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General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| CCL5 | 6352 | chemokine (C-C motif) ligand 5 | 17 | RANTES, SISd, TCP228, MGC17164 |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 22205974 | 2011 | Cell line : HT29, CT26 Source : ATCC Sample Type : Mouse model No. of Sample : - Stage : - | TaqMan real time PCR,proliferation assay,Immunohistochemistry | Up-regulation | - | Data demonstrate the involvement of CCL5 in the pathogenesis of colorectal carcinoma and point to its potential value as a therapeutic target. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Chemokine ligands, "Endogenous ligands" |
| Description | This gene is one of several chemokine genes clustered on the q-arm of chromosome 17. Chemokines form a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of the N-terminal cysteine residues of the mature peptide. This chemokine, a member of the CC subfamily, functions as a chemoattractant for blood monocytes, memory T helper cells and eosinophils. It causes the release of histamine from basophils and activates eosinophils. This cytokine is one of the major HIV-suppressive factors produced by CD8+ cells. It functions as one of the natural ligands for the chemokine receptor chemokine (C-C motif) receptor 5 (CCR5), and it suppresses in vitro replication of the R5 strains of HIV-1, which use CCR5 as a coreceptor. Alternative splicing results in multiple transcript variants that encode different isoforms. [provided by RefSeq, Jul 2013] | Chromosome | 17 |
| Location | 17q11.2-q1 |
| Start | 34198495 |
| End | 34207377 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 8883 |
| OMIM ID | 187011 |
| HGNC ID | HGNC:10632 |
| Unigene ID | Hs.514821 |
| Ensembl ID | ENSG00000161570 |
| PharmGKB ID | PA35564 |
mRNA Information
| mRNA ID | ?NM_002985.2 |
|---|---|
| Exon | join(1..144,1735..1846,7910..8883) | mRNA Sequence | Download Select all |
| Length | 1237 |
Protein Information
| Protein ID | NP_002976.2 |
|---|---|
| Protein Name | chemokine (C-C motif) ligand 5 |
| Molecular Wt. (Da) | 0 |
| Protein Sequence | Download Select all |
| Length | 91 |
| Uniprot ID | O14894 |
| Ensembl Protein ID | ENSP00000270560 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| S | Glycosylation | 27 |
| S | Glycosylation | 28 |
| P | Proteolytic Cleavage | 25 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 1462 | VCAN | 340 | NP_004376.2 | in vitro | 11083865 |
| 2532 | DARC | 192 | NP_001116423.1 | in vitro;in vivo | 1 208 119 517 416 740 |
| 2885 | GRB2 | 150 | NP_002077.1 | in vivo | 9009162 |
| 5284 | PIGR | 1436 | NP_002635.2 | in vivo | 11509627 |
| 6382 | SDC1 | 1718 | NP_002988.3 | in vivo | 14637022 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Chagas disease (American trypanosomiasis) | hsa05142 |
| Chemokine signaling pathway | hsa04062 |
| Cytokine-cytokine receptor interaction | hsa04060 |
| Cytosolic DNA-sensing pathway | hsa04623 |
| Epithelial cell signaling in Helicobacter pylori infection | hsa05120 |
| Herpes simplex infection | hsa05168 |
| Influenza A | hsa05164 |
| NOD-like receptor signaling pathway | hsa04621 |
| Prion diseases | hsa05020 |
| Rheumatoid arthritis | hsa05323 |
| TNF signaling pathway | hsa04668 |
| Toll-like receptor signaling pathway | hsa04620 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd00272 | 33-89 | Chemokine_CC |
| cl00134 | 33-89 | Chemokine superfamily |
| smart00199 | 31-88 | SCY |
| cd00169 | 33-88 | Chemokine |
| pfam00048 | 27-88 | IL8 |
| cd01119 | 33-88 | Chemokine_CC_DCCL |
| cd00273 | 34-89 | Chemokine_CXC |
| cd00271 | 34-89 | Chemokine_C |
| cd00274 | 41-89 | Chemokine_CX3C |
Ontology Information
| HPRD ID | 5411 |
|---|---|
| Molecular Class | Chemokine |
| Molecular Function | Protein binding (GO:0005515) |
| Biological Process | Cell surface receptor linked signal transduction (GO:0007166) |
Drug Information
No matching records could be found.