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General Information
- Evidence
- Gene
- mRNA
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- Protein
- PTM
- Enzyme
- PPi
- Pathway
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- Domain
- Ontology
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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 14592662 | 2003 | Cell line : - Source : Pathology Department of Norris Cancer Center/University of Southern California. Sample Type : Formalin-fixed, paraffin-embedded tissue No. of Sample : 90 Stage : TNM Stage I-IV | - | Up-regulation | - | Cyclin G overexpression is a frequent event in colorectal cancer. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | The eukaryotic cell cycle is governed by cyclin-dependent protein kinases (CDKs) whose activities are regulated by cyclins and CDK inhibitors. The protein encoded by this gene is a member of the cyclin family and contains the cyclin box. The encoded protein lacks the protein destabilizing (PEST) sequence that is present in other family members. Transcriptional activation of this gene can be induced by tumor protein p53. Two transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Jul 2008] | Chromosome | 5 |
| Location | 5q32-q34 |
| Start | 162864573 |
| End | 162872022 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 7450 |
| OMIM ID | 601578 |
| HGNC ID | HGNC:1592 |
| Unigene ID | Hs.79101 |
| Ensembl ID | ENSG00000113328 |
| PharmGKB ID | PA26157 |
mRNA Information
| mRNA ID | XM_011534685.1 |
|---|---|
| Exon | join(1..535,3809..4062,4617..4695,4776..4874,5105..5299, 6405..7747) | mRNA Sequence | Download Select all |
| Length | 2505 |
Protein Information
| Protein ID | XP_011532987.1 |
|---|---|
| Protein Name | cyclin G1 |
| Molecular Wt. (Da) | 18638 |
| Protein Sequence | Download Select all |
| Length | 161 |
| Uniprot ID | P46934 |
| Ensembl Protein ID | ENSP00000345530 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 1020 | CDK5 | 449 | NP_004926.1 | in vivo | 9013862 |
| 1029 | CDKN2A | 2542 | NP_478102.1 | in vitro;in vivo | 12556559 |
| 4193 | MDM2 | 1272 | NP_002383.2 | in vitro;in vivo | 12556559 |
| 4513 | MT-CO2 | 2470 | NP_776053.1 | in vivo | 10194136 |
| 5515 | PPP2CA | 8912 | NP_002706.1 | in vitro | 11956189 |
| 5524 | PPP2R4 | 2858 | NP_821068.1 | in vitro;in vivo | 8887688 |
| 7157 | TP53 | 1859 | NP_000537.3 | in vitro;in vivo | 12556559 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| MicroRNAs in cancer | hsa05206 |
| p53 signaling pathway | hsa04115 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd00043 | 59-142 | CYCLIN |
| cl00050 | 59-142 | CYCLIN superfamily |
| pfam00134 | 20-149 | Cyclin_N |
| smart00385 | 59-143 | CYCLIN |
| COG5024 | 66-143 | COG5024 |
| COG5333 | 48-172 | CCL1 |
Ontology Information
| HPRD ID | 4953 |
|---|---|
| Molecular Class | Cell cycle control protein |
| Molecular Function | Protein serine/threonine kinase activity (GO:0004674) |
| Biological Process | Cell communication (GO:0007154); Signal transduction (GO:0007165) |
Drug Information
No matching records could be found.