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General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| CCL25 | 6370 | Chemokine (C-C motif) ligand 25 | 19 | TECK; Ckb15; SCYA25 |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 22863617 | 2012 | Cell line : - Source : - Sample Type : - No. of Sample : - Stage : - | CCR9-constitutive and -inducible knockdown, SNAIL or CD26 knockdown | Unknown | - | Chemokine 25 (CCL25) and its cognate receptor chemokine receptor 9 (CCR9) inhibit & regulate colorectal cancer (CRC) invasion and metastasis. CCL25 stimulated cell proliferation by activating AKT signaling. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Chemokine ligands, Endogenous ligands |
| Description | This gene belongs to the subfamily of small cytokine CC genes. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity for dendritic cells, thymocytes, and activated macrophages but is inactive on peripheral blood lymphocytes and neutrophils. The product of this gene binds to chemokine receptor CCR9. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2011] | Chromosome | 19 |
| Location | 19p13.2 |
| Start | 8052340 |
| End | 8062663 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 10324 |
| OMIM ID | 602565 |
| HGNC ID | HGNC:10624 |
| Unigene ID | Hs.310511 |
| Ensembl ID | ENSG00000131142 |
| PharmGKB ID | - |
mRNA Information
| mRNA ID | XM_011528177.1 |
|---|---|
| Exon | join(1..181,425..483,661..783,3813..3930,4027..4160, 5462..5581,9879..10324) | mRNA Sequence | Download Select all |
| Length | 999 |
CDS Information
| Location | join(711..783,3813..3930,4027..4160,5462..5581,9879..9886) |
|---|---|
| CDS Sequence | Download Select all |
| CCDS ID | CCDS12194.1 |
Protein Information
| Protein ID | NP_001188288.1 |
|---|---|
| Protein Name | Chemokine (C-C motif) ligand 25 |
| Molecular Wt. (Da) | 14101 |
| Protein Sequence | Download Select all |
| Length | 149 |
| Uniprot ID | Q9NQC7 |
| Ensembl Protein ID | ENSP00000308928 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 2826 | CCR10 | 2586 | NP_057686.2 | in vitro | 10706668 |
| 51554 | CCRL1 | 7298 | NP_848540.1 | in vitro | 10706668 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Chemokine signaling pathway | hsa04062 |
| Cytokine-cytokine receptor interaction | hsa04060 |
| Intestinal immune network for IgA production | hsa04672 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd01119 | 28-91 | Chemokine_CC_DCCL |
| cl00134 | 28-91 | Chemokine superfamily |
| cd00272 | 30-91 | Chemokine_CC |
| pfam00048 | 28-90 | IL8 |
| smart00199 | 27-90 | SCY |
| cd00169 | 30-91 | Chemokine |
| cd00271 | 43-94 | Chemokine_C |
| cd00274 | 50-91 | Chemokine_CX3C |
Ontology Information
| HPRD ID | 420 |
|---|---|
| Molecular Class | Chemokine |
| Molecular Function | Catalytic activity (GO:0003824) |
| Biological Process | Metabolism (GO:0008152); Energy pathways (GO:0006091) |
Drug Information
No matching records could be found.