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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 20164542 | 2010 | Cell line : - Source : - Sample Type : CRC tumor tissue No. of Sample : Colon of 16 colorectal cancer patients 10 Dukes B, 6 Dukes D stage Stage : Duke stage B,D | Tissue microarrays,Immunohistochemistry,Affymetrix whole genome expression analysis. | Up-regulation | - | A marker set containing 6 proteins (CCNA1, AR, TOP1, TGFB, HSP60, ERK1) was developed which could differentiate normal specimen, early and late stage CRC with high sensitivity and specificity. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. The cyclin encoded by this gene was shown to be expressed in testis and brain, as well as in several leukemic cell lines, and is thought to primarily function in the control of the germline meiotic cell cycle. This cyclin binds both CDK2 and CDC2 kinases, which give two distinct kinase activities, one appearing in S phase, the other in G2, and thus regulate separate functions in cell cycle. This cyclin was found to bind to important cell cycle regulators, such as Rb family proteins, transcription factor E2F-1, and the p21 family proteins. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] | Chromosome | 13 |
| Location | 13q12.3-q1 |
| Start | 37005257 |
| End | 37017019 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 11763 |
| OMIM ID | 604036 |
| HGNC ID | HGNC:1577 |
| Unigene ID | Hs.417050 |
| Ensembl ID | ENSG00000133101 |
| PharmGKB ID | PA26147 |
Protein Information
| Protein ID | NP_001104515.1 |
|---|---|
| Protein Name | cyclin A1 |
| Molecular Wt. (Da) | 0 |
| Protein Sequence | Download Select all |
| Length | 465 |
| Uniprot ID | Q12802 |
| Ensembl Protein ID | ENSP00000354718 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 983 | CDK1 | 302 | NP_001777.1 | in vivo | 8565853 |
| 993 | CDC25A | 305 | NP_001780.2 | in vivo | 10926775 |
| 1017 | CDK2 | 310 | NP_001789.2 | in vitro;in vivo;yeast 2-hybrid | 90 411 941 055 998 800 000 000 |
| 1026 | CDKN1A | 298 | NP_510867.1 | in vitro | 74 785 821 002 292 600 000 000 |
| 1027 | CDKN1B | 2867 | NP_004055.1 | in vivo | 747 858 210 022 926 |
| 1869 | E2F1 | 1806 | NP_005216.1 | in vitro;in vivo | 10022926 |
| 2547 | XRCC6 | 1071 | NP_001460.1 | in vitro;in vivo;yeast 2-hybrid | 15159402 |
| 4175 | MCM6 | 3485 | NP_005906.2 | in vitro | 15232106 |
| 4605 | MYBL2 | 3247 | NP_002457.1 | in vitro;in vivo | 11264176 |
| 5925 | RB1 | 1574 | NP_000312.2 | in vitro;in vivo | 10022926 |
| 5933 | RBL1 | 312 | NP_002886.2 | in vitro;in vivo | 10022926 |
| 5934 | RBL2 | 1576 | NP_005602.3 | in vitro;in vivo | 10022926 |
| 5936 | RBM4 | 3982 | NP_002887.2 | in vitro;in vivo;yeast 2-hybrid | 15159402 |
| 10399 | GNB2L1 | 1503 | NP_006089.1 | in vitro;in vivo;yeast 2-hybrid | 15159402 |
| 147011 | PROCA1 | 7131 | NP_689678.1 | in vitro;in vivo;yeast 2-hybrid | 15159402 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Acute myeloid leukemia | hsa05221 |
| AMPK signaling pathway | hsa04152 |
| Cell cycle | hsa04110 |
| Epstein-Barr virus infection | hsa05169 |
| Hepatitis B | hsa05161 |
| Pathways in cancer | hsa05200 |
| Progesterone-mediated oocyte maturation | hsa04914 |
| Transcriptional misregulation in cancer | hsa05202 |
| Viral carcinogenesis | hsa05203 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd00043 | 243-332 | CYCLIN |
| cl00050 | 243-332 | CYCLIN superfamily |
| cd00043 | 340-427 | CYCLIN |
| cl00050 | 340-427 | CYCLIN superfamily |
| pfam00134 | 214-340 | Cyclin_N |
| pfam02984 | 342-459 | Cyclin_C |
| smart00385 | 249-333 | CYCLIN |
| smart00385 | 346-428 | CYCLIN |
| COG5024 | 187-454 | COG5024 |
| COG5333 | 208-429 | CCL1 |
Ontology Information
| HPRD ID | 2238 |
|---|---|
| Molecular Class | Cell cycle control protein |
| Molecular Function | Transcription regulator activity (GO:0030528) |
| Biological Process | Regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism (GO:0019219) |
Drug Information
No matching records could be found.