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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 25962181 | 2015 | Cell line : - Source : Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University (Hangzhou, China). Sample Type : CRC tumor and normal tissue No. of Sample : 150 Stage : TNM Stage I-IV | real-time PCR, Transfection,Cell migration assay,Western blotting ,Immunohistochemistry | Up-regulation | - | Cyclin B1 could suppress the invasion and metastasis of colorectal cancer cells through regulating E-cadherin expression, |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | The protein encoded by this gene is a regulatory protein involved in mitosis. The gene product complexes with p34(cdc2) to form the maturation-promoting factor (MPF). Two alternative transcripts have been found, a constitutively expressed transcript and a cell cycle-regulated transcript, that is expressed predominantly during G2/M phase. The different transcripts result from the use of alternate transcription initiation sites. [provided by RefSeq, Jul 2008] | Chromosome | 5 |
| Location | 5q12 |
| Start | 68462837 |
| End | 68474072 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 11236 |
| OMIM ID | 123836 |
| HGNC ID | HGNC:1579 |
| Unigene ID | Hs.23960 |
| Ensembl ID | ENSG00000134057 |
| PharmGKB ID | PA95 |
mRNA Information
| mRNA ID | NM_031966.3 |
|---|---|
| Exon | join(1..274,899..1069,1164..1334,4261..4443,7242..7400, 7868..8104,8388..8528,10230..10340,10515..11236) | mRNA Sequence | Download Select all |
| Length | 2177 |
Protein Information
| Protein ID | NP_114172.1 |
|---|---|
| Protein Name | cyclin B1 |
| Molecular Wt. (Da) | 48207 |
| Protein Sequence | Download Select all |
| Length | 433 |
| Uniprot ID | P40199 |
| Ensembl Protein ID | ENSP00000199764 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| S | Phosphorylation | 126 |
| S | Phosphorylation | 128 |
| S | Phosphorylation | 133 |
| S | Phosphorylation | 147 |
| K | Acetylation | 73 |
| S | Phosphorylation | 69 |
| T | Phosphorylation | 321 |
| S | Phosphorylation | 35 |
| S | Phosphorylation | 9 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 672 | BRCA1 | 218 | NP_009231.2 | in vitro;in vivo | 924 435 011 278 247 |
| 983 | CDK1 | 302 | NP_001777.1 | in vitro;in vivo | 257 063 610 362 260 |
| 993 | CDC25A | 305 | NP_001780.2 | in vitro | 1836978 |
| 1026 | CDKN1A | 298 | NP_510867.1 | in vivo | 8662825 |
| 4208 | MEF2C | 2809 | NP_002388.2 | in vitro | 16478538 |
| 55872 | PBK | 17822 | NP_060962.2 | in vitro | 15541388 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Cell cycle | hsa04110 |
| FoxO signaling pathway | hsa04068 |
| Oocyte meiosis | hsa04114 |
| p53 signaling pathway | hsa04115 |
| Progesterone-mediated oocyte maturation | hsa04914 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd00043 | 201-290 | CYCLIN |
| cl00050 | 201-290 | CYCLIN superfamily |
| cd00043 | 298-383 | CYCLIN |
| cl00050 | 298-383 | CYCLIN superfamily |
| pfam00134 | 173-298 | Cyclin_N |
| pfam02984 | 300-418 | Cyclin_C |
| smart00385 | 207-291 | CYCLIN |
| smart00385 | 304-385 | CYCLIN |
| COG5024 | 154-413 | COG5024 |
| COG5333 | 208-361 | CCL1 |
Ontology Information
| HPRD ID | 11960 |
|---|---|
| Molecular Class | Cell cycle control protein |
| Molecular Function | Oxidoreductase activity (GO:0016491) |
| Biological Process | Metabolism (GO:0008152); Energy pathways (GO:0006091) |
Drug Information
No matching records could be found.