Select all |
| Length | 2453 |
Protein Information
| Protein ID | XP_005253267.1 |
|---|---|
| Protein Name | cholecystokinin B receptor |
| Molecular Wt. (Da) | 55739 |
| Protein Sequence | Download Select all |
| Length | 516 |
| Uniprot ID | P55209 |
| Ensembl Protein ID | ENSP00000261182 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 885 | CCK | 321 | NP_000720.1 | in vitro;in vivo | 1 043 849 012 695 520 000 000 000 000 000 000 000 000 |
| 886 | CCKAR | 322 | NP_000721.1 | in vitro | 14534299 |
| 5781 | PTPN11 | 1470 | NP_002825.3 | in vitro;in vivo | 16963136 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Calcium signaling pathway | hsa04020 |
| Gastric acid secretion | hsa04971 |
| Neuroactive ligand-receptor interaction | hsa04080 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| pfam00001 | 77-390 | 7tm_1 |
| PHA03087 | 58-397 | PHA03087 |
| PHA02638 | 56-188 | PHA02638 |
| PHA02834 | 58-188 | PHA02834 |
| PHA03235 | 55-195 | PHA03235 |
| PHA03234 | 28-206 | PHA03234 |
Ontology Information
| HPRD ID | 1245 |
|---|---|
| Molecular Class | G protein coupled receptor |
| Molecular Function | RNA binding (GO:0003723) |
| Biological Process | Regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism (GO:0019219) |
Drug Information
| Uniprot ID | DrugBank ID | Name | Type |
|---|---|---|---|
| P32239 | DB00183 | Pentagastrin | SmallMoleculeDrug |