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General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| CCL19 | 6363 | chemokine (C-C motif) ligand 19 | 9 | ELC, MIP-3b, exodus-3, CKb11 |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 24705643 | 2014 | Cell line : SW620, SW1116, LoVo Source : - Sample Type : - No. of Sample : - Stage : - | real time RT-PCR, Western blotting and immunohistochemistry | Down-regulation | - | �CCL19�may play a suppressive role in�colorectal�tumorigenesis. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Chemokine ligands, "Endogenous ligands" |
| Description | This antimicrobial gene is one of several CC cytokine genes clustered on the p-arm of chromosome 9. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene may play a role in normal lymphocyte recirculation and homing. It also plays an important role in trafficking of T cells in thymus, and in T cell and B cell migration to secondary lymphoid organs. It specifically binds to chemokine receptor CCR7. [provided by RefSeq, Sep 2014] | Chromosome | 9 |
| Location | 9p13 |
| Start | 34689567 |
| End | 34691274 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 1708 |
| OMIM ID | 602227 |
| HGNC ID | HGNC:10617 |
| Unigene ID | Hs.50002 |
| Ensembl ID | ENSG00000172724 |
| PharmGKB ID | PA35550 |
mRNA Information
| mRNA ID | ?NM_006274.2 |
|---|---|
| Exon | join(1..187,936..1068,1255..1348,1439..1708) | mRNA Sequence | Download Select all |
| Length | 684 |
Protein Information
| Protein ID | NP_006265.1 |
|---|---|
| Protein Name | chemokine (C-C motif) ligand 19 |
| Molecular Wt. (Da) | 0 |
| Protein Sequence | Download Select all |
| Length | 98 |
| Uniprot ID | O60496 |
| Ensembl Protein ID | ENSP00000276420 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 1236 | CCR7 | 2588 | NP_001829.1 | in vitro;in vivo | 9153236 |
| 2826 | CCR10 | 2586 | NP_057686.2 | in vitro | 10706668 |
| 51554 | CCRL1 | 7298 | NP_848540.1 | in vitro | 10706668 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Chemokine signaling pathway | hsa04062 |
| Cytokine-cytokine receptor interaction | hsa04060 |
| NF-kappa B signaling pathway | hsa04064 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd01119 | 27-87 | Chemokine_CC_DCCL |
| cl00134 | 27-87 | Chemokine superfamily |
| cd00272 | 29-87 | Chemokine_CC |
| pfam00048 | 23-86 | IL8 |
| smart00199 | 27-86 | SCY |
| cd00169 | 29-86 | Chemokine |
| cd00271 | 30-95 | Chemokine_C |
| cd00274 | 22-95 | Chemokine_CX3C |
| cd00273 | 30-86 | Chemokine_CXC |
Ontology Information
| HPRD ID | 4760 |
|---|---|
| Molecular Class | Chemokine |
| Molecular Function | Cell adhesion molecule activity (GO:0005194) |
| Biological Process | Cell growth and/or maintenance (GO:0008151) |
Drug Information
No matching records could be found.