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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 24098334 | 2013 | Cell line : - Source : Department of Internal Medicine and Department of Paediatrics, Semmelweis University, Budapest, Hungary. Sample Type : CRC Tumor and adjecent normal tissue No. of Sample : Colorectal biopsies from healthy children (n1?=?14), healthy adults (n2?=?10), adult adenomas (n3?=?10) and CRCs (n4?=?10). Stage : - | Ki-67 immunohistochemistry , microarray, RT-PCR, TUNEL apoptosis assay. | Up-regulation | - | - |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK2, whose activity is required for cell cycle G1/S transition. This protein accumulates at the G1-S phase boundary and is degraded as cells progress through S phase. Overexpression of this gene has been observed in many tumors, which results in chromosome instability, and thus may contribute to tumorigenesis. This protein was found to associate with, and be involved in, the phosphorylation of NPAT protein (nuclear protein mapped to the ATM locus), which participates in cell-cycle regulated histone gene expression and plays a critical role in promoting cell-cycle progression in the absence of pRB. Two alternatively spliced transcript variants of this gene, which encode distinct isoforms, have been described. Two additional splice variants were reported but detailed nucleotide sequence information is not yet available. [provided by RefSeq, Jul 2008] | Chromosome | 19 |
| Location | 19q12 |
| Start | 30302805 |
| End | 30315224 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 12420 |
| OMIM ID | 123837 |
| HGNC ID | HGNC:1589 |
| Unigene ID | Hs.244723 |
| Ensembl ID | ENSG00000105173 |
| PharmGKB ID | PA96 |
mRNA Information
| mRNA ID | XM_005259370.2 |
|---|---|
| Exon | join(1..255,635..681,792..879,1072..1140,5240..5385, 5509..5644,8805..8951,9825..9920,10343..10454, 10549..10706,11758..12415) | mRNA Sequence | Download Select all |
| Length | 1912 |
Protein Information
| Protein ID | XP_005259427.1 |
|---|---|
| Protein Name | cyclin E1 |
| Molecular Wt. (Da) | 41608 |
| Protein Sequence | Download Select all |
| Length | 365 |
| Uniprot ID | Q9Y295 |
| Ensembl Protein ID | ENSP00000329715 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| S | Phosphorylation | 387 |
| T | Phosphorylation | 77 |
| S | Phosphorylation | 372 |
| T | Phosphorylation | 62 |
| S | Phosphorylation | 399 |
| T | Phosphorylation | 395 |
| T | Phosphorylation | 380 |
| S | Phosphorylation | 384 |
| S | Phosphorylation | 59;- |
| S | Phosphorylation | 44;- |
| S | Phosphorylation | 391 |
| S | Phosphorylation | 376 |
| S | Phosphorylation | 381 |
| S | Phosphorylation | 366 |
| S | Phosphorylation | 103 |
| S | Phosphorylation | 88 |
| S | Phosphorylation | 100 |
| S | Phosphorylation | 85 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 801 | CALM1 | 241 | NP_008819.1 | in vitro | 16627785 |
| 983 | CDK1 | 302 | NP_001777.1 | in vitro | 1388288 |
| 993 | CDC25A | 305 | NP_001780.2 | in vitro | 8617791 |
| 1018 | CDK3 | 446 | NP_001249.1 | in vivo | 11733001 |
| 1026 | CDKN1A | 298 | NP_510867.1 | in vitro | 8756624 |
| 5933 | RBL1 | 312 | NP_002886.2 | in vivo | 8230483 |
| 91768 | CABLES1 | 16461 | NP_001094089.1 | in vitro;in vivo | 11733001 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Cell cycle | hsa04110 |
| Hepatitis B | hsa05161 |
| Measles | hsa05162 |
| MicroRNAs in cancer | hsa05206 |
| Oocyte meiosis | hsa04114 |
| p53 signaling pathway | hsa04115 |
| Pathways in cancer | hsa05200 |
| PI3K-Akt signaling pathway | hsa04151 |
| Prostate cancer | hsa05215 |
| Small cell lung cancer | hsa05222 |
| Viral carcinogenesis | hsa05203 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd00043 | 144-234 | CYCLIN |
| cl00050 | 144-234 | CYCLIN superfamily |
| pfam00134 | 115-242 | Cyclin_N |
| smart00385 | 150-235 | CYCLIN |
| pfam02984 | 245-363 | Cyclin_C |
| cl00050 | 245-363 | CYCLIN superfamily |
| COG5024 | 114-242 | COG5024 |
Ontology Information
| HPRD ID | 11888 |
|---|---|
| Molecular Class | Cell cycle control protein |
| Molecular Function | Cell adhesion molecule activity (GO:0005194) |
| Biological Process | Cell communication (GO:0007154); Signal transduction (GO:0007165) |
Drug Information
No matching records could be found.