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General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| CCL7 | 6354 | chemokine (C-C motif) ligand 7 | 17 | MCP-3, NC28, FIC, MARC, MCP3 |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 22614322 | 2012 | Cell line : - Source : - Sample Type : CRC tumor and normal tissues No. of Sample : 30 Stage : - | PCR array analysis, Immunohistochemistry and real time PCR | Up-regulation | - | Correlation of CCL7 overexpression and its receptor expression with colon cancer liver metastasis suggests that CCL7 as a novel target in liver metastasis of CRC may be of potential clinical value for the prevention of hepatic recurrences. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Chemokine ligands, "Endogenous ligands" |
| Description | This gene encodes monocyte chemotactic protein 3, a secreted chemokine which attracts macrophages during inflammation and metastasis. It is a member of the C-C subfamily of chemokines which are characterized by having two adjacent cysteine residues. The protein is an in vivo substrate of matrix metalloproteinase 2, an enzyme which degrades components of the extracellular matrix. This gene is part of a cluster of C-C chemokine family members on chromosome 17q. [provided by RefSeq, Jul 2008] | Chromosome | 17 |
| Location | 17q11.2-q1 |
| Start | 32597235 |
| End | 32599261 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 2027 |
| OMIM ID | 158106 |
| HGNC ID | HGNC:10634 |
| Unigene ID | Hs.251526 |
| Ensembl ID | ENSG00000108688 |
| PharmGKB ID | PA35566 |
mRNA Information
| mRNA ID | ?NM_006273.3 |
|---|---|
| Exon | join(1..144,1735..1846,7910..8883) | mRNA Sequence | Download Select all |
| Length | 1237 |
Protein Information
| Protein ID | NP_006264.2 |
|---|---|
| Protein Name | chemokine (C-C motif) ligand 7 |
| Molecular Wt. (Da) | 0 |
| Protein Sequence | Download Select all |
| Length | 99 |
| Uniprot ID | O60271 |
| Ensembl Protein ID | ENSP00000262013 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| G | Proteolytic Cleavage | 37 |
| G | Proteolytic Cleavage | 27 |
| G | Proteolytic Cleavage | 37 |
| G | Proteolytic Cleavage | 27 |
| G | Proteolytic Cleavage | 37 |
| G | Proteolytic Cleavage | 27 |
| G | Proteolytic Cleavage | 37 |
| G | Proteolytic Cleavage | 27 |
| G | Proteolytic Cleavage | 37 |
| G | Proteolytic Cleavage | 27 |
| C | Disulfide Bridge | 44;69 |
| C | Disulfide Bridge | 45;85 |
| C | Disulfide Bridge | 34;59 |
| C | Disulfide Bridge | 35;75 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 9638 | FEZ1 | 9212 | NP_005094.1 | yeast 2-hybrid | 16169070 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Chemokine signaling pathway | hsa04062 |
| Cytokine-cytokine receptor interaction | hsa04060 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd00272 | 34-91 | Chemokine_CC |
| cl00134 | 34-91 | Chemokine superfamily |
| smart00199 | 31-90 | SCY |
| pfam00048 | 29-90 | IL8 |
| cd00169 | 34-91 | Chemokine |
| cd01119 | 34-91 | Chemokine_CC_DCCL |
| cd00274 | 24-94 | Chemokine_CX3C |
| cd00271 | 35-98 | Chemokine_C |
| cd00273 | 35-90 | Chemokine_CXC |
Ontology Information
| HPRD ID | 16037 |
|---|---|
| Molecular Class | Chemokine |
| Molecular Function | G-protein coupled receptor activity (GO:0004930) |
| Biological Process | Cell communication (GO:0007154); Signal transduction (GO:0007165) |
Drug Information
No matching records could be found.