Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| CCL20 | 6364 | chemokine (C-C motif) ligand 20 | 2 | LARC, MIP-3a, exodus-1, ST38, CKb4 |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 21912453 | 2011 | Cell line : - Source : - Sample Type : CRC tumor and normal tissue No. of Sample : 82 Stage : TNM Stage I-III | Real Time RT-PCR, ELISA, Western Blotting and immunohistochemistry | Up-regulation | - | - |
| 23790181 | 2013 | Cell line : - Source : - Sample Type : CRC tumor and normal tissue No. of Sample : Colorectal adenoma 15, colorectal adenocarcinoma 61 and colorectal liver metastases 16 Stage : TNM Stage I-IV | real time RT-PCR, ELISA and immunohistochemistry | Up-regulation | - | CCL20 and CCR6 may provide potential targets for novel treatment strategies of CRC. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Chemokine ligands, "Endogenous ligands" |
| Description | This antimicrobial gene belongs to the subfamily of small cytokine CC genes. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The protein encoded by this gene displays chemotactic activity for lymphocytes and can repress proliferation of myeloid progenitors. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2014] | Chromosome | 2 |
| Location | 2q36.3 |
| Start | 228678558 |
| End | 228682280 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 3723 |
| OMIM ID | 601960 |
| HGNC ID | HGNC:10619 |
| Unigene ID | Hs.75498 |
| Ensembl ID | ENSG00000115009 |
| PharmGKB ID | PA35551 |
mRNA Information
| mRNA ID | ?NM_001130046.1 |
|---|---|
| Exon | join(1..146,1613..1727,2466..2543,3221..3723) | mRNA Sequence | Download Select all |
| Length | 851 |
Protein Information
| Protein ID | NP_001123518.1 |
|---|---|
| Protein Name | chemokine (C-C motif) ligand 20 |
| Molecular Wt. (Da) | 0 |
| Protein Sequence | Download Select all |
| Length | 96 |
| Uniprot ID | Q8NFJ5 |
| Ensembl Protein ID | ENSP00000014914 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 1235 | CCR6 | 3498 | NP_004358.2 | in vitro;in vivo | 922 345 491 694 599 000 000 |
| 1462 | VCAN | 340 | NP_004376.2 | in vitro | 11083865 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Chemokine signaling pathway | hsa04062 |
| Cytokine-cytokine receptor interaction | hsa04060 |
| Rheumatoid arthritis | hsa05323 |
| TNF signaling pathway | hsa04668 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd01119 | 30-90 | Chemokine_CC_DCCL |
| cl00134 | 30-90 | Chemokine superfamily |
| pfam00048 | 26-89 | IL8 |
| cd00169 | 32-89 | Chemokine |
| cd00272 | 32-90 | Chemokine_CC |
| smart00199 | 31-89 | SCY |
| cd00271 | 33-92 | Chemokine_C |
| cd00274 | 52-83 | Chemokine_CX3C |
| cd00273 | 33-91 | Chemokine_CXC |
Ontology Information
| HPRD ID | 10440 |
|---|---|
| Molecular Class | Chemokine |
| Molecular Function | Molecular function unknown (GO:0005554) |
| Biological Process | Biological_process unknown (GO:0000004) |
Drug Information
No matching records could be found.