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General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| CCR2 | 729230 | chemokine (C-C motif) receptor 2 | 3 | CC-CKR-2, CKR2, MCP-1-R, CD192, FLJ78302 |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 22789541 | 2012 | Cell line : - Source : Erlangen Registry for Colorectal Carcinomas (ERCRC). Sample Type : CRC tumor and normal tissue No. of Sample : 39 Stage : UICC stage I-IV | Experimental Metastasis Assay,Vascular Permeability Assay | Up-regulation | - | CCL2-induced vascular permeability and metastasis is dependent on JAK2-Stat5 and p38MAPK signaling. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | GPCR / Class A : Chemokine receptors : C-C motif, "CD molecules" |
| Description | This gene encodes two isoforms of a receptor for monocyte chemoattractant protein-1, a chemokine which specifically mediates monocyte chemotaxis. Monocyte chemoattractant protein-1 is involved in monocyte infiltration in inflammatory diseases such as rheumatoid arthritis as well as in the inflammatory response against tumors. The receptors encoded by this gene mediate agonist-dependent calcium mobilization and inhibition of adenylyl cyclase. This gene is located in the chemokine receptor gene cluster region. Two alternatively spliced transcript variants are expressed by the gene. [provided by RefSeq, Mar 2009] | Chromosome | 3 |
| Location | 3p21 |
| Start | 46395235 |
| End | 46402413 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 7179 |
| OMIM ID | 601267 |
| HGNC ID | HGNC:1603 |
| Unigene ID | Hs.511794 |
| Ensembl ID | ENSG00000121807 |
| PharmGKB ID | PA26167 |
Protein Information
| Protein ID | NP_001116513.2 |
|---|---|
| Protein Name | chemokine (C-C motif) receptor 2 |
| Molecular Wt. (Da) | 0 |
| Protein Sequence | Download Select all |
| Length | 374 |
| Uniprot ID | P41597 |
| Ensembl Protein ID | ENSP00000292301 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
No matching records from HPRD source could be found.
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Chemokine signaling pathway | hsa04062 |
| Cytokine-cytokine receptor interaction | hsa04060 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| pfam00001 | 71-305 | 7tm_1 |
| PHA03087 | 21-312 | PHA03087 |
| PHA02638 | 3-313 | PHA02638 |
| PHA02834 | 48-316 | PHA02834 |
| PHA03235 | 79-364 | PHA03235 |
| PHA03234 | 76-317 | PHA03234 |
Ontology Information
| HPRD ID | 19667 |
|---|---|
| Molecular Class | Cytokine receptor |
| Molecular Function | Receptor activity (GO:0004872) |
| Biological Process | Inflammatory response (GO:0006954) |
Drug Information
No matching records could be found.